CH660961A5 - TOOTHPASTE IN A DISPENSER. - Google Patents

Description

The invention relates to a toothpaste in a delivery container which can be actuated mechanically or acts through pressure differences. The toothpaste contained in the dispensing container has such desired theological properties that it is suitable for the effective filling of a dispensing container that can be actuated mechanically or by pressure differences and can be easily pressed out of it.

Toothpastes or toothpaste, clear or opacified tooth gels are semi-solid masses that have a relatively solid structure on a toothbrush and are essentially flowable to liquid when mixed or when filled into a dispensing container or when squeezed out of it. The creamy consistency is achieved by a gelling or thickening agent.

So far, gelling agents have been used primarily to facilitate the distribution of toothpaste in the mouth, with 5 among others those based on cellulose derivatives, kelp derivatives, gums and clays were used. However, it has been shown that the gelling agents which are suitable for toothpastes packaged in toothpaste tubes are unsuitable for those toothpastes which are released into a delivery container which can be actuated mechanically or by pressure difference.

Toothpastes containing conventional polishing agents, such as alpha-aluminum oxide trihydrate and conventional walking aids, such as sodium carboxymethyl cellulose and / or Hy-15 hydroxyethyl cellulose, can be filled into toothpaste tubes and also mechanically operated dispensing containers without difficulty and pressed out of them. However, when the toothpaste contains numerous active ingredients, difficulties arise when filling the toothpaste 20 into such a mechanically operated or pressure-sensitive dispensing container and also when dispensing the toothpaste therefrom. In particular, toothpaste can leak out of the various openings of the dispensing container during filling or storage or shipping, and there can also be difficulties in dispensing the toothpaste in a rheologically desired strand form.

Thick toothpastes or toothpastes that tend to thicken are difficult to squeeze out of a 30 toothpaste tube after a long time. The consumer has to exert greater pressure on the toothpaste tube in order to push out the semi-solid toothpaste. So far, this has not been a major problem for conventional toothpastes, since the composition can be adjusted so that less gelling agent is used, so that the toothpaste is not too soft at the beginning of use and not too thick at the end of use it was left to the consumer to apply the pressure required on the toothpaste tube in order to apply the desired amount of toothpaste to the 40 toothbrush.

Even toothpastes that were too thin when squeezed out of a tube were tolerated by the consumer, since they solidified very quickly on the toothbrush within seconds. In general, a wide variety of gelling agents could be used for toothpastes packed in Tu-45 ben, and among other things. An iota-carrageenan or i-carrageenan as Genuvisco Type 0819 was also proposed as a possible thickening agent for toothpaste and also a product sold under the name “Viscarin TP-5” for a toothpaste containing disodium calcium phosphate or silicon dioxide. In addition, it is known from Japanese Patent Specification 56 115711 to use i-carrageenan as a thickener together with k-carrageenan and alkali alginate in a toothpaste which contains galactan-galactose 55.

In the case of delivery containers which are to be operated mechanically or by pressure difference, the usual measures for preventing the thickening of toothpaste are not completely satisfactory in comparison with the toothpaste to be filled into conventional tubes. Toothpaste for mechanically operated dispensing containers must be relatively thin during filling, but must regain their firmer consistency and be retained during transport, storage and use. In other words, after filling, the toothpaste must return to the consistency it had before it was liquefied by shear forces when filling. Common gelling agents, such as sodium carboxymethyl cellulose and / or hydroxyethyl cellulose

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óói) 9ól lulose are suitable for toothpastes that contain alpha-alumina trihydrate as a polishing agent and that are filled into dispensing containers. However, if such a toothpaste contains numerous other active ingredients, such as at least two fluorine suppliers, a desensitizing agent such as allantoin (C7H6N4O3) and vasodilatory additives such as pyridylcarbinol, there are difficulties when filling the toothpaste into delivery containers that can be operated mechanically or through pressure differences. In particular, the toothpaste can escape through the space between the piston and the actuating rod; leaks can also occur at the outlet opening. In addition, the toothpaste strand can emerge irregularly or not continuously from such dispensing containers.

