CL2017003475A1 - Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona - Google Patents

Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona

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Publication number
CL2017003475A1
CL2017003475A1 CL2017003475A CL2017003475A CL2017003475A1 CL 2017003475 A1 CL2017003475 A1 CL 2017003475A1 CL 2017003475 A CL2017003475 A CL 2017003475A CL 2017003475 A CL2017003475 A CL 2017003475A CL 2017003475 A1 CL2017003475 A1 CL 2017003475A1
Authority
CL
Chile
Prior art keywords
azetidin
piperidin
difluoro
fluoro
fumarate salt
Prior art date
Application number
CL2017003475A
Other languages
English (en)
Inventor
Adrian St Clair Brown
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56411938&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017003475(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of CL2017003475A1 publication Critical patent/CL2017003475A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

<p>LA PRESENTE DESCRIPCIÓN SE REFIERE A LA SAL DE FUMARATO CRISTALINA DE (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-YODOFENILAMINO)FENIL][3- HIDROXI-3-(PIPERIDIN-2-IL)AZETIDIN-1-IL]-METANONA. LA DESCRIPCIÓN TAMBIÉN SE REFIERE A COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN LA SAL DE FUMARATO CRISTALINA DE (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-YODOFENILAMINO)FENIL][3-HIDROXI-3-(PIPERIDIN-2-IL) AZETIDIN-1-IL]-METANONA. LA DESCRIPCIÓN TAMBIÉN SE REFIERE A MÉTODOS PARA TRATAR CÁNCERES QUE COMPRENDEN ADMINISTRARLE A UN PACIENTE QUE LO NECESITA LA SAL DE FUMARATO CRISTALINA DE (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-YODOFENILAMINO)FENIL][3-HIDROXI-3- (PIPERIDIN-2-IL)AZETIDIN-1-IL]-METANONA.</p>
CL2017003475A 2015-06-30 2017-12-29 Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona CL2017003475A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562187009P 2015-06-30 2015-06-30

Publications (1)

Publication Number Publication Date
CL2017003475A1 true CL2017003475A1 (es) 2018-07-13

Family

ID=56411938

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017003475A CL2017003475A1 (es) 2015-06-30 2017-12-29 Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona

Country Status (24)

