CO6440528A2 - Composiciones adyuvantes que comprenden un agente de isotonicidad no iónico. - Google Patents

Composiciones adyuvantes que comprenden un agente de isotonicidad no iónico.

Info

Publication number
CO6440528A2
CO6440528A2 CO11170871A CO11170871A CO6440528A2 CO 6440528 A2 CO6440528 A2 CO 6440528A2 CO 11170871 A CO11170871 A CO 11170871A CO 11170871 A CO11170871 A CO 11170871A CO 6440528 A2 CO6440528 A2 CO 6440528A2
Authority
CO
Colombia
Prior art keywords
compositions
adjutive
isotonicity agent
ionic
ionic isotonicity
Prior art date
Application number
CO11170871A
Other languages
English (en)
Inventor
Henderickx Veronique
Dominique Lemoine
Original Assignee
Glaxosmithkline Biolog Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40937237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6440528(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Biolog Sa filed Critical Glaxosmithkline Biolog Sa
Publication of CO6440528A2 publication Critical patent/CO6440528A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporcionan composiciones adyuvantes e inmunogénicas que comprenden un agonista de TLR-4 y una saponina en una formulación liposomal, y un agente deisotonicidad no iónico, en donde la concentración de cloruro de sodio o la concentración iónica es menor de 100 mM.
CO11170871A 2009-06-10 2011-12-12 Composiciones adyuvantes que comprenden un agente de isotonicidad no iónico. CO6440528A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0910046.2A GB0910046D0 (en) 2009-06-10 2009-06-10 Novel compositions

Publications (1)

Publication Number Publication Date
CO6440528A2 true CO6440528A2 (es) 2012-05-15

Family

ID=40937237

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11170871A CO6440528A2 (es) 2009-06-10 2011-12-12 Composiciones adyuvantes que comprenden un agente de isotonicidad no iónico.

Country Status (31)

Country Link
US (2) US20120087976A1 (es)
EP (1) EP2440242B1 (es)
JP (3) JP5647677B2 (es)
KR (1) KR101473686B1 (es)
CN (2) CN102458457B (es)
AU (1) AU2010257538B2 (es)
BR (1) BRPI1012890B1 (es)
CA (1) CA2764421C (es)
CL (1) CL2011003113A1 (es)
CO (1) CO6440528A2 (es)
CY (1) CY1115522T1 (es)
DK (1) DK2440242T3 (es)
DO (1) DOP2011000346A (es)
EA (1) EA024074B1 (es)
ES (1) ES2494442T3 (es)
GB (1) GB0910046D0 (es)
HR (1) HRP20140792T1 (es)
IL (1) IL216231A0 (es)
MA (1) MA33412B1 (es)
MX (1) MX2011013162A (es)
MY (1) MY159819A (es)
NZ (1) NZ596503A (es)
PE (1) PE20120319A1 (es)
PL (1) PL2440242T3 (es)
PT (1) PT2440242E (es)
RS (1) RS53550B1 (es)
SG (1) SG176638A1 (es)
SI (1) SI2440242T1 (es)
SM (1) SMT201400134B (es)
UA (1) UA104888C2 (es)
WO (1) WO2010142685A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3345903T (lt) 2009-06-10 2019-12-10 Chugai Pharmaceutical Co Ltd Tetracikliniai junginiai
RU2573392C3 (ru) 2010-08-20 2021-06-24 Чугаи Сейяку Кабусики Кайся Композиция, содержащая тетрациклические соединения
EP3593813A1 (en) * 2010-12-14 2020-01-15 GlaxoSmithKline Biologicals S.A. Mycobacterium antigenic composition
JP5759568B2 (ja) 2012-09-25 2015-08-05 中外製薬株式会社 Ｒｅｔ阻害剤
JP6608422B2 (ja) * 2014-03-25 2019-11-20 ザ ガバメント オブ ザ ユナイテッド ステイツ，アズ リプリゼンティッド バイ ザ セクレタリー オブ ジ アーミー モノホスホリルリピッドａ（ｍｐｌａ）含有リポソーム組成物およびサポニンを含む非毒性アジュバント製剤
KR20160142383A (ko) 2014-04-25 2016-12-12 추가이 세이야쿠 가부시키가이샤 4환성 화합물의 신규 결정
KR102478887B1 (ko) 2014-04-25 2022-12-16 추가이 세이야쿠 가부시키가이샤 4환성 화합물을 고용량 함유하는 제제
TWI718102B (zh) 2014-08-08 2021-02-11 日商中外製藥股份有限公司 ４環性化合物的非晶質體
CA2973857C (en) 2015-01-16 2023-11-07 Chugai Seiyaku Kabushiki Kaisha Combination drug
JP6900385B2 (ja) 2015-11-06 2021-07-07 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物
CA3045952A1 (en) * 2016-12-07 2018-06-14 Glaxosmithkline Biologicals Sa Novel process
CA3075822A1 (en) * 2017-10-16 2019-04-25 Adjuvance Technologies, Inc. Triterpene saponin analogues
JP2021504429A (ja) 2017-12-01 2021-02-15 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム サポニン抽出
CA3083078A1 (en) * 2017-12-01 2019-06-06 Glaxosmithkline Biologicals Sa Saponin purification
AR116113A1 (es) 2018-09-04 2021-03-31 Chugai Pharmaceutical Co Ltd Método para fabricar un compuesto tetracíclico
WO2024190865A1 (ja) * 2023-03-15 2024-09-19 ユナイテッド・イミュニティ株式会社 脂質粒子

