CL2023002682A1 - Uso de inhibidores de ehmt2 para tratar trastornos sanguíneos - Google Patents

Uso de inhibidores de ehmt2 para tratar trastornos sanguíneos

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Publication number
CL2023002682A1
CL2023002682A1 CL2023002682A CL2023002682A CL2023002682A1 CL 2023002682 A1 CL2023002682 A1 CL 2023002682A1 CL 2023002682 A CL2023002682 A CL 2023002682A CL 2023002682 A CL2023002682 A CL 2023002682A CL 2023002682 A1 CL2023002682 A1 CL 2023002682A1
Authority
CL
Chile
Prior art keywords
blood disorders
treat blood
ehmt2
present disclosure
ehmt2 inhibitors
Prior art date
Application number
CL2023002682A
Other languages
English (en)
Inventor
Penebre Elayne
Gibaja Veronica
Alejandra Raimondi Maria
Original Assignee
Epizyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme Inc filed Critical Epizyme Inc
Publication of CL2023002682A1 publication Critical patent/CL2023002682A1/es

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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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Abstract

La presente divulgación se refiere a un método para prevenir o tratar un trastorno sanguíneo (por ejemplo, enfermedad de células falciformes) mediante la administración de un compuesto inhibidor de EHMT2 desvelado en este documento o una composición farmacéutica del mismo a sujetos que lo necesitan. La presente divulgación también se refiere al uso de tales compuestos en investigación u otros fines no terapéuticos.
CL2023002682A 2017-10-18 2023-09-07 Uso de inhibidores de ehmt2 para tratar trastornos sanguíneos CL2023002682A1 (es)

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