CL2014002773A1 - Una forma de dosificacion subcutanea de una composicion farmaceutica de un factor de coagulacion sanguinea seleccionado de factor vii, viia, viii, ix, x, xa, xi, xiii, v, factor de von willebrand y proteina c, conjugado con una molecula de polietilenglicol (peg), en donde la dosificacion del factor es de 100 y 250 ui/kg o 25 y 50 ui/kg, y en donde la molecula de peg se conjuga directa o indirectamente. - Google Patents

Una forma de dosificacion subcutanea de una composicion farmaceutica de un factor de coagulacion sanguinea seleccionado de factor vii, viia, viii, ix, x, xa, xi, xiii, v, factor de von willebrand y proteina c, conjugado con una molecula de polietilenglicol (peg), en donde la dosificacion del factor es de 100 y 250 ui/kg o 25 y 50 ui/kg, y en donde la molecula de peg se conjuga directa o indirectamente.

Info

Publication number
CL2014002773A1
CL2014002773A1 CL2014002773A CL2014002773A CL2014002773A1 CL 2014002773 A1 CL2014002773 A1 CL 2014002773A1 CL 2014002773 A CL2014002773 A CL 2014002773A CL 2014002773 A CL2014002773 A CL 2014002773A CL 2014002773 A1 CL2014002773 A1 CL 2014002773A1
Authority
CL
Chile
Prior art keywords
factor
peg
conjugated
molecule
viia
Prior art date
Application number
CL2014002773A
Other languages
English (en)
Spanish (es)
Inventor
William Henry
Garraway Richard Wolf
Michael James Earl
John Charles Mayo
Original Assignee
Cantab Biopharmaceuticals Patents Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1206628.8A external-priority patent/GB201206628D0/en
Priority claimed from GBGB1213712.1A external-priority patent/GB201213712D0/en
Priority claimed from GBGB1214985.2A external-priority patent/GB201214985D0/en
Application filed by Cantab Biopharmaceuticals Patents Ltd filed Critical Cantab Biopharmaceuticals Patents Ltd
Publication of CL2014002773A1 publication Critical patent/CL2014002773A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CL2014002773A 2012-04-16 2014-10-15 Una forma de dosificacion subcutanea de una composicion farmaceutica de un factor de coagulacion sanguinea seleccionado de factor vii, viia, viii, ix, x, xa, xi, xiii, v, factor de von willebrand y proteina c, conjugado con una molecula de polietilenglicol (peg), en donde la dosificacion del factor es de 100 y 250 ui/kg o 25 y 50 ui/kg, y en donde la molecula de peg se conjuga directa o indirectamente. CL2014002773A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1206628.8A GB201206628D0 (en) 2012-04-16 2012-04-16 Subcutaneous administration of PEGylated blood clotting factors
GBGB1213712.1A GB201213712D0 (en) 2012-08-01 2012-08-01 Modified therapeutic agents
GBGB1214985.2A GB201214985D0 (en) 2012-08-22 2012-08-22 Modified therapeutic agents

Publications (1)

Publication Number Publication Date
CL2014002773A1 true CL2014002773A1 (es) 2015-01-16

Family

ID=48190923

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014002773A CL2014002773A1 (es) 2012-04-16 2014-10-15 Una forma de dosificacion subcutanea de una composicion farmaceutica de un factor de coagulacion sanguinea seleccionado de factor vii, viia, viii, ix, x, xa, xi, xiii, v, factor de von willebrand y proteina c, conjugado con una molecula de polietilenglicol (peg), en donde la dosificacion del factor es de 100 y 250 ui/kg o 25 y 50 ui/kg, y en donde la molecula de peg se conjuga directa o indirectamente.

