CL2018002467A1 - El uso de moduladores de receptores de glucocorticoides para potenciar los inhibidores de checkpoint - Google Patents
El uso de moduladores de receptores de glucocorticoides para potenciar los inhibidores de checkpointInfo
- Publication number
- CL2018002467A1 CL2018002467A1 CL2018002467A CL2018002467A CL2018002467A1 CL 2018002467 A1 CL2018002467 A1 CL 2018002467A1 CL 2018002467 A CL2018002467 A CL 2018002467A CL 2018002467 A CL2018002467 A CL 2018002467A CL 2018002467 A1 CL2018002467 A1 CL 2018002467A1
- Authority
- CL
- Chile
- Prior art keywords
- potentiate
- glucocorticoid receptor
- receptor modulators
- checkpoint inhibitors
- checkpoint inhibitor
- Prior art date
Links
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 title abstract 3
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 title abstract 3
- 229940117965 Glucocorticoid receptor modulator Drugs 0.000 title abstract 2
- 230000003389 potentiating effect Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
LA PRESENTE INVENCIÓN PROPORCIONA UN MÉTODO QUE COMBINA UN INHIBIDOR DE CHECKPOINT Y UN MODULADOR DEL RECEPTOR DE GLUCOCORTICOIDES PARA TRATAR CÁNCER, POR EJEMPLO, UN CÁNCER SENSIBLE A UN INHIBIDOR DE CHECKPOINT.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662302106P | 2016-03-01 | 2016-03-01 | |
US201662320276P | 2016-04-08 | 2016-04-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2018002467A1 true CL2018002467A1 (es) | 2018-11-23 |
Family
ID=59744340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018002467A CL2018002467A1 (es) | 2016-03-01 | 2018-08-29 | El uso de moduladores de receptores de glucocorticoides para potenciar los inhibidores de checkpoint |
Country Status (15)
Country | Link |
---|---|
US (2) | US10980797B2 (es) |
EP (1) | EP3423453A4 (es) |
JP (3) | JP6847120B2 (es) |
KR (1) | KR20180116372A (es) |
CN (1) | CN109071537A (es) |
AU (1) | AU2017228329B2 (es) |
BR (1) | BR112018067330A2 (es) |
CA (1) | CA3015218A1 (es) |
CL (1) | CL2018002467A1 (es) |
IL (2) | IL297201A (es) |
MX (1) | MX2018010564A (es) |
PH (1) | PH12018501848A1 (es) |
SG (1) | SG11201807421TA (es) |
WO (1) | WO2017151613A1 (es) |
ZA (1) | ZA201805787B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11684612B2 (en) | 2019-02-22 | 2023-06-27 | Corcept Therapeutics Incorporated | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
US9943505B2 (en) * | 2016-09-09 | 2018-04-17 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat pancreatic cancer |
JP2020515563A (ja) | 2017-03-31 | 2020-05-28 | コーセプト セラピューティクス, インコーポレイテッド | 子宮頸がんを処置するためのグルココルチコイドレセプターモジュレーター |
EP3641780A4 (en) | 2017-06-20 | 2021-02-24 | Corcept Therapeutics, Inc. | TREATMENT METHODS OF NEURO-EPITHELIAL TUMORS USING SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS |
WO2020067832A1 (ko) | 2018-09-28 | 2020-04-02 | 경북대학교 산학협력단 | 티아민 유도체를 포함하는 고코르티솔증 예방 또는 치료용 조성물 |
AU2019377864B2 (en) | 2018-11-09 | 2023-03-16 | Corcept Therapeutics Incorporated | Methods for shrinking pituitary tumors |
BR112021010461A2 (pt) | 2018-12-19 | 2021-08-24 | Corcept Therapeutics Incorporated | Formulação e dose unitária para administração oral de relacorilante |
US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
US11389432B2 (en) | 2018-12-19 | 2022-07-19 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
JP2022552422A (ja) * | 2019-10-16 | 2022-12-15 | コーセプト セラピューティクス, インコーポレイテッド | 選択的グルココルチコイド受容体拮抗物質を用いてがん患者における好中球/リンパ球比を正常化する方法 |
JP2023516885A (ja) * | 2020-01-29 | 2023-04-21 | コーセプト セラピューティクス, インコーポレイテッド | 選択的グルココルチコイド受容体モジュレーター(sgrm)及び抗体チェックポイント阻害剤による副腎皮質がん腫の処置 |
MX2022009781A (es) * | 2020-02-10 | 2022-09-09 | Corcept Therapeutics Inc | Metodos para estimular una respuesta antitumoral utilizando un modulador selectivo del receptor de glucocorticoides. |
