CL2022001325A1 - Terapia combinada que comprende un inhibidor de alk2 y un inhibidor de jak2. - Google Patents

Terapia combinada que comprende un inhibidor de alk2 y un inhibidor de jak2.

Info

Publication number
CL2022001325A1
CL2022001325A1 CL2022001325A CL2022001325A CL2022001325A1 CL 2022001325 A1 CL2022001325 A1 CL 2022001325A1 CL 2022001325 A CL2022001325 A CL 2022001325A CL 2022001325 A CL2022001325 A CL 2022001325A CL 2022001325 A1 CL2022001325 A1 CL 2022001325A1
Authority
CL
Chile
Prior art keywords
inhibitor
alk2
jak2
combination therapy
jak2 inhibitor
Prior art date
Application number
CL2022001325A
Other languages
English (en)
Inventor
Yaoyu Chen
Matthew C Stubbs
Ying-Nan Pan Chen
Michelle Pusey
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CL2022001325A1 publication Critical patent/CL2022001325A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Terapia de combinación que comprende un inhibidor de ALK2 y un inhibidor de JAK2; combinación farmacéutica que comprende un inhibidor de ALK2 y un inhibidor de JAK2; composición farmacéutica que comprende un inhibidor de ALK2 y un inhibidor de JAK2; método para tratar mielofibrosis (MF); método para tratar anemia inducida por meilofibrosis (MF).
CL2022001325A 2019-11-22 2022-05-19 Terapia combinada que comprende un inhibidor de alk2 y un inhibidor de jak2. CL2022001325A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962939241P 2019-11-22 2019-11-22
US202062980562P 2020-02-24 2020-02-24
US202063035194P 2020-06-05 2020-06-05
US202063056768P 2020-07-27 2020-07-27

Publications (1)

Publication Number Publication Date
CL2022001325A1 true CL2022001325A1 (es) 2023-03-24

Family

ID=73699492

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2022001325A CL2022001325A1 (es) 2019-11-22 2022-05-19 Terapia combinada que comprende un inhibidor de alk2 y un inhibidor de jak2.

Country Status (16)

Country Link
US (2) US11738026B2 (es)
EP (1) EP4061367A1 (es)
JP (1) JP2023502742A (es)
KR (1) KR20220107213A (es)
CN (1) CN115038443A (es)
AU (1) AU2020388638A1 (es)
BR (1) BR112022009710A2 (es)
CA (1) CA3160312A1 (es)
CL (1) CL2022001325A1 (es)
CR (1) CR20220280A (es)
EC (1) ECSP22044525A (es)
IL (1) IL293085A (es)
MX (1) MX2022006176A (es)
PE (1) PE20230251A1 (es)
TW (1) TW202131926A (es)
WO (1) WO2021102258A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020086963A1 (en) 2018-10-26 2020-04-30 Keros Therapeutics Crystal forms of an alk2 inhibitor
KR20230025444A (ko) 2020-06-16 2023-02-21 인사이트 코포레이션 빈혈 치료를 위한 alk2 저해제
WO2023081212A1 (en) * 2021-11-02 2023-05-11 Keros Therapeutics, Inc. Methods of using alk2 inhibitors
WO2023198114A1 (zh) * 2022-04-13 2023-10-19 杭州邦顺制药有限公司 Alk2激酶抑制剂

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Also Published As

Publication number Publication date
US20210154195A1 (en) 2021-05-27
ECSP22044525A (es) 2022-08-31
MX2022006176A (es) 2022-08-17
JP2023502742A (ja) 2023-01-25
CR20220280A (es) 2022-09-02
EP4061367A1 (en) 2022-09-28
KR20220107213A (ko) 2022-08-02
IL293085A (en) 2022-07-01
TW202131926A (zh) 2021-09-01
CA3160312A1 (en) 2021-05-27
CN115038443A (zh) 2022-09-09
US20240041887A1 (en) 2024-02-08
PE20230251A1 (es) 2023-02-07
AU2020388638A1 (en) 2022-06-30
US11738026B2 (en) 2023-08-29
BR112022009710A2 (pt) 2022-08-09
WO2021102258A1 (en) 2021-05-27

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