KR101592872B1 - 중합체 인공 눈물 시스템 - Google Patents

중합체 인공 눈물 시스템 Download PDF

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Publication number
KR101592872B1
KR101592872B1 KR1020107026488A KR20107026488A KR101592872B1 KR 101592872 B1 KR101592872 B1 KR 101592872B1 KR 1020107026488 A KR1020107026488 A KR 1020107026488A KR 20107026488 A KR20107026488 A KR 20107026488A KR 101592872 B1 KR101592872 B1 KR 101592872B1
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KR
South Korea
Prior art keywords
borate
formulation
galactomannan
present
sorbitol
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KR1020107026488A
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English (en)
Korean (ko)
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KR20110007228A (ko
Inventor
하워드 알렌 케텔슨
제임스 더블유. 데이비스
데이빗 엘. 메도우스
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알콘 리서치, 리미티드
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Application filed by 알콘 리서치, 리미티드 filed Critical 알콘 리서치, 리미티드
Publication of KR20110007228A publication Critical patent/KR20110007228A/ko
Application granted granted Critical
Publication of KR101592872B1 publication Critical patent/KR101592872B1/ko
Assigned to 알콘 리서치, 엘엘씨 reassignment 알콘 리서치, 엘엘씨 권리의 전부이전등록 Assignors: 알콘 리서치, 리미티드
Assigned to 알콘 인코포레이티드 reassignment 알콘 인코포레이티드 권리의 전부이전등록 Assignors: 알콘 리서치, 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020107026488A 2008-04-26 2009-04-24 중합체 인공 눈물 시스템 Active KR101592872B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4817508P 2008-04-26 2008-04-26
US61/048,175 2008-04-26

Publications (2)

Publication Number Publication Date
KR20110007228A KR20110007228A (ko) 2011-01-21
KR101592872B1 true KR101592872B1 (ko) 2016-02-12

Family

ID=40886688

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107026488A Active KR101592872B1 (ko) 2008-04-26 2009-04-24 중합체 인공 눈물 시스템

Country Status (17)

Country Link
US (3) US20090270345A1 (enExample)
EP (1) EP2278954B1 (enExample)
JP (1) JP5659149B2 (enExample)
KR (1) KR101592872B1 (enExample)
CN (1) CN102046150B (enExample)
AR (2) AR071834A1 (enExample)
AU (1) AU2009240488B2 (enExample)
BR (1) BRPI0910717A2 (enExample)
CA (1) CA2722508C (enExample)
CL (1) CL2009000985A1 (enExample)
ES (1) ES2818619T3 (enExample)
MX (1) MX2010011736A (enExample)
NZ (1) NZ589323A (enExample)
TW (1) TWI526213B (enExample)
UY (1) UY31785A1 (enExample)
WO (1) WO2009132294A1 (enExample)
ZA (1) ZA201007644B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20260082012A (ko) 2024-11-27 2026-06-04 허종욱 인공눈물의 효과 영향 및 안구 안정성 비교 연구 방법

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220431B2 (en) * 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
US20050137166A1 (en) * 2003-12-19 2005-06-23 Alcon, Inc. Use of cooling agents to relieve mild ocular irritation and enhance comfort
AR071834A1 (es) * 2008-04-26 2010-07-21 Alcon Res Ltd Sistema polimerico de lagrimas artificiales
TWI547522B (zh) 2009-07-07 2016-09-01 愛爾康研究有限公司 環氧乙烷環氧丁烷嵌段共聚物組成物
TWI478730B (zh) * 2009-12-03 2015-04-01 Alcon Res Ltd 眼科乳劑
HUE038821T2 (hu) * 2009-12-03 2018-11-28 Novartis Ag Karboxivinil polimert tartalmazó nanorészecske szuszpenziók
NZ603345A (en) * 2010-05-05 2014-12-24 Alcon Res Ltd Stabilized ophthalmic galactomannan formulations
UA113434C2 (uk) * 2012-05-04 2017-01-25 Алкон Рісерч, Лтд. Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням
US20130344619A1 (en) 2012-06-21 2013-12-26 Lightship Medical Limited Glucose sensor
US11730699B2 (en) 2018-02-21 2023-08-22 Alcon Inc. Lipid-based ophthalmic emulsion
TWI913170B (zh) 2018-02-21 2026-01-21 瑞士商愛爾康公司 基於脂質的眼用乳劑
JP6705495B1 (ja) * 2018-12-26 2020-06-03 株式会社Ｊｖｃケンウッド 車両用記録制御装置、車両用記録装置、車両用記録制御方法およびプログラム
US12329763B2 (en) * 2019-03-04 2025-06-17 Guangzhou Ocusun Ophthalmic Biotechnology Co., Ltd. Composition of lanosterol prodrug compound, preparation method therefor and use thereof
TWI757773B (zh) * 2019-06-28 2022-03-11 瑞士商愛爾康公司 眼用組成物
BR112022002467A2 (pt) 2019-09-18 2022-07-19 Alcon Inc Insertos oculares de hidrogel suave embalados a úmido
CN114191378A (zh) * 2021-11-23 2022-03-18 温州医科大学附属眼视光医院 一种地夸磷索缓释凝胶及其制备方法与应用
AU2025233965A1 (en) 2024-03-04 2026-07-16 Alcon Inc. Carbamoylphenylboronic acid-containing acrylic monomers and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006070A1 (en) 1997-07-29 1999-02-11 Alcon Laboratories, Inc. Switchable viscoelastic systems containing galactomannan polymers and borate
WO1999006023A1 (en) 1997-07-29 1999-02-11 Alcon Laboratories, Inc. Ophthalmic compositions containing galactomannan polymers and borate
US20040253202A1 (en) 2003-06-13 2004-12-16 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of three polymers

