JPS6122008A - Dentifrice composition - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to dentifrice compositions. In particular, the present invention relates to dentifrice compositions having desirable rheological properties suitable for effective filling into and extrusion from mechanically actuated or differential pressure dentifrice dispensers.

Dentifrice is generally recognized by its creamy or gel-like consistency and is commonly referred to as dental cream, toothpaste,
In some cases, it may be called a clear gel or an opacified gel toothpaste. In fact, it is characterized as semi-solid, for example when it is placed on the bristles of a toothbrush, it is essentially solid and during stirring manufacturing and filling of the container or when the dentifrice is forced out of its container under pressure. Liquid in nature.

The creamy consistency of dentifrices is imparted by gelling or binding agents. In the past, gelling agents have been selected primarily to provide ease of dispersion of dentifrices within the oral cavity. Many gelling agents satisfy this criterion, such as cellulosic materials, seaweed derivatives, gums and clays.

However, while certain gelling agents are generally desirable for dentifrices contained in flexible tubes, they pose drawbacks when the dentifrices are contained in mechanically actuated or differential pressure dispensers. .

Dentifrices containing conventional abrasives such as alpha-alumina trihydrate and sodium carboxymethylcellulose or hypyroxyethylcellulose matrices are preferably prepared in a flexible tube or in a mechanically actuated or differential pressure dispenser. They can be filled into and extruded from them. However, when the dentifrice contains many active ingredients, difficulties arise when attempting to fill the dentifrice into a mechanically actuated or differential pressure dispenser and/or when attempting to push it out of it. especially,
Leakage from the orifice in the dispenser occurs during filling or shipping, and the product is difficult to extrude in a rheologically desirable ribbon format.

Dentifrices that are viscous or tend to become viscous can become increasingly difficult for consumers to extrude from dentifrice tubes over long periods of time. In other words, the consumer must apply increased pressure to the dentifrice tube containing this type of dentifrice during the period of use in order to soften or liquefy and push the mass of semi-solid tooth polishing. This has not been a major problem in the past. This is because the formulation can be adjusted to balance using less gelling agent and not being too soft at the beginning and too thick at the end; The amount of pressure required to force the desired amount of dentifrice onto the bristles of the toothbrush has been adjusted.

Dentifrices that are not viscous when extruded from the tube are also
They have been tolerated during use if they clump harder on the toothbrush bristles within a few seconds. In this way, the type of gelling agent could be varied widely for the dentifrice contained within the tube.

In fact, Coinhagen Takuchin Factory of Little Skensved, Denmark (a subsidiary of Percules, of Wilmington, Praue, USA) has used its product Genubisco-type as a possible thickener for toothpastes. 0819, has proposed i-force radinan (i-force radinan). Marine colloids from F'MC, Springfield, New Chassis.
Hal-carrageenan obtained from the Division has also been proposed as Biscarin TP-5 for toothpastes with potential in the case of toothpastes containing dicalcium phosphate or silica. Moreover, I-carrageenan is disclosed in Japanese Patent Publication No. 56 11571 of September 11, 1981 by Lion Toothpaste Co., Ltd.
For dentifrices containing galactan galactose, it has been disclosed in No. 1, along with K-carrageenan and alkali metal alginates as thickening agent ingredients.

When using a dentifrice dispenser that is mechanically or differentially operated, it reduces the viscosity of the dentifrice.
-1 General techniques are not fully satisfactory. This is because, compared to toothpastes that are filled into flexible tubes, toothpastes are relatively non-viscous during filling, but lose their consistency during shipping, storage, and use. This is because it must be reacquired and maintained in its original state.

In other words, the dentifrice after filling regains the consistency it previously had of the liquefaction effect during shear filling for shipping, storage and use. sodium carboxymethyl cellulose,
It is desirable to use a conventional gelling agent such as human 50 xyethyl cellulose or mixtures thereof for dentifrices containing alpha-alumina trihydrate to be loaded into the Martinu® sensor. However, these toothpastes contain at least two sources of fluoride, plant-in (G7).
When the dentifrice contains multiple sources of active ingredients, such as desensitizing agents such as H6N403) and vasodilators such as pyridicarbinol, the dentifrice may be placed in a mechanical or differential pressure dispenser. Difficulties arise when filling. In particular, dentifrice seeps through the space between the rod and the piston particularly used in mechanically actuated dispensers, and the disk leaks at the orifice of the sensor. Additionally, the ribbon of dentifrice extruded from the mechanically actuated differential pressure dispenser may be irregular or discontinuous. Some active ingredients such as those mentioned above are carefully researched.
Because it is particularly desirable to create a dentifrice containing an alpha-alumina trihydrate abrasive based on its compatibility with abrasives, another gelling system was needed.

