KR920004817B1 - Dentifrice composition - Google Patents

Abstract

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Description

Toothpaste Composition

The present invention relates to a toothpaste composition. In particular, the present invention relates to toothpaste compositions having desirable fluidity suitable for efficiently filling and extruding from mechanical or pressure differential toothpaste dispensers.

Toothpastes usually have a creamy or gelled consistency and are commonly called dental creams, toothpastes or in some cases transparent gels, or opaque gel toothpastes. In fact, it is a semi-solid state, which is essentially solid when placed on the hard hair of a toothbrush, for example, and which is essentially liquid during agitation, during filling, or when extruded from the container by filling or pressure. There is a characteristic.

The creamy consistency of toothpastes is usually given by gelling agents or binders. In the past, gelling agents have been preferentially chosen to be able to easily disperse toothpaste in the oral cavity. Various gelling agents such as cellulose materials, seaweed derivatives, gums and clays are suitable for this condition. However, while some gelling agents are suitable for toothpaste filled in flexible tubes, they have caused disadvantages when filling toothpastes into mechanical or pressure differential dispensing containers.

Toothpastes containing conventional abrasives such as alpha alumina trihydrate and conventional gelling agents such as sodium carboxymethyl cellulose or hydroxyethyl cellulose or mixtures thereof are preferably filled into flexible tubes or mechanical or pressure differential dispensing containers. Or extruded therefrom. However, if the toothpaste contains many active ingredients, difficulties may arise when the toothpaste is filled in a mechanical or pressure differential dispensing container and / or extruded from it. In particular, leakage from small holes in the dispensing vessel may occur during filling or conveyance and it may be difficult for the product to be extruded into a rheologically desirable ribbon.

Thickening toothpastes or toothpastes that tend to thicken can increase the difficulty of the consumer extruding toothpaste from the toothpaste tube over time. In other words, the consumer must increase the pressure in the toothpaste tube containing such toothpaste in use to soften or liquefy the semisolid toothpaste mass to extrude. This allows the formulation to be adjusted to use a smaller amount of gelling agent in order to reach such a balance that it is not too thin at the beginning of use and not too concentrated at the end of use, and in any case, the amount of toothpaste desired by the consumer will be It has not been a major problem in the past because it has been easily controlled to apply the amount of pressure required to extrude onto the fur.

On extrusion from the tube, thin toothpaste has been allowed during use if they solidify in a few seconds on the bristles of the toothbrush in a few seconds. The type of gelling agent can therefore vary widely depending on the toothpaste being filled in the tube. Indeed, Copenhagen Pectin Fctory, Ltd. (Denmark, Little Skensved), Hercules, Inc. (U.S.A., Delaware, Wilmington) has presented its product Genuvisco Type 0819, i-corrageenan, which can be used as a toothpaste thickener. Marine Colloids Division of FMC Corp. It has been suggested that I-carrageenan phosphate, available as Viscarin TP-5 from New Jersey, Springfield, may be used in toothpaste in addition to toothpastes containing dicalcium or silica. I-carrageenan is also described by Lion Dentifrice Lte., Japanese Patent Publication No. 56 115711, issued on September 11, 1981, as a thickener component that can be used in galactan galactose-containing toothpastes with k-carrageenan and alkali metal alginates. Described.

When a machine operated or pressure differential toothpaste dispenser is used, the conventional technique of reducing the concentration of the toothpaste is not sufficiently satisfactory compared to the toothpaste filled in the flexible tube, and when the dispenser is used, the toothpaste is filled. It should be relatively thin, but its consistency should be restored or maintained during transportation, storage and use. Alternatively, after filling, the toothpaste must regain its consistency before liquefaction occurred during shear filling suitable for transport, storage and use. Conventional gelling agents such as sodium carboxymethyl cellulose, hydroxyethyl cellulose or mixtures thereof may be preferably used in dentifrices containing alpha-alumina trihydrate polishing agent filled in a dispensing container. However, these toothpastes can contain many active ingredients such as at least two sources of fluorine, sensitizers such as allatoin (C ₇ H ₆ N ₄ O ₃ ) and pyridyl carscales

If it contains a vasculature, such as when the toothpaste to fill the mechanical or pressure-differential dispensing container is difficult. In particular, the toothpaste may leak through the space between the rod and the piston, which is specially used in the mechanical dispensing container, and leaks occur in the dispensing container hole. In addition, toothpaste ribbons extruded from mechanical or pressure differential dispensing containers may be irregular or discontinuous. The preparation of an alpha-alumina trihydrate abrasive containing toothpaste comprising several active ingredients as mentioned above is particularly preferred because these materials are compatible with the abrasive and therefore another gelling agent is needed.