Country Status (29)

Country Link
US (2) US20150086524A1 (cg-RX-API-DMAC7.html)
EP (1) EP2838566A2 (cg-RX-API-DMAC7.html)
JP (3) JP2015512927A (cg-RX-API-DMAC7.html)
KR (1) KR102137290B1 (cg-RX-API-DMAC7.html)
CN (1) CN104411335A (cg-RX-API-DMAC7.html)
AP (1) AP2014008049A0 (cg-RX-API-DMAC7.html)
AU (3) AU2013248296A1 (cg-RX-API-DMAC7.html)
BR (1) BR112014025737A2 (cg-RX-API-DMAC7.html)
CA (1) CA2869993C (cg-RX-API-DMAC7.html)
CL (1) CL2014002773A1 (cg-RX-API-DMAC7.html)
CO (1) CO7151496A2 (cg-RX-API-DMAC7.html)
CR (1) CR20140475A (cg-RX-API-DMAC7.html)
EA (1) EA033469B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP14023048A (cg-RX-API-DMAC7.html)
GB (3) GB2516388A (cg-RX-API-DMAC7.html)
GE (1) GEP201706716B (cg-RX-API-DMAC7.html)
HK (1) HK1200695A1 (cg-RX-API-DMAC7.html)
IL (1) IL235129B (cg-RX-API-DMAC7.html)
IN (1) IN2014DN08598A (cg-RX-API-DMAC7.html)
MD (1) MD20140123A2 (cg-RX-API-DMAC7.html)
MX (2) MX2014012512A (cg-RX-API-DMAC7.html)
MY (1) MY190257A (cg-RX-API-DMAC7.html)
NI (1) NI201400122A (cg-RX-API-DMAC7.html)
NZ (1) NZ701205A (cg-RX-API-DMAC7.html)
PE (1) PE20150226A1 (cg-RX-API-DMAC7.html)
PH (1) PH12014502314B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201406492YA (cg-RX-API-DMAC7.html)
WO (1) WO2013156488A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201407370B (cg-RX-API-DMAC7.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109498815B (zh) * 2013-12-30 2022-07-22 江苏众红生物工程创药研究院有限公司 重组人激肽释放酶的化学修饰物及其应用
GB201417589D0 (en) 2014-10-06 2014-11-19 Cantab Biopharmaceuticals Patents Ltd Pharmaceutical Formulations
FR3034669B1 (fr) * 2015-04-07 2020-02-14 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Nouvelle utilisation du facteur von willebrand
EP3307237A1 (en) * 2015-06-12 2018-04-18 Laboratoire Français du Fractionnement et des Biotechnologies Injectable composition of factor vii and fillers
GB201518172D0 (en) 2015-10-14 2015-11-25 Cantab Biopharmaceuticals Patents Ltd Colloidal particles for use in medicine
GB201518170D0 (en) 2015-10-14 2015-11-25 Cantab Biopharmaceuticals Patents Ltd Colloidal particles for subcutaneous administration with intravenous administration of therapeutic agent
GB201518171D0 (en) 2015-10-14 2015-11-25 Cantab Biopharmaceuticals Patents Ltd Colloidal particles for topical administration with therapeutic agent
CN109998994B (zh) * 2018-02-13 2021-12-07 四川大学 包含药物的柔性脂质体及其制备方法
WO2021165226A1 (en) 2020-02-17 2021-08-26 Biotest Ag Subcutaneous administration of factor viii
EP4138888A1 (en) * 2020-04-23 2023-03-01 Eli Lilly and Company Subcutaneous absorption and bioavailability of antibodies

