CL2013002025A1 - Compuestos derivados de 1h-benzo[d]imidazol o sus sales; composicion farmaceutica; y uso en infecciones bacterianas. - Google Patents
Compuestos derivados de 1h-benzo[d]imidazol o sus sales; composicion farmaceutica; y uso en infecciones bacterianas.Info
- Publication number
- CL2013002025A1 CL2013002025A1 CL2013002025A CL2013002025A CL2013002025A1 CL 2013002025 A1 CL2013002025 A1 CL 2013002025A1 CL 2013002025 A CL2013002025 A CL 2013002025A CL 2013002025 A CL2013002025 A CL 2013002025A CL 2013002025 A1 CL2013002025 A1 CL 2013002025A1
- Authority
- CL
- Chile
- Prior art keywords
- benzo
- imidazole
- salts
- pharmaceutical composition
- bacterial infections
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 208000035143 Bacterial infection Diseases 0.000 title 1
- 208000022362 bacterial infectious disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161432965P | 2011-01-14 | 2011-01-14 | |
US201161499134P | 2011-06-20 | 2011-06-20 | |
US201161515174P | 2011-08-04 | 2011-08-04 | |
US201161515249P | 2011-08-04 | 2011-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2013002025A1 true CL2013002025A1 (es) | 2013-12-27 |
Family
ID=45567120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013002025A CL2013002025A1 (es) | 2011-01-14 | 2013-07-12 | Compuestos derivados de 1h-benzo[d]imidazol o sus sales; composicion farmaceutica; y uso en infecciones bacterianas. |
Country Status (18)
Country | Link |
---|---|
US (2) | US8481551B2 (es) |
EP (1) | EP2663557B1 (es) |
JP (1) | JP6085829B2 (es) |
KR (1) | KR101897952B1 (es) |
CN (1) | CN103443096B (es) |
AR (1) | AR084863A1 (es) |
AU (1) | AU2012205415B2 (es) |
BR (1) | BR112013017974B1 (es) |
CA (1) | CA2824516C (es) |
CL (1) | CL2013002025A1 (es) |
ES (1) | ES2545516T3 (es) |
IL (1) | IL227406A (es) |
MX (1) | MX339455B (es) |
RU (1) | RU2609259C2 (es) |
SG (1) | SG191946A1 (es) |
TW (1) | TWI546298B (es) |
WO (1) | WO2012097269A1 (es) |
ZA (1) | ZA201305233B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012097274A1 (en) * | 2011-01-14 | 2012-07-19 | Vertex Pharmaceuticals Incorporation | Process of making gyrase and topoisomerase iv inhibitors |
KR101897950B1 (ko) * | 2011-01-14 | 2018-09-12 | 스페로 트리넴, 인코포레이티드 | 자이라제 억제제 (r)1에틸3[5[2{1하이드록시1메틸에틸}피리미딘5일]7(테트라하이드로푸란2일}1h벤즈이미다졸2일]우레아의 고체 형태 |
RU2625305C2 (ru) * | 2011-01-14 | 2017-07-13 | Сперо Тринем, Инк. | Твердые формы ингибитора гиразы (r)-1-этил-3-[6-фтор-5[2-(1-гидрокси-1-метил-этил) пиримидин-5-ил]-7-(тетрагидрофуран-2-ил)-1н-бензимидазол-2-ил] мочевины |
AU2012205415B2 (en) | 2011-01-14 | 2017-02-02 | Spero Therapeutics, Inc. | Pyrimidine gyrase and topoisomerase IV inhibitors |
TWI554515B (zh) * | 2011-06-20 | 2016-10-21 | 維泰克斯製藥公司 | 旋轉酶(gyrase)及拓樸異構酶抑制劑之磷酸酯 |
US9018216B2 (en) | 2012-07-18 | 2015-04-28 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof |
US9572809B2 (en) | 2012-07-18 | 2017-02-21 | Spero Trinem, Inc. | Combination therapy to treat Mycobacterium diseases |
CA2938459A1 (en) | 2014-02-03 | 2015-08-06 | Spero Gyrase, Inc. | Antibacterial compounds |
BR112019000290B1 (pt) * | 2016-07-07 | 2022-10-18 | Cyclerion Therapeutics, Inc | Prófármacos de fósforo dos estimuladores da sgc |
JPWO2018174288A1 (ja) | 2017-03-24 | 2020-01-23 | 大正製薬株式会社 | 2(1h)−キノリノン誘導体 |
US20200345637A1 (en) * | 2018-01-19 | 2020-11-05 | Aiviva Biopharma, Inc. | Suspension compositions of multi-target inhibitors |
CN109464471B (zh) * | 2019-01-17 | 2023-09-19 | 广西医科大学 | 一种铜绿假单胞菌家兔脓胸脓絮状物生物膜模型建立方法 |
CN109464472B (zh) * | 2019-01-17 | 2023-09-15 | 广西医科大学 | 一种铜绿假单胞菌家兔脓胸引流管生物膜模型建立方法 |
CA3236710A1 (en) * | 2021-10-26 | 2023-05-04 | Spero Therapeutics, Inc. | Human efficacious dose and dosage schedule of spr720 |
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US8404852B2 (en) | 2003-01-31 | 2013-03-26 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
