SE461012B - Toothpaste containing carrageenan - Google Patents

Description

461 012 10 20 from nozzles in the containers arise during filling or shipping and the product can be difficult to extrude in a rheologically desired extruded form.

Toothpastes that are thick or have a tendency to thicken can become increasingly difficult for a consumer to extrude from a toothpaste tube over a period of time. In other words, the consumer may need to increase the pressure on the toothpaste tube containing such a toothpaste during the period of use to soften or transfer to liquid form the semi-solid toothpaste mass to extrude it. This has not been a major problem in the past, as compositions can be adjusted so that smaller gelling agents are used to balance so that it is not too soft at the beginning of use and too thick at the end, and in any case consumers have readily adapted. to apply the compressive force necessary to extrude the desired amount of toothpaste onto the bristles of the toothbrush.

Toothpaste, which is thin when extruded from a tube, has also been tolerated during use, if it changes to a more solid form on the toothbrush bristles within a few seconds.

Thus, the type of gelling agent could vary greatly for toothpastes packaged in tubes. In fact, Copenhagen has Pectin Factory Ltd. in Little Skensved, Denmark, a subsidiary of Hercules Inc. of Wilmington, Delaware, USA, has proposed its Genuvisco Type 0819 product, an i-carrageenan, as a possible thickener for toothpaste. The I-carrageenan from the Marine Colloids Division of FMC Corp. of Springfield, New Jersey, in the form of Viscarin TP-5 has also been proposed for use in toothpaste containing dicalcium phosphate or silica. Furthermore, i-carrageenan has been described as a thickener component together with k-carrageenan and alkali metal alginate for a toothpaste containing galactan galactose in Japanese Patent Publication 56 115711, published September 11, 1981, in the name of Lion Dentifrice Ltd.

When a toothpaste dispenser which is mechanically affected or by pressure difference is used, conventional techniques for reducing the thickening of the toothpaste may not be completely satisfactory, because compared to a toothpaste filled in a soft tube, when a dispenser is used the toothpaste must be relatively thin during filling but then regains its consistency and remains so during periods of shipping, storage and use. In other words, after filling, the toothpaste regains essentially the consistency it had before the transfer to liquid during shear filling before shipping, storage and use. Conventional gelling agents such as sodium carboxymethylcellulose, hydroxyethylcellulose or mixtures thereof can be suitably used for toothpaste containing semi-alumina trihydrate as a polishing agent to be filled in a dispenser. However, when such a toothpaste contains many sources of active ingredients, such as at least two sources of fluorine, a desensitizing agent such as allantoin (C7H6N4O3) and a vasodilator such as pyridylcarbinol N - CH2-- OH, difficulties arise when the toothpaste is filled in a mechanical or pressurized dispenser. In particular, toothpaste can seep through the space between a rod and a piston, which is especially used in a mechanically actuated dispenser and leakage occurs at dispenser nozzles. Furthermore, the toothpaste strand that is extruded from a mechanically or pressure-affected dispenser may be irregular or non-continuous. Since it is particularly desirable to prepare a toothpaste containing CK-alumina trihydrate as a polishing agent, which comprises several active agents, such as those set forth above, depending on the compatibility of these materials 1. »- 10 15 20 25 30 461 012 , an alternative gelling system was required.

Quite unexpectedly, among the alternative types of gelling agents present a mixture of a cellulosic gelling agent and the i-carrageenan has been found to provide an excellent toothpaste containing OC alumina trihydrate and a variety of active ingredients, which are to be replenished and extruded from a mechanical or pressurized dispenser. It should be noted that xanthan is not compatible with cellulosic gel, as it may contain cellulase.

An advantage of the present invention is that it provides a toothpaste that can be easily filled and extruded from a mechanically or pressure-affected toothpaste dispenser.

Other advantages of the invention will become apparent from the following description.

According to certain aspects, the invention relates to a toothpaste in a mechanically or pressure-affected dispenser comprising approx. 20-80% by weight of an aqueous humectant vehicle, approx. 0.1-5% by weight of gelling agent mixture, approx. 20-75% by weight of walking alumina trihydrate as a polishing agent, sodium fluoride and sodium monofluorophosphate in an amount which gives approx. 300 to 10000 ppm fluorine, approx. 0.05-0.5% by weight of allantoin as desensitizer and approx. 0.05-0.5% by weight of pyridylcarbinol as a vasodilator, said gelling agent mixture being a mixture of a cellulosic gelling agent or xanthan and i-carrageenan in a weight ratio of either cellulose gelling agent or xanthan to i-carrageenan of 5 : 1 to approx. 1: 5.