Surprisingly, among other types of gelling agents, mixtures of cellulosic gelling agents and I-carrageenan can be loaded into a mechanically actuated or differential pressure dispenser and extruded therefrom. 1. To provide a dentifrice containing alpha-alumina trihydrate and several active ingredients. It is noteworthy that xanthan was not compatible with cellulosic gelling agents since it contains cellulases.

It is an advantage of the present invention to provide a dentifrice that can be easily filled and extruded into a mechanically actuated or differential pressure dentifrice dispenser.

Other advantages will become apparent from consideration of the following specification.

According to some of its aspects, the invention provides about 20-
Approximately 0.1-5% by weight to 80% by weight water-based moisturizer
a gelling agent mixture of about 20-75% by weight alpha-alumina trihydrate abrasive, sodium fluoride and sodium monofluorophosphate in an amount providing about 300-110,000 pp of fluorine, about 0.05-0.5% by weight of an alpha-alumina trihydrate abrasive; % by weight of an allantoin sensitizing agent, and about 0.05-0.5% by weight of a pyridylcarbinol vasodilator in a mechanically actuated or differential pressure dispenser, If the gelling agent mixture is a cellulosic gelling agent or a mixture of xanthan and i-carrageenan, the weight ratio of either cellulosic gelling agent f or xanthan to l-carrageenan is about 5. :1 to about 1=
It is in 5.

In dentifrice formulations, the dentifrice vehicle consists of a liquid phase in proportion to a gelling agent to form an extrudable creamy mass of the desired consistency. The liquid phase in dentifrice is mainly water and humectants such as glycerin, sorbitol, maltitol, xylitol, and low molecular weight tJ-lyethylene glycols (e.g. A
000 or 600), professional rangercol, and appropriate mixtures thereof. It is usually advantageous to use water as the liquid phase and a humectant such as glycerin, sorbitol or polyethylene glycol, typically in amounts of about 10-55% by weight water and about 20-50% by weight humectant. It is.

The toothpaste is alpha alumina trihydrate abrasive about 20-7
Contains in an amount of 5% by weight. Alpha-alumina trihydrate is typically made by the Bayer process and is used as particles having a particle size of less than about 40 microns, primarily about 6-20 microns. Other abrasives may also be included, such as insoluble sodium metaphosphate, dicalcium phosphate, calcined alumina, silica or calcium carbonate, in small amounts relative to the alpha-alumina trihydrate.

The gelling agent mixture of the present invention is present in the dentifrice in an amount of about 0.1-5% by weight. it contains either a cellulosic gelling agent or xanthan together with i-carrageenan;
The weight ratio of the cellulosic gelling agent or xanthan to i-carrageenan is about 5=1 to about 1:5, preferably about 1=1 to about 1=6, and the total gelling agent The mixture is preferably about 0.2-3% by weight.

As mentioned above, iota carrageenan is available commercially as Genubisco Type 0819 and Biscarin TP-5 and has been recommended for use in toothpastes. This type of usage in toothpaste is described in Lion Tobashisha's Japanese Patent Publication No. 56.
115711, in which l-carrageenan is mentioned as a possible component of the gelling system together with l-carrageenan and alkali metal alginate. Scottoto, U.S. Pat. No. 4,353,890, l-carrageenan is disclosed as a toothpaste gelling agent in place of l-carrageenan, in which the toothpaste is exposed to microwave radiation and carrageenan is removed. Reduces the tendency to become sticky during general manufacturing.
0 This carrageenan may be the sole gelling agent or may be mixed with other gelling agents. In the present invention, the i-carrageenan-containing dentifrice to be loaded into a mechanically actuated or differential pressure dispenser does not require microwave radiation.

The prior art methods generally discussed above require that the cellulose gelling agent and i-carrageenan gelling system have the properties necessary for effective loading into and extrusion from a mechanically actuated or differential pressure taster. However, it has not been shown that it is possible to provide a dentifrice containing an alpha-alumina trihydrate abrasive and a number of active ingredients.

