CN105147871A - External-use traditional Chinese medicine composition for treating hyperlipidaemia - Google Patents
External-use traditional Chinese medicine composition for treating hyperlipidaemia Download PDFInfo
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Abstract
Provided are an external-use traditional Chinese medicine composition for treating hyperlipidaemia and a preparation method of the external-use traditional Chinese medicine composition. The external-use traditional Chinese medicine composition for treating hyperlipidaemia is prepared from garden balsam stems, vervain, hematoxylon and alumen. The traditional Chinese medicine is used for treating hyperlipidaemia through external use, the treatment effect is good, the liver and kidney are not injured, and relapse is avoided after lipid lowering.
Description
Technical field
The present invention relates to the preparation for the treatment of hyperlipemia, more particularly, relate to external medicine composition for the treatment of hyperlipemia and preparation method thereof.
Background technology
Hyperlipemia is a kind of clinical common metabolic disease.Cardiovascular diseases has become first cause of death of China city and rural crowd, and the feature of China cardiovascular diseases is that apoplexy is occurred frequently and Incidence of CHD is lower, but recent 20 years Incidence of CHD and mortality rate progressively rise.Economic development faster big city as Beijing, monitoring result shows, from 1984 to 1999, hemorrhagic apoplexy sickness rate was obvious downward trend, and cerebral infarction sickness rate obviously rises, indicate that the sickness rate of the ischemic cardiovascular (comprising coronary heart disease and cerebral infarction) based on atherosclerosis raises.The cohort study of China shows, it is one of independent hazard factor of coronary heart disease and cerebral infarction that serum total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) raise.For this reason, must attach the importance early to the control of hyperlipemia.
Although Chinese population blood lipid level and hyperlipemia prevalence are still lower than most western countries, along with socioeconomic development, the raising of living standards of the people and the change of life style, the serum TC level of people's group mean just progressively raises.Meanwhile, with dyslipidemia closely-related diabetes and metabolism syndrome also very common in China.Hyperlipemia, as the performance of lipidosis, also belongs to metabolic disease, but it is then main at cardiovascular system to the infringement of health, causes coronary heart disease and other atherosclerosis.The main object of hyperlipemia therapeutic is to prevent and treat coronary heart disease, so should according to whether having the danger such as coronary heart disease or coronary heart disease disease, and with or without cardiovascular risk factors, carry out thoroughly evaluating in conjunction with blood lipid level, to determine the target level of remedy measures and blood fat.
Therefore, the treatment of hyperlipemia both should be included in population the generation preventing dyslipidemia, also should comprise the treatment of existing dyslipidemia person.The treatment of Western medicine to hyperlipemia is generally statin or the special class of shellfish, nicotinic acid and derivant and fish oil preparation etc.These fat-reducing medicaments have definite curative effect, but also there is untoward reaction: as the infringement to hepatic and renal function, muscle poison etc., and easily rebound after drug withdrawal, limit the performance of its Clinical practice and maximum utility.Hyperlipemia is as atherosclerotic main pathogenic, utilize external medicine composition, particularly herbal fumigation preparation, to preventing dyslipidemia, person develops into coronary heart disease and other atherosclerosis, and Lipid modulating is carried out to the patient of existing coronary heart disease and other atherosclerosis, have great importance.
The invention provides the external medicine composition for the treatment of hyperlipemia, effectively can treat hyperlipemia, without hepatorenal damage, and should not rebound.
Summary of the invention
The invention provides the external medicine composition for the treatment of hyperlipemia, effectively can treat hyperlipemia, without hepatorenal damage, and should not rebound.
For solving the problems of the technologies described above, the invention provides a kind of external medicine composition for the treatment of hyperlipemia, comprising following Chinese medicinal components: Herba speranskiae tuberculatae, Herba Verbenae, Lignum Sappan, Alumen.
As preferably, described Chinese medicine composition, based on parts by weight, comprises: Herba speranskiae tuberculatae 10-50 part, Herba Verbenae 10-50 part, Lignum Sappan 10-50 part, Alumen 10-50 part.