It is therefore an object of the present invention to improve a toothpaste containing alpha * aluminum oxide trihydrate as the polishing agent, which contains numerous other active constituents which are compatible with the polishing agent, with regard to the thickening agent.

Surprisingly, it has been found that a mixture of a cellulose thickener and i-carra-geenan results in an excellent toothpaste containing alpha-alumina trihydrate and other active ingredients, which can be easily filled into a dispensing container and dispensed from it mechanically or by pressure difference can be. In this context, it is noteworthy that xanthan was considered incompatible with gelling agents based on cellulose because of its cellulose content.

According to the present invention, a toothpaste is made available in a delivery container which can be actuated mechanically or acts through pressure differences and which can be easily filled into this delivery container and pressed out of it.

The toothpaste according to the invention contains a) 20 to 80% by weight of an aqueous humectant as carrier,

b) 0.1 to 5% by weight of a gelling agent mixture,

c) 20 to 75% by weight of alpha-aluminum oxide trihydrate as a polishing agent,

d) sodium fluoride and sodium monofluorophosphate in a 300 to 10,000 ppm fluorine-releasing amount,

e) 0.05 to 0.5% by weight of allantoin as a desensitizing agent and f) 0.05 to 0.5% by weight of pyridylcarbinol as a vasodilatory additive, and it is characterized in that the gelling agent mixture consists of i) a cellulose gelling agent or xanthan and ii) i-carrageenan in a weight ratio of 5: 1 to 1: 5.

In the case of toothpaste, the liquid phase is formed as a carrier by an aqueous humectant, which is adjusted with the gelling agent so that an extrudable creamy mass of the desired consistency is obtained. The liquid phase of the toothpaste consists mainly of water and a humectant such as polyols such as glycerin, sorbitol, maltitol, xylitol, low molecular weight polyethylene glycol with a molecular weight of e.g. 400 to 600, propylene glycol and mixtures of these components. The liquid phase preferably consists of 10 to 55% by weight of water and 20 to 50% by weight of water of a humectant such as glycerin, sorbitol or polyethylene glycol.

The toothpaste contains 20 to 75% by weight of alpha-alumina-5-oxide trihydrate as a polishing agent, which is usually produced by the Bayer process and whose particle size is in a range from 40 (in and mostly in a range from 3 to 20 | xm. There may be other polishing agents such as insoluble sodium metaphosphate, dicalcium phosphate, callinated aluminum oxide, silica or calcium carbonate in smaller amounts compared to the alpha-aluminum oxide trihydrate.

The gelling agent mixture present in an amount of 0.1 to 5% by weight contains a gelling agent based on Cel-15 lulose or xanthan in a mixture with i-carrageenan, the weight ratio of the cellulose gelling agent or xanthane to the i-carrageenan in one Range is from 5: 1 to 1: 5 and preferably 1: 1 to 1: 3, the total content of gelling agent preferably being in a range from 0.2 to 20 3% by weight.

From U.S. Patent 4,353,890, it is known to use i-carrageenan as an alternative to k-carrageenan as a gelling agent for a toothpaste, the toothpaste being subjected to microwave radiation to reduce the tendency of the carrageenan to thin during manufacture . Carrageenan can be the only gelling agent or can be mixed with other gelling agents. In the case of the toothpaste according to the invention, the toothpaste to be filled into a delivery container which is to be mechanically actuated or which acts by means of pressure differences does not have to be subjected to microwave radiation.

The prior art gives no indication that gelling agent systems consisting of a cellulose gelling agent and i-carrageenan for toothpastes with alpha-alumina-35 trihydrate as a polishing agent and numerous other constituents give the properties required for these toothpastes to be dispensed in mechanically actuated or pressure differential dispensing containers fill in or squeeze out of them.