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1479268A (en) 1973-07-05 1977-07-13 Beecham Group Ltd Pharmaceutical compositions
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
CH596313A5 (cg-RX-API-DMAC7.html) 1975-05-30 1978-03-15 Battelle Memorial Institute
US4414147A (en) 1981-04-17 1983-11-08 Massachusetts Institute Of Technology Methods of decreasing the hydrophobicity of fibroblast and other interferons
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0229108B1 (en) 1985-06-26 1990-12-27 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
AU5858690A (en) * 1989-06-14 1991-01-08 Cetus Corporation Polymer/antibiotic conjugate
WO1994005332A2 (en) 1992-09-01 1994-03-17 Berlex Laboratories, Inc. Glycolation of glycosylated macromolecules
DE69332928T2 (de) 1992-09-28 2004-05-06 Research Corp. Technologies, Inc., Tucson Peptidekupplungsreagentien
US5621039A (en) * 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
IL113010A0 (en) 1994-03-31 1995-10-31 Pharmacia Ab Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration
JPH0892294A (ja) * 1994-09-29 1996-04-09 Teijin Ltd ヒト活性化プロテインｃ誘導体
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
JPH08325270A (ja) * 1995-05-31 1996-12-10 Bristol Myers Squibb Co β−ラクタマーゼに対するポリマープロドラッグおよびその使用
SE9503380D0 (sv) * 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
ATE200030T1 (de) 1997-01-29 2001-04-15 Polymasc Pharmaceuticals Plc Pegylationsverfahren
WO1999043357A1 (en) * 1998-02-25 1999-09-02 Micrologix Biotech Inc. Indolicidin and cationic peptides conjugated with polymers
RU2278123C2 (ru) * 2000-02-11 2006-06-20 Максиджен Холдингз Лтд. Молекулы, подобные фактору vii или viia
JP5090605B2 (ja) 2000-05-03 2012-12-05 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 凝固因子ｖｉｉの皮下投与
US20030211094A1 (en) * 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
DE60336555D1 (de) * 2002-06-21 2011-05-12 Novo Nordisk Healthcare Ag Pegylierte glykoformen von faktor vii
DK1517710T3 (da) * 2002-06-21 2011-07-18 Novo Nordisk Healthcare Ag Pegylerede faktor VII-glycoformer
DK1596887T3 (da) * 2003-02-26 2022-06-20 Nektar Therapeutics Polymer-Faktor VIII-konjugat
ES2512499T3 (es) * 2003-04-08 2014-10-24 Yeda Research And Development Co., Ltd. Fármacos pegilados reversibles
US20130137157A1 (en) * 2003-04-09 2013-05-30 Novo Nordisk A/S Glycopegylated factor vii and factor viia
GB0316294D0 (en) 2003-07-11 2003-08-13 Polytherics Ltd Conjugated biological molecules and their preparation
US20060198819A1 (en) 2003-08-08 2006-09-07 Novo Nordisk Healthcare A/G Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest
CN100515422C (zh) 2004-03-04 2009-07-22 卫材R&D管理有限公司 含有苄脒衍生物的组合物及苄脒衍生物的稳定化方法
CA2571292C (en) * 2004-06-30 2013-05-21 Nektar Therapeutics Al, Corporation Polymer-factor ix moiety conjugates
JP2008507990A (ja) 2004-08-02 2008-03-21 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｆｖｉｉの抱合体
US20080255026A1 (en) 2005-05-25 2008-10-16 Glycopegylated Factor 1X Glycopegylated Factor Ix
EP1893632B1 (en) 2005-06-17 2015-08-12 Novo Nordisk Health Care AG Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
US20090305967A1 (en) * 2005-08-19 2009-12-10 Novo Nordisk A/S Glycopegylated factor vii and factor viia
KR20080108147A (ko) * 2006-03-31 2008-12-11 백스터 인터내셔널 인코포레이티드 페질화된 인자 ｖｉｉｉ
EP2059527B1 (en) 2006-09-01 2014-12-03 Novo Nordisk Health Care AG Modified glycoproteins
BRPI0720282B8 (pt) 2006-12-15 2021-05-25 Baxalta GmbH construção proteica, composição farmacêutica, e, kit
US8133865B2 (en) * 2006-12-27 2012-03-13 Nektar Therapeutics von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage
WO2008081024A1 (en) 2007-01-03 2008-07-10 Novo Nordisk Health Care Ag Subcutaneous administration of coagulation factor viia-related popypeptdes
WO2008119815A1 (en) * 2007-04-02 2008-10-09 Novo Nordisk A/S Subcutaneous administration of coagulation factor ix
KR20150067772A (ko) 2007-04-13 2015-06-18 카탈리스트 바이오사이언시즈, 인코포레이티드 변형 제ｖｉｉ 인자 폴리펩타이드 및 이의 용도
EP2014299A1 (en) 2007-07-11 2009-01-14 Novo Nordisk A/S Subcutaneous administration of coagulation factor VII
BRPI0818288A2 (pt) 2007-10-09 2015-04-14 Polytherics Ltd Proteínas conjugadas e peptídeos.
US8552046B2 (en) 2007-10-16 2013-10-08 Pharmacyclics, Inc. Manufacture, compositions and uses of coagulation factor VIIa modulator
ES2476690T3 (es) 2008-02-27 2014-07-15 Novo Nordisk A/S Moléculas conjugadas del Factor VIII
TWI538916B (zh) 2008-04-11 2016-06-21 介控生化科技公司 經修飾的因子vii多肽和其用途
JP2011517950A (ja) * 2008-04-16 2011-06-23 バイエル・ヘルスケア・エルエルシー 第ｉｘ因子の部位特異的修飾
WO2009130602A2 (en) * 2008-04-24 2009-10-29 Celtic Pharma Peg Ltd. Factor ix conjugates with extended half-lives
CN102083459A (zh) * 2008-05-23 2011-06-01 诺沃-诺迪斯克保健股份有限公司 包括含有peg化的gla-结构域的蛋白质的低粘度组合物
KR101763559B1 (ko) 2008-07-21 2017-08-14 폴리테릭스 리미티드 생물학적 분자의 컨쥬게이팅을 위한 신규한 시약 및 방법
CA2738064C (en) * 2008-10-15 2013-03-19 Baxter International Inc. Pegylation of recombinant blood coagulation factors in the presence of bound antibodies
US20100099616A1 (en) * 2008-10-17 2010-04-22 Baxter International Inc. Modified blood factors comprising a low degree of water soluble polymer
US20120121613A1 (en) * 2009-01-19 2012-05-17 Bayer Healthcare Llc Protein conjugate having an endopeptidase- cleavable bioprotective moiety
AU2010281453C1 (en) * 2009-07-27 2019-08-15 Takeda Pharmaceutical Company Limited Blood coagulation protein conjugates
CN102770449B (zh) * 2010-02-16 2016-02-24 诺沃—诺迪斯克有限公司 具有降低的vwf结合的因子viii分子
GB201007356D0 (en) 2010-04-30 2010-06-16 Leverton Licence Holdings Ltd Conjugated factor VIIa
GB201007357D0 (en) * 2010-04-30 2010-06-16 Leverton Licence Holdings Ltd Conjugated factor VIII
DK2598172T3 (da) * 2010-07-30 2019-07-01 Baxalta GmbH Nukleofile katalysatorer til oximforbindelse
WO2012088123A1 (en) * 2010-12-22 2012-06-28 Nektar Therapeutics Polymer-factor vii moiety conjugates