As preferred embodiment, described Chinese medicine composition, based on parts by weight, comprises: Herba speranskiae tuberculatae 50 parts, Herba Verbenae 50 parts, Lignum Sappan 50 parts, Alumen 50 parts.
As preferred embodiment, described Chinese medicine composition, based on parts by weight, comprises: Herba speranskiae tuberculatae 30 parts, Herba Verbenae 30 parts, Lignum Sappan 30 parts, Alumen 30 parts.
As preferred embodiment, described Chinese medicine composition, based on parts by weight, comprises: Herba speranskiae tuberculatae 10 parts, Herba Verbenae 10 parts, Lignum Sappan 10 parts, Alumen 10 parts.
As preferably, for pachylosis drying person, based on parts by weight, described external medicine composition also comprises following component: Pericarpium Granati 10-50 part, Aloe 10-50 part.
As preferably, for the dark and gloomy unglazed person of skin, based on parts by weight, described external medicine composition also comprises following component: Semen Vaccariae 10-50 part, Radix Angelicae Dahuricae 10-50 part.
As preferably, for cold-blooder, based on parts by weight, described external medicine composition also comprises following component: Folium Artemisiae Argyi 10-50 part, Olibanum 10-50 part, Myrrha 10-50 part.
As preferably, for tuberosity or increase survivor, based on parts by weight, described external medicine composition also comprises following component: Radix Salviae Miltiorrhizae 10-50 part, Sargassum 10-50 part, Thallus Laminariae (Thallus Eckloniae) 10-50 part, Spina Gleditsiae 10-50 part.
In external medicine composition of the present invention, the pharmacology of each raw medicinal material is as follows:
Herba speranskiae tuberculatae: acrid in the mouth, hardship, warm in nature.Slightly poisonous.Return liver, kidney channel.Effect expelling wind and removing dampness, removing toxic substances pain relieving.Cure mainly rheumatalgia.
Herba Verbenae: bitter in the mouth, cool in nature.Return liver, spleen channel.Effect promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema.Cure mainly lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria etc.
Lignum Sappan: sweet in the mouth, salty, pungent, property is put down.GUIXIN, Liver Channel.Effect is invigorated blood circulation and is cured the wound, and blood stasis dispelling stimulates the menstrual flow.Stasis, the stasis of blood is stagnant to swell and ache.
Alumen: sour in the mouth, puckery, cold in nature.Return lung, spleen, liver, large intestine channel.Effect external removing toxic substances parasite killing, dampness removing to stop itchin.Eczema pruritus is controlled in external, skin infection scabies.
Pericarpium Granati: sour in the mouth, puckery, warm in nature.Return large intestine channel.Effect relieving diarrhea with astringents, parasite killing, astringing to arrest bleeding.Cure mainly chronic diarrhea, chronic dysentery, abdominal pain due to worm stagnation, metrorrhagia, have blood in stool.
Aloe: bitter in the mouth, cold in nature.Return liver, stomach, large intestine channel.Effect liver heat removing, parasite killing.Cure mainly fidgety infantile convulsion, can external curing tinea skin ulcer etc.
Semen Vaccariae: bitter in the mouth, property is put down.Return liver, stomach warp.Effect promoting blood circulation to restore menstrual flow, stimulating milk secretion eliminating carbuncle, inducing diuresis for treating stranguria syndrome.Cure mainly blood stasis amenorrhea, acute mastitis swells and ache.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature.Return lung, stomach, large intestine channel.Effect is induced sweat cold expelling, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.Cure mainly anemofrigid cold, headache, sore and toxic, skin rheumatism pruritus, whitening etc.
Folium Artemisiae Argyi: acrid in the mouth, hardship, warm in nature.Slightly poisonous.Return liver,spleen,kidney warp.Effect warming the meridian for stopping bleeding, cold expelling regulating menstruation, antiabortive.Cure mainly out blood disorder, menoxenia, dysmenorrhea, frequent fetal movement etc.
Olibanum: acrid in the mouth, hardship, warm in nature.GUIXIN, liver, spleen channel.The pain relieving of effect blood-activating and qi-promoting, detumescence and promoting granulation.Cure mainly traumatic injury, skin infection carbuncle, the pain card etc. of qi depression to blood stasis.
