CL2009000985A1 - Composicion oftalmica que comprende entre 0,16 y 0,19% p/v de un galactomanano, alrededor de 0,7% p/v de un borato, cis-diol y menos de 5 ppm de concentracion de cationes divalentes; y su uso para lubricar el ojo. - Google Patents
Composicion oftalmica que comprende entre 0,16 y 0,19% p/v de un galactomanano, alrededor de 0,7% p/v de un borato, cis-diol y menos de 5 ppm de concentracion de cationes divalentes; y su uso para lubricar el ojo.Info
- Publication number
- CL2009000985A1 CL2009000985A1 CL2009000985A CL2009000985A CL2009000985A1 CL 2009000985 A1 CL2009000985 A1 CL 2009000985A1 CL 2009000985 A CL2009000985 A CL 2009000985A CL 2009000985 A CL2009000985 A CL 2009000985A CL 2009000985 A1 CL2009000985 A1 CL 2009000985A1
- Authority
- CL
- Chile
- Prior art keywords
- galactomannan
- borate
- diol
- cis
- lubricate
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 title abstract 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 title abstract 2
- 229920000926 Galactomannan Polymers 0.000 title abstract 2
- 150000001768 cations Chemical class 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000607 artificial tear Substances 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 239000003974 emollient agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4817508P | 2008-04-26 | 2008-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2009000985A1 true CL2009000985A1 (es) | 2010-01-15 |
Family
ID=40886688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2009000985A CL2009000985A1 (es) | 2008-04-26 | 2009-04-24 | Composicion oftalmica que comprende entre 0,16 y 0,19% p/v de un galactomanano, alrededor de 0,7% p/v de un borato, cis-diol y menos de 5 ppm de concentracion de cationes divalentes; y su uso para lubricar el ojo. |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20090270345A1 (enExample) |
| EP (1) | EP2278954B1 (enExample) |
| JP (1) | JP5659149B2 (enExample) |
| KR (1) | KR101592872B1 (enExample) |
| CN (1) | CN102046150B (enExample) |
| AR (2) | AR071834A1 (enExample) |
| AU (1) | AU2009240488B2 (enExample) |
| BR (1) | BRPI0910717A2 (enExample) |
| CA (1) | CA2722508C (enExample) |
| CL (1) | CL2009000985A1 (enExample) |
| ES (1) | ES2818619T3 (enExample) |
| MX (1) | MX2010011736A (enExample) |
| NZ (1) | NZ589323A (enExample) |
| TW (1) | TWI526213B (enExample) |
| UY (1) | UY31785A1 (enExample) |
| WO (1) | WO2009132294A1 (enExample) |
| ZA (1) | ZA201007644B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7220431B2 (en) * | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| US20050137166A1 (en) * | 2003-12-19 | 2005-06-23 | Alcon, Inc. | Use of cooling agents to relieve mild ocular irritation and enhance comfort |
| EP2278954B1 (en) * | 2008-04-26 | 2020-08-26 | Alcon Inc. | Polymeric artificial tear system |
| TWI547522B (zh) * | 2009-07-07 | 2016-09-01 | 愛爾康研究有限公司 | 環氧乙烷環氧丁烷嵌段共聚物組成物 |
| TWI478730B (zh) * | 2009-12-03 | 2015-04-01 | Alcon Res Ltd | 眼科乳劑 |
| AU2010326099B2 (en) * | 2009-12-03 | 2013-03-07 | Novartis Ag | Carboxyvinyl polymer-container nanoparticle suspensions |
| NZ603345A (en) * | 2010-05-05 | 2014-12-24 | Alcon Res Ltd | Stabilized ophthalmic galactomannan formulations |
| UA113434C2 (uk) * | 2012-05-04 | 2017-01-25 | Алкон Рісерч, Лтд. | Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням |
| US20130344619A1 (en) | 2012-06-21 | 2013-12-26 | Lightship Medical Limited | Glucose sensor |
| US11730699B2 (en) | 2018-02-21 | 2023-08-22 | Alcon Inc. | Lipid-based ophthalmic emulsion |
| TWI884130B (zh) * | 2018-02-21 | 2025-05-21 | 瑞士商愛爾康公司 | 基於脂質的眼用乳劑 |
| JP6705495B1 (ja) * | 2018-12-26 | 2020-06-03 | 株式会社Ｊｖｃケンウッド | 車両用記録制御装置、車両用記録装置、車両用記録制御方法およびプログラム |
| WO2020177714A1 (zh) * | 2019-03-04 | 2020-09-10 | 中山大学中山眼科中心 | 一种羊毛甾醇前药化合物的组合物及其制备方法和应用 |
| TWI757773B (zh) | 2019-06-28 | 2022-03-11 | 瑞士商愛爾康公司 | 眼用組成物 |
| AU2020347951B2 (en) | 2019-09-18 | 2023-11-02 | Alcon Inc. | Wet-packed soft hydrogel ocular inserts |
| CN114191378A (zh) * | 2021-11-23 | 2022-03-18 | 温州医科大学附属眼视光医院 | 一种地夸磷索缓释凝胶及其制备方法与应用 |
| WO2025186704A1 (en) | 2024-03-04 | 2025-09-12 | Alcon Inc. | Mucoadhesive hydrophilic copolymers and uses thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1593954A (en) * | 1977-01-31 | 1981-07-22 | American Home Prod | Xanthan gum or locust bean gum topical therapeutic compositions |