Unexpectedly, among alternative types of gelling agents, an excellent toothpaste containing a mixture of cellulose gelling agent and i-carrageenan containing alpha-alumina trihydrate and various active ingredients to be filled into and extruded from a mechanical or pressure differential dispensing vessel. Provides. It should be noted that x-slans may contain cellulase and therefore are not compatible with cellulosic gelling agents.

It is an advantage of the present invention to provide a toothpaste that can be easily filled into and easily extruded from a mechanically or pressure-differential toothpaste dispenser.

Still other advantages will be apparent from the description below.

According to one aspect of the invention, the invention provides about 20-80% by weight of an aqueous moisturizing excipient, about 0.1-5% by weight of a gelling agent mixture, about 20-75% by weight of an alpha-alumina trihydrate abrasive, about fluorine Mechanical operation consisting of sodium fluoride and sodium monofluorophosphate in an amount capable of providing 300-10000 ppm, about 0.05-0.5% by weight of allantoin sensitizer and about 0.05-0.5% by weight of pyridyl carbinol vasodilator, or A toothpaste in a pressure differential dispensing container, wherein the gelling agent mixture is a mixture in which the weight ratio of the cellulosic gelling agent or xanthan to i-carrageenan is about 5: 1-1: 5.

In toothpaste formulations, the toothpaste excipient is composed of a gelling agent and a liquid phase present in a proportion to form an extruded creamy mass with a desired consistency. Liquids in toothpastes are mainly moisturizing agents such as polyols, which include water and analogs including glycerin, sorbitol, maltitol, xylitol, low molecular weight polyethylene glycols (e.g. 400 or 600), prefilled glycols or suitable mixtures thereof. Will be constructed. It is generally advantageous to use water and moisturizers such as glycerin, sorbitol or polyethylene glycol in amounts of about 10-55% by weight of water and about 20-50% by weight of moisturizer.

Toothpastes contain about 20-75% by weight of alpha-alumina trihydrate abrasive. Alpha-alumina trihydrate is usually produced by the Bayer method and is used as particles of about 40 microns or less, mainly about 3-20 microns in size. Other abrasives, such as insoluble titanium phosphate, dicalcium phosphate, calcined alumina, silica or calcium carbonate, may be included in small amounts relative to alpha-alumina trihydrate.

The gelling agent mixture of the present invention is present in the toothpaste in an amount of about 0.1-5% by weight. It contains either a cellulosic gelling agent or xanthan in admixture with i-carrageenan, wherein the weight ratio of the cellulosic gelling agent or xanthan to the i-carrageenan is about 5: 1-1: 5 Preferably about 1: 1-1: 3, and the total gelling agent mixture is preferably about 0.2-3% by weight.

As mentioned above, Iota carrageenan is commercially available under the trade names Genubiscotype 0819 and Biscarin TP-5 and has been recommended for use in toothpaste. Use in such toothpastes is known from Japanese Patent Publication No. 56 115711 (Lion Dentifrice Ltd.), where i-carrageenan is mentioned as a possible gelling agent component along with k-carrageenan and alkali metal alginate. In US Pat. No. 4,353,890 by Scott, i-carrageenan is described as a toothpaste gelling agent as a substitute for k-carrageenan, where toothpaste is subjected to microwave irradiation to reduce the tendency of carrageenan to be generally thin during manufacture. did. Carrageenan can be used as the only gelling agent or in admixture with other gelling agents. In the present invention, the i-carrageenan-containing toothpaste to be filled in a mechanically or pressure differential dispensing container does not need to be irradiated with microwaves.