Myrrha: acrid in the mouth, hardship, property is put down.GUIXIN, liver, spleen channel.Effect promoting blood circulation and stopping pain, detumescence and promoting granulation.Cure mainly the stagnant pain of the traumatic injury stasis of blood, ulcer sore pain, skin infection does not close up for a long time after bursting and the stagnant pain card of all stasis of bloods etc.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.GUIXIN, pericardium, Liver Channel.Effect promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, relieving restlessness is calmed the nerves.Cure mainly that blood stasis is pained, epigastric pain, lumps in the chest and abdomen, traumatic injury and rheumatism arthromyodynia etc.
Sargassum: salty in the mouth, cold in nature.Return liver, kidney channel.Effect eliminating phlegm and softening indurated mass, inducing diuresis to remove edema.Cure mainly goiter, scrofula, phlegm retention edema etc.
Thallus Laminariae (Thallus Eckloniae): salty in the mouth, cold in nature.Return liver, kidney channel.Effect eliminating phlegm and softening indurated mass, inducing diuresis to remove edema.Cure mainly goiter, scrofula, phlegm retention edema etc.
Spina Gleditsiae: acrid in the mouth, warm in nature.Effect detumescence and apocenosis, wind dispelling insecticide.For skin sore from the beginning of or the card of difficulty in discharging of pus and tinea, leprosy etc.The routed person of carbuncle avoids use.
The invention provides the external medicine composition for the treatment of hyperlipemia, it is characterized in that, can as herbal fumigation preparation.
Herbal fumigation preparation of the present invention is adopted to fumigate, herbal fumigation preparation is put into heating fumigating in fumigating device, under certain temperature and pressure effect, capillary permeability is increased, strengthen the sweat gland on skin, sebaceous gland to the absorption of Chinese medicine fumigant, accelerate blood flow, medicine is sent to therapeutic effect that whole body reaches warming YANG to expel cold, disperse blood stasis and dredge collateral, not only blood fat can be reduced, discharge turbid damp and the toxin of alluvial in body simultaneously, reach that damp eliminatingization is turbid, the therapeutic effect of nourishing face and eliminating toxin, and should not rebound after blood fat reducing.
External medicine composition of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., be prepared into the conventional external preparation of any one with the method for Chinese medicinal of routine, wherein, external preparation can be decoction, powder and sachet agent etc.
Another aspect of the present invention, also provides a kind of decoction of external medicine composition, its preparation method, comprises the following steps: (1), each for described Chinese medicine component is weighed in proportion and mixed; (2), above-mentioned mixed medical material is soaked 2-4 hour; (3), by medical material decocting 2-3 time after soaking, each 20-40 minute and filter; (4), the filtrate of twice filtration mixed and be concentrated into 300-500 milliliter; (5), above-mentioned concentrated solution is made decoction.
Another aspect of the present invention, also provides a kind of powder of external medicine composition, its preparation method, comprises the following steps: (1), each for described Chinese medicine component is weighed in proportion and mixed; (2), above-mentioned mixed medicine is pulverized, sieved; In this step after each component drug co-grinding, cross 100-200 mesh sieve.(3), the fine powder subpackage after shining will be crossed, load in non-woven fabrics medicated bag, make powder.
Another aspect of the present invention, also provides a kind of sachet agent of external medicine composition, its preparation method, comprises the following steps: (1), each for described Chinese medicine component is weighed in proportion, mixed; (2), mix rear loading in non-woven fabrics medicated bag, make sachet agent and save backup.
In addition, the external medicine composition that prepared by the present invention has carried out clinical trial.It is good that test proves that Chinese medicine composition of the present invention has lipid-lowering effect, not easily rebounds after blood fat reducing, without the advantage of hepatorenal damage, and also easy to use, preparation is simple.
Detailed description of the invention
Below the present invention is described in further detail, but not as a limitation of the invention.
Embodiment 1
Herba speranskiae tuberculatae 15 grams, Herba Verbenae 15 grams, Lignum Sappan 15 grams, Alumen 15 grams
Above-mentioned external medicine composition is prepared into decoction, and the preparation method of decoction comprises: each for described Chinese medicine component is weighed in proportion and mixed; Mixed medical material is soaked 3 hours; By the medical material decocting 2 times after soaking, each 30 minutes and filter; The filtrate of twice filtration is mixed and is concentrated into 400 milliliters; Above-mentioned concentrated solution is made decoction.