It is noteworthy that US Pat. No. 4,029,760 to Resokura discloses oral compositions in which 1-carrageenin is indicated as an anti-gingival moxibustion agent in place of other carrageenes. Carrageenes are highly depolymerized derivatives of carragietens. Carrageenan does not appear to provide anti-gingivitis effects.

Dentifrices are normally prepared by a low temperature process, e.g. at about 25°C, or by a thermal process, e.g. at about 60"G.
Manufactured in i-Carrageenan can be used in either low temperature or thermal processing techniques. Since xanthan is produced by low temperature processing, it can be readily mixed with I-carrageenan and incorporated into dentifrices with it by low temperature processing. l-Karaditene 11 can only be used with thermal treatment.

The physical properties of i-carrageenan of Genubisco type 0819 are as follows: 1. A 0% solution of Genubisco type 0819 in a poor solvent made using a thermal process (60°C) Viscosity: At 2 rpm Viscosity -110 ± 17 centipoise At 6 Arpm Viscosity - 70 ± 11 centipoise 1
Viscosity -45±7 centipoise at 28 rpm Haak-Rothvisco RV 3-C-measurement at 25°C.

2 Viscosity of a 0.30% solution of Genubisco type 0819 in poor solvent 1:μ made using a low temperature process (25°C): At 32 rpm mlC Viscosity -85 ± 16 centiboise At 6 Arpm Viscosity -55 ± 8 centiboise 1
Viscosity -37 ± 6 cm at 28 rpmff Measured at 25°C on a Boyeshaak-Rothvisco RV3.

6. Particle size: 0.075 mm secondary sieve (DIN80).

200 US sieve) less than 1% rubbery 4 Moisture content: 12% or less 5, pJ (: 0.5'% in distilled water at 25 °C) bath solution, 8, 5 + 1.5 6 Color: white Cream color.

Viscarin TP-5 I-N has the following physical properties: Color: Light brown to brown Particle size: More than 95.0% passes US standard sieve, 25 nm.

Moisture: Maximum 120% (Senco water scale) pH: 7.0 to 95.1.5% solution, 30°C Typical and desirable cellulosic gelling agents are alkali metals,
□ Contains ruboxymethylcellulose, methylcellulose, hydroxymethylcellulose and hydroxypropylcellulose. Sodium carboxymethyl cellulose is preferred. Mixed gel type is about 0.1-5% by weight of toothpaste.
present in an amount of from about 5:1 to about 1:5, preferably about 1:5 by weight of cellulosic gelling agent to I-carrageenan.
1 to about 1:63, most preferably about 1:1.

Thus, a typical preferred dentifrice contains about 0.3-0.9% each of cellulose p-gelling agent and ivy-carrageenan.
The weight ratio between the two is about 1:1 to about 1:1 to 1:6.
It can contain about 0.9-1.2% gelling agent.

It is worth noting that the brands of sodium carboxymethyl cellulose that can be used are: i-carrageenan and cellulosic gelling agents that can be mechanically combined together before mixing with the liquid phase of the dental cream, or Separately, the liquid phase can be mixed with thermal (typically about 60° C.) or cold (typically about 25° C.) techniques.

Xanthan gums are fermentation products produced by the action of bacteria of the genus Xanthomonas on carbohydrates. The four species of Xanthomonas, namely, Xcan, Tris, and
Farzeori, X Maruboshiryorum, and X Karote,
has been reported in the literature to be the most effective rubber producer.

Although the exact chemical structure has not been determined, it is generally accepted that it is a heterohO lisatsucharide with a molecular weight in the millions. It contains D-glucose, D-mannose and D-glucuronic acid at 2.8
:3:2.0 molar ratio.

The molecule contains 47% acetyl and approximately 3% pyruvate. The proposed chemical structure is based on Matsukuni and Kanta's “Industrial Rubber J (R,L, edited by Reisler, 0HX
X1.2 edition, New York.

(1976). Methods for the growth, isolation and purification of xanthan gums are also found in that publication. Further description of xanthan gum substance is M
manufacturing chem-ist, 196
May 0, pages 206-208 (including a discussion on page 208 of the potential use of the gums described therein for formulating toothpastes).

The i-carrageenan and xanthan can be mixed with the liquid phase of the dental cream vehicle using low temperature processing (typically about 25° C.) techniques.