Also Published As

Publication number Publication date
CN104411335A (zh) 2015-03-11
KR20140146171A (ko) 2014-12-24
ZA201407370B (en) 2017-09-27
US20180036229A1 (en) 2018-02-08
HK1200695A1 (en) 2015-08-14
EP2838566A2 (en) 2015-02-25
PH12014502314B1 (en) 2020-01-31
WO2013156488A3 (en) 2014-01-16
GEP201706716B (en) 2017-08-10
GB201910190D0 (en) 2019-08-28
AU2018200111A1 (en) 2018-01-25
CR20140475A (es) 2015-01-23
NI201400122A (es) 2016-12-02
MX2014012512A (es) 2015-01-15
IL235129A0 (en) 2014-12-31
NZ701205A (en) 2016-02-26
JP2015512927A (ja) 2015-04-30
EA033469B1 (ru) 2019-10-31
JP2019131593A (ja) 2019-08-08
JP2018024684A (ja) 2018-02-15
US11351112B2 (en) 2022-06-07
MY190257A (en) 2022-04-11
AU2013248296A1 (en) 2014-11-13
IL235129B (en) 2022-06-01
AP2014008049A0 (en) 2014-11-30
EA201491702A1 (ru) 2015-03-31
PH12014502314A1 (en) 2015-01-12
GB201910184D0 (en) 2019-08-28
BR112014025737A2 (pt) 2017-07-04
US20150086524A1 (en) 2015-03-26
JP6550107B2 (ja) 2019-07-24
AU2018200111B2 (en) 2019-11-07
MD20140123A2 (ro) 2015-04-30
ECSP14023048A (es) 2015-11-30
GB201418864D0 (en) 2014-12-03
IN2014DN08598A (cg-RX-API-DMAC7.html) 2015-05-22
AU2020200842A1 (en) 2020-02-27
SG11201406492YA (en) 2014-11-27
MX2020014208A (es) 2021-03-09
KR102137290B1 (ko) 2020-07-23
GB2516388A (en) 2015-01-21
CA2869993A1 (en) 2013-10-24
CA2869993C (en) 2023-05-23
WO2013156488A2 (en) 2013-10-24
PE20150226A1 (es) 2015-02-14
CO7151496A2 (es) 2014-12-29