Embodiment 2
Herba speranskiae tuberculatae 10 grams, Herba Verbenae 10 grams, Lignum Sappan 10 grams, Alumen 10 grams
Above-mentioned external medicine composition is prepared into powder, and the preparation method of powder comprises: each for described Chinese medicine component is weighed in proportion and mixed; Above-mentioned mixed medicine is pulverized, crossed 100-200 mesh sieve; The fine powder subpackage after shining will be crossed, load in non-woven fabrics medicated bag, make powder.
Embodiment 3
Herba speranskiae tuberculatae 50 grams, Herba Verbenae 50 grams, Lignum Sappan 50 grams, Alumen 50 grams
Above-mentioned external medicine composition is prepared into sachet agent, and the preparation method of sachet agent comprises: each for described Chinese medicine component weighed in proportion, mix rear average portioning and become suitable size to load in non-woven fabrics medicated bag, make sachet agent and save backup.
Embodiment 4
Herba speranskiae tuberculatae 15 grams, Herba Verbenae 15 grams, Lignum Sappan 15 grams, Alumen 15 grams,
In the embodiment of the present invention, using the decoction of above-mentioned external medicine composition, powder or sachet agent as herbal fumigation product formulation use, herbal fumigation preparation can be put into the heating liner of fumigating device, fumigating bed temperature is set in 40 DEG C-45 DEG C, notes temperature in order to avoid scald, when temperature reaches preset temperature in stifling cabin, hyperlipidemia patient enters in cabin stifling, can fumigate every day or stifling 2-3 time weekly, can fumigate 15-20 minute, every 8 weeks is a course for the treatment of at every turn.
Embodiment 5
Herba speranskiae tuberculatae 15 grams, Herba Verbenae 15 grams, Lignum Sappan 15 grams, Alumen 15 grams, Pericarpium Granati 30 parts, Aloe 15 parts
In the embodiment of the present invention, using the decoction of above-mentioned external medicine composition, powder or sachet agent as herbal fumigation product formulation use, herbal fumigation preparation can be put into the heating liner of fumigating device, fumigating bed temperature is set in 40 DEG C-45 DEG C, notes temperature in order to avoid scald, when temperature reaches preset temperature in stifling cabin, hyperlipemia and the patient of pachylosis drying enter in cabin stifling, can fumigate every day or stifling 2-3 time weekly, can fumigate 15-20 minute, every 8 weeks is a course for the treatment of at every turn.
Embodiment 6
Herba speranskiae tuberculatae 15 grams, Herba Verbenae 15 grams, Lignum Sappan 15 grams, Alumen 15 grams, Semen Vaccariae 15 parts, the Radix Angelicae Dahuricae 15 parts
In the embodiment of the present invention, using the decoction of above-mentioned external medicine composition, powder or sachet agent as herbal fumigation product formulation use, herbal fumigation preparation can be put into the heating liner of fumigating device, fumigating bed temperature is set in 40 DEG C-45 DEG C, notes temperature in order to avoid scald, when temperature reaches preset temperature in stifling cabin, hyperlipemia and the dark and gloomy unglazed patient of skin enter in cabin stifling, can fumigate every day or stifling 2-3 time weekly, can fumigate 15-20 minute, every 8 weeks is a course for the treatment of at every turn.
Embodiment 7
Herba speranskiae tuberculatae 15 grams, Herba Verbenae 15 grams, Lignum Sappan 15 grams, Alumen 15 grams, Folium Artemisiae Argyi 15 parts, Olibanum 15 parts, Myrrha 15 parts
In the embodiment of the present invention, using the decoction of above-mentioned external medicine composition, powder or sachet agent as herbal fumigation product formulation use, herbal fumigation preparation can be put into the heating liner of fumigating device, fumigating bed temperature is set in 40 DEG C-45 DEG C, notes temperature in order to avoid scald, when temperature reaches preset temperature in stifling cabin, hyperlipemia and the patient be afraid of cold enter in cabin stifling, can fumigate every day or stifling 2-3 time weekly, can fumigate 15-20 minute, every 8 weeks is a course for the treatment of at every turn.