The dentifrice is packaged in a container from which it can be easily extruded, such as a differential pressure or mechanically actuated dental cream dispenser. Its rheological properties were determined in 19819.
It is highly desirable when using a mechanically actuated dispensing container of the type described in British Patent Application No. 2.070,695A, published 9th May.

This dispensing container has a dispensing Kawaguchi gun, a tension member, a center rod,
Consists of a piston and a hand control for actuation. The disclosure of this published application is incorporated herein by reference.

The differential pressure dispensing container can be of the aerosol or vacuum type. Suitable differential pressure dispensing devices include those consisting of a collapsible product storage bag disposed within a rigid container containing a rand fluid. In such a dispensing container,
The pulp operation allows the release of only 14 articles, and the pro-propellant fluid is separated from the product by a fluid-impermeable bag. This type of dispenser is covered by U.S. Patent No. 828,977.
3.838,976. These four are the so-called sebro dis, ξ sa. So-called Excel containers also use pressure.

Yet another type of dispensing container is US special P4,1
71,757. Containers of this type include a valve, a product storage chamber, and an essentially fluid-tight barrier piston that separates the runt fluid from the contained product (so-called diamond containers).

The dentifrice contains a mixture of sodium fluoride and sodium monofluorophosphate as active agents and contains approximately 300-10,000 pp.
m, for example about 750-2000 ppm, especially about 1 ao
o-2000ppm e.g. about IA[]Q-1670pp
m of fluorine is provided. Preferably, a two-component fluoride system of sodium monofluorophosphate and sodium fluoride is used;
In some systems, about 50-AO% (eg, about 30-35%) of the fluorine is provided by sodium fluoride.

Sodium monofluorophosphate as commercially available
2P03F varies considerably in purity. It may be used in any suitable purity so long as the purity does not substantially adversely affect the desired properties. Generally, a purity of at least 80% is desirable. For best results, it should be at least 85%, preferably at least 90% by weight monofluorophosphate, with the remainder being primarily sodium fluoride and water-soluble sodium phosphate salts. It is a manufacturing by-product or impurity. Stated another way, the sodium monofluorophosphate used has a total fluoride content of at least about 12%, preferably 127%, and contains no more than 15% free fluoride (IJ). Preferably it is not more than 1.2%; it should preferably be at least 121%, all calculated as fluoride.

As noted above, the sodium fluoride in the binary mixture is a separate fluorine cargo component from the sodium monofluorophosphate. Approximately 22
Preferably, 5-800 ppm of fluorine is provided to the dental cream by sodium fluoride+C.

“Additional active agent is provided to the dentifrice by the presence of about 0.05-0.5% by weight, preferably about 0.08-02%, of an allantoin desensitizer. Allantoin can be obtained from A, 8M Industrial Products Ltd., Wood 5 Leigh, Stockport, Cheshire, UK.

about 0.05-5.0% by weight, preferably about 008-02
The pyridyl carbinol active agent in the amount of % by weight imparts a vasodilatory effect to the dentifrice.

When using a dentifrice containing an alpha-alumina trihydrate abrasive, a two-component fluoride system, an allantoin desensitizer, and a pyridylcarbinol vasodilator, as described above, a mechanically actuated or differential pressure dispenser is used. Filling and extrusion using gel systems of the present invention are effective and rheologically desirable.

Filling is performed by conventional techniques. For example, when using a mechanically actuated dispenser of the type described in British Patent Application No. 2,070,695A, a predetermined amount of dentifrice is forced through a nozzle to fill a dispenser that is open at the bottom and includes a center bar. .

A piston having a diameter corresponding to the inner diameter of the dispenser and a center hole that allows insertion of the center rod is slid into the piston. The disk is then sealed with a bottom disc.

Any suitable surfactant or detergent material can be included in the dentifrice composition. Such compatible materials are desirable and similarly selected to provide additional cleaning, foaming, and antimicrobial properties depending on the particular type of surfactant. These detergents are usually water-soluble compounds and may be anionic, nonionic or cationic in structure. It is usually preferred to use water-soluble non-soap or synthetic organic detergents. Suitable detergent materials are known and include, for example, water-soluble salts of higher fatty acid monoglyceride monosulfate detergents (e.g. sodium coconut fatty acid monoglyride monosulfate), higher alkyl sulfates (e.g. sodium lauryl sulfate), alkylaryl sulfonates (e.g. sodium lauryl sulfate), Examples include sodium dodecylbenzenesulfonate, higher fatty acid ester of 1;2-dihydroxypropanesulfonate), and the like.

