MX385775B - Aparatos y métodos de selección de anticuerpo. - Google Patents

Aparatos y métodos de selección de anticuerpo.

Info

Publication number
MX385775B
MX385775B MX2016006571A MX2016006571A MX385775B MX 385775 B MX385775 B MX 385775B MX 2016006571 A MX2016006571 A MX 2016006571A MX 2016006571 A MX2016006571 A MX 2016006571A MX 385775 B MX385775 B MX 385775B
Authority
MX
Mexico
Prior art keywords
methods
antibody
antibody selection
articles
selecting
Prior art date
Application number
MX2016006571A
Other languages
English (en)
Other versions
MX2016006571A (es
Inventor
Vikas K Sharma
Thomas W Patapoff
Trevor E Swartz
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2016006571A publication Critical patent/MX2016006571A/es
Publication of MX385775B publication Critical patent/MX385775B/es

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/20—Screening of libraries
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C10/00—Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Library & Information Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Computing Systems (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a un método para determinar la idoneidad de un anticuerpo para la inclusión en una composición farmacéutica, en donde el método incluye determinar una o más características fisicoquímicas del anticuerpo, las cuales pueden basarse en parámetros estructurales del mismo.
MX2016006571A 2013-11-29 2014-11-26 Aparatos y métodos de selección de anticuerpo. MX385775B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361910200P 2013-11-29 2013-11-29
PCT/US2014/067580 WO2015081176A2 (en) 2013-11-29 2014-11-26 Antibody selection apparatus and methods

Publications (2)

Publication Number Publication Date
MX2016006571A MX2016006571A (es) 2016-08-05
MX385775B true MX385775B (es) 2025-03-18

Family

ID=52273498

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016006571A MX385775B (es) 2013-11-29 2014-11-26 Aparatos y métodos de selección de anticuerpo.

Country Status (10)

Country Link
US (3) US10861584B2 (es)
EP (1) EP3074772B1 (es)
JP (2) JP7156777B2 (es)
KR (1) KR102362002B1 (es)
CN (2) CN105793850B (es)
BR (1) BR112016009862B1 (es)
CA (1) CA2924448C (es)
MX (1) MX385775B (es)
RU (1) RU2742070C2 (es)
WO (1) WO2015081176A2 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12444477B2 (en) 2013-11-29 2025-10-14 Genentech, Inc. Antibody selection apparatus and methods

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WO2017160799A1 (en) * 2016-03-15 2017-09-21 Amgen Inc. Reducing probability of glass breakage in drug delivery devices
WO2021025951A1 (en) * 2019-08-02 2021-02-11 Genentech, Inc. Multipole moment based coarse grained representation of antibody electrostatics
BR112022002797A2 (pt) * 2019-08-20 2022-08-09 Regeneron Pharma Otimização de formulação para anticorpos biespecíficos
CN114746951B (zh) * 2019-09-25 2025-09-26 杨森制药公司 药物施用装置的数据的远程聚合
JP7602034B2 (ja) * 2020-11-02 2024-12-17 リジェネロン・ファーマシューティカルズ・インコーポレイテッド バイオ医薬品開発のための方法およびシステム
CN112986206B (zh) * 2021-05-20 2021-07-30 北京百奥纳芯生物科技有限公司 一种检测基因芯片杂交结果的方法
US20250037798A1 (en) * 2021-12-08 2025-01-30 The Johns Hopkins University Generative language models and related aspects for peptide and protein sequence design
US20250316328A1 (en) * 2022-05-18 2025-10-09 Sanofi Method, System and Apparatus for Predicting PK Values of Antibodies
WO2024208261A1 (zh) * 2023-04-04 2024-10-10 南京金斯瑞生物科技有限公司 用于抗体药物开发的黏度预测方法
EP4705760A1 (en) * 2023-05-05 2026-03-11 F. Hoffmann-La Roche AG A multi-stage apparatus for automated sample preparation and online peptide mapping analysis