Embodiment 8
Herba speranskiae tuberculatae 15 grams, Herba Verbenae 15 grams, Lignum Sappan 15 grams, Alumen 15 grams, Radix Salviae Miltiorrhizae 15 parts, Sargassum 15 parts, Thallus Laminariae (Thallus Eckloniae) 15 parts, Spina Gleditsiae 15 parts.
In the embodiment of the present invention, using the decoction of above-mentioned external medicine composition, powder or sachet agent as herbal fumigation product formulation use, herbal fumigation preparation can be put into the heating liner of fumigating device, fumigating bed temperature is set in 40 DEG C-45 DEG C, notes temperature in order to avoid scald, when temperature reaches preset temperature in stifling cabin, the patient of hyperlipemia companion's tuberosity or hypertrophy enters in cabin stifling, can fumigate every day or stifling 2-3 time weekly, can fumigate 15-20 minute, every 8 weeks is a course for the treatment of at every turn.
Some patients data is as follows:
Zhang, female, 52 years old, people from Beijing, in January, 2014 was diagnosed as " hypercholesterolemia ", cholesterol (TC) 6.50mmol/L, uses embodiment 1 external curing after 2 months, cholesterol (TC) 4.05mmol/L, recovers normal.
Stone, man, 46 years old, people from Hebei province, in May, 2014 was diagnosed as " hypertriglyceridemia ", triglyceride (TG) 3.70mmol/L, uses embodiment 2 external curing after 2 months, triglyceride (TG) 1.03mmol/L, recovers normal.
Money, man, 43 years old, people from Beijing, in June, 2014 is diagnosed as " hyperlipemia ", low density lipoprotein, LDL (LDL-C) 4.44mmol/L, use embodiment 3 external curing after 3 months, low density lipoprotein, LDL (LDL-C) 2.19mmol/L, recover normal.
Lee, female, 56 years old, people from Shandong Province, in April, 2014 is diagnosed as " combined hyperlipidemia familial ", cholesterol (TC) 6.44mmol/L, triglyceride (TG) 3.26mmol/L, uses embodiment 4 herbal fumigation preparation after 2 months, cholesterol (TC) 4.95mmol/L, triglyceride (TG) 1.36mmol/L, all recover normal.
Thank certain, female, 63 years old, people from Tianjin, was diagnosed as " combined hyperlipidemia familial " in March, 2014, cholesterol (TC) 8.03mmol/L, triglyceride (TG) 3.55mmol/L, companion's pachylosis is dry, uses embodiment 5 herbal fumigation preparation after 2 months, cholesterol (TC) 4.79mmol/L, triglyceride (TG) 1.33mmol/L, all recover normal, and skin wet recover normal.
Field, man, 32 years old, people from Guizhou Province, was diagnosed as " combined hyperlipidemia familial " in May, 2014, cholesterol (TC) 6.57mmol/L, triglyceride (TG) 3.73mmol/L, companion's skin is dark and gloomy unglazed, uses embodiment 6 herbal fumigation preparation after 2 months, cholesterol (TC) 4.51mmol/L, triglyceride (TG) 1.29mmol/L, all recover normal, and whiteness of skin.
Grandson, female, 43 years old, people from Heilungkiang, was diagnosed as " combined hyperlipidemia familial " in June, 2014, cholesterol (TC) 7.14mmol/L, triglyceride (TG) 3.85mmol/L, time sense coldness of the body cold extremities, use embodiment 7 herbal fumigation preparation after 2 months, cholesterol (TC) 4.65mmol/L, triglyceride (TG) 1.24mmol/L, all recover normal, and sensation of not now being afraid of cold.
Wu, man, 59 years old, people from Anhui Province, was diagnosed as " combined hyperlipidemia familial " in April, 2014, cholesterol (TC) 6.91mmol/L, triglyceride (TG) 3.64mmol/L, companion oxter unknown cause lump 3cm × 2cm, uses embodiment 8 herbal fumigation preparation after 2 months, cholesterol (TC) 4.53mmol/L, triglyceride (TG) 1.22mmol/L, all recover normal, and lump disappear.