Other surfactants include substantially saturated higher aliphatic acylamides of lower aliphatic aminocarboxylic acid compounds having 12 to 16 carbons in the acyl group. The amino acid moiety is generally derived from a lower aliphatic saturated monoaminocarboxylic acid having about 2 to 6 carbons, usually a monocarboxylic acid compound. A suitable compound is glycine,
Sarcosine, alanine, 6-aminopropionic acid, and a fatty acid amide of vallinine having about 12 to 16 carbons in the acyl group. N-lauroyl, myristoyl,
However, it is preferred to use sarcocytoyl compounds of and valmitoyl for optimal effect.

The amide compounds can be used in the free acid form or preferably as their water-soluble salts, such as alkali metal, ammonium, amine and alkylolamine salts.

Particular examples thereof are sodium and potassium N-lauroyl, myritele and ethanolamine N-lauroylglyside and alanine. For convenience, expressions such as "amine carboxylic acid compound" and "sarcoside" refer to compounds of this type having a free carboxylic acid group of a water-soluble carboxylate salt.

Such materials are utilized in pure or substantially pure form. They should contain as little as possible soaps or similar higher fatty acids, which tend to reduce the activity of these compounds. In normal practice, the amount of such higher fatty acid materials is less than 15% by weight of the amide, which is insufficient to substantially adversely affect the amide, and is preferred. It is about 10% or less.

Various other materials may be incorporated into the dentifrice of the present invention.

Examples of these are colorants, brighteners, preservatives such as methyl p-hydroxybenzoate, stabilizers, tetrasodium phosphate, silicones, chlorophyll compounds, and mixtures of urea, diphosphate, ammonium and the like. ammoniated substances, such as These adjuvants may be incorporated into the compositions of the present invention in amounts that do not materially adversely affect the desired properties and characteristics, and may be used in any suitable (C) selected and conventional amounts.

For certain purposes, it may also be desirable to include antimicrobial agents in the compositions of the present invention. A representative antimicrobial agent that can be used in an amount of about 0.01% to about 5%, preferably about 0.05% to about 10% by weight of the dentifrice composition is Ge-A (chlorobenzyl-N).
5-<2.1-dichlorobenzyl dichlorobenzyl chloride 9; p-10 p-10 p-10 p-chlorobenzyl chloride; 4-chloropenzhydrylhydryl hydryl chloride; A-chlorobenzhydryl hydryl urea; N-6-rauloxypropyl -N5 p-chlorobenzyl bigrinide 9; 1,6-di-p-chloropenzylguanide; 1-(lauryldimethylammonium)-8-(p-chlorobenzyldimethylammonium)-octane dichlorite;
.

5.6-:) Chloro-2-guanine dinobenzimidazole;
- methyl, xahydropyrimidine; and their non-toxic acid addition salts.

Any suitable seasoning or sweetening agent may be used to flavor the compositions of the present invention.

Examples of suitable seasoning ingredients include aromatic oils such as oils of orlandish, pepper, sassafras, clover, zalvia, eucalyptus, majorana, cinnamon, lemon and orange, and methyl salicylate. Suitable sweeteners include sucrose, lactose, maltose, sorbitol, sodium cyclamate, dichobutide of sodium saccharin (U.S. Pat. No. 3,939,261) and oxathine salts (U.S. Pat. No. 3,932,606).
including.

Suitable seasonings and seasonings may be combined to make about 0.0% of the composition.
It can consist of 0.01 to 5% or more.

Dentifrice has a practical pH for use. 6 to 105 p
H is particularly desirable. This reference to pH is meant to be the pH measured directly on the dentifrice. If desired, benzoic acid or citric acid can be added to adjust r+H, for example from 4 to 85.

The following examples further illustrate the nature of the invention, but are not to be construed as limiting the invention or thereto. Amounts of various ingredients are by weight unless otherwise specified.

