CL2014000543A1 - Compuestos derivados de imidazopiridazinas sustituidas con amino, inhibidores de la quinasa ,mknk2; metodo de preparacion; compuestos intermediarios y su uso; composicion farmaceutica; combinacion farmaceutica; y su uso para el tratamiento del cancer. - Google Patents

Compuestos derivados de imidazopiridazinas sustituidas con amino, inhibidores de la quinasa ,mknk2; metodo de preparacion; compuestos intermediarios y su uso; composicion farmaceutica; combinacion farmaceutica; y su uso para el tratamiento del cancer.

Info

Publication number
CL2014000543A1
CL2014000543A1 CL2014000543A CL2014000543A CL2014000543A1 CL 2014000543 A1 CL2014000543 A1 CL 2014000543A1 CL 2014000543 A CL2014000543 A CL 2014000543A CL 2014000543 A CL2014000543 A CL 2014000543A CL 2014000543 A1 CL2014000543 A1 CL 2014000543A1
Authority
CL
Chile
Prior art keywords
compounds
mknk2
cancer
preparation
treatment
Prior art date
Application number
CL2014000543A
Other languages
English (en)
Spanish (es)
Inventor
Ludwig Zorn
Philip Lienau
Marion Hitchcock
Ulf Bömer
Arne Scholz
Knut Eis
Florian Puehler
Mark Jean Gnoth
Judith Günther
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47831558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014000543(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of CL2014000543A1 publication Critical patent/CL2014000543A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
  • Fats And Perfumes (AREA)
CL2014000543A 2011-09-06 2014-03-06 Compuestos derivados de imidazopiridazinas sustituidas con amino, inhibidores de la quinasa ,mknk2; metodo de preparacion; compuestos intermediarios y su uso; composicion farmaceutica; combinacion farmaceutica; y su uso para el tratamiento del cancer. CL2014000543A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11180129 2011-09-06
EP11182440 2011-09-23
EP12179902 2012-08-09

Publications (1)

Publication Number Publication Date
CL2014000543A1 true CL2014000543A1 (es) 2014-09-26

Family

ID=47831558

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014000543A CL2014000543A1 (es) 2011-09-06 2014-03-06 Compuestos derivados de imidazopiridazinas sustituidas con amino, inhibidores de la quinasa ,mknk2; metodo de preparacion; compuestos intermediarios y su uso; composicion farmaceutica; combinacion farmaceutica; y su uso para el tratamiento del cancer.

Country Status (36)