In the above-mentioned prior art, a cellulosic gelling agent and a gelling agent of i-carrageenan are used in combination with alpha-alumina trihydrate abrasives having the properties necessary to effectively fill and extrude mechanically or pressure differential dispensing containers. It is described that a toothpaste containing the ingredient may be provided.

It should be noted that US Patent 4,029,760, by de Roeck and colleagues, introduces an oral composition in which i-carakenin is given as an gingivitis inhibitor unlike other carrageenins. Carrageenin is a highly depolymerized derivative of carrageenan. Carrageenan shows no gingivitis effect.

Toothpastes are usually prepared by low temperature methods (eg at about 25 ° C.) or high temperature methods (eg at 60 ° C.). I-carrageenan can be used in both low and high temperature methods. Since xanthan is made by low temperature method, when used, it can be easily mixed with i-carrageenan by low temperature method and incorporated into toothpaste. I-carrageenan can only be used in high temperature methods.

The physical properties of Genubisco type 0819 i-carrageenan are shown below:

0.30% solution viscosity in lean solvent of Genubisco type 0819 prepared using high temperature method (60 ℃):

Viscosity = 110 ± 17 ^cp (at 32 rpm)

Viscosity = 70 ± 11 ^cp (at 64rpm)

Viscosity = 45 ± 7 ^cp (at 128 rpm)

Measured at 25 ° C., HAAKE Rotovisco RV 3.

2. 0.30% solution viscosity in lean solvent of Getubisco type 0819 prepared using low temperature method (25 ° C):

Viscosity = 450 ± 60 ^cp (25 ° C, measured on Brookfield Viscometer LVT)

Viscosity = 85 ± 13 ^cp (at 32 rpm)

Viscosity = 55 ± 8 ^cp (at 64rpm)

Viscosity = 37 ± 6 ^cp (at 128 rpm)

Measured at 25 ° C., HAAKE Rotovisco RV 3.

3. Particle size: Less than 1% of gum on 0.075mm test specimen (DIN 80,200US mesh).

4. Water content: less than 12%.

5. pH: 8.5 ± 1.5 (at 25 ° C. in% solution in distilled water).

6. Color: White-Cream.

Biscarin TP-5i-carrageenan has the following physical properties.

Color: Pale yellow-brown.

Particle size: 95.0% of the materials passed US standard, 250mm (Series # 60).

Moisture: up to 12.0% (Cenco Moisture Balance).

pH: 7.0-9.5 (30 ° C., 1.5% solution).

Typical preferred cellulose gelling agents include alkali metal carboxymethyl cellulose, methyl cellulose, hydroxymethyl cellulose and hydroxypropyl cellulose. Sodium carboxymethyl cellulose is preferred. The mixed gel system is present in an amount of about 0.1-5% by weight of the toothpaste and the weight ratio of the cellulose gelling agent to i-carrageenan is about 5: 1-1: 5, preferably about 1: 1: 1-1: 3, most preferably Is about 1: 1. Thus, typically a preferred toothpaste may contain about 0.3-0.9% of a cellulose gelling agent and i-carrageenan respectively, and a total of 0.9-1.2% of a total gelling agent having a weight ratio of about 1: 1-1: 3 between the two. have.

The grades of sodium carboxymethyl cellulose that may be used include the following:

TABLE 1

Hydroxyethyl cellulose grades that may also be used include the following.

TABLE 2

i-carrageenan and cellulosic gelling agents are mechanically mixed or mixed separately with liquid phase of dental cream excipient in high temperature (usually about 60 ° C) or low temperature (usually about 25 ° C) I can do it.

