CL2012000192A1 - Proceso para la obtencion de sulfonamidas por reaccion entre una diamina y un derivado de ciclopropan sulfonamida; y el compuesto intermediario derivado de ciclopropan sulfonamida considerado. - Google Patents
Proceso para la obtencion de sulfonamidas por reaccion entre una diamina y un derivado de ciclopropan sulfonamida; y el compuesto intermediario derivado de ciclopropan sulfonamida considerado.Info
- Publication number
- CL2012000192A1 CL2012000192A1 CL2012000192A CL2012000192A CL2012000192A1 CL 2012000192 A1 CL2012000192 A1 CL 2012000192A1 CL 2012000192 A CL2012000192 A CL 2012000192A CL 2012000192 A CL2012000192 A CL 2012000192A CL 2012000192 A1 CL2012000192 A1 CL 2012000192A1
- Authority
- CL
- Chile
- Prior art keywords
- cyclopropan
- sulfonamide
- sulfonamides
- diamine
- obtaining
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- WMSPXQIQBQAWLL-UHFFFAOYSA-N cyclopropanesulfonamide Chemical class NS(=O)(=O)C1CC1 WMSPXQIQBQAWLL-UHFFFAOYSA-N 0.000 title 2
- 150000004985 diamines Chemical class 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- -1 3,4-difluoro-2 (2-fluoro-4 iodophenylamino) -6-methoxyphenyl Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
- C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL2015001030A CL2015001030A1 (es) | 2009-07-24 | 2015-04-22 | Proceso para preparar (s)-n-(3,4-difluoro-2-(2-fluoro-4-yodofenilamino)-6-metoxifenil)-1-(2,3-dihidroxipropil) ciclopropan-1-sulfonamida y compuestos intermediarios (div. sol. 192-12). |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22850109P | 2009-07-24 | 2009-07-24 | |
| US22850909P | 2009-07-24 | 2009-07-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012000192A1 true CL2012000192A1 (es) | 2012-10-05 |
Family
ID=42830488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012000192A CL2012000192A1 (es) | 2009-07-24 | 2012-01-24 | Proceso para la obtencion de sulfonamidas por reaccion entre una diamina y un derivado de ciclopropan sulfonamida; y el compuesto intermediario derivado de ciclopropan sulfonamida considerado. |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US8513443B2 (https=) |
| EP (1) | EP2462111B1 (https=) |
| JP (1) | JP5776115B2 (https=) |
| KR (1) | KR101763437B1 (https=) |
| CN (2) | CN103848808B (https=) |
| AR (1) | AR079183A1 (https=) |
| AU (1) | AU2010275780B2 (https=) |
| BR (1) | BR112012001592A2 (https=) |
| CA (2) | CA2990097A1 (https=) |
| CL (1) | CL2012000192A1 (https=) |
| CO (1) | CO6491075A2 (https=) |
| CR (1) | CR20120044A (https=) |
| CU (1) | CU24113B1 (https=) |
| DO (1) | DOP2012000017A (https=) |
| EA (1) | EA023623B1 (https=) |
| EC (1) | ECSP12011621A (https=) |
| GT (1) | GT201200017A (https=) |
| HN (1) | HN2012000142A (https=) |
| IL (1) | IL217312A (https=) |
| IN (1) | IN2012DN00696A (https=) |
| MA (1) | MA33452B1 (https=) |
| MX (2) | MX2012001063A (https=) |
| MY (1) | MY160421A (https=) |
| NZ (1) | NZ597738A (https=) |
| PE (1) | PE20120573A1 (https=) |
| PH (1) | PH12014500158B1 (https=) |
| SG (1) | SG177535A1 (https=) |
| TN (1) | TN2012000027A1 (https=) |
| TW (1) | TWI524890B (https=) |
| UY (1) | UY32800A (https=) |
| WO (1) | WO2011009541A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI524890B (zh) * | 2009-07-24 | 2016-03-11 | 亞德生化公司 | （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備 |
| PH12013502446A1 (en) * | 2011-05-27 | 2014-01-20 | Bayer Ip Gmbh | Chiral synthesis of n-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides |
| JPWO2013094546A1 (ja) * | 2011-12-19 | 2015-04-27 | 住友化学株式会社 | スルホン酸塩の製造方法 |