Country Link
US (1) US9499547B2 (OSRAM)
EP (1) EP2758401B1 (OSRAM)
JP (1) JP6174583B2 (OSRAM)
KR (1) KR20140059268A (OSRAM)
CN (1) CN103958515B (OSRAM)
AP (1) AP2014007496A0 (OSRAM)
AU (1) AU2012306422B2 (OSRAM)
BR (1) BR112014004687A2 (OSRAM)
CA (1) CA2847514A1 (OSRAM)
CL (1) CL2014000543A1 (OSRAM)
CO (1) CO6900146A2 (OSRAM)
CR (1) CR20140113A (OSRAM)
CY (1) CY1119433T1 (OSRAM)
DK (1) DK2758401T3 (OSRAM)
DO (1) DOP2014000051A (OSRAM)
EA (1) EA025688B1 (OSRAM)
EC (1) ECSP14013231A (OSRAM)
ES (1) ES2638319T3 (OSRAM)
GT (1) GT201400043A (OSRAM)
HR (1) HRP20171248T1 (OSRAM)
IL (1) IL231351A (OSRAM)
LT (1) LT2758401T (OSRAM)
MA (1) MA35422B1 (OSRAM)
ME (1) ME02951B (OSRAM)
MX (1) MX348064B (OSRAM)
MY (1) MY168413A (OSRAM)
PE (1) PE20141593A1 (OSRAM)
PH (1) PH12014500501A1 (OSRAM)
PL (1) PL2758401T3 (OSRAM)
PT (1) PT2758401T (OSRAM)
RS (1) RS56179B1 (OSRAM)
SG (1) SG11201400219PA (OSRAM)
SI (1) SI2758401T1 (OSRAM)
UA (1) UA117092C2 (OSRAM)
WO (1) WO2013034570A1 (OSRAM)
ZA (1) ZA201402498B (OSRAM)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2625854T3 (es) 2011-06-01 2017-07-20 Bayer Intellectual Property Gmbh Aminoimidazopiridazinas sustituidas
UA117092C2 (uk) 2011-09-06 2018-06-25 Байєр Інтеллектуал Проперті Гмбх Амінозаміщені імідазопіридазини
CA2849345A1 (en) * 2011-09-23 2013-03-28 Bayer Intellectual Property Gmbh Substituted imidazopyridazines
EP2804864B1 (en) 2011-12-12 2017-09-06 Bayer Intellectual Property GmbH Amino-substituted imidazopyridazines
CA2868673A1 (en) 2012-03-29 2013-10-03 Bayer Intellectual Property Gmbh Amino-substituted imidazopyridazines
CA2869212A1 (en) 2012-04-04 2013-10-10 Bayer Pharma Aktiengesellschaft Amino-substituted imidazopyridazines
WO2014076162A1 (en) 2012-11-19 2014-05-22 Bayer Pharma Aktiengesellschaft Aminoimidazopyridazines
WO2014110574A1 (en) 2013-01-14 2014-07-17 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
PL2945939T3 (pl) 2013-01-15 2020-08-24 Incyte Holdings Corporation Tiazolokarboksyamidy i związki pirydynokarboksyamidowe przydatne jako inhibitory kinaz pim
HK1211578A1 (en) * 2013-01-30 2016-05-27 拜耳医药股份公司 Amidoimidazopyridazines as mknk-1 kinase inhibitors
HK1212699A1 (zh) * 2013-02-20 2016-06-17 拜耳医药股份公司 作为mknk1抑制剂的取代的咪唑并[1，2-b]哒嗪类化合物
EP3036238A1 (en) 2013-08-23 2016-06-29 Incyte Corporation Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
US10214545B2 (en) 2014-01-09 2019-02-26 Bayer Pharma Aktiengesellschaft Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016102427A1 (en) * 2014-12-23 2016-06-30 Bayer Pharma Aktiengesellschaft 6-hydroxybenzofuranyl- and 6-alkoxybenzofuranyl-substituted imidazopyridazines
CA2982984C (en) 2015-04-20 2023-10-17 Effector Therapeutics, Inc. Inhibitors of immune checkpoint modulators for use in treating cancer and infections
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
TW201718546A (zh) 2015-10-02 2017-06-01 英塞特公司 適用作pim激酶抑制劑之雜環化合物
US20170191136A1 (en) 2015-12-31 2017-07-06 Effector Therapeutics, Inc. Mnk biomarkers and uses thereof
WO2017157418A1 (en) 2016-03-15 2017-09-21 Bayer Pharma Aktiengesellschaft Combination of mknk1-inhibitors
WO2019113487A1 (en) 2017-12-08 2019-06-13 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4408047A (en) 1980-03-28 1983-10-04 Merck & Co., Inc. Imidazodiazines
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
FR2619818B1 (fr) 1987-09-01 1990-01-12 Sanofi Sa Imidazo (1,2-b) pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US20040254189A1 (en) 2001-08-23 2004-12-16 Hideaki Nagaya Jnk inhibitors
WO2007013673A1 (en) 2005-07-29 2007-02-01 Astellas Pharma Inc. Fused heterocycles as lck inhibitors
WO2007025090A2 (en) 2005-08-25 2007-03-01 Kalypsys, Inc. Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase
DE102005042742A1 (de) 2005-09-02 2007-03-08 Schering Ag Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
US7750000B2 (en) * 2005-09-02 2010-07-06 Bayer Schering Pharma Ag Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments
WO2007033080A2 (en) 2005-09-12 2007-03-22 Emory University Alzheimer's disease imaging agents
DE102006029447A1 (de) * 2006-06-21 2007-12-27 Bayer Schering Pharma Ag Oxo-substituierte Imidazo[1,2b]pyridazine, deren Herstellung und Verwendung als Arzneimittel
ES2340093T3 (es) 2006-06-22 2010-05-28 Biovitrum Ab (Publ) Derivados pirazina y piridina como inhibidores de cinasa mnk.
US8217177B2 (en) 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
EP1900739A1 (en) * 2006-08-30 2008-03-19 Cellzome Ag Diazolodiazine derivatives as kinase inhibitors
CA2663091A1 (en) * 2006-09-07 2008-03-13 Biogen Idec Ma Inc. Modulators of interleukin-1 receptor-associated kinase
CA2667962A1 (en) 2006-10-30 2008-05-08 Novartis Ag Heterocyclic compounds as antiinflammatory agents
WO2008058126A2 (en) 2006-11-06 2008-05-15 Supergen, Inc. Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
WO2008072682A1 (ja) 2006-12-15 2008-06-19 Daiichi Sankyo Company, Limited イミダゾ［１，２－ｂ］ピリダジン誘導体
AR064420A1 (es) 2006-12-21 2009-04-01 Alcon Mfg Ltd Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop).
PA8792501A1 (es) 2007-08-09 2009-04-23 Sanofi Aventis Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met.
EP2217601A1 (en) 2007-11-08 2010-08-18 Centro Nacional de Investigaciones Oncológicas (CNIO) Imidazopyridazines for use as protein kinase inhibitors
JP2011507902A (ja) 2007-12-21 2011-03-10 ワイス・エルエルシー 肝臓Ｘ受容体のモジュレーターとしてのイミダゾ［１，２−ｂ］ピリダジン化合物
US20140288069A1 (en) 2011-05-17 2014-09-25 Bayer Intellectual Property Gmbh Amino-substituted imidazopyridazines as mknk1 kinase inhibitors
ES2625854T3 (es) 2011-06-01 2017-07-20 Bayer Intellectual Property Gmbh Aminoimidazopiridazinas sustituidas
CN103764656A (zh) 2011-06-22 2014-04-30 拜耳知识产权有限责任公司 杂环基氨基咪唑并哒嗪
AR087701A1 (es) 2011-08-31 2014-04-09 Japan Tobacco Inc Derivados de pirazol con actividad inhibidora de sglt1
JO3192B1 (ar) 2011-09-06 2018-03-08 Novartis Ag مركب بنزوثيازولون
UA117092C2 (uk) 2011-09-06 2018-06-25 Байєр Інтеллектуал Проперті Гмбх Амінозаміщені імідазопіридазини
CA2849345A1 (en) 2011-09-23 2013-03-28 Bayer Intellectual Property Gmbh Substituted imidazopyridazines
US9353081B2 (en) 2011-09-23 2016-05-31 Hoffmann-La Roche Inc. Bicyclic dihydroquinoline-2-one derivatives
EP2804864B1 (en) 2011-12-12 2017-09-06 Bayer Intellectual Property GmbH Amino-substituted imidazopyridazines
CA2868673A1 (en) 2012-03-29 2013-10-03 Bayer Intellectual Property Gmbh Amino-substituted imidazopyridazines
CA2869212A1 (en) 2012-04-04 2013-10-10 Bayer Pharma Aktiengesellschaft Amino-substituted imidazopyridazines
WO2014076162A1 (en) 2012-11-19 2014-05-22 Bayer Pharma Aktiengesellschaft Aminoimidazopyridazines
HK1211578A1 (en) 2013-01-30 2016-05-27 拜耳医药股份公司 Amidoimidazopyridazines as mknk-1 kinase inhibitors
HK1212699A1 (zh) 2013-02-20 2016-06-17 拜耳医药股份公司 作为mknk1抑制剂的取代的咪唑并[1，2-b]哒嗪类化合物
US10214545B2 (en) 2014-01-09 2019-02-26 Bayer Pharma Aktiengesellschaft Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders