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GB0724349D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Antibacterial agents |
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MX339000B (es) | 2009-10-16 | 2016-05-09 | Melinta Therapeutics Inc | Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos. |
AU2011313820A1 (en) | 2010-10-08 | 2013-04-11 | Biota Europe Ltd | Antibacterial compounds |
RU2625305C2 (ru) | 2011-01-14 | 2017-07-13 | Сперо Тринем, Инк. | Твердые формы ингибитора гиразы (r)-1-этил-3-[6-фтор-5[2-(1-гидрокси-1-метил-этил) пиримидин-5-ил]-7-(тетрагидрофуран-2-ил)-1н-бензимидазол-2-ил] мочевины |
KR101897950B1 (ko) * | 2011-01-14 | 2018-09-12 | 스페로 트리넴, 인코포레이티드 | 자이라제 억제제 (r)1에틸3[5[2{1하이드록시1메틸에틸}피리미딘5일]7(테트라하이드로푸란2일}1h벤즈이미다졸2일]우레아의 고체 형태 |
AU2012205415B2 (en) | 2011-01-14 | 2017-02-02 | Spero Therapeutics, Inc. | Pyrimidine gyrase and topoisomerase IV inhibitors |
WO2012097274A1 (en) * | 2011-01-14 | 2012-07-19 | Vertex Pharmaceuticals Incorporation | Process of making gyrase and topoisomerase iv inhibitors |
TWI554515B (zh) | 2011-06-20 | 2016-10-21 | 維泰克斯製藥公司 | 旋轉酶(gyrase)及拓樸異構酶抑制劑之磷酸酯 |
US9604976B2 (en) | 2012-03-22 | 2017-03-28 | Spero Gyrase, Inc. | Antibacterial compounds |
US9018216B2 (en) * | 2012-07-18 | 2015-04-28 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof |
US9572809B2 (en) * | 2012-07-18 | 2017-02-21 | Spero Trinem, Inc. | Combination therapy to treat Mycobacterium diseases |
-
2012
- 2012-01-13 AU AU2012205415A patent/AU2012205415B2/en active Active
- 2012-01-13 US US13/349,789 patent/US8481551B2/en active Active
- 2012-01-13 MX MX2013008162A patent/MX339455B/es active IP Right Grant
- 2012-01-13 CN CN201280012742.5A patent/CN103443096B/zh active Active
- 2012-01-13 BR BR112013017974-0A patent/BR112013017974B1/pt active IP Right Grant
- 2012-01-13 RU RU2013137750A patent/RU2609259C2/ru active
- 2012-01-13 WO PCT/US2012/021270 patent/WO2012097269A1/en active Application Filing
- 2012-01-13 SG SG2013053426A patent/SG191946A1/en unknown
- 2012-01-13 KR KR1020137018403A patent/KR101897952B1/ko active IP Right Grant
- 2012-01-13 TW TW101101534A patent/TWI546298B/zh active
- 2012-01-13 CA CA2824516A patent/CA2824516C/en active Active
- 2012-01-13 ES ES12702920.5T patent/ES2545516T3/es active Active
- 2012-01-13 EP EP12702920.5A patent/EP2663557B1/en active Active
- 2012-01-13 JP JP2013549575A patent/JP6085829B2/ja active Active
- 2012-01-16 AR ARP120100137A patent/AR084863A1/es active IP Right Grant
-
2013
- 2013-06-03 US US13/908,593 patent/US8969359B2/en active Active
- 2013-07-10 IL IL227406A patent/IL227406A/en active IP Right Grant
- 2013-07-11 ZA ZA2013/05233A patent/ZA201305233B/en unknown
- 2013-07-12 CL CL2013002025A patent/CL2013002025A1/es unknown
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CA2824516C (en) | 2019-02-26 |
RU2609259C2 (ru) | 2017-01-31 |
US20120184512A1 (en) | 2012-07-19 |
RU2013137750A (ru) | 2015-02-20 |
US8481551B2 (en) | 2013-07-09 |
BR112013017974A2 (pt) | 2018-05-02 |
EP2663557B1 (en) | 2015-05-27 |
JP2014503557A (ja) | 2014-02-13 |
US8969359B2 (en) | 2015-03-03 |
CA2824516A1 (en) | 2012-07-19 |
AR084863A1 (es) | 2013-07-10 |
CN103443096A (zh) | 2013-12-11 |
JP6085829B2 (ja) | 2017-03-01 |
NZ612961A (en) | 2015-10-30 |
MX339455B (es) | 2016-05-27 |
KR20140037031A (ko) | 2014-03-26 |
BR112013017974B1 (pt) | 2021-05-25 |
WO2012097269A1 (en) | 2012-07-19 |
ES2545516T3 (es) | 2015-09-11 |
IL227406A0 (en) | 2013-09-30 |
TW201309677A (zh) | 2013-03-01 |
MX2013008162A (es) | 2013-08-27 |
TWI546298B (zh) | 2016-08-21 |
SG191946A1 (en) | 2013-08-30 |
ZA201305233B (en) | 2014-11-26 |
AU2012205415B2 (en) | 2017-02-02 |
AU2012205415A1 (en) | 2013-08-01 |
EP2663557A1 (en) | 2013-11-20 |
KR101897952B1 (ko) | 2018-09-12 |
CN103443096B (zh) | 2016-06-29 |
IL227406A (en) | 2017-02-28 |
US20130289002A1 (en) | 2013-10-31 |
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