CH661438A5 - Composizioni farmaceutiche ad azione antianossica e metabolica cerebrale. - Google Patents
Composizioni farmaceutiche ad azione antianossica e metabolica cerebrale. Download PDFInfo
- Publication number
- CH661438A5 CH661438A5 CH1774/84A CH177484A CH661438A5 CH 661438 A5 CH661438 A5 CH 661438A5 CH 1774/84 A CH1774/84 A CH 1774/84A CH 177484 A CH177484 A CH 177484A CH 661438 A5 CH661438 A5 CH 661438A5
- Authority
- CH
- Switzerland
- Prior art keywords
- coenzyme
- phospholipids
- pharmaceutical compositions
- administration
- antianossica
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title description 10
- 210000004556 brain Anatomy 0.000 title description 6
- 230000002503 metabolic effect Effects 0.000 title description 2
- 150000003904 phospholipids Chemical class 0.000 description 30
- 235000017471 coenzyme Q10 Nutrition 0.000 description 29
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 28
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 27
- 239000005515 coenzyme Substances 0.000 description 19
- 229940110767 coenzyme Q10 Drugs 0.000 description 17
- 239000000203 mixture Substances 0.000 description 14
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 11
- 239000008347 soybean phospholipid Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 9
- 229940035936 ubiquinone Drugs 0.000 description 9
- 235000005911 diet Nutrition 0.000 description 8
- 230000037213 diet Effects 0.000 description 8
- 241000700159 Rattus Species 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 239000000787 lecithin Substances 0.000 description 6
- 235000010445 lecithin Nutrition 0.000 description 6
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 5
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 229940067606 lecithin Drugs 0.000 description 5
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 5
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 5
- 150000003905 phosphatidylinositols Chemical class 0.000 description 5
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 4
- 208000002381 Brain Hypoxia Diseases 0.000 description 4
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 4
- 230000003143 atherosclerotic effect Effects 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 231100000027 toxicology Toxicity 0.000 description 4
- 206010029216 Nervousness Diseases 0.000 description 3
- 230000000923 atherogenic effect Effects 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000002969 morbid Effects 0.000 description 3
- 230000002107 myocardial effect Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- 230000002110 toxicologic effect Effects 0.000 description 3
- 244000144725 Amygdalus communis Species 0.000 description 2
- 206010002660 Anoxia Diseases 0.000 description 2
- 241000976983 Anoxia Species 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 description 2
- 235000020224 almond Nutrition 0.000 description 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 230000007953 anoxia Effects 0.000 description 2
- 230000000496 anti-anoxic effect Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- -1 glycerophospholipid compounds Chemical class 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000026139 Memory disease Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102000015439 Phospholipases Human genes 0.000 description 1
- 108010064785 Phospholipases Proteins 0.000 description 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 1
- 238000003831 Wilkinson decarbonylation reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000007321 biological mechanism Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- 229960002061 ergocalciferol Drugs 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 150000002327 glycerophospholipids Chemical class 0.000 description 1