Also Published As

Publication number Publication date
AP2014007496A0 (en) 2014-03-31
RS56179B1 (sr) 2017-11-30
AP3853A (OSRAM) 2016-09-30
NZ622129A (en) 2016-06-24
MY168413A (en) 2018-11-09
LT2758401T (lt) 2017-08-25
BR112014004687A2 (pt) 2017-03-28
AU2012306422A1 (en) 2014-03-27
HRP20171248T1 (hr) 2017-10-20
ES2638319T3 (es) 2017-10-19
MX2014002697A (es) 2014-04-25
SI2758401T1 (sl) 2017-10-30
PE20141593A1 (es) 2014-11-12
CN103958515A (zh) 2014-07-30
EA201400311A1 (ru) 2014-09-30
ZA201402498B (en) 2017-09-27
US9499547B2 (en) 2016-11-22
AU2012306422B2 (en) 2017-10-26
JP6174583B2 (ja) 2017-08-02
CR20140113A (es) 2014-05-02
EP2758401A1 (en) 2014-07-30
WO2013034570A1 (en) 2013-03-14
PL2758401T3 (pl) 2017-11-30
MA35422B1 (fr) 2014-09-01
CN103958515B (zh) 2016-11-09
IL231351A0 (en) 2014-04-30
ECSP14013231A (es) 2014-04-30
UA117092C2 (uk) 2018-06-25
DOP2014000051A (es) 2014-06-01
CA2847514A1 (en) 2013-03-14
EA025688B1 (ru) 2017-01-30
EP2758401B1 (en) 2017-05-31
HK1199732A1 (en) 2015-07-17
PT2758401T (pt) 2017-08-30
GT201400043A (es) 2015-04-06
PH12014500501A1 (en) 2021-06-02
ME02951B (me) 2018-07-20
CY1119433T1 (el) 2018-03-07
IL231351A (en) 2017-01-31
DK2758401T3 (en) 2017-09-11
KR20140059268A (ko) 2014-05-15
JP2014525469A (ja) 2014-09-29
CO6900146A2 (es) 2014-03-20
SG11201400219PA (en) 2014-03-28
US20140296231A1 (en) 2014-10-02
MX348064B (es) 2017-05-26

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