| EP2848246A1 (en) | 2013-09-13 | 2015-03-18 | Bayer Pharma Aktiengesellschaft | Pharmaceutical compositions containing refametinib |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1912636T1 (sl) * | 2005-07-21 | 2014-08-29 | Ardea Biosciences, Inc. | N-(arilamino)-sulfonamidni inhibitorji MEK |
| US8101799B2 (en) * | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
| US7842836B2 (en) | 2006-04-11 | 2010-11-30 | Ardea Biosciences | N-aryl-N'alkyl sulfamides as MEK inhibitors |
| MX2008013097A (es) | 2006-04-18 | 2008-10-27 | Ardea Biosciences Inc | Piridona sulfonamidas y piridona sulfamidas como inhibidores de metiletilcetona. |
| UA99731C2 (ru) * | 2007-07-30 | 2012-09-25 | Ардеа Биосайенсис, Инк | Кристаллические полиморфные формы n-(ариламино)сульфонамидов как ингибиторы мэк, композиция (варианты) и применение |
| US8808742B2 (en) * | 2008-04-14 | 2014-08-19 | Ardea Biosciences, Inc. | Compositions and methods for preparing and using same |
| TWI524890B (zh) * | 2009-07-24 | 2016-03-11 | 亞德生化公司 | （ｒ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺及（ｓ）－ｎ－（３，４－二氟－２－（２－氟－４－碘苯胺基）－６－甲氧基苯基）－１－（２，３－二羥丙基）環丙烷－１－磺醯胺之製備 |
-
2010
- 2010-07-09 TW TW099122740A patent/TWI524890B/zh not_active IP Right Cessation
- 2010-07-10 MY MYPI2012000099A patent/MY160421A/en unknown
- 2010-07-10 CU CUP2012000014A patent/CU24113B1/es active IP Right Grant
- 2010-07-10 EP EP10734043.2A patent/EP2462111B1/en active Active
- 2010-07-10 CA CA2990097A patent/CA2990097A1/en not_active Abandoned
- 2010-07-10 BR BR112012001592A patent/BR112012001592A2/pt not_active Application Discontinuation
- 2010-07-10 IN IN696DEN2012 patent/IN2012DN00696A/en unknown
- 2010-07-10 JP JP2012520927A patent/JP5776115B2/ja not_active Expired - Fee Related
- 2010-07-10 NZ NZ597738A patent/NZ597738A/en not_active IP Right Cessation
- 2010-07-10 US US13/386,519 patent/US8513443B2/en not_active Expired - Fee Related
- 2010-07-10 EA EA201200175A patent/EA023623B1/ru not_active IP Right Cessation
- 2010-07-10 SG SG2012000964A patent/SG177535A1/en unknown
- 2010-07-10 CN CN201310670649.XA patent/CN103848808B/zh not_active Expired - Fee Related
- 2010-07-10 CA CA2768788A patent/CA2768788C/en not_active Expired - Fee Related
- 2010-07-10 MA MA34562A patent/MA33452B1/fr unknown
- 2010-07-10 KR KR1020127001737A patent/KR101763437B1/ko not_active Expired - Fee Related
- 2010-07-10 MX MX2012001063A patent/MX2012001063A/es active IP Right Grant
- 2010-07-10 PE PE2012000092A patent/PE20120573A1/es not_active Application Discontinuation
- 2010-07-10 CN CN201080031572.6A patent/CN102471246B/zh not_active Expired - Fee Related
- 2010-07-10 WO PCT/EP2010/004222 patent/WO2011009541A1/en not_active Ceased
- 2010-07-10 AU AU2010275780A patent/AU2010275780B2/en not_active Ceased
- 2010-07-22 UY UY0001032800A patent/UY32800A/es not_active Application Discontinuation
- 2010-07-23 AR ARP100102678A patent/AR079183A1/es unknown
-
2012
- 2012-01-01 IL IL217312A patent/IL217312A/en not_active IP Right Cessation
- 2012-01-19 TN TNP2012000027A patent/TN2012000027A1/en unknown
- 2012-01-23 CR CR20120044A patent/CR20120044A/es unknown
- 2012-01-24 CL CL2012000192A patent/CL2012000192A1/es unknown
- 2012-01-24 CO CO12010431A patent/CO6491075A2/es active IP Right Grant
- 2012-01-24 DO DO2012000017A patent/DOP2012000017A/es unknown
- 2012-01-24 MX MX2014000732A patent/MX344965B/es unknown
- 2012-01-24 GT GT201200017A patent/GT201200017A/es unknown
- 2012-01-24 EC EC2012011621A patent/ECSP12011621A/es unknown
- 2012-01-24 HN HN2012000142A patent/HN2012000142A/es unknown
-
2013
- 2013-04-23 US US13/868,621 patent/US8884058B2/en not_active Expired - Fee Related
-
2014
- 2014-01-16 PH PH12014500158A patent/PH12014500158B1/en unknown
- 2014-08-25 US US14/467,424 patent/US9296686B2/en not_active Expired - Fee Related
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