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
GB1593954A (en) * 1977-01-31 1981-07-22 American Home Prod Xanthan gum or locust bean gum topical therapeutic compositions
US5505953A (en) * 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
IT1298758B1 (it) * 1998-03-19 2000-02-02 Angelini Ricerche Spa Soluzione umettante e lubrificante per uso oftalmico
WO2005060933A1 (en) * 2003-12-11 2005-07-07 Alcon, Inc. Ophthalmic compositions containing a polysaccharide/borate gelling system
DE102006031500A1 (de) 2006-07-06 2008-04-17 Henkel Kgaa O/W-Emulsion
WO2008036855A2 (en) * 2006-09-21 2008-03-27 Alcon Research, Ltd. Self-preserved aqueous pharmaceutical compositions
US8119112B2 (en) * 2008-01-31 2012-02-21 Bausch & Lomb Incorporated Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid
US9096819B2 (en) * 2008-01-31 2015-08-04 Bausch & Lomb Incorporated Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer
AR071834A1 (es) * 2008-04-26 2010-07-21 Alcon Res Ltd Sistema polimerico de lagrimas artificiales
NZ603345A (en) * 2010-05-05 2014-12-24 Alcon Res Ltd Stabilized ophthalmic galactomannan formulations

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006070A1 (en) 1997-07-29 1999-02-11 Alcon Laboratories, Inc. Switchable viscoelastic systems containing galactomannan polymers and borate
WO1999006023A1 (en) 1997-07-29 1999-02-11 Alcon Laboratories, Inc. Ophthalmic compositions containing galactomannan polymers and borate
US20040253202A1 (en) 2003-06-13 2004-12-16 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of three polymers

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20260082012A (ko) 2024-11-27 2026-06-04 허종욱 인공눈물의 효과 영향 및 안구 안정성 비교 연구 방법

Also Published As

Publication number Publication date
TWI526213B (zh) 2016-03-21
CA2722508C (en) 2016-08-16
US9259472B2 (en) 2016-02-16
EP2278954B1 (en) 2020-08-26
CL2009000985A1 (es) 2010-01-15
CN102046150A (zh) 2011-05-04
BRPI0910717A2 (pt) 2015-09-29
ES2818619T3 (es) 2021-04-13
EP2278954A1 (en) 2011-02-02
US8685945B2 (en) 2014-04-01
NZ589323A (en) 2012-04-27
CN102046150B (zh) 2013-07-24
AR112286A2 (es) 2019-10-09
JP5659149B2 (ja) 2015-01-28
ZA201007644B (en) 2011-12-28
US20120070402A1 (en) 2012-03-22
MX2010011736A (es) 2011-01-21
AU2009240488A1 (en) 2009-10-29
US20090270345A1 (en) 2009-10-29
KR20110007228A (ko) 2011-01-21
UY31785A1 (es) 2009-08-03
CA2722508A1 (en) 2009-10-29
TW200948367A (en) 2009-12-01
US20140161760A1 (en) 2014-06-12
AR071834A1 (es) 2010-07-21
AU2009240488B2 (en) 2013-02-21
JP2011518842A (ja) 2011-06-30
WO2009132294A1 (en) 2009-10-29

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