Xanthan gum is a fermentation product produced by reacting bacteria in the genus Xanthomonas to carbohydrates. Four xanthomonas, namely, X campetris, X phaseol, X malvocearum and X carotae, are reported in the literature as the most effective gum forms. Although the exact chemical structure is not determined, it is generally considered to be a heteropolysaccharide having millions of molecular weights. It contains D-glucose, D-mannose and D-glucuronic acid in a molar ratio of 2.8: 3: 2.0. This molecule contains 4.7% acetyl and about 3% pyruvate. The chemical structures shown are shown in the literature. McNeely and Kang, Industrial Gums, ed R. L. Whistler, CH XXI, 2nd Edition, New York, 1973. The growth, isolation and purification of xanthan gum are also shown in the literature. Another reference to xanthan gum can be found in other literature, Manufacturing Chemist, May 1960, P206-208 (in P208, the gums mentioned therein can be used in toothpaste formulations).

i-carrageenan and xanthan can be mixed mechanically or separately from the liquid phase prior to mixing with the liquid cream excipient liquid using a cooling method (25 ° C).

Toothpaste is filled into a container that can be easily extruded, such as a pressure dispensing or mechanical tooth dispensing container. When using this type of machine-operated dispensing vessel described in British Patent Application No. 2,070,695A (published Sep. 9, 1981), fluidity is very desirable. The dispensing container consists of a dispensing inlet, a tension member, a central rod, a piston and a manual operation adjustment. The description part of this application is incorporated herein by reference.

Pressure differential dispense vessels may be aerosol or vacuum. Suitable pressure differential dispensing containers include those in which an extrudable product-containing bag is arranged in a rigid container containing the injection liquid. In such dispensing vessels, only the product is released by operating the valve, and the injection liquid is separated from the product by a fluid impermeable bag. Dispensing containers of this type are known from US Pat. Nos. 3,828,977 and 3,838,976. These are called sopro dispensing containers. Excel containers also use pressure.

Another type of dispensing container is a barrier piston container known from US Pat. No. 4,171,757. Such vessels include a fluid barrier piston (usually called a diamond vessel) that separates the valve, the product-containing compartment and the injection liquid from the contained product.

Toothpaste contains as a active mixture a mixture of sodium fluoride and sodium monofluorophosphate which provides about 300-10000 ppm of fluorine, such as about 750-2000 ppm, in particular 1400-2000 ppm, ie 1400-1670 ppm. Binary fluoride systems of sodium monofluorophosphate and sodium fluoride, in which about 30-40% of fluorine (such as about 30-35%) are provided by sodium fluoride, are preferably used.

Commercially available sodium monofluorophosphate, Na ₂ PO ₃ F, varies considerably in pure terms. Any suitable purity can be used as long as any impurities do not substantially adversely affect the desired properties. In general, the purity is preferably at least 80%. For best results, the purity should be at least 85%, preferably at least 90% sodium monofluorophosphate, with the remainder being primarily by-products or impurities in the preparation, such as sodium fluoride and water soluble sodium phosphate salts. In other words, the sodium monofluorophosphate used has a total fluoride content of 12% or more, preferably 12.7% or more and free sodium fluoride 1.5% or less, preferably 1.2% or less: At least 12% and preferably at least 12.1%.

As mentioned above, sodium fluoride in the binary mixture is a fluorine-containing component separated from sodium monofluorophosphate. Preferably, about 225-800 ppm of fluorine is supplied to the dental cream by sodium fluoride.

As another active ingredient, about 0.05-0.5% by weight, preferably about 0.8-0.2% by weight of an alloin sensitizer is present in the toothpaste. These drugs reduce the sense of damaged root tissue and promote their healing. Allatoin can be obtained from ABM Industrial Prodcuts Ltd (Woodley, Stockport, Cheshirk, England).

Pyridyl carbinol active ingredient in an amount of about 0.05-0.5% by weight, preferably about 0.08-0.2% by weight provides vasodilating effect to the toothpaste.

Filling and extrusion using mechanical or pressure-differential dispensing vessels is efficient when using toothpastes containing alpha-alumina trihydrate abrasives, bicomponent fluorides, allantoin sensitizers and pyridyl carbinol vasodilators as described above. In addition, the preferred fluidity is obtained together with the gel system of the present invention.

