CL2007002607A1 - Compuestos derivados de aril-sulfonamida o piridin-sulfonamida; proceso de preparacion; composicion farmaceutica; y uso para el tratamiento de una enfermedad o trastorno mediado por las interacciones de los linfocitos, tales como artritis reumatoide, - Google Patents
Compuestos derivados de aril-sulfonamida o piridin-sulfonamida; proceso de preparacion; composicion farmaceutica; y uso para el tratamiento de una enfermedad o trastorno mediado por las interacciones de los linfocitos, tales como artritis reumatoide,Info
- Publication number
- CL2007002607A1 CL2007002607A1 CL200702607A CL2007002607A CL2007002607A1 CL 2007002607 A1 CL2007002607 A1 CL 2007002607A1 CL 200702607 A CL200702607 A CL 200702607A CL 2007002607 A CL2007002607 A CL 2007002607A CL 2007002607 A1 CL2007002607 A1 CL 2007002607A1
- Authority
- CL
- Chile
- Prior art keywords
- sulfonamide
- piridin
- aril
- lymphocytes
- interactions
- Prior art date
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- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP06120403 | 2006-09-08 |
Publications (1)
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CL2007002607A1 true CL2007002607A1 (es) | 2008-05-16 |
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Family Applications (1)
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CL200702607A CL2007002607A1 (es) | 2006-09-08 | 2007-09-07 | Compuestos derivados de aril-sulfonamida o piridin-sulfonamida; proceso de preparacion; composicion farmaceutica; y uso para el tratamiento de una enfermedad o trastorno mediado por las interacciones de los linfocitos, tales como artritis reumatoide, |
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US (1) | US20100029609A1 (es) |
EP (1) | EP2081888A1 (es) |
JP (1) | JP2010502675A (es) |
KR (1) | KR20090060333A (es) |
CN (1) | CN101511783A (es) |
AR (1) | AR062677A1 (es) |
AU (1) | AU2007293653B2 (es) |
BR (1) | BRPI0716598A2 (es) |
CA (1) | CA2662091A1 (es) |
CL (1) | CL2007002607A1 (es) |
MX (1) | MX2009002558A (es) |
PE (1) | PE20080769A1 (es) |
RU (1) | RU2009112719A (es) |
TW (1) | TW200819418A (es) |
WO (1) | WO2008028937A1 (es) |
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EP2173752B2 (en) | 2007-06-13 | 2022-07-13 | Incyte Holdings Corporation | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
AU2009225869B2 (en) * | 2008-03-18 | 2014-01-23 | Merck Sharp & Dohme Llc | Substituted 4-hydroxypyrimidine-5-carboxamides |
MX354134B (es) | 2008-07-23 | 2018-02-14 | Arena Pharm Inc | Derivados de acido 1,2,3,4-tetrahidrociclopenta [b] indol-3-il) acetico sustituidos utiles en el tratamiento de enfermedades autoinmune e inflamatorias. |
CA2733671C (en) | 2008-08-27 | 2018-01-02 | Arena Pharmaceuticals, Inc. | Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders |
US20100168079A1 (en) * | 2008-12-23 | 2010-07-01 | Daniela Angst | Biaryl Benzylamine Derivatives |
WO2010085968A1 (en) * | 2008-12-30 | 2010-08-05 | European Molecular Biology Laboratory (Embl) | Toluidine sulfonamides and their use as hif-inhibitors |
MA33358B1 (fr) | 2009-05-15 | 2012-06-01 | Novartis Ag | Arylpyridine en tant qu'inhibiteurs de l'aldostérone synthase |
TWI484962B (zh) | 2009-05-22 | 2015-05-21 | Incyte Corp | 作為jak抑制劑之3-〔4-(7h-吡咯并〔2,3-d〕嘧啶-4-基)-1h-吡唑-1-基〕辛烷或庚腈 |
US8716303B2 (en) | 2009-05-22 | 2014-05-06 | Incyte Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
UY32858A (es) * | 2009-08-31 | 2011-03-31 | Abbott Healthcare Products Bv | Derivados de (tio)morfolina como moduladores de sip |
US9249145B2 (en) | 2009-09-01 | 2016-02-02 | Incyte Holdings Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
WO2011074643A1 (ja) * | 2009-12-16 | 2011-06-23 | ポーラ化成工業株式会社 | 色素沈着予防又は改善剤 |
EP4148045A1 (en) | 2010-01-27 | 2023-03-15 | Arena Pharmaceuticals, Inc. | Intermediate compounds for the preparation of (r)-2-(7-(4-cyclopentyl-3- (trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b] indol-3-yl)acetic acid and salts thereof |
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KR102354472B1 (ko) | 2010-03-10 | 2022-01-21 | 인사이트 홀딩스 코포레이션 | Jak1 저해제로서의 피페리딘4일 아제티딘 유도체 |
EP2560969B1 (en) | 2010-04-23 | 2015-08-12 | Bristol-Myers Squibb Company | 4-(5-isoxazolyl or 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelic acid amides as sphingosin-1-phosphate 1 receptor agonists |
EP2574168B9 (en) | 2010-05-21 | 2016-10-05 | Incyte Holdings Corporation | Topical formulation for a jak inhibitor |
TW201206893A (en) | 2010-07-09 | 2012-02-16 | Abbott Healthcare Products Bv | Bisaryl (thio) morpholine derivatives as S1P modulators |
TWI522361B (zh) | 2010-07-09 | 2016-02-21 | 艾伯維公司 | 作為s1p調節劑的稠合雜環衍生物 |
TW201643169A (zh) | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