It should also be mentioned that dental care products are known from US Pat. No. 4,029,760, in which i-carrageenin is proposed as a gingivitis-preventing agent instead of other carrageenins. The carrageenins are highly depolymerized derivatives of carrageenan; Carra-45 geenan itself shows no gingivitis-preventing effect. Toothpastes usually get cold, i.e. H. prepared at about 25 C, or warm at 60 C for example. The i-carrageenan can be used for both cold and warm production. Since xanthan is used in the cold process, it can be easily mixed with i-carrageenan, if available, and processed together with it using the cold process to toothpaste. The i-carrageenan can only be used for warm processing.

55 The physical properties of the i-carrageenan known as Genuvisco Type 0819 are as follows:

1. The viscosity of a 0.30% solution in a solvent and after the warm process at 60 C is

60 110 + 17 10 ~ 3 Pa.s at 32 U / min 70 +11 10 "3 Pa.s at 64 U / min 45+ 7 10 ~ 3 Pa.s at 128 U / min.

measured with a Haake Rotovisco RV3 viscometer at 25 C.

65

2. The viscosity of a 0.30% solution in a solvent for the product produced by the cold process at 25 C is as follows:

660 961

450 ± 60 10 3 Pa.s measured with a Brookfield visco-simulated LVT at 25 ° C 85 ± 13 IO-3 Pa.s at 32 rpm 55 ± 8 IO-3 Pa.s at 64 rpm 37 ± 6 IO-3 Pa.s at 128 rpm measured with a Haake Rotovisco RV3 device at 25 'C.

3. Particle size:

less than 1% gum on a 0.075 mm test sieve according to DIN 80.

4. Moisture content:

less than 12%.

5. pH:

8.5 + 1.5 in 0.5% solution in distilled water at 25 = C.

6. Color:

white to off-white.

The i-carrageenan commercially available under the name Viscarin TP-5 has the following physical properties:

Colour:

slightly yellowish to yellowish brown particle size:

more than 95.0% pass through a US standard sieve, 250 nm. (series No. 60).

Moisture content:

maximum 12.0% (Cenco moisture residue)

PH value:

7.0 to 9.5 in a 1.5% solution at 30 ° C.

Suitable cellulose gelling agents are alkali carboxy methyl cellulose, methyl cellulose, hydroxymethyl cellulose and hydroxypropyl cellulose, sodium carboxymethyl cellulose being preferred. The gelling agent mixture is present in an amount of 0.1 to 5% by weight, based on the toothpaste, the weight ratio of cellulose gelling agent to i-carrageenan in a range from 5: 1 to 1: 5 and preferably from 1: 1 to 1: 3 and especially 1: 1. A preferred toothpaste may contain 0.9 to 1.2% of total gelling agent and about 0.3 to about 0.9% each of cellulose gelling agent and i-carrageenan, the weight ratio between these two components preferably being 1: 1 to 1: 3 is.

The following products can be used as sodium carboxymethyl cellulose:

The following types of hydroxyethyl cellulose can also be used:

Manufacturer

Manufacturer

CMC Type

Viscosity in 10-3 Pa.s

Hercules

7MXF

300-500

Hercules

7MFD

300-500

Hercules

9M31F

900-1200

Hercules

9M31XF

900-1200

Hercules

12M31XF

900-1200

Hercules

7MF

300-500

Hercules

12M31PD

900-1200

Hercules

7M8SXF

200-800

Wolff Walsrode

Walocel CRT 1000 PA 07

700-1200

Nyma

Nymcel ZMF.33 *

50-80

Enka

Akucell AC 1642 *

80-120

Enka

Akucell AC 1632 *

60-120

Cros

Cellogen HP-SA

700-900

Uddeholm

Cekol MVEP

500-800

Maximum

Tylose CB 200 **

120-260

HEC type

Viscosity in IO-3 Pa.s

Hercules Hercules

I0 Hercules

BP Chemicals BP Chemicals Hoechst 15 Hoechst

Natrosol 250M and MR Natrosol 250 HR * and 250 H *

Natrosol 250 HHR * and 250 HH Cellobond 5000 A Cellobond 7000 A Tylose H 4000 P ** TyloseH 10 000 P **

4500-6500 1500-2500

3400-5000

4200-5600 6000-7000 3000-5000 7000-12 000

* 1% solution shaved at 25 C with a Brookfield device ** measured on a 2% solution at 20 C with a Hoeppler viscometer.