US20210369690A1 (en) * | 2020-05-27 | 2021-12-02 | Corcept Therapeutics Incorporated | Concomitant administration of glucocorticoid receptor modulator relacorilant and cyp2c8 substrates |
JP2023532840A (ja) * | 2020-05-27 | 2023-08-01 | コーセプト セラピューティクス, インコーポレイテッド | グルココルチコイド受容体モジュレーターレラコリラントおよびcyp2c9基質の併用投与 |
WO2022134033A1 (en) * | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
WO2023102569A1 (en) * | 2021-12-03 | 2023-06-08 | Board Of Regents, The University Of Texas System | Glucocorticoid receptor blockade with mifepristone to sensitize pancreatic cancer to immunotherapy |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1735308B1 (en) | 2004-03-09 | 2008-09-10 | Corcept Therapeutics, Inc. | Fused ring azadecalin glucocorticoid receptor modulators |
WO2010132445A1 (en) | 2009-05-12 | 2010-11-18 | Corcept Therapeutics, Inc. | Solid forms and process for preparing |
US8710035B2 (en) * | 2010-03-24 | 2014-04-29 | The University Of Chicago | Methods and compositions related to glucocorticoid receptor antagonists and breast cancer |
CA2830234A1 (en) | 2011-03-15 | 2012-09-20 | Abbvie Inc. | Nuclear hormone receptor modulators |
WO2013039916A1 (en) * | 2011-09-12 | 2013-03-21 | The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services | Compositions for and methods of treatment and enhanced detection of non-pituitary tumors |
KR102009007B1 (ko) | 2011-10-04 | 2019-08-08 | 인비비스 파마슈티컬스 인코포레이티드 | 항-프로게스틴 민감성 종양을 확인하고 치료하기 위한 방법 및 시스템 |
WO2013169971A1 (en) | 2012-05-10 | 2013-11-14 | Bristol-Myers Squibb Company | Anti-tumor antibodies as predictive or prognostic biomarkers of efficacy and survival in ipilimumab-treated patients |
US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
PT3338781T (pt) * | 2012-05-25 | 2019-11-29 | Corcept Therapeutics Inc | Moduladores de recetores de glucocorticoides de azadecalina fundida com heteroaril-cetonas |
CA2927794A1 (en) * | 2013-10-25 | 2015-04-30 | Pharmacyclics Llc | Treatment using bruton's tyrosine kinase inhibitors and immunotherapy |
MX2016005915A (es) * | 2013-11-11 | 2016-12-16 | Armo Biosciences Inc | Metodos de uso de interleucina-10 para tratar enfermedades y trastornos. |
US20160299146A1 (en) | 2013-11-20 | 2016-10-13 | Dana-Farber Cancer Institute, Inc. | Kynurenine Pathway Biomarkers Predictive of Anti-Immune Checkpoint Inhibitor Response |
PL3560493T3 (pl) | 2013-11-25 | 2021-10-04 | Corcept Therapeutics Incorporated | Skondensowane oktahydroazadekaliny będące modulatorami receptora glukokortykoidowego |
WO2015095811A2 (en) * | 2013-12-20 | 2015-06-25 | The Board Institute Inc. | Combination therapy with neoantigen vaccine |
DK3466949T3 (da) * | 2013-12-24 | 2021-03-15 | Bristol Myers Squibb Co | Tricyklisk forbindelse som anticancermidler |
WO2015181343A2 (en) * | 2014-05-30 | 2015-12-03 | Ventana Medical Systems, Inc. | Multiplex assay for improved scoring of tumor tissues stained for pd-l1 |
US20180064679A1 (en) * | 2015-03-05 | 2018-03-08 | Abraxis Bioscience, Llc | Method for treating cancer based on level of glucocorticoid receptor |
-
2017
- 2017-02-28 CN CN201780027063.8A patent/CN109071537A/zh active Pending
- 2017-02-28 SG SG11201807421TA patent/SG11201807421TA/en unknown
- 2017-02-28 CA CA3015218A patent/CA3015218A1/en active Pending
- 2017-02-28 MX MX2018010564A patent/MX2018010564A/es unknown
- 2017-02-28 KR KR1020187027525A patent/KR20180116372A/ko active Search and Examination
- 2017-02-28 IL IL297201A patent/IL297201A/en unknown
- 2017-02-28 EP EP17760608.4A patent/EP3423453A4/en active Pending
- 2017-02-28 JP JP2018545599A patent/JP6847120B2/ja active Active
- 2017-02-28 BR BR112018067330A patent/BR112018067330A2/pt active Search and Examination
- 2017-02-28 AU AU2017228329A patent/AU2017228329B2/en active Active
- 2017-02-28 WO PCT/US2017/019948 patent/WO2017151613A1/en active Application Filing
- 2017-02-28 US US16/080,617 patent/US10980797B2/en active Active
-
2018