Example 1 The following dentifrice was made by a conventional room temperature cryogenic process and filled into a mechanically actuated dispenser as described in British Patent Publication 2,070,695A.

part sorbitol 26.000
Sodium saccharin [],
170・i-carrageenan (Genubisco 0819)
0.500 Sodium Carboxymethyl Cellulose (7MFD)
0.500 Methyl p-hydroxybenzoate 0.0807 Lantoin
0150 Sodium fluoride
0.100 Sodium monofluorine phosphate 0.760 Pyridyl carbinol 0.100 Furfur alumina trihydrate (Alcoa C-333) 51.0
00benzoic acid 0.
140 Sodium lauryl sulfate 1
．． 667 titanium dioxide
0.500 Flavor O'1.200 Deionized water 20.133
This Tooth 1 extension agent is effectively filled into the disk and into the holder, and A
No leakage occurred during storage for one month at 3°C. This dentifrice was well extruded from the dispenser even after being stored at A3°C for one month.

Similar satisfactory results were obtained when the dentifrice contained 0.55 parts each of i-carrageenan and sodium carboxymethyl cellulose in the first case and 0.45 parts each of i-carrageenan and sodium carboxymethyl cellulose in the second case. When modified to contain sodium carboxymethyl cellulose and correspondingly adjust the water content, C) was obtained. In fact, at 46°C
Good extrudability with no leakage for several months is observed for these dentifrices.

Each of the three dentifrices described above were combined with one set of these dentifrices containing 50,000 parts alpha-alumina trihydrate and the second set containing 52,000 parts alpha-alumina trihydrate. Satisfactory results were again obtained with modification to include salts and adjust the water content accordingly.

Example 2 The following dentifrice is made by a low temperature process and filled into the same dispenser as in Example 1.

part sorbitol (70%>23.0
00 Sodium Saccharin 0
170 dishes - Chikara Rajinan (Genubisco 0819)
0.666 Sodium Carpoxymethyl Cellulose (7MFD) 0.33a Methyl p-Hydroxybenzoate 0.0807 Lantoin 0.150 Sodium Fluoride 0.1 [ ] [3 Sodium Monofluorophosphate 0.760
Pyridyl carbinol 0100
Alpha alumina trihydrate (Alpha G-ro 3ro)
51500 benzoic acid
Q, IAQ sodium lauryl sulfate
'+, 667 titanium dioxide
Ro500 flavoring agent
1.200 deionized water
19.633 This toothpaste was efficiently filled into a dispenser and was extruded well without leaking from the dispenser even after being stored in A filter for one month.

Similar desirable effects are obtained when the example dentifrice is loaded into a differential pressure dispenser.

When sodium carboxymethyl cellulose is used as a gelling agent, extrusion failures occur. Leakage occurs when hydroxyethyl cellulose is used as the only gelling agent.

However, when hydroxyethylcellulose is mixed with i-carrageenan, desirable filling and extrusion are achieved.

Example 3 The following dentifrice was made by a conventional room temperature and low temperature process,
Fill into a mechanically actuated dispenser in British Patent Publication 2,070,695A.

Sorbitol (70%) 23.0
00 Sodium Saccharin [
], 17Qi-Carrageenan (Genubisco 0819)
0.500 xanthan (Geltrol)
0.500 Methyl p-hydroxybenzoate 0.08'07 Lantoin
0.150 Sodium fluoride 3.100 Sodium monofluorophosphate 0.760 Pyridyl carbinol Q, 10
0 Alpha alumina trihydrate (Alcoa C-333)
51.000benzoic acid
0. I40 Sodium lauryl sulfate
1.667 titanium dioxide
0.500 flavoring
t200 deionized water
The dentifrice in 20.13 is efficiently filled into the dispenser and does not leak during storage at 46°C for one month.

After storage for one month at 63° C., it is well extruded from the dispenser.

Similar results show that this dentifrice was used in one case at 0.55% each.
part I-carrageenan and xanthan and in the second case 0.45 parts each of l-carrageenan and xanthan, obtained when modified to adjust the water content accordingly. In fact, no leakage and good extrudability after storage for 3 months at 0°C, respectively. Xanthan and i in part A5
- observed for dentifrices containing carrageenan.

Again, each of the three dentifrices described above was combined with 50,000 parts of alpha-alumina trihydrate in one set of these dentifrices and 52,000 parts of alpha-alumina trihydrate in the second set. Satisfactory results are observed upon modification to adjust the water content accordingly.

Phosphoric acid can be used in place of benzoic acid with the same results.