* 1% solution measured at 25 CC using a Brookfield device ** measured on a 2% solution at 20 ° C using a Hoeppler viscometer.

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The i-carrageenan and the cellulose gelling agent can be mechanically mixed together before being mixed with the liquid phase of the toothpaste; they can also be mixed separately with the liquid phase, for 2 seconds both in the hot processing method at about 60 ° C. or in the cold processing method at about 25 CC.

Xanthan gum is a fermentation product which is obtained by the action of Xanthomonas bacteria on carbon hydrates, the strains X. campetris, X. phaseoli, X. malvocearum and X. carotae being described as particularly suitable. Although the exact chemical structure is not determined, it is believed to be heteropolysaccharides with a molecular weight 35 of several million. It contains D-glucose, D-mannose and D-glucuronic acid in a molar ratio of 2.8: 3: 2.0. The molecule contains 4.7% acetyl and about 3% pyruvate; the presumed structure is listed in McNeely and Kang "Industriai Gums", ed. R. L. Whistler, CH XXI, 40 2nd edition, New York (1973); This literature also mentions information about growing, isolating and cleaning xanthan gums. A further description of xanthan gums can be found in “Manufacturing Chemist”, May 1960, pp. 206 to 208, and page 208 also describes 45 possible uses of these gums for toothpastes.

The i-carrageenan and xanthan can be mechanically mixed with one another before being mixed with the liquid phase of the carrier material or can thus be mixed separately with the liquid phase in the cold processing which is usually carried out at 25 ° C.

Because of their good theological properties, the toothpaste is preferably packaged in such dispensing containers as described in GB-PS 2 070 695A and 55 which have a tensioning element, a central guide rod, a piston and an operating lever. The dispensing containers operating with a pressure difference can be conventional aerosol containers or those that work with vacuum. Suitable dispensing devices are those in which pouches containing the product, which are compressible with propellant, are arranged in a solid container. With such dispensing containers, the product can only be dispensed after actuation of a valve, the propellant being separated from the product by a liquid-impermeable bag 65; dispensing devices of this type are described in US Pat. Nos. 3,828,977 and 3,838,976 and are referred to as sepro dispensers. Other dispensing containers such as the Exxel containers work under pressure. Other dispensing containers with

660 961

a sealing piston is described in U.S. Patent 4,171,757; these have a valve, a chamber containing the product and an essentially liquid-tight separating piston which separates the propellant from the product in the container; these dispensing containers are also called diamond containers.

The toothpaste contains as active ingredients a mixture of sodium fluoride and sodium monofluorophosphate in an amount which releases 300 to 10,000 ppm fluorine, for example 750 to 2000 ppm fluorine, and in particular 1400 to 2000 ppm fluorine such as 1400 to 1670 ppm fluorine. The binary fluorine system consisting of sodium monofluorophosphate and sodium fluoride is preferably present in such a way that 30 to 40% of the fluorine, such as 30 to 35% of the fluorine, is provided by the sodium fluoride.

Sodium monofluorophosphate Na2P03F is a common commercial product which can vary considerably in terms of its purity; it can be used in any form, provided that the contaminants do not affect the desired properties. In general, the purity of the product is at least 80%, with 85% and especially 90% sodium monofluorophosphate types being preferred, the rest being primarily impurities or by-products from manufacture, such as e.g. Sodium fluoride or water soluble sodium phosphate salt. In other words, the sodium monofluorophosphate should have a total fluoride content of over 12% and preferably over 12.7% and contain no more than 1.5 and preferably no more than 1.2% free sodium fluoride, at least 12%, preferably at least 12.1 % Total fluoride is present.

The sodium fluoride is a separate fluorine-containing component in the binary mixture; preferably from 225 to 800 ppm fluorine is provided by the sodium fluoride.