In the toothpaste composition, the dental vehicle comprises a liquid phase proportional to the gelling agent to form an extrudable creamy mass of desired consistency. The liquid phase of the toothpaste mainly comprises water and humectant such as polyols comprising glycerin, sorbitol, maltitol, xylitol, low molecular weight polyethylene glycol (eg 400 or 600), propylene glycol or the like including suitable mixtures thereof. It is usually advantageous to use water as a liquid phase and a humectant such as glycerin, sorbitol or polyethylene glycol, typically in amounts of approx. 10-55% by weight of water and approx. 20-50% by weight humectant.

The toothpaste contains bran-alumina trihydrate as a polishing meal in amounts of approx. 20-75 wt-s. O-alumina trihydrate is typically prepared by the Bayer process and used in the form of particles having a size below about 40 .mu.m, mainly about 3-20 .mu.m. Other polishing agents may be included, such as insoluble sodium metaphosphate, dicalcium phosphate, calcined alumina, silica or calcium carbonate in a smaller amount relative to OC alumina trihydrate.

The gelling agent composition of the present invention is present in the toothpaste in an amount of about 0.1-5% by weight. It contains either a cellulose gelling agent or xanthan mixed with i-carrageenan, the weight ratio of said cellulose gel or xanthan to said i-carrageenan amounting to from about 5: 1 to approx. 1: 5, preferably from approx. 1: 1 to approx. 1: 3, and the total gelling agent mixture preferably constitutes approx. 0.2-3% by weight.

As mentioned above, i-carrageenan is commercially available in the form of Genuvisco type 0819 and Viscarin TP-5 and has been recommended for use in toothpaste. Such use in toothpaste is described in Japanese Patent Publication No. 56 115711 of Lion Dentifrice Ltd., in which the i-carrageenan is mentioned as a possible component in a gelling system together with k-carrageenan and alkali metal alginate. U.S. Patent 4,353,890 discloses i-carrageenan as an alternative to k-carrageenan as a toothpaste gelling agent, wherein the toothpaste is subjected to microwave radiation to reduce the tendency of carrageenan to generally become thin during manufacture.

Carrageenan can be a single gelling agent or mixed with other gelling agents. According to the present invention, toothpaste containing the i-carrageenan to be filled in a mechanically or pressure-actuated dispenser does not require microwave radiation.

The prior art discussed above does not suggest that gelling systems with cellulose gelling agent and in-carrageenan can provide toothpastes containing OC-alumina trihydrate as a polishing agent and many active ingredients with properties required for effective filling in a mechanically or pressure-actuated dispenser and extrusion therefrom. .

It should be noted that U.S. Patent 4,029,760 discloses an oral composition in which i-carrageenin is presented as an antiging agent as an alternative to other carrageenans. Carrageenans are highly depolymerized derivatives of carrageenans. Carrageenans do not appear to have any antigivine effect.

Toothpastes are usually prepared in a cold process, i.e. Ä at approx. 25 ° C, or with a hot process, e.g. at approx. 60 ° C. I-carrageenan can be used in both cold and hot processes. Since xanthan is produced by cold process, when used, it can be easily mixed with the i-carrageenan and incorporated therewith into the toothpaste by cold working. I-carrageenan can only be used in: hot preparation. 461 012 Physical properties of Genuvisco type 0819 i-carrageenan are given below: 5 10 2. 15 20 25 Viscosity of a 0.30 μg solution of Genuvisco type 0819 in soft solvent was prepared by a hot process (60 ° C): Viscosity = Viscosity Viscosity Data measured on Viscosity for a 0.30 μg solution in soft solvent prepared by 110 70 45 process (25 ° C): Viscosity = Viscosity = Viscosity = Viscosity = * 17 cP at 32 rpm. ll cP at 64 rpm. 7 cP at 128 rpm.

Haake Rotovisco RV3 H- H 'via 2s ° c.