Country Link
US (3) US10590102B2 (es)
EP (1) EP3317264A1 (es)
JP (3) JP7338950B2 (es)
KR (1) KR102695324B1 (es)
CN (2) CN107810183A (es)
AR (1) AR105483A1 (es)
AU (2) AU2016288209B2 (es)
CA (1) CA2990222C (es)
CL (1) CL2017003475A1 (es)
CO (1) CO2018000086A2 (es)
CR (1) CR20180056A (es)
HK (1) HK1252433A1 (es)
IL (2) IL256423B (es)
MA (1) MA42301A (es)
MX (1) MX2017017037A (es)
MY (1) MY192545A (es)
PE (1) PE20180692A1 (es)
PH (1) PH12017502414A1 (es)
RU (2) RU2762181C2 (es)
SG (1) SG10202105196YA (es)
TW (2) TWI775187B (es)
UA (1) UA124728C2 (es)
WO (1) WO2017004393A1 (es)
ZA (1) ZA201708760B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104837826B (zh) 2012-10-12 2018-07-27 埃克塞里艾克西斯公司 制备用于治疗癌症的化合物的新型方法
TWI795344B (zh) * 2015-06-30 2023-03-11 美商建南德克公司 含藥物之立即釋放錠劑及形成該錠劑的方法
AR105483A1 (es) 2015-06-30 2017-10-11 Exelixis Inc Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona
CA3049926A1 (en) 2017-01-17 2018-07-26 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
GB201717809D0 (en) * 2017-10-30 2017-12-13 Azad Pharmaceutical Ingredients Ag Process for the production of cobimetinib
WO2020187674A1 (en) 2019-03-15 2020-09-24 Sandoz Ag Crystalline (s)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl][3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl]methanone hemisuccinate
WO2024111001A1 (en) * 2022-11-25 2024-05-30 Msn Laboratories Private Limited, R&D Center Crystalline forms of n-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide fumarate and process for its preparation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1802579T1 (sl) 2004-10-20 2014-03-31 Merck Serono Sa Derivati 3-arilaminopiridina
MX2007014782A (es) 2005-05-23 2008-02-19 Novartis Ag Formas cristalinas y otras formas de las sales de acido lactico de 4-amino-5-fluoro-3-[6-(4-metilpiperazin-1-il)-1h-bencimidazol-2 -il]-1h quinolin-2-ona.
BRPI0617165B1 (pt) 2005-10-07 2023-10-03 Exelixis Inc Compostos inibidores mek, composições farmacêuticas que os contem e métodos de uso dos mesmos
AU2007284562B2 (en) 2006-08-16 2013-05-02 Exelixis, Inc. Using PI3K and MEK modulators in treatments of cancer
CN111643496A (zh) 2006-12-14 2020-09-11 埃克塞利希斯股份有限公司 使用mek抑制剂的方法
WO2008124085A2 (en) 2007-04-03 2008-10-16 Exelixis, Inc. Methods of using combinations of mek and jak-2 inhibitors
CN104837826B (zh) 2012-10-12 2018-07-27 埃克塞里艾克西斯公司 制备用于治疗癌症的化合物的新型方法
RU2708247C2 (ru) 2013-03-05 2019-12-05 Юниверсити Оф Теннесси Рисерч Фаундейшн Соединение для лечения рака
MX2015010854A (es) 2013-03-14 2016-07-20 Genentech Inc Combinaciones de un compuesto inhibidor de mek con un compuesto inhibidor de her3/egfr y metodos de uso.
AR105483A1 (es) 2015-06-30 2017-10-11 Exelixis Inc Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona

Also Published As

Publication number Publication date
JP2018519318A (ja) 2018-07-19
CR20180056A (es) 2018-05-25
US11254649B2 (en) 2022-02-22
CN118290395A (zh) 2024-07-05
BR112017028516A2 (pt) 2018-08-28
TW201718535A (zh) 2017-06-01
WO2017004393A1 (en) 2017-01-05
CO2018000086A2 (es) 2018-04-10
SG10202105196YA (en) 2021-06-29
MX2017017037A (es) 2018-04-30
CA2990222C (en) 2023-09-26
AR105483A1 (es) 2017-10-11
AU2021200202A1 (en) 2021-03-18
JP2023025000A (ja) 2023-02-21
AU2021200202B2 (en) 2022-09-08
EP3317264A1 (en) 2018-05-09
JP7338950B2 (ja) 2023-09-05
RU2762181C2 (ru) 2021-12-16
IL295052A (en) 2022-09-01
TWI775187B (zh) 2022-08-21
US20200255398A1 (en) 2020-08-13
JP2021035967A (ja) 2021-03-04
PH12017502414A1 (en) 2018-06-25
TW202108568A (zh) 2021-03-01
US20220056010A1 (en) 2022-02-24
CN107810183A (zh) 2018-03-16
PE20180692A1 (es) 2018-04-23
RU2018103172A3 (es) 2019-10-31
TWI710556B (zh) 2020-11-21
AU2016288209A1 (en) 2018-02-08
UA124728C2 (uk) 2021-11-10
US20180346442A1 (en) 2018-12-06
US10590102B2 (en) 2020-03-17
IL256423B (en) 2022-09-01
RU2021132394A (ru) 2021-11-18
MY192545A (en) 2022-08-26
KR20180021775A (ko) 2018-03-05
AU2016288209B2 (en) 2020-10-22
HK1252433A1 (zh) 2019-05-24
ZA201708760B (en) 2022-06-29
KR102695324B1 (ko) 2024-08-13
MA42301A (fr) 2018-05-09
IL256423A (en) 2018-02-28
RU2018103172A (ru) 2019-07-31
CA2990222A1 (en) 2017-01-05

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