As a further active ingredient, toothpaste contains 0.05 to 0.5% by weight and preferably 0.08 to 0.2% by weight of allantoin as an anti-inflammatory agent or as a substance for desensitization; it relieves sore periodontal tissue and promotes its healing.

The pyridylcarbinol present in an amount of 0.05 to 0.5 and preferably 0.08 to 0.2% by weight gives the toothpaste a vasodilatory effect.

If a toothpaste containing alpha-aluminum oxide trihydrate as a polishing agent contains the binary fluorine system, allantoin and pyridylcarbinol, the filling and the indication of the toothpaste in or from mechanically actuated or pressure-sensitive dispensing containers is special due to the gelling agent mixture contained in the toothpaste according to the invention good and extremely practical in terms of the theological properties.

These containers can be filled in the usual way. In a device described, for example, in GB-PS 2 070 695A, a predetermined amount of the toothpaste is extruded via a delivery piece into the open-bottomed container, which is equipped with a piston, the diameter of which corresponds to the inside diameter of the container and a hole in the middle has to accommodate the piston rod, which is then inserted. The dispenser is then closed on the floor with a disc.

The method for producing the toothpaste present in a mechanically operated delivery container is characterized in that a predetermined amount of the toothpaste according to the invention is extruded through a mouthpiece into the mechanically operated container, which is open at the bottom, in order to fill the container which dispensing container a central rod is arranged and a piston is pushed over this central rod. which has a diameter which corresponds to the inner diameter of the dispensing container and has a central opening for receiving the central rod, and that the dispensing container is then closed with a base plate.

The toothpaste according to the invention can contain conventional surfactants or cleaning components which, in addition to their cleaning action, increase the foaming power and antibacterial properties depending on the type of surfactant. In general, water-soluble anionic, nonionic or cationic surfactants are used, with synthetic surfactants being preferred. Suitable substances are water-soluble salts of fatty acid monoglyceride monosulfates, such as, for example, the sodium salt of coconut fatty acid monoglyceride monosulfate, higher alkyl sulfates, such as, for example, sodium umlauryl sulfate, alkylarylsulfonates, such as, for example, Natri-20 umdodecylbenzenesulfonate or higher dihydroxy fatty acid ester of 1,2-fatty acid ester.

Further preferred surfactants are the substantially saturated higher aliphatic acylamides of lower aliphatic aminocarboxylic acids which have, for example, 12 to 16 25 carbon atoms in the acyl radical. The amino acid part generally comes from lower aliphatic saturated monoamine carboxylic acids having 2 to 6 carbon atoms, monocarboxylic acids usually being used. Suitable compounds are fatty acid amides of glycerol, Sarco-30 sin, alanine, 3-aminopropanoic acid and valine with 12 to 16 carbon atoms in the acyl radical. N-Lauroyl, myristoyl and palmitoyl sarcoside compounds are preferably used.

The amide compound can be used either as the free acid or preferably as the water-soluble salt thereof, for example as the alkali salt, ammonium, amine or alkylolamine salt. be used. Sodium and potassium N-lauroyl, myristoyl and palmitoyl sarcosides as well as ammonium and ethanolamine N-lauroyl glycides and alanine 40 can be mentioned as examples. The term "aminocarboxylic acid compound" or "sarcoside" and the like refers to those compounds which have a free carboxylic acid of the water-soluble carboxylate salt.

These compounds are generally used in pure or almost pure form; they should be as soap-free as possible and should not contain any similar higher fatty acids that impair the activity of these compounds. In general, the proportion of such higher fatty acid products is less than 15% by weight of the amide and preferably less than about 10%, so that there are no adverse effects.