- 210000002288 golgi apparatus Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229940040371 lecithin 10 mg Drugs 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000006680 metabolic alteration Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 210000001700 mitochondrial membrane Anatomy 0.000 description 1
- 230000006540 mitochondrial respiration Effects 0.000 description 1
- 201000006938 muscular dystrophy Diseases 0.000 description 1
- 208000015706 neuroendocrine disease Diseases 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1774/84A CH661438A5 (it) | 1984-04-09 | 1984-04-09 | Composizioni farmaceutiche ad azione antianossica e metabolica cerebrale. |
| DE3417857A DE3417857C2 (de) | 1984-04-09 | 1984-05-14 | Nicht-liposomales pharmazeutisches Mittel |
| GB08508452A GB2157171B (en) | 1984-04-09 | 1985-04-01 | Pharmaceutical compositions having cerebral antianoxic and metabolic activities |
| US06/718,884 US4684520A (en) | 1984-04-09 | 1985-04-02 | Pharmaceutical compositions having cerebral antianoxic and metabolic activities |
| IT20271/85A IT1201412B (it) | 1984-04-09 | 1985-04-05 | Composizioni farmaceutiche ad azione antianossica e metabolica cerebrale |
| JP7339485A JPS6133118A (ja) | 1984-04-09 | 1985-04-06 | 抗脳性酸素欠乏症代謝賦活剤 |
| FR858505338A FR2562422B1 (fr) | 1984-04-09 | 1985-04-09 | Compositions pharmaceutiques a action anti-anoxique et metabolique cerebrale |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1774/84A CH661438A5 (it) | 1984-04-09 | 1984-04-09 | Composizioni farmaceutiche ad azione antianossica e metabolica cerebrale. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH661438A5 true CH661438A5 (it) | 1987-07-31 |
Family
ID=4218293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1774/84A CH661438A5 (it) | 1984-04-09 | 1984-04-09 | Composizioni farmaceutiche ad azione antianossica e metabolica cerebrale. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4684520A (OSRAM) |
| JP (1) | JPS6133118A (OSRAM) |
| CH (1) | CH661438A5 (OSRAM) |
| DE (1) | DE3417857C2 (OSRAM) |
| FR (1) | FR2562422B1 (OSRAM) |
| GB (1) | GB2157171B (OSRAM) |
| IT (1) | IT1201412B (OSRAM) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH661443A5 (en) * | 1984-11-22 | 1987-07-31 | Seuref Ag | Pharmaceutical compositions having metabolic activity |
| JPH01305033A (ja) * | 1988-06-01 | 1989-12-08 | Sanwa Kagaku Kenkyusho Co Ltd | 循環改善剤及び循環改善機能性食品並びにし好品 |
| JPH01305032A (ja) * | 1988-06-01 | 1989-12-08 | Sanwa Kagaku Kenkyusho Co Ltd | 機能後退性消耗疾患治療予防剤及び飲食、し好物 |
| JPH02188523A (ja) * | 1989-01-13 | 1990-07-24 | M S C:Kk | 睡眠時無呼吸症治療薬 |
| US6461593B1 (en) * | 1992-02-19 | 2002-10-08 | Biomedical And Clinical Research | Therapy with coenzyme Q10 to reduce subgingival microorganisms in patients with periodontal disease |
| AU5832794A (en) * | 1993-01-06 | 1994-08-15 | T.S. Consult Aps | Medium comprising a pharmacological/biological active substance |
| US6312703B1 (en) | 1998-02-06 | 2001-11-06 | Lecigel, Llc | Compressed lecithin preparations |
| US20030040505A1 (en) * | 2000-03-31 | 2003-02-27 | The Regents Of The University Of California | Synthetic phospholipids to ameliorate atherosclerosis and other inflammatory conditions |
| US7723303B2 (en) * | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
| US7166578B2 (en) | 2000-08-24 | 2007-01-23 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| US7144862B2 (en) * | 2000-08-24 | 2006-12-05 | The Regents Of The University Of California | Orally administered peptides to ameliorate atherosclerosis |
| US7148197B2 (en) * | 2000-08-24 | 2006-12-12 | The Regents Of The University Of California | Orally administered small peptides synergize statin activity |
