CL2020001884A1 - Anticuerpos humanos para la hemaglutinina de influenza. - Google Patents
Anticuerpos humanos para la hemaglutinina de influenza.Info
- Publication number
- CL2020001884A1 CL2020001884A1 CL2020001884A CL2020001884A CL2020001884A1 CL 2020001884 A1 CL2020001884 A1 CL 2020001884A1 CL 2020001884 A CL2020001884 A CL 2020001884A CL 2020001884 A CL2020001884 A CL 2020001884A CL 2020001884 A1 CL2020001884 A1 CL 2020001884A1
- Authority
- CL
- Chile
- Prior art keywords
- antibodies
- influenza
- influenza hemagglutinin
- human antibodies
- bind
- Prior art date
Links
- 101710154606 Hemagglutinin Proteins 0.000 title abstract 4
- 101710093908 Outer capsid protein VP4 Proteins 0.000 title abstract 4
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 title abstract 4
- 101710176177 Protein A56 Proteins 0.000 title abstract 4
- 239000000185 hemagglutinin Substances 0.000 title abstract 4
- 206010022000 influenza Diseases 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000026502 entry into host cell Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención proporciona anticuerpos monoclonales, o fragmentos de unión al antígeno de estos, que se unen a la proteína hemaglutinina (HA) de influenza, composiciones farmacéuticas que comprenden los anticuerpos y métodos de uso. Los anticuerpos de la invención son útiles para inhibir o neutralizar la actividad del virus de influenza, y proporcionan así un medio para tratar o prevenir la infección por influenza en seres humanos. En algunas modalidades, la invención proporciona el uso de uno o más anticuerpos que se unen a la HA de influenza para prevenir el acoplamiento viral y/o la entrada en células huésped. Los anticuerpos de la invención pueden usarse profilácticamente o terapéuticamente y pueden usarse solos o en combinación con uno o más de otros agentes o vacunas antivirales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862622480P | 2018-01-26 | 2018-01-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020001884A1 true CL2020001884A1 (es) | 2020-12-11 |
Family
ID=66286952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020001884A CL2020001884A1 (es) | 2018-01-26 | 2020-07-17 | Anticuerpos humanos para la hemaglutinina de influenza. |
Country Status (17)
Country | Link |
---|---|
US (1) | US11780907B2 (es) |
EP (1) | EP3743442A1 (es) |
JP (2) | JP7372925B2 (es) |
KR (1) | KR20200115517A (es) |
CN (1) | CN111670195A (es) |
AU (1) | AU2019212480A1 (es) |
BR (1) | BR112020014849A2 (es) |
CA (1) | CA3088194A1 (es) |
CL (1) | CL2020001884A1 (es) |
CO (1) | CO2020009043A2 (es) |
EA (1) | EA202091563A1 (es) |
IL (1) | IL275884A (es) |
MA (1) | MA51681A (es) |
MX (1) | MX2020007772A (es) |
PH (1) | PH12020551051A1 (es) |
SG (1) | SG11202006379UA (es) |
WO (1) | WO2019147867A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2023519930A (ja) * | 2020-04-01 | 2023-05-15 | ユニバーシティ オブ ロチェスター | インフルエンザh3n2ウイルスのヘマグルチニン(ha)およびノイラミニダーゼ(na)に対するモノクローナル抗体 |
IL302938A (en) * | 2020-11-23 | 2023-07-01 | Vir Biotechnology Inc | Antibodies against influenza A viruses |
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US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
US7850962B2 (en) | 2004-04-20 | 2010-12-14 | Genmab A/S | Human monoclonal antibodies against CD20 |
US8257740B1 (en) | 2011-08-15 | 2012-09-04 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
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AU2008297586B2 (en) | 2007-09-13 | 2013-06-20 | National Institute Of Health Research And Development (Nihrd)- Ministry Of Health Of The Republic Of Indonesia | Monoclonal antibodies specific to hemagglutinin from influenza virus H5-subtype and uses thereof |
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AU2008349862B2 (en) | 2008-02-05 | 2014-02-06 | Temasek Life Sciences Laboratory Limited | Binding protein and epitope-blocking ELISA for the universal detection of H5-subtype influenza viruses |
EP2274334A2 (en) | 2008-03-28 | 2011-01-19 | Sea Lane Biotechnologies,llc. | Neutralizing molecules to viral antigens |
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WO2010074656A1 (en) | 2008-12-24 | 2010-07-01 | Temasek Life Sciences Laboratory Limited | Monoclonal antibodies specific to the fusion peptide from hemagglutinin from influenza a viruses and uses thereof |
WO2010073647A1 (ja) * | 2008-12-25 | 2010-07-01 | 国立大学法人大阪大学 | 抗ヒトインフルエンザウイルス・ヒト型抗体 |
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-
2019
- 2019-01-24 EA EA202091563A patent/EA202091563A1/ru unknown
- 2019-01-24 SG SG11202006379UA patent/SG11202006379UA/en unknown
- 2019-01-24 US US16/964,579 patent/US11780907B2/en active Active
- 2019-01-24 CN CN201980009873.XA patent/CN111670195A/zh active Pending
- 2019-01-24 JP JP2020539709A patent/JP7372925B2/ja active Active
- 2019-01-24 EP EP19719656.1A patent/EP3743442A1/en active Pending
- 2019-01-24 AU AU2019212480A patent/AU2019212480A1/en active Pending
- 2019-01-24 BR BR112020014849-0A patent/BR112020014849A2/pt unknown
- 2019-01-24 WO PCT/US2019/015029 patent/WO2019147867A1/en unknown
- 2019-01-24 MA MA051681A patent/MA51681A/fr unknown
- 2019-01-24 CA CA3088194A patent/CA3088194A1/en active Pending
- 2019-01-24 KR KR1020207022064A patent/KR20200115517A/ko active Search and Examination
- 2019-01-24 MX MX2020007772A patent/MX2020007772A/es unknown
-
2020
- 2020-07-06 IL IL275884A patent/IL275884A/en unknown
- 2020-07-07 PH PH12020551051A patent/PH12020551051A1/en unknown
- 2020-07-17 CL CL2020001884A patent/CL2020001884A1/es unknown
- 2020-07-23 CO CONC2020/0009043A patent/CO2020009043A2/es unknown
-
2023
- 2023-02-28 JP JP2023030129A patent/JP2023060018A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
PH12020551051A1 (en) | 2021-08-23 |
JP7372925B2 (ja) | 2023-11-01 |
US20210371505A1 (en) | 2021-12-02 |
KR20200115517A (ko) | 2020-10-07 |
MA51681A (fr) | 2021-05-05 |
JP2023060018A (ja) | 2023-04-27 |
JP2021511043A (ja) | 2021-05-06 |
MX2020007772A (es) | 2020-09-18 |
US11780907B2 (en) | 2023-10-10 |
EP3743442A1 (en) | 2020-12-02 |
CA3088194A1 (en) | 2019-08-01 |
EA202091563A1 (ru) | 2020-10-08 |
AU2019212480A1 (en) | 2020-09-10 |
CN111670195A (zh) | 2020-09-15 |
CO2020009043A2 (es) | 2020-07-31 |
IL275884A (en) | 2020-08-31 |
BR112020014849A2 (pt) | 2020-12-08 |
WO2019147867A9 (en) | 2019-11-07 |
WO2019147867A1 (en) | 2019-08-01 |
SG11202006379UA (en) | 2020-07-29 |
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