Adopt herbal fumigation preparation of the present invention, hyperlipemia is treated.Therapeutic outcome is as follows: patient 30 example, wherein male patient 15 example, female patient 15 example.Age 16-70 year.After this programme treats 2 months, take a turn for the better 26 examples, effective 4 examples, improvement rate 86.67%, effective percentage 100%.
Certainly, be more than the preferred embodiment of the present invention.It should be pointed out that for those skilled in the art, under the prerequisite not departing from its general principles, can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.
Claims (10)
1. treat an external medicine composition for hyperlipemia, it is characterized in that, comprise each component of following weight portion: Herba speranskiae tuberculatae, Herba Verbenae, Lignum Sappan, Alumen, described Herba speranskiae tuberculatae 10-50 part, Herba Verbenae 10-50 part, Lignum Sappan 10-50 part, Alumen 10-50 part.
2. external medicine composition according to claim 1, is characterized in that, Herba speranskiae tuberculatae 30 parts, Herba Verbenae 30 parts, Lignum Sappan 30 parts, Alumen 30 parts.
3. external medicine composition according to claim 1, is characterized in that, based on parts by weight, described Chinese medicine composition also comprises following component: Pericarpium Granati 10-50 part, Aloe 10-50 part.
4. external medicine composition according to claim 1, is characterized in that, based on parts by weight, described Chinese medicine composition also comprises following component: Semen Vaccariae 10-50 part, Radix Angelicae Dahuricae 10-50 part.
5. external medicine composition according to claim 1, is characterized in that, based on parts by weight, described Chinese medicine composition also comprises following component: Folium Artemisiae Argyi 10-50 part, Olibanum 10-50 part, Myrrha 10-50 part.
6. external medicine composition according to claim 1, is characterized in that, based on parts by weight, described Chinese medicine composition also comprises following component: Radix Salviae Miltiorrhizae 10-50 part, Sargassum 10-50 part, Thallus Laminariae (Thallus Eckloniae) 10-50 part, Spina Gleditsiae 10-50 part.
7. the external medicine composition according to the arbitrary claim of claim 1 to 6, it is characterized in that, described Chinese medicine composition is herbal fumigation preparation, decoction, powder or sachet agent.
8. external medicine composition according to claim 7, is characterized in that, described external medicine composition is prepared into decoction, and its preparation method comprises the following steps:
S1, each for described Chinese medicine component is weighed in proportion and mixed;
S2, above-mentioned mixed medical material is soaked 2-4 hour;
S3, by medical material decocting 2-3 time after soaking, each 20-40 minute and filter;
S4, the filtrate of twice filtration mixed and is concentrated into 300-500 milliliter;
S5, above-mentioned concentrated solution is made decoction.
9. external medicine composition according to claim 7, is characterized in that, described external medicine composition is prepared into powder, and its preparation method comprises the following steps:
S1, each for described Chinese medicine component is weighed in proportion and mixed;
S2, above-mentioned mixed medicine is pulverized, sieved; In this step S2 after each component drug co-grinding, cross 100-200 mesh sieve.
S3, the fine powder subpackage after shining will be crossed, and load in non-woven fabrics medicated bag, make powder.
10. external medicine composition according to claim 7, is characterized in that, described external medicine composition is prepared into sachet agent, and its preparation method comprises the following steps:
S1, each for described Chinese medicine component is weighed in proportion, mixed;
Load in non-woven fabrics medicated bag after S2, mixing, make sachet agent and save backup.
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CN111905041A (en) * | 2020-08-10 | 2020-11-10 | 王玉梅 | Traditional Chinese medicine composition for treating hyperlipidemia by steam therapy and preparation method thereof |
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CN1724002A (en) * | 2005-07-13 | 2006-01-25 | 马淑珍 | Medicinal composition, and its pharmaceutical use |
CN103751537A (en) * | 2014-01-05 | 2014-04-30 | 张波 | Preparation method of traditional Chinese medicine for treating hyperlipemia caused by overeating deep-fried food |
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