| US7199102B2 (en) * | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| US6441050B1 (en) * | 2000-08-29 | 2002-08-27 | Raj K. Chopra | Palatable oral coenzyme Q liquid |
| AUPR549901A0 (en) | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
| DE60140141D1 (de) * | 2000-11-14 | 2009-11-19 | Vital Health Sciences Pty Ltd | Zusammensetzungen umfassend Komplexe von Tocopherolphosphatderivaten |
| CN1547475B (zh) * | 2001-07-27 | 2010-12-15 | 生命健康科学有限公司 | 含电子转移试剂的磷酸酯衍生物的皮肤制剂 |
| AUPR684801A0 (en) * | 2001-08-06 | 2001-08-30 | Vital Health Sciences Pty Ltd | Supplement therapy |
| EP1460995B1 (en) * | 2001-12-13 | 2010-11-10 | Vital Health Sciences Pty Ltd. | Transdermal transport of compounds |
| JP2003261456A (ja) * | 2002-03-08 | 2003-09-16 | Howaizu:Kk | 脳の老化予防剤 |
| AU2002950713A0 (en) | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
| ATE534384T1 (de) * | 2003-01-17 | 2011-12-15 | Vital Health Sciences Pty Ltd | Verbindungen mit proliferationshemmenden eigenschaften |
| AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
| US8252322B2 (en) * | 2003-06-03 | 2012-08-28 | Corn Products Development, Inc. | Delivery system with increased bioavailability |
| TW200524541A (en) * | 2003-11-17 | 2005-08-01 | Cargill Inc | Lecithin-containing granular compositions and methods of their preparation |
| US20060069157A1 (en) * | 2004-02-19 | 2006-03-30 | U.S. Department Of Veterans Affairs | Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as Huntington's disease, by sodium butyrate chemotherapy |
| CA2557354C (en) | 2004-03-03 | 2013-05-07 | Vital Health Sciences Pty Ltd. | Alkaloid formulations |
| EP1799242A4 (en) * | 2004-09-16 | 2009-11-11 | Univ California | TYPE G PEPTIDES AND OTHER ACTIVE SUBSTANCES TO REDUCE ATHEROSCLEROSIS AND OTHER DISEASES |
| US7901675B2 (en) * | 2004-10-13 | 2011-03-08 | U.S. Department Of Veterans Affairs | Method of using coenzyme Q10 to treat Huntington's disease |
| BRPI0517148A (pt) | 2004-12-06 | 2008-09-30 | Univ California | método de aperfeiçoamento da estrutura e/ou função arterìola; agente ativo e kit para tratamento |
| US20060135612A1 (en) * | 2004-12-17 | 2006-06-22 | U.S. Department Of Veterans Affairs | Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent |
| CA2599424A1 (en) * | 2005-03-03 | 2006-09-08 | Vital Health Sciences Pty Ltd | Compounds having anti-cancer properties |
| WO2006118805A2 (en) * | 2005-04-29 | 2006-11-09 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| US20080293639A1 (en) * | 2005-04-29 | 2008-11-27 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| CA2611831C (en) * | 2005-06-17 | 2014-09-16 | Vital Health Sciences Pty Ltd. | A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
| DE102005056558B4 (de) * | 2005-11-25 | 2009-04-30 | Gisela Susilo | Kombinationspräparate enthaltend physiologische Zellmembran-Bestandteile |
| BRPI0621081A2 (pt) * | 2005-12-23 | 2011-11-29 | Vital Health Sciences Pty Ltd | método de modulação de uma ou mais citocinas imuno-reguladoras, uso de um ou mais derivados de fosfato de um ou mais hidróxi cromanos ou complexos dos mesmos, método de inibição de uma resposta inflamatória e/ou de estimulação de uma resposta anti-inflamatória, método de tratamento e/ou de profilaxia de distúbios imunológicos, distúrbios inflamatórios e/ou distúrbios proliferativos celulares, agente imuno-modulador, agente anti-inflamatório ou agente anti-cáncer e um ou mais derivado de fosfato de um ou mais hidróxi cromanos ou complexos dos mesmos |
| GB0603975D0 (en) * | 2006-03-01 | 2006-04-05 | Etren | Methods and agents for reducing oxidative stress |
| CN101443010A (zh) * | 2006-04-10 | 2009-05-27 | 三菱瓦斯化学株式会社 | 脑功能改善剂及含有该改善剂的功能性食品 |