Filling is carried out in a conventional manner. For example, if a mechanical dispense container of the type described in published UK patent application 2,070,695A is used, a predetermined amount of toothpaste is extruded from the nozzle, the bottom of which is opened, and filled into a dispense container having a central rod. Will be. A piston having a diameter corresponding to the inner diameter of the dispensing vessel and having a central hole is inserted therein so that the central rod can be inserted therein. The dispensing vessel is then sealed with a lower disk.

In the dentifrice composition, any suitable surfactant or cleaning material may be contained. Such compatible materials are preferably and similarly selected to provide additional cleaning, foaming and antibacterial activity depending on the specific form of the surfactant. These detergents are generally water soluble compounds and may have an anionic, nonionic or cationic structure. It is usually preferred to use water soluble non-soap or synthetic organic detergents. Suitable cleaning materials are known and include, for example, water-soluble salts of higher fatty acid monoglyceride monosulfate detergents (e.g., sodium fatty acid monoglyceride monosulfate), higher alkyl sulfates (e.g. sodium lauryl sulfate), alkylarylsulfonates (E.g. sodium dodecylbenzene sulfonate, higher fatty acid ester of 1,2-dihydroxypropane sulfonate).

Still other surfactants include substantially saturated higher aliphatic acylamides of lower aliphatic amino carboxylic acid compounds having 12-16 carbons in the acyl radicals. Amino acid moieties are generally derived from lower aliphatic saturated monoaminocarboxylic acids, typically monocarboxylic acid compounds, containing about 2-6 carbon atoms. Suitable compounds are fatty acid amides of glycerin, salconsin, alanine, 3-aminopropanoic acid and valine, those having about 12-16 carbon atoms in the acyl group. However, to obtain the optimum effect, it is preferable to use N-lauroyl, myristoyl and palitoyl salcoside compounds.

The amide compounds can be used in the form of the free acid or preferably its water-soluble salts, such as, for example, alkali metal, ammonium, amine and alkylolamine salts. Special examples include sodium and potassium N-lauroyl, myristoyl and palmitoyl salcosides, ammonium and ethanolamine N-lauroyl glycid and alanine.

As used herein, "amino carboxylic acid compound", "salcoside", and the like are compounds having a free carboxyl group of a water-soluble carboxylate salt.

These materials are available in pure or nearly pure form. They should not be affected by soaps or similar higher fatty acid substances which tend to reduce the activity of these compounds. In fact, the amount of such higher fatty acid materials is less than 15% by weight of the amide, insufficient to have a substantially bad effect, and preferably less than about 10% by weight of the amide material.

Various other substances may be incorporated into the toothpaste of the present invention. Examples include colorants or whitening agents, preservatives such as methyl P-hydroxybenzoate, stabilizers, tetrasodium pyrophosphate, silicones, chlorophyll compounds and ammonialation materials such as urea, diammonium phosphate and mixtures thereof. These adjuvants are incorporated into the present compositions in an amount that does not substantially adversely affect the desired properties and properties, and are appropriately selected and used in conventional amounts.

For some purposes, it may be desirable to include antimicrobials in the compositions of the present invention. Typical antimicrobials that can be used in an amount of about 0.01-5% by weight, preferably about 0.05-1.0% by weight of the dentifrice composition include the following. N ^1-4 (chlorobenzyl) -n ^5- (2,4-dichlorobenzyl) biguanide; P-chlorophenyl biguanide; 4-chlorobenz hydryl biguanide; 4-chlorobenz hydryl guanylurea; N-3-lauoxyoxy-N ⁵ -P-chlorobenzyl biguanide; 1,6-di-P-chlorobenzylbiguanide; 1- (lauryldimethylammonium) -8- (P-chlorobenzyldimethylammonium) octane dichloride; 5,6-dichloro-2-guanidinobenzimidazole; N ¹ -P-chlorophenyl-N ⁵ -laurylbiguanide; 5-amino-1,3-bis (2-ethylhexyl) -5-methylhexahydropyridinedine; And nontoxic acid salts thereof.