The toothpaste can also contain other additives, such as coloring agents, whitening agents, preservatives such as methyl p-hydroxybenzoate, stabilizers, tetrasodium pyrophosphate, silicones, chlorophyll compounds and ammonia-like compounds such as urea or diammonium phosphate. Bactericidal agents may also be present in the toothpaste in amounts of about 0.01 to 5 and preferably 0.05 to 1% by weight, such as 6oN'-4- (chlorobenzyl-N5- (2,4-dichlorobenzyl) - biguanide; p-chlorophenyl biguanide;

4-chlorobenzhydryl biguanide; 4-chlorobenzhydrylguanyl urea; N-3-lauroxypropyl-N5-chlorobenzyl biguanide; 65 1,6-di-p-chlorobenzyl biguanide;

l- (lauryldimethylammonium) -8- (p-chlorobenzyldimethyl-

ammonium) octane dichloride; 5,6-dichloro-2-guanidinobenzimidazole;

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6

N1-p-chlorophenyl-N5-lauryl biguanide; 5-amino-1,3-bis (2-ethylhexyl) -5-methylhexahydro-pyrimidine or their non-toxic acid addition salts.

The toothpastes can also contain flavorings, such as flavoring oils, spearmint, peppermint, wintergreen, sassafras, clover, sage, eucalyptus, marjoram, cinnamon, lime and orange and methyl salicylate. The toothpaste may further contain sweeteners such as sucrose, lactose, maltose, sorbitol, sodium cyclamate, sodium saccharin dipeptides according to US Pat. No. 3,939,261 and oxathiazine salts according to US Pat. No. 3,932,606. Flavors and sweeteners are usually added in amounts of 0.01 to 5% by weight or more.

The pH of toothpastes can range from 3 to 10.5; it is determined directly on the toothpaste. Various compounds such as benzoic acid or citric acid can be used to adjust the pH to, for example, 4 to 8.5.

In the following, the invention will be explained using examples; unless otherwise stated, all information is based on weight.

In all examples, a toothpaste from the following

manufactured components and filled into a mechanically operated dispensing container according to GB-PS 2 070 695A.

Components

Parts by weight

Sorbitol (70%)

23,000

Sodium saccharin

0.170

Methyl p-hydroxybenzoate

0.080

Allantoin

0.150

Sodium fluoride

0.100

Sodium monofluorophosphate

0.760

Pyridylcarbinol

0.100

alpha alumina trihydrate (Alcoa C-333) 51,000

Benzoic acid

0.140

Sodium lauryl sulfate

1,667

Titanium dioxide

0.500

Flavorings

1,200

example 1

The toothpaste of the above basic composition also contained i-carrageenan (Genuvisco 0819) 0.500 parts by weight

Sodium carboxymethyl cellulose (7MFD) 0.500 parts by weight of demineralized water 20.133 parts by weight.

The toothpaste prepared in this way was very easy to fill in the dispensing container and after a storage period of one month at 43 C there was no leakage of material and was easy to remove from the container.

Similar satisfactory results were obtained when equal amounts of 0.55 part by weight or, in a further case, 0.45 part by weight of i-carrageenan and after carboxymethyl cellulose were used with corresponding adjustment of the water content. After 3 months of storage at 43 ° C, these toothpastes showed no leakage of components and Hesse gave off well from the container.

In a further application of the three toothpastes, 50.0 parts by weight and in another case 52.0 parts by weight of alpha-aluminum oxide trihydrate were used with appropriate adjustment of the water content and the same good results were obtained.

Example 2

The following ingredients were added to a toothpaste having the above starting composition: i-Carrageenan (Genuvisco 0819) 0.666 parts by weight of sodium carboxymethyl cellulose (7MFD) 0.334 parts by weight of demineralized water 19.633 parts by weight.

This toothpaste was easy to fill into the dispensing container and showed no leakage of components after one month of storage at 43 ° C; the toothpaste was easy to extrude.

The same results were obtained when filling into a container with a pressure difference.

If sodium carboxymethyl cellulose is used as the only gelling agent, the extrusion behavior 15 is poor. When hydroxyethyl cellulose is used as the only gelling agent, components leak out of the container. However, when hydroxyethyl cellulose is mixed with i-carrageenan, there is no difficulty in filling when dispensing the toothpaste.