Genuvisco type 0819 using a cold 450 3 60 cP measured on a Brookfield Viscometer LVT at 25 ° C. 85 SS 37 | + l-l- H- l3 cP at 32 rpm. 8 cP at 64 rpm. 6 cP at 128 rpm.

Data measured on Haake Rotovisco RV3 at 25 ° C.

Particle size: Moisture content: pH: Color: Properties: Viscarin TP-5 in ~ carrageenan Less than 1% rubber on 0.075 mmzs test screen (DIN 80,200 US mesh).

Less than 12%. s, s 1 1.5 1 o, s%% solution 1 distilled water at 25 ° C.

White to cream. had the following physical color Light brown to brown Particle size: More than 95.0% through a US standard sieve, 250 nm (series ff 60).

Humidity: Max. 12.0% (Cenco Moisture Balance). pH: 7.0 to 9.5, 1.5-g solution at 30 ° C.

Typical desired cellulose gelling agents include alkali metal 1-carboxymethylcellulose, methylcellulose, hydroxymethylcellulose and hydroxypropylcellulose. Sodium carboxymethylcellulose is preferred. The mixed gel system is present in an amount of approx. 0.1-5% by weight of the toothpaste, and the weight ratio of cellulose gelling agent to the i-carrageenan amounts to approx. 5: 1 to approx. 1: 5, preferably approx. 1: 1 to approx. 1: 3, and preferably approx. lzl. Thus, a typical preferred toothpaste may contain approx. 0.9-1, 2% total gelling agent comprising approx. 0.3-0.92 of each cellulose gelling agent and i-carrageenan, the weight ratio between the two amounting to from approx. 1: 1 to 1: 3.

It should be noted that the degrees of sodium carboxymethylcellulose that can be used include the following: 20 * la-ig solution (srQoxf1e1a; 2s ° c) ** Hoeppler Viscometer (2%; 20 ° C) 461 012 9 TABLE 1 Manufacturer CMC quality viscosity Hercules' vnxr 3oo-soo Hercules 7MFD 300-500 Hercules 9M31F 900-1200 Hercules 9M31XF 900-1200 Hercules l2M31XF 900-1200 Hercules 7MF 300-500 Hercules 12M31PD 900-1200 Hercules 7M8SXF 200-800 Wolff Walscals 700-1200 Nyma Nymcel ZMF.33 * 50-80 Enka Akucell AC 1642 * 80-120 Enka Akucell AC 1632 * 60-120 Cros Cellogen HP-SA 700-900 Uddeholm Cekol MVEP 500-800 Hoechst Tylose CB 200 ** 120- 260 Furthermore, the grades of hydroxyethylcellulose that can be used include the following: 10 15 20 25 461 012 10 TABLE 2 Manufacturer HEC quality Viscosity Hercules Natrosol 250M and MR 4500-6500 Hercules Natrosol 250 HR * 1500-2500 and 250 H * Hercules Natrosol 250 HHR * 3400-5000 and 250 HH BP Chemicals Cellobond 5000 A 4200-5600 BP Chemicals Cellobond 7000 A 6000-7000 Hoechst Tylose H 4000 P ** 3000-5000 Hoechst Tylose H 10000 P ** 7000-12000 * liquid solution (ßro0xfie1a; 2s ° c).

** Heoppler Viscometer (2%; 25 ° C).

I-carrageenan and cellulose gelling agents may be mechanically mixed with each other prior to mixing with the liquid phase of the dental cream vehicle or they may be mixed separately with the liquid phase, by hot working (typically about 60 ° C) or cold working (typically about 25 ° C).

Xanthan gum is a fermentation product produced by the action of the bacterium of the genus Xantomonas on carbohydrates. Four types of Xantomonas, i.e. X campetris, X phaseoli, X malvo- cearum and X carotae are stated in the literature to be the most effective rubber producers. Although the exact chemical structure has not been determined, it is generally accepted that it is a heteropolysaccharide with a molecular weight of several million. It contains D-glucose, D-mannose and D-glycuronic acid in the molar ratio 2.8: 3: 2.0. The molecule contains 4.7% acetyl and approx. 3% pyruvate. The proposed chemical structure configuration can be found in McNeely and Kang, Industrial Gums, ed. R.L. Whistler, 10 15 20 25 30 461 012 11 CH XXI, Second Edition, New York, 1973. The procedure for growing, isolating and purifying xanthan gum is also found in said publication. Further description of xanthan gum can be found in Manufacturing Chemist, May 1960, pages 206-208 (including the mention on page 208 of potential use of rubber for the composition of toothpastes).