Any suitable fragrance or sweetener may be used to flavor the compositions of the present invention. Examples of suitable fragrance components include fragrance oils such as spearmint oil, peppermint oil, donglock oil, sasapras oil, clover oil, sage oil, eucalyptus oil, marjoram oil, cinnamon oil, lemon oil and orange oil and methyl salicylate. Suitable sweeteners include sucrose, lactose, maltose, sorbitol, sodium cyclate, sodium saccharin dipeptide of US Pat. No. 3,939,261, and oxathiazine salt of US Pat. No. 3,932,606. Suitable fragrances and sweeteners may together constitute about 0.01-5% or more of the composition.

Toothpaste should have a suitable pH for use. pH 3-10.5 is particularly preferred. Related to pH refers to the pH measured directly on the toothpaste. If desired, the pH can be adjusted to, for example, 5-8.5 by adding substances such as benzoic acid or citric acid.

The following examples are presented to further illustrate the nature of the invention and should not be construed as limiting the invention thereto. The amounts of the various components are all by weight unless otherwise indicated.

Example 1

The following toothpaste was prepared by a low temperature method operated at a conventional room temperature and then filled into a mechanical dispensing container described in British Patent No. 2,070,695A.

part

Sorbitol (70%) 23.000

Sodium saccharin 0.170

I-Karagenan (Genubisko 0819) 0.500

Sodium Cagoximethyl Cellulose (7MFD) 0.500

Methyl P-hydroxybenzoate 0.080

Allantoin 0.150

Sodium Fluoride 0.100

Sodium Monofluorophosphate 0.760

Pyridyl Carbinol 0.100

Alpha Alumina Trihydrate (Alcoa C-333) 51.000

Benzoic Acid 0.140

Sodium Lauryl Sulfate 1.667

Titanium Dioxide 0.500

Air freshener 1.200

Deionized Water 20.133

Toothpaste is efficiently filled in the dispensing container and did not leak during storage for one month at 43 ° C. It extruded well from the dispensing vessel even after 1 month storage at 43 ° C.

The first case contains 0.55 parts of i-carrageenan and sodium carboxymethyl cellulose, and the second case contains 0.45 parts of i-carrageenan and sodium carboxymethyl cellulose, and the amount of water is adjusted accordingly to change the toothpaste composition. Similarly, satisfactory results were obtained. After 3 months storage at 43 ° C., these toothpastes did not leak and had excellent extrudability.

Again, in each of the three toothpastes described above, the first set of these toothpastes contained 50,000 parts of alpha-alumina trihydrate and the second set contained 52,000 parts of alpha-alumina trihydrate and the amount of water adjusted accordingly changed the composition. The result was observed.

Example 2

The following toothpaste was prepared by a low temperature method and then filled into a dispensing container as in Example 1.

part

Sorbitol (70%) 23.000

Sodium saccharin 0.170

I-Carrageenan (Genubisco 0819) 0.666

Sodium Kagoximethyl Cellulose (7MFD) 0.334

Methyl P-hydroxybenzoate 0.080

Allantoin 0.150

Sodium Fluoride 0.100

Sodium Monofluorophosphate 0.760

Pyridyl Carbinol 0.100

Alpha Alumina Trihydrate (Alcoa C-333) 51.500

Benzoic Acid 0.140

Sodium Lauryl Sulfate 1.667

Titanium Dioxide 0.500

Air freshener 1.200

Deionized Water 19.633

The toothpaste was efficiently filled into the dispensing container, did not leak after being stored at 43 ° C. for more than one month, and was extruded well from the dispensing container.

Similarly desirable effects were obtained when the toothpaste of the examples was filled in a pressure-fitting dispenser.

Extrusion was poor when only sodium carboxymethyl cellulose was used as the gelling agent. Leakage was seen when only hydroxyethyl cellulose was used as the gelling agent. However, when hydroxyethyl cellulose was mixed with i-carrageenan it was preferably packed and extruded.