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Example 3

The following ingredients were added to the toothpaste according to the basic composition:

i-Carrageenan (Genuvisco 0819) 0.500 parts by weight

25 xanthan gum (Keltrol) 0.500 parts by weight of demineralized water 20.133 parts by weight.

This toothpaste was easy to fill in the dispenser and showed no leakage of components after one month of storage at 43 ° C; it was easy to extrude. 30 Similarly good results are achieved if i-carrageenan and xanthan are used in an amount of 0.55 parts by weight each time and in another case in an amount of 0.45 parts by weight each, the water content being corrected accordingly. After three months of storage at 43 ° C. for three months, toothpaste containing only 0.45 parts by weight of these two constituents also showed no toothpaste escaping from the container; it was easy to extrude.

In two further batches, the content of alpha-40 aluminum oxide trihydrate was set to 50.00 parts by weight or to 52,000 parts by weight with a corresponding change in the water content; good results were also achieved here.

Instead of benzoic acid, 45 phosphoric acid can be used with the same result.

Example 4

The following toothpaste was mixed with the following mixture of thickeners:

so i-carrageenan (Genuvisco 0819) 0.750 parts by weight

Xanthan (Keltrol) 0.250 parts by weight of demineralized water 20.133 parts by weight.

This toothpaste was easy to fill into the dispensing container and showed no material leakage after three months of storage at 43 ° C; the toothpaste was easy to extrude.

Similarly good results were obtained when the alpha alumina trihydrate content was only 50.00 parts by weight.

60 In further experiments, 0.825 parts by weight of i-carrageenan and 0.275 parts by weight of xanthan were used once, while in a further batch 0.675 parts by weight of i-carrageenan and 0.225 parts by weight of xanthan were used.

65 Even when using a dispensing container that works by means of a pressure difference, the same advantageous effects were achieved both when filling and when dispensing the toothpaste.

Claims (7)

660 961 2nd PATENT CLAIMS 1. Toothpaste in a delivery container which can be actuated mechanically or acts by pressure difference and contains a) 20 to 80% by weight of an aqueous humectant as carrier, b) 0.1 to 5% by weight of a gelling agent mixture, c) 20 to 75% by weight of alpha-aluminum oxide trihydrate as a polishing agent, d) sodium fluoride and sodium monofluorophosphate in a 300 to 10,000 ppm fluorine-releasing amount, e) 0.05 to 0.5% by weight of allantoin as a desensitizing agent and f) 0.05 to 0.5% by weight of pyridylcarbinol as a vasodilatory additive, characterized in that the gelling agent mixture consists of i) a cellulose gelling agent or xanthan and ii) i-carrageenan in a weight ratio of 5: 1 to 1: 5. 2. Toothpaste according to claim 1, characterized in that the weight ratio of cellulose gelling agent or xanthan to i-carrageenan is 3: 1 to 1: 3 and the gelling agent mixture in a total amount of 0.2 to 3% by weight is present. 3. Toothpaste according to claim 2, characterized in that the cellulose gelling agent is sodium carboxymethyl cellulose. 4. Toothpaste according to claim 1, characterized in that the weight ratio of cellulose gelling agent or xanthan to i-carrageenan is about 1: 1. 5. Toothpaste according to claims 1 to 4, characterized in that sodium fluoride and sodium monofluorophosphate are present in a quantity delivering 750 to 2000 ppm fluorine and that 30 to 40% by weight of the fluorine is supplied by sodium fluoride. 6. Toothpaste according to claim 1, characterized in that it is present in a mechanically operated dispensing container. 7. A process for producing the toothpaste present in a mechanically operated delivery container according to claim 6, characterized in that a predetermined amount of the toothpaste defined in claim 1 is extruded through a mouthpiece into the mechanically operated delivery container, which is open at the bottom, through a mouthpiece fill, in which dispenser a central rod is arranged and over this central rod a piston is pushed, which has a diameter which corresponds to the inner diameter of the dispenser, and has a central opening for receiving the central rod, and that then Closes the dispensing container with a base plate.