- 2018-08-29 CL CL2018002467A patent/CL2018002467A1/es unknown
- 2018-08-29 ZA ZA2018/05787A patent/ZA201805787B/en unknown
- 2018-08-30 PH PH12018501848A patent/PH12018501848A1/en unknown
- 2018-08-30 IL IL261502A patent/IL261502B2/en unknown
- 2018-10-30 JP JP2018204171A patent/JP2019023228A/ja active Pending
-
2021
- 2021-03-23 US US17/210,245 patent/US20210205294A1/en active Pending
-
2023
- 2023-03-01 JP JP2023031195A patent/JP2023060061A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11684612B2 (en) | 2019-02-22 | 2023-06-27 | Corcept Therapeutics Incorporated | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
Also Published As
Publication number | Publication date |
---|---|
IL261502B (en) | 2022-11-01 |
US20190083486A1 (en) | 2019-03-21 |
AU2017228329A1 (en) | 2018-09-06 |
US10980797B2 (en) | 2021-04-20 |
JP2019507159A (ja) | 2019-03-14 |
AU2017228329B2 (en) | 2021-03-11 |
KR20180116372A (ko) | 2018-10-24 |
JP6847120B2 (ja) | 2021-03-24 |
PH12018501848A1 (en) | 2019-01-28 |
JP2023060061A (ja) | 2023-04-27 |
CN109071537A (zh) | 2018-12-21 |
JP2019023228A (ja) | 2019-02-14 |
WO2017151613A1 (en) | 2017-09-08 |
IL297201A (en) | 2022-12-01 |
ZA201805787B (en) | 2020-05-27 |
US20210205294A1 (en) | 2021-07-08 |
EP3423453A4 (en) | 2019-11-06 |
IL261502A (en) | 2018-10-31 |
MX2018010564A (es) | 2018-11-09 |
CA3015218A1 (en) | 2017-09-08 |
IL261502B2 (en) | 2023-03-01 |
BR112018067330A2 (pt) | 2019-01-22 |
SG11201807421TA (en) | 2018-09-27 |
EP3423453A1 (en) | 2019-01-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2018002467A1 (es) | El uso de moduladores de receptores de glucocorticoides para potenciar los inhibidores de checkpoint | |
CL2019002314A1 (es) | Compuestos moduladores del receptor de hidrocarburos de arilo (ahr). | |
CL2019000820A1 (es) | Compuestos, composiciones y sus usos para inhibir la actividad arginasa. (divisional solicitud 201801134) | |
CL2019002108A1 (es) | Compuestos moduladores del receptor de hidrocarburos de arilo (ahr). | |
CL2019002112A1 (es) | Compuestos moduladores del receptor de hidrocarburos de arilo (ahr). | |
CR20150664A (es) | Moduladores de los receptores de estrógeno y sus usos | |
CO2018013298A2 (es) | Anticuerpos anti-gitr y sus usos. | |
CO2019001212A2 (es) | Composiciones y métodos de inhibición del masp-3 para el tratamiento de diversas enfermedades y trastornos | |
CL2018000687A1 (es) | Nuevos compuestos bicíclicos como inhibidores de atx. | |
DOP2018000258A (es) | Anticuerpos anti-cd40 y sus usos | |
BR112018013995A2 (pt) | terapia de combinação de vírus oncolítico e inibidor de ponto de verificação | |
CR20180151A (es) | Antcuierpos anti-pd1 y métodos de uso | |
CL2016000400A1 (es) | Moduladores del receptor p2x3 y p2x2/3 de diaminopiridina para el tratamiento de la tos aguda, sub-aguda o crónica. | |
CL2015003200A1 (es) | Potenciador de inhibidores del homólogo de zeste | |
CL2015002151A1 (es) | Biaril amide compuestos como inhibidores de quinasa | |
CR20160500A (es) | Anticuerpos anti-ox40 y métodos de uso | |
ECSP17023281A (es) | Inhibidores de mk2 y sus usos | |
BR112017024555A2 (pt) | moduladores de ccr2 | |
CL2019000508A1 (es) | Formulaciones, kits y métodos de anticuerpos inhibidores de masp-2 de baja viscosidad altamente concentrados. | |
CL2017001046A1 (es) | Inhibidoes del bromodominio | |
BR112017017700A2 (pt) | métodos, composições e kits para tratamento do câncer | |
CL2018001252A1 (es) | Métodos para tratar esclerosis múltiple usando compuestos de pirimidina y piridina con actividad inhibidora de tirosina cinasa de bruton | |
BR112019004123A2 (pt) | sistemas e métodos para atuar dispositivos hidraulicamente atuados | |
CL2015000976A1 (es) | Compuestos de 2-fenil-5-heterociclil-tetrahidro-2h-piran-3-amina para uso en el tratamiento de diabetes y sus trastornos asociados. | |
CL2015002113A1 (es) | Compuestos de azetidinloxifenilpirrolidina |