CL2022002466A1 - Agonista del receptor de glp-1, composición farmacéutica, y método de preparación - Google Patents
Agonista del receptor de glp-1, composición farmacéutica, y método de preparaciónInfo
- Publication number
- CL2022002466A1 CL2022002466A1 CL2022002466A CL2022002466A CL2022002466A1 CL 2022002466 A1 CL2022002466 A1 CL 2022002466A1 CL 2022002466 A CL2022002466 A CL 2022002466A CL 2022002466 A CL2022002466 A CL 2022002466A CL 2022002466 A1 CL2022002466 A1 CL 2022002466A1
- Authority
- CL
- Chile
- Prior art keywords
- same
- pharmaceutical composition
- glp
- receptor agonist
- preparing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/44—Palladium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention relates to a novel compound useful as an agent for treatment or prophylaxis of various metabolic diseases such as obesity or diabetes and hyperlipidemia, by means of excellent GLP-1 agonist activity and an excellent DMPK profile, an isomer thereof or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound, and a method for preparing the compound.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20200033477 | 2020-03-18 | ||
KR1020210034452A KR102563111B1 (ko) | 2020-03-18 | 2021-03-17 | Glp-1 수용체 효능제, 이를 포함하는 약학적 조성물 및 이의 제조방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2022002466A1 true CL2022002466A1 (es) | 2023-03-03 |
Family
ID=77771773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2022002466A CL2022002466A1 (es) | 2020-03-18 | 2022-09-09 | Agonista del receptor de glp-1, composición farmacéutica, y método de preparación |
Country Status (13)
Country | Link |
---|---|
US (1) | US20230203021A1 (es) |
AU (1) | AU2021237185B2 (es) |
BR (1) | BR112022018646A2 (es) |
CA (1) | CA3171173A1 (es) |
CL (1) | CL2022002466A1 (es) |
CO (1) | CO2022014271A2 (es) |
IL (1) | IL296336A (es) |
JO (1) | JOP20220213A1 (es) |
MX (1) | MX2022011349A (es) |
PE (1) | PE20230175A1 (es) |
TW (1) | TWI825398B (es) |
WO (1) | WO2021187886A1 (es) |
ZA (1) | ZA202210199B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI751585B (zh) | 2019-06-28 | 2022-01-01 | 美商美國禮來大藥廠 | 類升糖素肽1受體促效劑 |
JP2022552735A (ja) | 2019-10-25 | 2022-12-19 | ギリアード サイエンシーズ, インコーポレイテッド | Glp-1r調節化合物 |
WO2022028572A1 (en) | 2020-08-06 | 2022-02-10 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
EP4204415A1 (en) | 2020-08-28 | 2023-07-05 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
WO2022109182A1 (en) | 2020-11-20 | 2022-05-27 | Gilead Sciences, Inc. | Polyheterocyclic glp-1 r modulating compounds |
EP4304711A1 (en) | 2021-03-11 | 2024-01-17 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
US20240217966A1 (en) | 2021-03-24 | 2024-07-04 | Shionogi & Co., Ltd. | Pharmaceutical composition containing glp-1 receptor agonist having fused ring |
WO2022216094A1 (ko) * | 2021-04-08 | 2022-10-13 | 주식회사 엘지화학 | Glp-1 수용체 효능제, 이를 포함하는 약학적 조성물 및 이의 제조방법 |