Example 2 The following dentifrice was made by a low-temperature process and
Fill into the same dispenser as N3.

Sorbitol (70%) 23.
00ronodium saccharin
0,17θl-Karazinan (Genubisco 0819)
0.750 Xanthan (geltrol) 0.250 Methyl p-hydroxybenzoate 0.0807 Lantoin 0.150 Sodium fluoride 0.100
Sodium monofluorophosphate 0760
Hydrolysyl carbinol 0.
100 Alfuryo-Alumina trihydrate (Alcoa C-333
) 51000 benzoic acid
01AO Sodium lauryl sulfate
1.667 titanium dioxide
0.500 flavoring
1200 deionized water
20.1 The dentifrice of the rotor is efficiently filled into the disc and is extruded well without leakage from the disc after being stored for 3 months at A °C.

Similar desirable results were obtained with 50,000 parts of alpha-alumina trihydrate. (a) 0.825 parts of i-
Carrageenan and 0275 parts of xanthan, and (1)
l O, 675 copies! Variations involving gel systems containing nan and 0.225 parts of xanthan also gave similar results.

A similar desirable effect is obtained when the example dentifrice is filled into a differential pressure dispenser.

It will be apparent to those skilled in the art that other variations of the embodiment illustrating the invention may be made.

Patent Applicant: Corday Palmolive Company
−? -1 Procedures Amendment Document June 20, 1985 Patent Application No. 272721 of 1988 2 Name of the invention Dentifrice composition 6 Relationship with the case of the person making the amendment Patent applicant's address Name Colcate Palmolive Company 4, Agent 6, Contents of amendment (1) Amend the specification cylinder to the lower limit.

・Page Line Before correction After correction Preferably at least 12% Preferably

Claims (1)

Claims: 1. about 20-80% by weight aqueous humectant vehicle;
1-5% gelling agent mixture, about 20-75% alpha-alumina trihydrate abrasive, about 300 to 10% by weight
Sodium fluoride and sodium monofluorophosphate in an amount to provide 000 ppm of fluorine, about 0.05-0.5% by weight
of allantoin desensitizer, and about 0.05-0.5
% by weight of a pyridyl carbinol vasodilator, wherein the gelling agent mixture comprises about 5% by weight of a cellulosic gelling agent or a xanthan and an i-carrageenan to an i-carrageenan. A dentifrice in a mechanically actuated or differential pressure dispenser in a weight ratio of: 1:1 to about 1:5. 2. The weight ratio of the cellulosic gelling agent to the i-carrageenan or the xanthan to the i-carrageenan is from about 3:1 to about 1:3, and the gelling agent mixture is about 0.2 - present in an amount of 3% by weight;
Toothpastes listed in section. 3. Claim 2, wherein the cellulosic gelling agent is present and is sodium carboxymethyl cellulose.
Toothpastes listed in section. 4. The dentifrice according to claim 2, wherein the xanthan is present. 5. The dentifrice of claim 2, wherein the weight ratio of said cellulosic gelling agent to said i-carrageenan or said xanthan to said i-carrageenan is about 1:1. 6. Claims wherein said sodium fluoride and said sodium monofluorophosphate are present in an amount to provide about 750-2000 ppm fluorine, and about 30-40% of the fluorine is provided by said sodium fluoride. The dentifrice according to item 1. 7. The dentifrice of claim 1, wherein the dentifrice is contained in a mechanically actuated dispenser. 8. about 20-80% by weight aqueous humectant vehicle, about 0.8% by weight aqueous humectant vehicle;
1-5% gelling agent mixture, about 20-75% alpha-alumina trihydrate abrasive, about 300 to 10% by weight
Sodium fluoride and sodium monofluorophosphate in an amount to provide 000 ppm fluorine, about 0.05-0.5% by weight
of an allantoin desensitizer and about 0.05-0.5 wt. agent vs. i-carrageenan is about 5
A method of manufacturing a dispenser containing a dentifrice, which is a mixture in a weight ratio of from 1:1 to about 1:5, comprising: forcing a predetermined amount of the dentifrice into a mechanically actuated dispenser through a nozzle; Filling a dispenser open at the bottom and containing a center rod, sliding a piston around said center rod having a diameter corresponding to the inner diameter of the dispenser and a center hole for receiving said center rod, and then closing said dispenser. A method consisting of sealing with a bottom disc.