BR112022025889A2 - Métodos de medição de carfilzomibe - Google Patents

Métodos de medição de carfilzomibe

Info

Publication number
BR112022025889A2
BR112022025889A2 BR112022025889A BR112022025889A BR112022025889A2 BR 112022025889 A2 BR112022025889 A2 BR 112022025889A2 BR 112022025889 A BR112022025889 A BR 112022025889A BR 112022025889 A BR112022025889 A BR 112022025889A BR 112022025889 A2 BR112022025889 A2 BR 112022025889A2
Authority
BR
Brazil
Prior art keywords
carfilzomib
sample
measurement methods
concentration
analytical
Prior art date
Application number
BR112022025889A
Other languages
English (en)
Inventor
Harper Emma
Elyse Cohen Dawn
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BR112022025889A2 publication Critical patent/BR112022025889A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

MÉTODOS DE MEDIÇÃO DE CARFILZOMIBE. São proporcionados neste documento métodos melhorados para medir a concentração de carfilzomibe em uma amostra. O método compreende as etapas de diluição da amostra com um diluente compreendendo água e menos de 50% em volume de acetonitrila para formar uma amostra analítica; e submeter a amostra analítica a cromatografia líquida de alto desempenho (HPLC) para determinar a concentração de carfilzomibe na amostra.
BR112022025889A 2020-06-19 2021-06-18 Métodos de medição de carfilzomibe BR112022025889A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063041141P 2020-06-19 2020-06-19
PCT/US2021/038002 WO2021257941A1 (en) 2020-06-19 2021-06-18 Methods of measuring carfilzomib

Publications (1)

Publication Number Publication Date
BR112022025889A2 true BR112022025889A2 (pt) 2023-01-10

Family

ID=77071733

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022025889A BR112022025889A2 (pt) 2020-06-19 2021-06-18 Métodos de medição de carfilzomibe

Country Status (12)

Country Link
US (1) US20230349863A1 (pt)
EP (1) EP4168148A1 (pt)
JP (1) JP2023530942A (pt)
KR (1) KR20230029789A (pt)
CN (1) CN115715224A (pt)
AU (1) AU2021292417A1 (pt)
BR (1) BR112022025889A2 (pt)
CA (1) CA3187142A1 (pt)
CL (1) CL2022003621A1 (pt)
IL (1) IL298857A (pt)
MX (1) MX2022016131A (pt)
WO (1) WO2021257941A1 (pt)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130303482A1 (en) * 2012-05-08 2013-11-14 Onyx Therapeutics, Inc. Cylodextrin Complexation Methods for Formulating Peptide Proteasome Inhibitors
ES2888800T3 (es) * 2015-05-21 2022-01-07 Laurus Labs Ltd Procedimiento mejorado para la preparación de carfilzomib o sales farmacéuticamente aceptables del mismo
CN107402259B (zh) * 2016-05-18 2020-10-13 石药集团中奇制药技术（石家庄）有限公司 卡非佐米中手性异构体的检测方法
CN110964085B (zh) * 2018-09-28 2023-07-07 扬子江药业集团有限公司 一种卡非佐米及其衍生物的制备方法
WO2020255059A1 (en) * 2019-06-19 2020-12-24 Laurus Labs Limited Purification method of carfilzomib

Also Published As

Publication number Publication date
MX2022016131A (es) 2023-02-09
CL2022003621A1 (es) 2023-07-07
KR20230029789A (ko) 2023-03-03
CA3187142A1 (en) 2021-12-23
US20230349863A1 (en) 2023-11-02
CN115715224A (zh) 2023-02-24
WO2021257941A1 (en) 2021-12-23
IL298857A (en) 2023-02-01
JP2023530942A (ja) 2023-07-20
AU2021292417A1 (en) 2023-01-19
EP4168148A1 (en) 2023-04-26

Similar Documents

Publication Publication Date Title
Soule et al. Environmental metabolomics: Analytical strategies
Zhang et al. Evaluation of mobile phase characteristics on three zwitterionic columns in hydrophilic interaction liquid chromatography mode for liquid chromatography-high resolution mass spectrometry based untargeted metabolite profiling of Leishmania parasites
Farrés et al. Chemometric evaluation of Saccharomyces cerevisiae metabolic profiles using LC–MS
Koek et al. Microbial metabolomics with gas chromatography/mass spectrometry
Ivanov et al. Capillary electrophoresis coupled with 1, 1′-thiocarbonyldiimidazole derivatization for the rapid detection of total homocysteine and cysteine in human plasma
BRPI0509068A (pt) métodos para determinar quantitativamente heparinas de constituição especìfica ou heparinas de baixo peso molecular usando hplc
Go et al. Analysis of hypoxanthine and lactic acid levels in vitreous humor for the estimation of post-mortem interval (PMI) using LC–MS/MS
Zhou et al. Combination of microporous membrane liquid–liquid extraction and capillary electrophoresis for the analysis of aromatic amines in water samples
Wang et al. Rapid microchip-based FAIMS determination of trimethylamine, an indicator of pork deterioration
Kassler et al. Ultrahigh‐performance liquid chromatography/electrospray ionization linear ion trap Orbitrap mass spectrometry of antioxidants (amines and phenols) applied in lubricant engineering
Schmidberger et al. Advanced online monitoring of cell culture off‐gas using proton transfer reaction mass spectrometry
BR112022025889A2 (pt) Métodos de medição de carfilzomibe
Mairinger et al. GC–QTOFMS with a low-energy electron ionization source for advancing isotopologue analysis in 13 C-based metabolic flux analysis
CN108535395B (zh) 一种同时快速测定保健酒中32种游离脂肪酸的方法
Gao et al. Separation of phospholipids by capillary zone electrophoresis with indirect ultraviolet detection
Warren Development of liquid chromatography mass spectrometry method for analysis of organic N monomers in soil
Karlsson et al. Determination of airborne isocyanates as di-n-butylamine derivatives using liquid chromatography and tandem mass spectrometry
See et al. Determination of creatine and phosphocreatine in muscle biopsy samples by capillary electrophoresis with contactless conductivity detection
Kvitvang et al. Quantitative analysis of amino and organic acids by methyl chloroformate derivatization and GC-MS/MS analysis
Albahrani et al. Comparison of three commercial calibrators for alpha-tocopherol using liquid chromatography–tandem mass spectrometry
BR0314654A (pt) Método de determinação de grupamentos especìficos que constituem as heparinas ou as heparinas de baixo peso molecular
Xu et al. Development of a capillary zone electrophoresis method for determination of mebendazole and levamisole hydrochloride in a combined tablet and a comparison with a LC method
CN105527368A (zh) 一种高效液相色谱串联二级质谱技术检测尿液中8-羟基脱氧鸟苷和8-羟基鸟苷的方法
BR112019007138A2 (pt) método e sistema de análise para testagem de uma amostra
BR112018010634A2 (pt) método analítico