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5804381A (en) 1996-10-03 1998-09-08 Cornell Research Foundation Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof
SG48309A1 (en) * 1993-03-23 1998-04-17 Smithkline Beecham Biolog Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a
UA56132C2 (uk) * 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
DE19803453A1 (de) * 1998-01-30 1999-08-12 Boehringer Ingelheim Int Vakzine
BR9907691B1 (pt) 1998-02-05 2011-05-31 derivado de antìgeno e antìgeno da famìlia mage associado a tumor, seqüência de ácido nucléico, codificando os mesmos, seus usos na preparação de vacina, processo para produção de vacina e vacina.
ATE375803T1 (de) * 1998-05-07 2007-11-15 Corixa Corp Adjuvanszusammensetzung und methoden zu deren verwendng
JP3765232B2 (ja) 2000-11-16 2006-04-12 株式会社ジェイテクト 電動式パワーステアリング装置及びこれに用いる歯車の製造方法
GB0409940D0 (en) 2004-05-04 2004-06-09 Glaxosmithkline Biolog Sa Vaccine
GB0411411D0 (en) * 2004-05-21 2004-06-23 Glaxosmithkline Biolog Sa Vaccines
WO2006056142A1 (fr) * 2004-11-29 2006-06-01 Changchun Huapu Biotechnology Co., Ltd. Desoxynucleotides cpg a brin unique a utiliser comme adjuvant
PT2351578T (pt) * 2005-06-27 2017-04-07 Glaxosmithkline Biologicals Sa Processo para o fabrico de vacinas
TWI457133B (zh) * 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
JP5391080B2 (ja) 2007-01-15 2014-01-15 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン
DK2118128T3 (da) 2007-01-15 2013-02-18 Glaxosmithkline Biolog Sa Fusionsproteiner omfattende tumorrejektionantigenerne NY-ESO-1 og LAGE-1
KR20110091817A (ko) * 2007-05-24 2011-08-12 글락소스미스클라인 바이오로지칼즈 에스.에이. 동결건조 항원 조성물
GB0910045D0 (en) * 2009-06-10 2009-07-22 Glaxosmithkline Biolog Sa Novel compositions

Also Published As

Publication number Publication date
US20180021417A1 (en) 2018-01-25
ES2494442T3 (es) 2014-09-15
JP2016193912A (ja) 2016-11-17
MY159819A (en) 2017-02-15
SG176638A1 (en) 2012-01-30
MX2011013162A (es) 2012-01-30
SI2440242T1 (sl) 2014-09-30
PE20120319A1 (es) 2012-04-16
KR101473686B1 (ko) 2014-12-18
HRP20140792T1 (hr) 2014-10-10
RS53550B1 (en) 2015-02-27
CN104367997B (zh) 2019-01-22
EA201190286A1 (ru) 2012-06-29
MA33412B1 (fr) 2012-07-03
UA104888C2 (uk) 2014-03-25
JP2012529464A (ja) 2012-11-22
KR20120031497A (ko) 2012-04-03
WO2010142685A1 (en) 2010-12-16
EP2440242B1 (en) 2014-06-25
BRPI1012890A2 (pt) 2018-02-27
CA2764421C (en) 2016-12-06
JP6261647B2 (ja) 2018-01-17
AU2010257538B2 (en) 2016-10-20
JP5647677B2 (ja) 2015-01-07
GB0910046D0 (en) 2009-07-22
CN104367997A (zh) 2015-02-25
US20120087976A1 (en) 2012-04-12
JP5977789B2 (ja) 2016-08-24
PL2440242T3 (pl) 2014-11-28
NZ596503A (en) 2013-08-30
CA2764421A1 (en) 2010-12-16
CY1115522T1 (el) 2017-01-04
CN102458457A (zh) 2012-05-16
EA024074B1 (ru) 2016-08-31
SMT201400134B (it) 2014-11-10
BRPI1012890B1 (pt) 2022-03-22
CN102458457B (zh) 2015-05-20
DK2440242T3 (da) 2014-09-01
IL216231A0 (en) 2012-01-31
PT2440242E (pt) 2014-08-29
JP2015042646A (ja) 2015-03-05
DOP2011000346A (es) 2012-01-15
CL2011003113A1 (es) 2012-08-31
AU2010257538A1 (en) 2011-12-08
EP2440242A1 (en) 2012-04-18

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