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US6172213B1 (en) * 1997-07-02 2001-01-09 Genentech, Inc. Anti-IgE antibodies and method of improving polypeptides
WO2004039337A2 (en) * 2002-10-31 2004-05-13 Protein Design Labs, Inc. Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization
ME00226B (me) * 2004-07-15 2011-02-10 Medarex Llc Humana anti-ngf neutrališuća antitijela kao selektivni inhibitori ngf signalne kaskade
CN101023101A (zh) * 2004-07-20 2007-08-22 西福根有限公司 抗－恒河猴d重组多克隆抗体和生产方法
BRPI0607203A2 (pt) * 2005-02-18 2009-08-25 Medarex Inc anticorpo anti-cd30 isolado, célula hospedeira, métodos para inibir o crescimento de células cd30+, e, uso de um anticorpo anti-cd30 desfucosilado
IN2014DN10515A (es) * 2006-03-31 2015-08-21 Chugai Pharmaceutical Co Ltd
ES2707815T3 (es) * 2007-06-14 2019-04-05 Biogen Ma Inc Formulaciones de anticuerpo natalizumab
MX336725B (es) * 2007-09-26 2016-01-28 Chugai Pharmaceutical Co Ltd Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
AR066172A1 (es) * 2007-09-28 2009-07-29 Chugai Pharmaceutical Co Ltd Metodo para la preparacion de un anticuerpo antiglipicano 3 con modulada cinetica plasmatica mediante variacion de la semivida plasmatica.
US20130236448A1 (en) * 2009-08-04 2013-09-12 F. Hoffmann-La Roche Ag (Roche Glycart Ag) Concentrated polypeptide formulations with reduced viscosity
US20110256135A1 (en) * 2010-03-17 2011-10-20 Wolfgang Fraunhofer Anti-nerve growth factor (ngf) antibody compositions
CN104023748B (zh) * 2011-10-28 2018-03-02 诚信生物公司 含有氨基酸的蛋白质制剂
WO2013177470A1 (en) * 2012-05-23 2013-11-28 Genentech, Inc. Selection method for therapeutic agents
US10762980B2 (en) * 2013-05-17 2020-09-01 Massachusetts Institute Of Technology Computer-implemented methods of determining protein viscosity
KR102362002B1 (ko) 2013-11-29 2022-02-10 제넨테크, 인크. 항체 선택 장치 및 방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12444477B2 (en) 2013-11-29 2025-10-14 Genentech, Inc. Antibody selection apparatus and methods

Also Published As

Publication number Publication date
US20210065843A1 (en) 2021-03-04
CN105793850A (zh) 2016-07-20
RU2742070C2 (ru) 2021-02-02
WO2015081176A2 (en) 2015-06-04
WO2015081176A3 (en) 2015-10-08
US20170091377A1 (en) 2017-03-30
EP3074772B1 (en) 2025-06-04
CA2924448A1 (en) 2015-06-04
US12444477B2 (en) 2025-10-14
EP3074772C0 (en) 2025-06-04
BR112016009862A2 (pt) 2017-08-01
RU2016119424A (ru) 2018-01-09
MX2016006571A (es) 2016-08-05
US10861584B2 (en) 2020-12-08
CN111402950A (zh) 2020-07-10
CN111402950B (zh) 2024-03-19
JP7481844B2 (ja) 2024-05-13
EP3074772A2 (en) 2016-10-05
CN105793850B (zh) 2020-04-24
KR102362002B1 (ko) 2022-02-10
JP7156777B2 (ja) 2022-10-19
JP2020090504A (ja) 2020-06-11
US20260004872A1 (en) 2026-01-01
BR112016009862B1 (pt) 2021-12-21
JP2017512750A (ja) 2017-05-25
KR20160088318A (ko) 2016-07-25
CA2924448C (en) 2021-12-14

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