JP5659149B2 - ポリマー性人工涙液系 - Google Patents

ポリマー性人工涙液系 Download PDF

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Publication number
JP5659149B2
JP5659149B2 JP2011506485A JP2011506485A JP5659149B2 JP 5659149 B2 JP5659149 B2 JP 5659149B2 JP 2011506485 A JP2011506485 A JP 2011506485A JP 2011506485 A JP2011506485 A JP 2011506485A JP 5659149 B2 JP5659149 B2 JP 5659149B2
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Japan
Prior art keywords
formulation
galactomannan
borate
cis
diol
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JP2011506485A
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English (en)
Japanese (ja)
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JP2011518842A (ja
JP2011518842A5 (enExample
Inventor
ホワード アレン ケテルソン，
ホワード アレン ケテルソン，
ジェイムス ダブリュー． デイビス，
ジェイムス ダブリュー． デイビス，
デイビッド エル． メドウズ，
デイビッド エル． メドウズ，
Original Assignee
アルコン リサーチ， リミテッド
アルコン リサーチ， リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011506485A 2008-04-26 2009-04-24 ポリマー性人工涙液系 Active JP5659149B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4817508P 2008-04-26 2008-04-26
US61/048,175 2008-04-26
PCT/US2009/041699 WO2009132294A1 (en) 2008-04-26 2009-04-24 Polymeric artificial tear system

Publications (3)

Publication Number Publication Date
JP2011518842A JP2011518842A (ja) 2011-06-30
JP2011518842A5 JP2011518842A5 (enExample) 2013-03-14
JP5659149B2 true JP5659149B2 (ja) 2015-01-28

Family

ID=40886688

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011506485A Active JP5659149B2 (ja) 2008-04-26 2009-04-24 ポリマー性人工涙液系

Country Status (17)