The I-carrageenan and xanthan can be mechanically mixed before mixing with the liquid phase in the dental cream vehicle or it can be mixed separately with the liquid phase, with cold working technique (typically about 25 ° C).

The toothpaste is packaged in a container from which it can be easily extruded, such as a pressure-actuated or mechanically actuated dental cream dispenser. The rheological properties are highly desirable when a mechanically actuated discharge container of the type described in British patent application 2 on sssn, published September 9, 1981, is utilized.

This dispensing container comprises a dispensing nozzle, a clamping part, a central rod, a piston and operating handle.

The description in this published application shall be included as part of this.

Pressurized dispensing containers can be of the aerosol or vacuum type. Suitable pressure dispensers include those containing a collapsible product-containing bag disposed within a rigid container containing a propellant fluid. In such dispensing containers, actuation of the valve allows only the release of the product, the propellant fluid being separated from the product by the fluid-permeable bag. Dispensers of this type are described in U.S. Patents 3,828,977 and 3,838,976. These are the so-called Sepro- dispensers. The s.k. The Exxel containers also use pressure. Yet another type of dispenser is the barrier piston container described in U.S. Patent 4,171,757. Such containers comprise a valve, a product-containing chamber and a substantially fluid-tight sealing piston, which separates the driving fluid from the contained product (the so-called Diamond container).

The toothpaste contains as active agents a mixture of sodium fluoride and sodium monofluorophosphate which gives approx. 300-10000 ppm fluorine, for example approx. 750-2000 ppm, and especially approx. 1400-2000 ppm, such as approx. 1400-1670 ppm. A binary fluoride system containing sodium monofluorophosphate and sodium fluoride is preferably used, with approx. 30-40% of the fluorine (eg about 30-35%) is provided by the sodium fluoride.

Sodium monofluorophosphate, Na2PO3F, in commercially available form can vary considerably in purity. It can be used in any suitable degree of purity provided that any contaminants do not significantly adversely affect the desired properties. In general, the purity is preferably at least 80%. For best results, it should be at least 85% and preferably at least 90% by weight of the sodium monofluorophosphate, the remainder being primary impurities or by-products of the preparation, such as sodium fluoride and water-soluble sodium phosphate salt. In other words, the sodium monofluorophosphate used should have a total fluoride content exceeding 12%, preferably above 1.2.7%, a content of not more than 1,5%, preferably not more than 1,2% free sodium fluoride; preferably at least 12.1%, all counted as fluoride.

As indicated above, sodium fluoride in the binary mixture is a separate fluorine-containing component relative to sodium monofluorophosphate. Approx. 225-800 ppm fluorine is preferably provided to the sodium fluoride dental cream. 10 15 20 25 30 461 012 13 Additional active agent is provided to the toothpaste by the presence of approx. 0.05-0.5 wt-3, preferably approx. 0.08-2.2% alumina desensitizer. This agent counteracts the sensitivity of damaged periodontal tissue and promotes its healing. Allantoin is available from ABM Industrial Products Ltd of Woodley, Stockport, Cheshire, England.

Pyridylcarbinol as active agent in an amount of approx. 0.05-0.5% by weight, preferably approx. 0.08-0.2%, gives the toothpaste a vasodilating effect ..

When a toothpaste containing <1 H-alumina trihydrate as a polishing agent, the binary fluoride system, allantoin as a desensitizing agent and pyridylcarbinol as a vasodilator, as described above, is used, the filling and extrusion can be made effective using the mechanism of pressure or pressure. as well as giving desired rheological properties with the gel system according to the invention.

Filling is accomplished with conventional techniques. For example, when a mechanically actuated dispenser of the type described in published British patent application 2,070,695A is extruded, a predetermined amount of the toothpaste is extruded through a nozzle for filling the dispenser, which is open at its bottom and which contains a central bar. A piston with a diameter corresponding to the inner diameter of the dispenser and a central hole for inserting the central rod therein is pushed into place. The dispenser is then sealed with a base plate.