| US4136173A (en) * | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Mixed xanthan gum and locust beam gum therapeutic compositions |
| US5505953A (en) * | 1992-05-06 | 1996-04-09 | Alcon Laboratories, Inc. | Use of borate-polyol complexes in ophthalmic compositions |
| AU8570498A (en) * | 1997-07-29 | 1999-02-22 | Alcon Laboratories, Inc. | Switchable viscoelastic systems containing galactomannan polymers and borate |
| US6403609B1 (en) * | 1997-07-29 | 2002-06-11 | Alcon Manufacturing, Ltd. | Ophthalmic compositions containing galactomannan polymers and borate |
| IT1298758B1 (it) * | 1998-03-19 | 2000-02-02 | Angelini Ricerche Spa | Soluzione umettante e lubrificante per uso oftalmico |
| TWI336257B (en) * | 2003-06-13 | 2011-01-21 | Alcon Inc | Ophthalmic compositions containing a synergistic combination of three polymers |
| CA2545947A1 (en) * | 2003-12-11 | 2005-07-07 | Alcon, Inc. | Ophthalmic compositions containing a polysaccharide/borate gelling system |
| DE102006031500A1 (de) | 2006-07-06 | 2008-04-17 | Henkel Kgaa | O/W-Emulsion |
| WO2008036855A2 (en) * | 2006-09-21 | 2008-03-27 | Alcon Research, Ltd. | Self-preserved aqueous pharmaceutical compositions |
| US9096819B2 (en) * | 2008-01-31 | 2015-08-04 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer |
| US8119112B2 (en) * | 2008-01-31 | 2012-02-21 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid |
| EP2278954B1 (en) * | 2008-04-26 | 2020-08-26 | Alcon Inc. | Polymeric artificial tear system |
| NZ603345A (en) * | 2010-05-05 | 2014-12-24 | Alcon Res Ltd | Stabilized ophthalmic galactomannan formulations |
-
2009
- 2009-04-24 EP EP09734932.8A patent/EP2278954B1/en active Active
- 2009-04-24 BR BRPI0910717A patent/BRPI0910717A2/pt not_active Application Discontinuation
- 2009-04-24 JP JP2011506485A patent/JP5659149B2/ja active Active
- 2009-04-24 AR ARP090101464A patent/AR071834A1/es not_active Application Discontinuation
- 2009-04-24 ES ES09734932T patent/ES2818619T3/es active Active
- 2009-04-24 MX MX2010011736A patent/MX2010011736A/es active IP Right Grant
- 2009-04-24 AU AU2009240488A patent/AU2009240488B2/en active Active
- 2009-04-24 WO PCT/US2009/041699 patent/WO2009132294A1/en not_active Ceased
- 2009-04-24 KR KR1020107026488A patent/KR101592872B1/ko active Active
- 2009-04-24 CL CL2009000985A patent/CL2009000985A1/es unknown
- 2009-04-24 TW TW098113635A patent/TWI526213B/zh active
- 2009-04-24 CN CN2009801189624A patent/CN102046150B/zh active Active
- 2009-04-24 US US12/429,942 patent/US20090270345A1/en not_active Abandoned
- 2009-04-24 NZ NZ589323A patent/NZ589323A/en not_active IP Right Cessation
- 2009-04-24 UY UY31785A patent/UY31785A1/es not_active Application Discontinuation
- 2009-04-24 CA CA2722508A patent/CA2722508C/en active Active
-
2010
- 2010-10-26 ZA ZA2010/07644A patent/ZA201007644B/en unknown
-
2011
- 2011-11-22 US US13/302,439 patent/US8685945B2/en active Active
-
2014
- 2014-02-14 US US14/180,396 patent/US9259472B2/en active Active
-
2018
- 2018-07-26 AR ARP180102103 patent/AR112286A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20090270345A1 (en) | 2009-10-29 |
| KR101592872B1 (ko) | 2016-02-12 |
| US20120070402A1 (en) | 2012-03-22 |
| MX2010011736A (es) | 2011-01-21 |
| JP5659149B2 (ja) | 2015-01-28 |
| AU2009240488B2 (en) | 2013-02-21 |
| US9259472B2 (en) | 2016-02-16 |
| KR20110007228A (ko) | 2011-01-21 |
| NZ589323A (en) | 2012-04-27 |
| AU2009240488A1 (en) | 2009-10-29 |
| CN102046150A (zh) | 2011-05-04 |
| AR112286A2 (es) | 2019-10-09 |
| ZA201007644B (en) | 2011-12-28 |
| AR071834A1 (es) | 2010-07-21 |
| WO2009132294A1 (en) | 2009-10-29 |
| CA2722508A1 (en) | 2009-10-29 |
| TWI526213B (zh) | 2016-03-21 |
| CA2722508C (en) | 2016-08-16 |
| EP2278954B1 (en) | 2020-08-26 |
| EP2278954A1 (en) | 2011-02-02 |
| JP2011518842A (ja) | 2011-06-30 |
| US8685945B2 (en) | 2014-04-01 |
| TW200948367A (en) | 2009-12-01 |
| BRPI0910717A2 (pt) | 2015-09-29 |
| UY31785A1 (es) | 2009-08-03 |
| US20140161760A1 (en) | 2014-06-12 |
| CN102046150B (zh) | 2013-07-24 |
| ES2818619T3 (es) | 2021-04-13 |
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