CL2022003621A1 - Métodos de medición de carfilzomib - Google Patents

Métodos de medición de carfilzomib

Info

Publication number
CL2022003621A1
CL2022003621A1 CL2022003621A CL2022003621A CL2022003621A1 CL 2022003621 A1 CL2022003621 A1 CL 2022003621A1 CL 2022003621 A CL2022003621 A CL 2022003621A CL 2022003621 A CL2022003621 A CL 2022003621A CL 2022003621 A1 CL2022003621 A1 CL 2022003621A1
Authority
CL
Chile
Prior art keywords
carfilzomib
sample
measurement methods
concentration
analytical
Prior art date
Application number
CL2022003621A
Other languages
English (en)
Inventor
Harper Emma
Elyse Cohen Dawn
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CL2022003621A1 publication Critical patent/CL2022003621A1/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En el presente documento se proporcionan métodos mejorados para medir la concentración de carfilzomib en una muestra. El método comprende las etapas de diluir la muestra con un diluyente que comprende agua y menos del 50% en volumen de acetonitrilo para formar una muestra analítica; y someter la muestra analítica a cromatografía de líquidos de alto rendimiento (HPLC) para determinar la concentración de carfilzomib en la muestra.
CL2022003621A 2020-06-19 2022-12-16 Métodos de medición de carfilzomib CL2022003621A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063041141P 2020-06-19 2020-06-19

Publications (1)

Publication Number Publication Date
CL2022003621A1 true CL2022003621A1 (es) 2023-07-07

Family

ID=77071733

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2022003621A CL2022003621A1 (es) 2020-06-19 2022-12-16 Métodos de medición de carfilzomib

Country Status (12)

Country Link
US (1) US20230349863A1 (es)
EP (1) EP4168148A1 (es)
JP (1) JP2023530942A (es)
KR (1) KR20230029789A (es)
CN (1) CN115715224A (es)
AU (1) AU2021292417A1 (es)
BR (1) BR112022025889A2 (es)
CA (1) CA3187142A1 (es)
CL (1) CL2022003621A1 (es)
IL (1) IL298857A (es)
MX (1) MX2022016131A (es)
WO (1) WO2021257941A1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR087863A1 (es) * 2012-05-08 2014-04-23 Onyx Therapeutics Inc Procedimientos para la formacion de complejos de ciclodextrina para formular inhibidores del proteasoma peptidico
WO2016185450A1 (en) * 2015-05-21 2016-11-24 Laurus Labs Private Limited An improved processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof
CN107402259B (zh) * 2016-05-18 2020-10-13 石药集团中奇制药技术（石家庄）有限公司 卡非佐米中手性异构体的检测方法
CN110964085B (zh) * 2018-09-28 2023-07-07 扬子江药业集团有限公司 一种卡非佐米及其衍生物的制备方法
WO2020255059A1 (en) * 2019-06-19 2020-12-24 Laurus Labs Limited Purification method of carfilzomib

Also Published As

Publication number Publication date
WO2021257941A1 (en) 2021-12-23
KR20230029789A (ko) 2023-03-03
JP2023530942A (ja) 2023-07-20
CN115715224A (zh) 2023-02-24
AU2021292417A1 (en) 2023-01-19
MX2022016131A (es) 2023-02-09
EP4168148A1 (en) 2023-04-26
IL298857A (en) 2023-02-01
CA3187142A1 (en) 2021-12-23
BR112022025889A2 (pt) 2023-01-10
US20230349863A1 (en) 2023-11-02

Similar Documents

Publication Publication Date Title
PE20141768A1 (es) Sistema para el analisis quimico cuantitativo de muestras, en particular en el campo medico, con calibracion de la respuesta instrumental de la instrumentacion usada para detectar la informacion cuantitativa de los analitos presentes en las muestras analizadas, y el metodo correspondiente
Shen et al. Hydrogen sulfide measurement using sulfide dibimane: critical evaluation with electrospray ion trap mass spectrometry
MX2018014867A (es) Metodo de espectrometria de masa para deteccion y cuantificacion de metabolitos.
Kaufmann et al. Easy and fast method for the determination of biogenic amines in fish and fish products with liquid chromatography coupled to orbitrap tandem mass spectrometry
CN103869015B (zh) 一种定量检测白酒中14种反式-2-烯醛类和二烯醛类化合物的方法
MX2014010312A (es) Metodos analiticos mejorados para analizar y determinar impurezas en dianhidrogalactitol.
CL2022003621A1 (es) Métodos de medición de carfilzomib
Zhou et al. Combination of microporous membrane liquid–liquid extraction and capillary electrophoresis for the analysis of aromatic amines in water samples
CN108535395B (zh) 一种同时快速测定保健酒中32种游离脂肪酸的方法
AR120312A1 (es) Método para la detección de materia orgánica sólida y fluidos en una roca shale mediante rmn de campo bajo
Gao et al. Separation of phospholipids by capillary zone electrophoresis with indirect ultraviolet detection
Wang et al. Detection of biogenic amines in C57BL/6 mice brain by capillary electrophoresis electrokinetic supercharging
Zhang et al. A highly sensitive method for analyzing marker phytoplankton pigments: Ultra‐high‐performance liquid chromatography‐tandem triple quadrupole mass spectrometry
CN103983729B (zh) 一种气相色谱-质谱检测土壤溶液中酰基高丝氨酸内酯的方法
CN105548402A (zh) 高效液相色谱串联二级质谱技术检测尿液中8-羟基脱氧鸟苷和8-羟基鸟苷的试剂盒
CN105527368A (zh) 一种高效液相色谱串联二级质谱技术检测尿液中8-羟基脱氧鸟苷和8-羟基鸟苷的方法
BR112018010634A2 (pt) método analítico
US7992428B2 (en) Method and device for ingredient analysis
CN108088917B (zh) 萘二磺酸同分异构体的检测方法
BR112022019406A2 (pt) Um método para detectar a presença de espécies de micobactérias em uma amostra de teste
Sahoo et al. Solid phase extraction and quantification of diclofenac sodium in human plasma by liquid chromatography-tandem mass spectrometry
Zhang et al. Analysis of reproducibility and variability from a frozen sample aliquotter by metabolomics analysis
CN108107026B (zh) 一种化学衍生荧光-质谱分析识别磺胺类药物的方法
AR096629A1 (es) Métodos para analizar composiciones de cisteamina
AR102355A1 (es) Determinación de analitos en la matriz de muestra por extracción de solvente