WO2012040532A1 (en) | 2010-09-24 | 2012-03-29 | Bristol-Myers Squibb Company | Substituted oxadiazole compounds and their use as s1p1 agonists |
WO2012068450A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
JP5917544B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン |
TWI477287B (zh) * | 2010-12-21 | 2015-03-21 | Pola Chem Ind Inc | 絲胺酸衍生物及製造色素沉澱之預防或改善劑之用途 |
JP5876146B2 (ja) | 2011-06-20 | 2016-03-02 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤としてのアゼチジニルフェニル、ピリジル、またはピラジニルカルボキサミド誘導体 |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
BR112014020773A2 (pt) | 2012-02-22 | 2020-10-27 | Sanford-Burnham Medical Research Institute | compostos de sulfonamida e seus usos como inibidores tnap |
AR091079A1 (es) | 2012-05-18 | 2014-12-30 | Incyte Corp | Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak |
HUE055894T2 (hu) | 2012-11-15 | 2021-12-28 | Incyte Holdings Corp | A ruxolitinib nyújtott felszabadulású dózisformái |
WO2014085453A2 (en) * | 2012-11-29 | 2014-06-05 | The Scripps Research Institute | Small molecule lxr inverse agonists |
PE20151902A1 (es) | 2013-03-06 | 2015-12-26 | Incyte Corp | Proceso e intermedios para hacer un inhibidor de jak |
EP3721873A1 (en) | 2013-08-07 | 2020-10-14 | Incyte Corporation | Sustained release dosage forms for a jak1 inhibitor |
WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
AU2016205361C1 (en) | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
IL285890B (en) | 2015-06-22 | 2022-07-01 | Arena Pharm Inc | Slate-free crystal of the arginine salt of (Ar)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-4,3,2,1-tetrahydro-cyclopent[b]indole-3-yl ) acetic acid |
TW202246215A (zh) | 2015-12-18 | 2022-12-01 | 美商亞德利克斯公司 | 作為非全身tgr5促效劑之經取代之4-苯基吡啶化合物 |
CN109715615A (zh) | 2016-06-29 | 2019-05-03 | 蒙特利尔大学 | 联芳甲基杂环 |
TW201811766A (zh) | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
US11478448B2 (en) | 2017-02-16 | 2022-10-25 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
US11534424B2 (en) | 2017-02-16 | 2022-12-27 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
DK3746429T3 (da) | 2018-01-30 | 2022-05-02 | Incyte Corp | Fremgangsmåder til fremstilling af (1-(3-fluor-2-(trifluormethyl)isonicotinyl)piperidin-4-on) |
IL277538B1 (en) | 2018-03-30 | 2024-05-01 | Incyte Corp | Use of JAK inhibitors to treat hidradenitis suppurativa |
US11555015B2 (en) | 2018-09-06 | 2023-01-17 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
AU2020373047A1 (en) | 2019-10-31 | 2022-05-19 | ESCAPE Bio, Inc. | Solid forms of an S1P-receptor modulator |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
CN114394946A (zh) * | 2022-02-21 | 2022-04-26 | 艾美科健(中国)生物医药有限公司 | 一种氟雷拉纳的合成方法 |
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US4315014A (en) * | 1980-09-24 | 1982-02-09 | Warner-Lambert Company | Antibacterial amide compounds and pharmaceutical composition containing the same |
WO2003066579A2 (en) * | 2002-02-07 | 2003-08-14 | Axys Pharmaceuticals | Novel bicyclic hydroxamates as inhibitors of histone deacetylase |
EP1539674A1 (en) * | 2002-09-13 | 2005-06-15 | Novartis AG | Amino-propanol derivatives |
US20050019746A1 (en) * | 2003-01-23 | 2005-01-27 | Eirx Therapeutics Limited | Apoptosis-related kinase/GPCRs |
AU2003304638A1 (en) * | 2003-12-04 | 2005-07-14 | Wyeth | Biaryl sulfonamides and methods for using same |
AU2006290442B2 (en) * | 2005-09-16 | 2010-07-29 | Arrow Therapeutics Limited | Biphenyl derivatives and their use in treating hepatitis C |
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- 2007-09-06 PE PE2007001190A patent/PE20080769A1/es not_active Application Discontinuation
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- 2007-09-06 BR BRPI0716598-6A2A patent/BRPI0716598A2/pt not_active IP Right Cessation
- 2007-09-06 CA CA002662091A patent/CA2662091A1/en not_active Abandoned
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- 2007-09-06 MX MX2009002558A patent/MX2009002558A/es not_active Application Discontinuation
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- 2007-09-06 EP EP07803280A patent/EP2081888A1/en not_active Withdrawn
- 2007-09-07 TW TW096133616A patent/TW200819418A/zh unknown
- 2007-09-07 CL CL200702607A patent/CL2007002607A1/es unknown
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BRPI0716598A2 (pt) | 2013-12-10 |
AU2007293653B2 (en) | 2011-02-17 |
AR062677A1 (es) | 2008-11-26 |
EP2081888A1 (en) | 2009-07-29 |
CN101511783A (zh) | 2009-08-19 |
US20100029609A1 (en) | 2010-02-04 |
RU2009112719A (ru) | 2010-10-20 |
TW200819418A (en) | 2008-05-01 |
MX2009002558A (es) | 2009-03-20 |
CA2662091A1 (en) | 2008-03-13 |
JP2010502675A (ja) | 2010-01-28 |
KR20090060333A (ko) | 2009-06-11 |
PE20080769A1 (es) | 2008-08-14 |
AU2007293653A1 (en) | 2008-03-13 |
WO2008028937A1 (en) | 2008-03-13 |
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