Any suitable surfactant or detergent material may be included in the toothpaste compositions. Such compatible materials are desirable to impart additional detersive, foaming and antibacterial properties, depending on the specific type of surfactant, and are selected accordingly. These detergents are usually water-soluble compounds, and may be anionic, nonionic or cationic in structure. The use of water-soluble non-soaps or synthetic organic detergents is generally preferred. Suitable detersive materials are known and include, for example, water-soluble salts of higher fatty acid monoglyceride monosulfate detergent (eg sodium coconut fatty acid monoglyceride monosulfate), higher alkyl sulphate (eg sodium lauryl sulphate), alkylaryl sulphonate. eg sodium dodecylbenzene sulfonate, higher fatty acid esters of 1,2-dihydroxypropanesulfonate) and the like.

Additional surfactants include the substantially saturated higher aliphatic acylamides of lower aliphatic aminocarboxylic acid compounds, such as those having 12-16 carbon atoms in the acyl radical. The amino acid content is usually derived from the lower aliphatic saturated monoaminocarboxylic acids with approx. 2-6 carbon atoms, usually the monocarboxylic acid compounds. Suitable compounds are the fatty acid amides of glycerin, sarcosine, alanine, 3-aminopropanoic acid and valine with approx. 12-16 carbon atoms in the acyl group. Preferably, the N-lauroyl, myristoyl and palmitoyl sarcoside compounds were used for optimal effects.

The amide compounds can be used in the form of the free acid or preferably as water-soluble salts thereof, such as the alkali metal, ammonium, amine and acylolamine salts. Specific examples of this are the sodium and potassium N-lauroyl, myristoyl and palmitoyl sarcosides, ammonium and ethanolamine N-lauroyl glycide and alanine. For simplicity, reference to "aminocarboxylic acid compound", "sarcoside", and the like, means those compounds which have a free carboxylic acid group in the water-soluble carboxylate salts. Such materials are used in pure or substantially pure form. pure form.

They should be as free as practicable from soap or similar higher fatty acid materials, which tend to reduce the activity of these compounds. In normal use, the amount of such higher fatty acid materials is less than 15% by weight of the amide and insufficient to substantially adversely affect it, and preferably less than about 10% of said amide material.

Various other materials may be incorporated into the toothpaste of the present invention. Examples are colorants or whitening agents, preservatives such as methyl p-hydroxybenzoate, stabilizers, tetrasodium pyrophosphate, silicones, chlorophyll compounds and ammonia-treated materials such as urea, diammonium phosphate and mixtures thereof. These aids are incorporated into the compositions in question in an amount which does not substantially adversely affect the desired properties and are selected and used appropriately in normal amounts.

For certain purposes, it may be desirable to include antibacterial agents in the compositions of the present invention. Typical antibacterial agents, which can be used in amounts of approx. 0.01 to approx. 5% by weight, preferably approx. 0.05 to approx. 1.0 wt-8 of the toothpaste composition comprises: N1-4 (chlorobenzyl-N5- (2,4-dichlorobenzyl) biguanide; p-chlorophenyl biguanide; 4-chlorobenzhydryl biguanide; 4-chlorobenzhydrylguanylurea; N-3-lauroxypropyl-N5-p-chlorobenzyl 1,6-di-p-chlorobenzyl biguanide; 1- (lauryl dimethylammonium) -8- (p-chlorobenzyldimethylammonium) octane dichloride: 5,6-dichloro-2-guanidinobenzimidazole; N1-p-chlorophenyl-N5-lauryl biguanide 5-amino-1,3-bis (2-ethylhexyl) -5-methylhexahydropyrimidine; 46 and 461 461 012 16 and their non-toxic acid addition salts.

Any suitable flavoring or sweetening agent may be used to provide a flavoring for the compositions of the present invention. Examples of suitable flavoring ingredients include aromatic oils, e.g. oils of spearmint, peppermint, evergreens, sassafras, cloves, sage, eucalyptus, marjoram, cinnamon, lemon and orange as well as methyl salicylate. Suitable sweeteners include sucrose, lactose, maltose, sorbitol, sodium cyclamate, sodium saccharin dipeptides according to U.S. Pat. No. 3,939,261 and oxathiazine salts of U.S. Pat. 3,932,606.

Suitable flavoring and sweetening agents can together constitute from approx. 0.01 to 5% or more of the composition.