Country Link
US (3) US20090270345A1 (enExample)
EP (1) EP2278954B1 (enExample)
JP (1) JP5659149B2 (enExample)
KR (1) KR101592872B1 (enExample)
CN (1) CN102046150B (enExample)
AR (2) AR071834A1 (enExample)
AU (1) AU2009240488B2 (enExample)
BR (1) BRPI0910717A2 (enExample)
CA (1) CA2722508C (enExample)
CL (1) CL2009000985A1 (enExample)
ES (1) ES2818619T3 (enExample)
MX (1) MX2010011736A (enExample)
NZ (1) NZ589323A (enExample)
TW (1) TWI526213B (enExample)
UY (1) UY31785A1 (enExample)
WO (1) WO2009132294A1 (enExample)
ZA (1) ZA201007644B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220431B2 (en) * 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
US20050137166A1 (en) * 2003-12-19 2005-06-23 Alcon, Inc. Use of cooling agents to relieve mild ocular irritation and enhance comfort
EP2278954B1 (en) * 2008-04-26 2020-08-26 Alcon Inc. Polymeric artificial tear system
TWI547522B (zh) * 2009-07-07 2016-09-01 愛爾康研究有限公司 環氧乙烷環氧丁烷嵌段共聚物組成物
TWI478730B (zh) * 2009-12-03 2015-04-01 Alcon Res Ltd 眼科乳劑
AU2010326099B2 (en) * 2009-12-03 2013-03-07 Novartis Ag Carboxyvinyl polymer-container nanoparticle suspensions
NZ603345A (en) * 2010-05-05 2014-12-24 Alcon Res Ltd Stabilized ophthalmic galactomannan formulations
UA113434C2 (uk) * 2012-05-04 2017-01-25 Алкон Рісерч, Лтд. Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням
US20130344619A1 (en) 2012-06-21 2013-12-26 Lightship Medical Limited Glucose sensor
US11730699B2 (en) 2018-02-21 2023-08-22 Alcon Inc. Lipid-based ophthalmic emulsion
TWI884130B (zh) * 2018-02-21 2025-05-21 瑞士商愛爾康公司 基於脂質的眼用乳劑
JP6705495B1 (ja) * 2018-12-26 2020-06-03 株式会社Ｊｖｃケンウッド 車両用記録制御装置、車両用記録装置、車両用記録制御方法およびプログラム
WO2020177714A1 (zh) * 2019-03-04 2020-09-10 中山大学中山眼科中心 一种羊毛甾醇前药化合物的组合物及其制备方法和应用
TWI757773B (zh) 2019-06-28 2022-03-11 瑞士商愛爾康公司 眼用組成物
AU2020347951B2 (en) 2019-09-18 2023-11-02 Alcon Inc. Wet-packed soft hydrogel ocular inserts
CN114191378A (zh) * 2021-11-23 2022-03-18 温州医科大学附属眼视光医院 一种地夸磷索缓释凝胶及其制备方法与应用
WO2025186704A1 (en) 2024-03-04 2025-09-12 Alcon Inc. Mucoadhesive hydrophilic copolymers and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593954A (en) * 1977-01-31 1981-07-22 American Home Prod Xanthan gum or locust bean gum topical therapeutic compositions
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
US5505953A (en) * 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
AU8570498A (en) * 1997-07-29 1999-02-22 Alcon Laboratories, Inc. Switchable viscoelastic systems containing galactomannan polymers and borate
US6403609B1 (en) * 1997-07-29 2002-06-11 Alcon Manufacturing, Ltd. Ophthalmic compositions containing galactomannan polymers and borate
IT1298758B1 (it) * 1998-03-19 2000-02-02 Angelini Ricerche Spa Soluzione umettante e lubrificante per uso oftalmico
TWI336257B (en) * 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
CA2545947A1 (en) * 2003-12-11 2005-07-07 Alcon, Inc. Ophthalmic compositions containing a polysaccharide/borate gelling system
DE102006031500A1 (de) 2006-07-06 2008-04-17 Henkel Kgaa O/W-Emulsion
WO2008036855A2 (en) * 2006-09-21 2008-03-27 Alcon Research, Ltd. Self-preserved aqueous pharmaceutical compositions
US9096819B2 (en) * 2008-01-31 2015-08-04 Bausch & Lomb Incorporated Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer
US8119112B2 (en) * 2008-01-31 2012-02-21 Bausch & Lomb Incorporated Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid
EP2278954B1 (en) * 2008-04-26 2020-08-26 Alcon Inc. Polymeric artificial tear system
NZ603345A (en) * 2010-05-05 2014-12-24 Alcon Res Ltd Stabilized ophthalmic galactomannan formulations

Also Published As

Publication number Publication date
US20090270345A1 (en) 2009-10-29
KR101592872B1 (ko) 2016-02-12
US20120070402A1 (en) 2012-03-22
MX2010011736A (es) 2011-01-21
AU2009240488B2 (en) 2013-02-21
US9259472B2 (en) 2016-02-16
KR20110007228A (ko) 2011-01-21
NZ589323A (en) 2012-04-27
AU2009240488A1 (en) 2009-10-29
CN102046150A (zh) 2011-05-04
AR112286A2 (es) 2019-10-09
ZA201007644B (en) 2011-12-28
AR071834A1 (es) 2010-07-21
WO2009132294A1 (en) 2009-10-29
CA2722508A1 (en) 2009-10-29
TWI526213B (zh) 2016-03-21
CA2722508C (en) 2016-08-16
EP2278954B1 (en) 2020-08-26
EP2278954A1 (en) 2011-02-02
JP2011518842A (ja) 2011-06-30
US8685945B2 (en) 2014-04-01
TW200948367A (en) 2009-12-01
BRPI0910717A2 (pt) 2015-09-29
UY31785A1 (es) 2009-08-03
CL2009000985A1 (es) 2010-01-15
US20140161760A1 (en) 2014-06-12
CN102046150B (zh) 2013-07-24
ES2818619T3 (es) 2021-04-13

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