| WO2008062559A1 (en) * | 2006-11-22 | 2008-05-29 | Asahi Kasei Pharma Corporation | Dietary supplement, anti-fatigue agent or physical endurance enhancer, functional food, or cosmetic |
| DK2195331T3 (da) | 2007-08-28 | 2014-02-03 | Uab Research Foundation | Syntetiske polypeptider, der efterligner apolipoprotein e, og anvendelsesmetoder |
| JP2010537638A (ja) | 2007-08-28 | 2010-12-09 | ユーエービー リサーチ ファウンデーション | 合成アポリポ蛋白質ｅ模倣ポリペプチドおよび使用方法 |
| EP2531047B1 (en) | 2010-02-05 | 2024-11-13 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
| EP2552486B1 (en) | 2010-03-30 | 2020-08-12 | Phosphagenics Limited | Transdermal delivery patch |
| WO2012122586A1 (en) | 2011-03-15 | 2012-09-20 | Phosphagenics Limited | New composition |
| US9132117B2 (en) | 2013-06-17 | 2015-09-15 | Kgk Synergize, Inc | Compositions and methods for glycemic control of subjects with impaired fasting glucose |
| USRE50320E1 (en) | 2014-07-31 | 2025-03-04 | Uab Research Foundation | APOE mimetic peptides and higher potency to clear plasma cholesterol |
| CA3007587C (en) | 2015-12-09 | 2023-12-05 | Phosphagenics Limited | Pharmaceutical formulation |
| CN110662733A (zh) | 2016-12-21 | 2020-01-07 | 埃维科生物技术有限公司 | 方法 |
| US12264593B1 (en) | 2023-11-09 | 2025-04-01 | Pratt & Whitney Canada Corp. | Damped bladed rotor for gas turbine engine |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5938202B2 (ja) * | 1976-03-05 | 1984-09-14 | エーザイ株式会社 | 難聴治療剤 |
| JPS5356315A (en) * | 1976-11-01 | 1978-05-22 | Eisai Co Ltd | Emulsified solution of fat soluble drugs |
| US4221784A (en) * | 1979-04-05 | 1980-09-09 | Massachusetts Institute Of Technology | Process and composition for treating disorders by administering lecithin |
| FR2472384A1 (fr) * | 1979-12-27 | 1981-07-03 | Sederma Sa | Utilisation en cosmetologie de complexes naturels constitues d'ubiquinones et de phospholipides |
| JPS5742616A (en) * | 1980-08-27 | 1982-03-10 | Furointo Sangyo Kk | Ubiquinone pharmaceutical having improved absorption |
| JPS5775916A (en) * | 1980-10-29 | 1982-05-12 | Nippon Chemiphar Co Ltd | Coenzyme q pharmaceutical and its preparation |
| JPS57142911A (en) * | 1981-02-28 | 1982-09-03 | Furointo Sangyo Kk | Absorption-improving agent |
| JPS58113127A (ja) * | 1981-12-28 | 1983-07-05 | Ajinomoto Co Inc | ユビデカレノン含有水性液 |
| CH649917A5 (en) * | 1982-03-19 | 1985-06-28 | Italfarmaco Sa | Pharmaceutical formulations containing the coenzyme Q(10) suitable for topical administration |
| JPS58201711A (ja) * | 1982-05-19 | 1983-11-24 | Eisai Co Ltd | ユビデカレノン含有リポソ−ム被覆体 |
-
1984
- 1984-04-09 CH CH1774/84A patent/CH661438A5/it not_active IP Right Cessation
- 1984-05-14 DE DE3417857A patent/DE3417857C2/de not_active Expired - Lifetime
-
1985
- 1985-04-01 GB GB08508452A patent/GB2157171B/en not_active Expired
- 1985-04-02 US US06/718,884 patent/US4684520A/en not_active Expired - Lifetime
- 1985-04-05 IT IT20271/85A patent/IT1201412B/it active
- 1985-04-06 JP JP7339485A patent/JPS6133118A/ja active Granted
- 1985-04-09 FR FR858505338A patent/FR2562422B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0530813B2 (OSRAM) | 1993-05-11 |
| FR2562422B1 (fr) | 1989-03-31 |
| GB8508452D0 (en) | 1985-05-09 |
| IT1201412B (it) | 1989-02-02 |
| GB2157171A (en) | 1985-10-23 |
| IT8520271A0 (it) | 1985-04-05 |
| DE3417857A1 (de) | 1985-10-17 |
| DE3417857C2 (de) | 1997-04-24 |
| JPS6133118A (ja) | 1986-02-17 |
| FR2562422A1 (fr) | 1985-10-11 |
| US4684520A (en) | 1987-08-04 |
| GB2157171B (en) | 1988-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NV | New agent |
Representative=s name: E. BLUM & CO. PATENTANWAELTE |
|
| PUE | Assignment |
Owner name: SEUREF AG TRANSFER- F.W. WIRTZ & CO. GMBH |
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| PL | Patent ceased |