SG11202006379UA - Human antibodies to influenza hemagglutinin - Google Patents

Human antibodies to influenza hemagglutinin

Info

Publication number
SG11202006379UA
SG11202006379UA SG11202006379UA SG11202006379UA SG11202006379UA SG 11202006379U A SG11202006379U A SG 11202006379UA SG 11202006379U A SG11202006379U A SG 11202006379UA SG 11202006379U A SG11202006379U A SG 11202006379UA SG 11202006379U A SG11202006379U A SG 11202006379UA
Authority
SG
Singapore
Prior art keywords
human antibodies
influenza hemagglutinin
hemagglutinin
influenza
antibodies
Prior art date
Application number
SG11202006379UA
Inventor
Lisa A Purcell
Jonathan Viau
William Olson
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11202006379UA publication Critical patent/SG11202006379UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
SG11202006379UA 2018-01-26 2019-01-24 Human antibodies to influenza hemagglutinin SG11202006379UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862622480P 2018-01-26 2018-01-26
PCT/US2019/015029 WO2019147867A1 (en) 2018-01-26 2019-01-24 Human antibodies to influenza hemagglutinin

Publications (1)

Publication Number Publication Date
SG11202006379UA true SG11202006379UA (en) 2020-07-29

Family

ID=66286952

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202006379UA SG11202006379UA (en) 2018-01-26 2019-01-24 Human antibodies to influenza hemagglutinin

Country Status (17)

Country Link
US (1) US11780907B2 (en)
EP (1) EP3743442A1 (en)
JP (2) JP7372925B2 (en)
KR (1) KR20200115517A (en)
CN (1) CN111670195A (en)
AU (1) AU2019212480A1 (en)
BR (1) BR112020014849A2 (en)
CA (1) CA3088194A1 (en)
CL (1) CL2020001884A1 (en)
CO (1) CO2020009043A2 (en)
EA (1) EA202091563A1 (en)
IL (1) IL275884A (en)
MA (1) MA51681A (en)
MX (1) MX2020007772A (en)
PH (1) PH12020551051A1 (en)
SG (1) SG11202006379UA (en)
WO (1) WO2019147867A1 (en)

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* Cited by examiner, † Cited by third party
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US20230107644A1 (en) * 2020-04-01 2023-04-06 University Of Rochester Monoclonal antibodies against the hemagglutinin (ha) and neuraminidase (na) of influenza h3n2 viruses
JP2023551666A (en) * 2020-11-23 2023-12-12 ヴィア・バイオテクノロジー・インコーポレイテッド Antibodies against influenza A virus

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Also Published As

Publication number Publication date
JP7372925B2 (en) 2023-11-01
WO2019147867A9 (en) 2019-11-07
PH12020551051A1 (en) 2021-08-23
US20210371505A1 (en) 2021-12-02
KR20200115517A (en) 2020-10-07
JP2023060018A (en) 2023-04-27
AU2019212480A1 (en) 2020-09-10
BR112020014849A2 (en) 2020-12-08
MA51681A (en) 2021-05-05
JP2021511043A (en) 2021-05-06
WO2019147867A1 (en) 2019-08-01
CO2020009043A2 (en) 2020-07-31
CA3088194A1 (en) 2019-08-01
IL275884A (en) 2020-08-31
EP3743442A1 (en) 2020-12-02
CL2020001884A1 (en) 2020-12-11
US11780907B2 (en) 2023-10-10
MX2020007772A (en) 2020-09-18
EA202091563A1 (en) 2020-10-08
CN111670195A (en) 2020-09-15

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