CL2020001019A1 - Métodos de uso de inhibidores de ehmt2 para tratar o prevenir trastornos sanguíneos. - Google Patents

Métodos de uso de inhibidores de ehmt2 para tratar o prevenir trastornos sanguíneos.

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Publication number
CL2020001019A1
CL2020001019A1 CL2020001019A CL2020001019A CL2020001019A1 CL 2020001019 A1 CL2020001019 A1 CL 2020001019A1 CL 2020001019 A CL2020001019 A CL 2020001019A CL 2020001019 A CL2020001019 A CL 2020001019A CL 2020001019 A1 CL2020001019 A1 CL 2020001019A1
Authority
CL
Chile
Prior art keywords
treat
methods
prevent blood
blood disorders
ehmt2
Prior art date
Application number
CL2020001019A
Other languages
English (en)
Inventor
Elayne Penebre
Veronica Gibaja
Maria Alejandra Raimondi
Original Assignee
Epizyme Inc
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Filing date
Publication date
Application filed by Epizyme Inc filed Critical Epizyme Inc
Publication of CL2020001019A1 publication Critical patent/CL2020001019A1/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

La presente divulgación se refiere a un método para prevenir o tratar un trastorno sanguíneo (por ejemplo, enfermedad de células falciformes) mediante la administración de un compuesto inhibidor de EHMT2 desvelado en este documento o una composición farmacéutica del mismo a sujetos que lo necesitan. La presente divulgación también se refiere al uso de tales compuestos en investigación u otros fines no terapéuticos.
CL2020001019A 2017-10-18 2020-04-16 Métodos de uso de inhibidores de ehmt2 para tratar o prevenir trastornos sanguíneos. CL2020001019A1 (es)

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