MX2023012418A (es) | 2021-04-21 | 2023-10-31 | Gilead Sciences Inc | Compuestos de modulacion de glp-1r de carboxi-bencimidazol. |
TWI843104B (zh) | 2021-05-20 | 2024-05-21 | 美商美國禮來大藥廠 | 類升糖素肽1受體促效劑 |
CN118215478A (zh) | 2021-09-08 | 2024-06-18 | 盐野义制药株式会社 | 用于预防和治疗与抗肥胖作用有关的疾病的药物 |
CA3236708A1 (en) | 2021-10-25 | 2023-05-04 | Terns Pharmaceuticals, Inc. | Compounds as glp-1r agonists |
WO2023222084A1 (zh) * | 2022-05-20 | 2023-11-23 | 成都地奥九泓制药厂 | 苯并咪唑或氮杂苯并咪唑类化合物、其制备方法及其应用 |
WO2024063140A1 (ja) * | 2022-09-22 | 2024-03-28 | 塩野義製薬株式会社 | Glp-1受容体アゴニスト作用を有する単環化合物 |
WO2024102625A1 (en) | 2022-11-11 | 2024-05-16 | Eli Lilly And Company | Glucagon-like peptide 1 receptor agonists |
WO2024107781A1 (en) | 2022-11-16 | 2024-05-23 | Eli Lilly And Company | Glucagon-like peptide 1 receptor agonists |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101564806B1 (ko) * | 2010-05-13 | 2015-10-30 | 암젠 인크 | Pde10 저해제로서 유용한 질소 헤테로시클릭 화합물 |
CN104080767A (zh) * | 2011-12-12 | 2014-10-01 | 瑞塞普托斯公司 | 新的glp-1受体调节剂 |
RS63849B9 (sr) * | 2016-12-16 | 2023-06-30 | Pfizer | Agonisti glp-1 receptora i njihova upotreba |
CN110799190B (zh) * | 2017-03-27 | 2024-04-19 | 卡都瑞恩医药有限公司 | 杂环化合物 |
RU2765721C1 (ru) * | 2018-06-15 | 2022-02-02 | Пфайзер Инк. | Агонисты glp-1 рецептора и их применение |
TWI751585B (zh) * | 2019-06-28 | 2022-01-01 | 美商美國禮來大藥廠 | 類升糖素肽1受體促效劑 |
JP2022552735A (ja) * | 2019-10-25 | 2022-12-19 | ギリアード サイエンシーズ, インコーポレイテッド | Glp-1r調節化合物 |
EP4069686A4 (en) * | 2019-12-02 | 2022-11-09 | Hyundai Pharm Co., Ltd. | GLP-1 RECEPTOR AGONIST |
-
2021
- 2021-03-17 CA CA3171173A patent/CA3171173A1/en active Pending
- 2021-03-17 PE PE2022001989A patent/PE20230175A1/es unknown
- 2021-03-17 US US17/912,129 patent/US20230203021A1/en active Pending
- 2021-03-17 WO PCT/KR2021/003287 patent/WO2021187886A1/ko active Application Filing
- 2021-03-17 JO JOP/2022/0213A patent/JOP20220213A1/ar unknown
- 2021-03-17 IL IL296336A patent/IL296336A/en unknown
- 2021-03-17 BR BR112022018646A patent/BR112022018646A2/pt unknown
- 2021-03-17 AU AU2021237185A patent/AU2021237185B2/en active Active
- 2021-03-17 TW TW110109865A patent/TWI825398B/zh active
- 2021-03-17 MX MX2022011349A patent/MX2022011349A/es unknown
-
2022
- 2022-09-09 CL CL2022002466A patent/CL2022002466A1/es unknown
- 2022-09-14 ZA ZA2022/10199A patent/ZA202210199B/en unknown
- 2022-10-05 CO CONC2022/0014271A patent/CO2022014271A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW202200559A (zh) | 2022-01-01 |
IL296336A (en) | 2022-11-01 |
PE20230175A1 (es) | 2023-02-01 |
TWI825398B (zh) | 2023-12-11 |
CO2022014271A2 (es) | 2022-10-21 |
WO2021187886A1 (ko) | 2021-09-23 |
JOP20220213A1 (ar) | 2023-01-30 |
AU2021237185B2 (en) | 2023-11-30 |
CA3171173A1 (en) | 2021-09-23 |
MX2022011349A (es) | 2022-11-10 |
BR112022018646A2 (pt) | 2022-11-08 |
ZA202210199B (en) | 2023-06-28 |
JP2023520181A (ja) | 2023-05-16 |
AU2021237185A1 (en) | 2022-10-06 |
US20230203021A1 (en) | 2023-06-29 |
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