Example 3

The following toothpaste was prepared by a low temperature method operated at conventional room temperature and then filled into a mechanical dispense container of British Patent No. 2,070,695A.

part

Sorbitol (70%) 23.000

Sodium saccharin 0.170

I-Karagenan (Genubisko 0819) 0.500

Xanthan 0.500

Methyl P-hydroxybenzoate 0.080

Allantoin 0.150

Sodium Fluoride 0.100

Sodium Monofluorophosphate 0.760

Pyridyl Carbinol 0.100

Alpha Alumina Trihydrate (Alcoa C-333) 51.000

Benzoic Acid 0.140

Sodium Lauryl Sulfate 1.667

Titanium Dioxide 0.500

Air freshener 1.200

Deionized Water 20.133

Toothpaste is efficiently filled in the dispensing container and did not leak during storage for more than 1 month at 43 ° C. It was well extruded from the dispensing vessel after 1 month storage at 483 ° C.

The first case contains 0.55 parts of i-carrageenan and xanthan, and the second case contains 0.45 parts of i-carrageenan and xanthan, respectively. A satisfactory result was obtained. Toothpaste containing 0.45 parts each of xanthan and i-carrageenan did not leak after storage at 43 ° C. for 3 months, and excellent extrudability was observed.

In each of the three toothpastes described above, satisfactory results were observed when the first set of these toothpastes contained 50,000 parts of α-alumina trihydrate and 52,000 parts in the second set and the amount of water was adjusted accordingly.

Similar results were obtained when phosphoric acid was used instead of benzoic acid.

Example 4

The following toothpaste was prepared by the low temperature method and then filled into the same dispensing container as in Example 3.

part

Sorbitol (70%) 23.000

Sodium saccharin 0.170

I-Karagenan (Genubisko 0819) 0.750

Keltrol 0.250

Methyl P-hydroxybenzoate 0.080

Allantoin 0.150

Sodium Fluoride 0.100

Sodium Monofluorophosphate 0.760

Pyridyl Carbinol 0.100

Alpha Alumina Trihydrate (Alcoa C-333) 51.000

Benzoic Acid 0.140

Sodium Lauryl Sulfate 1.667

Titanium Dioxide 0.500

Air freshener 1.200

Deionized Water 20.133

The toothpaste was efficiently filled into the dispensing vessel, stored at 43 ° C. for 3 months, did not leak, and was extruded well from the dispensing vessel.

Similarly favorable results were obtained when using 50.000 parts of alpha alumina trihydrate. Similar results were obtained when gel systems containing (a) 0.825 parts i-carrageenan and 0.275 parts xanthine and (b) 0.675 parts i-carrageenan and 0.225 parts xanthan were used.

Similar desirable effects were obtained when the toothpastes of the examples were filled in a pressure differential dispenser.

It will be apparent to those skilled in the art that the above-described embodiments of the present invention can be further modified.

Claims (7)

About 20-80% by weight of an aqueous moisturizing excipient; About 0.1-5% by weight of a gelling agent mixture; About 20-75% by weight of alpha-alumina trihydrate abrasive; Sodium fluoride and sodium monofluorophosphate in an amount capable of providing about 300-10000 ppm of fluorine; About 0.05-0.5% by weight allantoin sensitizer and about 0.05-0.5% by weight pyridylcarbinol vasodilator, wherein the gelling agent mixture is a mixture of i-carrageenan with one of a cellulosic gelling agent or xanthan Toothpaste in a mechanically or pressure-differential dispensing container, wherein the weight ratio of the cellulosic gelling agent to i-carrageenan is about 5: 1-1: 5. The toothpaste of claim 1 wherein the weight ratio of said cellulosic gelling agent or said xanthan to said i-carrageenan is about 3: 1-1: 3 and the gelling agent mixture is present in an amount of about 0.2-0.3 wt%. 3. The toothpaste of claim 2, wherein said cellulosic gelling agent is present and it is sodium carboxymethyl cellulose. 3. The toothpaste of claim 2, wherein said xanthan is present. 3. The toothpaste of claim 2 wherein the weight ratio of said cellulosic gelling agent or said xanthan to said i-carrageenan is about 1: 1. The toothpaste of claim 1 wherein said sodium fluoride and said sodium monofluorophosphate are present in an amount capable of supplying about 750-2000 ppm of fluorine, wherein the sodium fluoride is supplied with about 30-40% fluorine. 2. The toothpaste of claim 1, wherein said toothpaste is contained in a mechanical dispense container.