CL2016001135A1 - Celula que coexpresa un primer receptor antigenico quimerico (car) y un segundo car en la superficie celular, y cada car comprende un dominio de unión a antígenos, un espaciador, un dominio transmembranal y un endodominio. - Google Patents

Celula que coexpresa un primer receptor antigenico quimerico (car) y un segundo car en la superficie celular, y cada car comprende un dominio de unión a antígenos, un espaciador, un dominio transmembranal y un endodominio.

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Publication number
CL2016001135A1
CL2016001135A1 CL2016001135A CL2016001135A CL2016001135A1 CL 2016001135 A1 CL2016001135 A1 CL 2016001135A1 CL 2016001135 A CL2016001135 A CL 2016001135A CL 2016001135 A CL2016001135 A CL 2016001135A CL 2016001135 A1 CL2016001135 A1 CL 2016001135A1
Authority
CL
Chile
Prior art keywords
car
cell
coexpresses
endodomain
spacer
Prior art date
Application number
CL2016001135A
Other languages
English (en)
Spanish (es)
Inventor
Martin Pule
Khai Kong
Shaun Cordoba
Original Assignee
Ucl Business Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201320573A external-priority patent/GB201320573D0/en
Priority claimed from GB201410934A external-priority patent/GB201410934D0/en
Application filed by Ucl Business Plc filed Critical Ucl Business Plc
Publication of CL2016001135A1 publication Critical patent/CL2016001135A1/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/0011—Cancer antigens
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K40/31—Chimeric antigen receptors [CAR]
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CL2016001135A 2013-11-21 2016-05-12 Celula que coexpresa un primer receptor antigenico quimerico (car) y un segundo car en la superficie celular, y cada car comprende un dominio de unión a antígenos, un espaciador, un dominio transmembranal y un endodominio. CL2016001135A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201320573A GB201320573D0 (en) 2013-11-21 2013-11-21 T Cell
GB201410934A GB201410934D0 (en) 2014-06-19 2014-06-19 T cell

Publications (1)

Publication Number Publication Date
CL2016001135A1 true CL2016001135A1 (es) 2016-12-23

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CL2016001135A CL2016001135A1 (es) 2013-11-21 2016-05-12 Celula que coexpresa un primer receptor antigenico quimerico (car) y un segundo car en la superficie celular, y cada car comprende un dominio de unión a antígenos, un espaciador, un dominio transmembranal y un endodominio.
CL2016001134A CL2016001134A1 (es) 2013-11-21 2016-05-12 Celula t o celula asesina natural (nk) que expresa dos receptores de antigeno quimerico (car), donde un car comprende un endodominio activador y el otro un dominio inhibitorio de proteina tirosina fosfatasa que contiene el dominio src (sh2); acido nucleico; vector; metodo de produccion; composicion; uso para preparar medicamento.

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ES2861501T3 (es) 2021-10-06
JP2016538854A (ja) 2016-12-15
SG11201603484PA (en) 2016-05-30
JP2019041775A (ja) 2019-03-22
US10172885B2 (en) 2019-01-08
PL3071222T3 (pl) 2021-04-19
IL245573A0 (en) 2016-06-30
KR101962524B1 (ko) 2019-07-17
JP2016538855A (ja) 2016-12-15
AU2014351558A1 (en) 2016-05-26
RU2717984C2 (ru) 2020-03-27
US20200016204A1 (en) 2020-01-16
CN105792840B (zh) 2020-10-13
RU2732236C2 (ru) 2020-09-14
US20210154229A1 (en) 2021-05-27
MX2016006303A (es) 2016-11-07
CA2930215C (en) 2021-04-27
HUE051523T2 (hu) 2021-03-01
US20240033289A1 (en) 2024-02-01
RU2016124280A (ru) 2017-12-26
DK3071223T3 (da) 2021-03-29
RU2016124278A (ru) 2017-12-22
CA2930215A1 (en) 2015-05-28
HK1223553A1 (en) 2017-08-04
NZ719859A (en) 2020-11-27
EP3858379A1 (en) 2021-08-04
US20240033292A1 (en) 2024-02-01
CL2016001134A1 (es) 2017-05-19
AU2014351557A1 (en) 2016-05-26
EP3071223B1 (en) 2021-01-13
EP3858378A1 (en) 2021-08-04
HK1223554A1 (en) 2017-08-04
SG11201603479TA (en) 2016-05-30
BR112016011460A2 (pt) 2017-09-26
MX377283B (es) 2025-03-07
MX373687B (es) 2020-07-07
WO2015075468A1 (en) 2015-05-28
US20160296562A1 (en) 2016-10-13
JP2021045172A (ja) 2021-03-25
PL3071223T3 (pl) 2021-08-16
CA2929984C (en) 2021-05-18
IL245572A0 (en) 2016-06-30
AU2014351558B2 (en) 2018-08-02
AU2014351557B2 (en) 2019-04-18
JP6538684B2 (ja) 2019-07-03
EP3071221A1 (en) 2016-09-28
EP3071222A1 (en) 2016-09-28
US20210187026A1 (en) 2021-06-24
KR20160085348A (ko) 2016-07-15
CN105792840A (zh) 2016-07-20
BR112016011459A2 (pt) 2017-09-26
EP3626261A1 (en) 2020-03-25
KR20160085347A (ko) 2016-07-15
US20190038672A1 (en) 2019-02-07
WO2015075470A1 (en) 2015-05-28
JP6433498B2 (ja) 2018-12-05
US10172886B2 (en) 2019-01-08
WO2015075469A1 (en) 2015-05-28
CN105848673B (zh) 2020-02-14
US20200016203A1 (en) 2020-01-16
ES2832586T3 (es) 2021-06-10
US20160289294A1 (en) 2016-10-06
CA2929984A1 (en) 2015-05-28
EP3071223A1 (en) 2016-09-28
PT3071222T (pt) 2020-11-20
CN105848673A (zh) 2016-08-10
KR101991555B1 (ko) 2019-06-20
PT3071223T (pt) 2021-03-25

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