Similar Documents

Publication Publication Date Title
CL2014002773A1 (es) Una forma de dosificacion subcutanea de una composicion farmaceutica de un factor de coagulacion sanguinea seleccionado de factor vii, viia, viii, ix, x, xa, xi, xiii, v, factor de von willebrand y proteina c, conjugado con una molecula de polietilenglicol (peg), en donde la dosificacion del factor es de 100 y 250 ui/kg o 25 y 50 ui/kg, y en donde la molecula de peg se conjuga directa o indirectamente.
CY1123675T1 (el) Πολυαιθυλενογλυκολιωμενου φαρμακου-συνδετες για βελτιωμενες φαρμακοκινητικες προϊοντος συζευξης προσδετη-φαρμακου
EP3835296A4 (en) KETOAMIDE COMPOUND AND METHOD FOR THE PREPARATION, PHARMACEUTICAL COMPOSITION AND USE THEREOF
MX2020000083A (es) Factor de von willebrand recombinante ( rvwf ) y factor viii recombinante ( rfviii ) para usarse en un metodo para tratar la enfermedad de von willebrand.
PE20140616A1 (es) Composicion que comprende aflibercept, acido folinico, 5-fluorouracilo (5-fu) e irinotecan (folfiri)
CL2012003340A1 (es) Composicion farmaceutica de administracion oral de bendamustina y su uso en el tratamiento oral de una condicion medica seleccionada de leucemia linfocitica cronica, cancer de mama, entre otras.
CL2014001858A1 (es) Compuestos derivados de pirrolidina-2-carboxamidas sustituidas, antagonistas de mdm2; composicion farmacetica; y su uso en el tratamiento o profilaxis del cancer.
CY1120098T1 (el) Συνθεσεις που περιεχουν βορτιοξετινη και δονεπεζιλη
NI201200160A (es) Factor viii conjugado para coagulación de la sangre.
MX381365B (es) Composiciones de resina reciclada y dispositivos medicos desechables preparados a partir de las anteriores.
EP3318282A4 (en) AGGREGATE COMPOSITION CARRIER AND COMPOSITION THEREOF
MY160510A (en) Polyethylene gycol conjugated blood coagulation factor viia
CY1114190T1 (el) Νεα μορφη χορηγησης της ρασεκαδοτριλης
CL2014003148A1 (es) Composición farmacéutica acuosa que contiene un agente terapéutico biológico y guanidina o un derivado de la guanidina y una inyección que incluye la composición.
EP3556352A4 (en) COMPOSITION OF AMPHIPHILIC SEQUENCED COPOLYMER WITH IMPROVED MICELLAR STABILITY AND PHARMACEUTICAL COMPOSITION COMPRISING IT
CL2012003322A1 (es) Compuestos derivados de benzamida sustituidas; composicion farmacéutica; y uso en el tratamiento del cancer.
MX2017014503A (es) Polipeptidos de factor de von willebrand truncado para tratar hemofilia.
MX389026B (es) Una composicion farmaceutica y el uso de la misma.
CY1121566T1 (el) Νευροπροστατευτικο και ενδειξη αυτου
IL269962A (en) Article of manufacture comprising local anesthetic, buffer, and glycosaminoglycan in syringe with improved stability
EA201691860A1 (ru) Пептидный медикамент в виде сухого порошка
MX375186B (es) Composiciones de anfetamina transdérmica estable y métodos de fabricación.
PL3648788T3 (pl) Leczenie krwawienia z przewodu pokarmowego u pacjentów z ciężką chorobą von willebranda poprzez podanie rekombinowanego vwf
EP3539978A4 (en) FRAGMENT OF NKX3.2 AND PHARMACEUTICAL COMPOSITION CONSISTING IT AS AN ACTIVE SUBSTANCE
EP2993206A4 (en) TITANIUM OXYGENIC COMPOSITION, POLYMERIC COMPOSITION AND FORM BODY