The toothpastes should have a pH suitable for use. A pH range of 3 to 10.5 is particularly desirable. By a pH is meant here a pH determination directly on the toothpaste. If desired, materials of the benzoic acid or citric acid type can be added to adjust the pH to, say, 4 to 8.5.

The following examples further illustrate the present invention, but it is to be understood that the invention is not limited thereto. All quantities of the various ingredients are by weight unless otherwise indicated. Example 1 The following toothpaste is prepared by a conventional cold process at room temperature and is filled into a mechanically actuated dispenser described in British Patent Application 2,070,695A.

Parts Sorbitol (70%) 23,000 Sodium Saccharin 0.170 I-Carrageenan (Genuvisco 0819) 0.500 Sodium Carboxymethylcellulose (7MFD) 0.500 Methyl p-hydroxybenzoate 0.080 Allantoin 0.150 Sodium Fluoride 0.100 Sodium Monofluorophosphate 1,000 B Titanium dioxide 0.500 Flavor 1,200 Deionized water 20,133 The toothpaste can be effectively filled in the dispenser and no leakage occurs during storage at 43 ° C for more than 1 month. It can be extruded well from the dispenser after 1 month of storage at 43 ° C.

Similar satisfactory results were obtained when the toothpaste was modified to contain 0.55 parts of each i-carrageenan and sodium carboxymethylcellulose in one case and 0.45 parts of each of i-carrageenan and sodium carboxymethylcellulose in another case, with corresponding adjustment of the water content. In fact, no leakage occurred and the toothpastes showed extrusionability after storage at 43 ° C for 3 months. Again, satisfactory results were obtained when each of the three toothpastes described above was modified to contain 50,000 parts of OC-alumina trihydrate in a series of said toothpastes and 52,000 parts of CX3-alumina trihydrate in a second set of said three toothpastes, with corresponding adjustments of water - len.

Example 2 The following toothpaste was prepared by a cold process and filled into the same dispenser as in Example 1. 92111: Sorbitol (70%) 23,000 Sodium saccharin 0.170 I-carrageenan (Genuvisco 0819) 0.666 Sodium carboxymethylcellulose (7MFD) 0.334 Methyl p-hydroxybenzoate Sodium fluoride 0,100 Sodium monofluorophosphate 0,760 Pyridylcarbinol 0,100 CN: -Alumium oxide trihydrate (Alcoa C-333) 51,500 Benzoic acid 0,140 Sodium lauryl sulphate 1,667 Titanium dioxide 0,500 Flavor 1,200 Deionised water is effective in dispensing water 43 ° C. if fl- s i 10 15 20 25 30 461 012 19 The same desired effects were achieved when the toothpastes according to the examples were filled in a pressure dispenser.

When sodium carboxymethylcellulose is used as the sole gelling agent, poor extrusion occurs. When hydroxyethylcellulose is used as the sole gelling agent, leakage occurs. However, when hydroxyethylcellulose is mixed with the i-carrageenan, the desired filling and extrusion properties are achieved.

Example 3 The following toothpaste was prepared by a conventional cold process at room temperature and filled into a mechanically actuated dispenser according to British Patent Publication 2,070,695A.

D_el _ = _ § Sorbitol (70%) 23,000 Sodium saccharin 0,170 I-carrageenan (Genuvisco 0819) 0,500 Xanthan (Keltrol) 0,500 Methyl p-hydroxybenzoate 0,080 Allantoin 0,150 Sodium fluoride 0,100 Sodium monofluorophosphate 0,760 Pyridylcarbinol 51100 PyridylCarbinol ooo Benzoic acid 0.140 Sodium lauryl sulphate 1,667 Titanium dioxide 0,500 Flavor 1,200 Deionized water 20,133 The toothpaste effectively fills the dispenser and no leakage occurs when stored at 43 ° C for more than 1 month. It can be extruded well from the dispenser after 1 month. Ring at 43 DEG C. 10 15 20 25 30 461 012 20 Similar satisfactory results were obtained when the toothpaste was modified to contain 0.55 parts of each of the i-carrageenan and xanthan in one case and 0.45 parts of each. i-carrageenan and xanthan in another case, with corresponding adjustment of the water contents. In fact, no leakage occurred and the extrusionability was good after storage at 43 ° C for 3 months at the toothpaste containing 0.45 parts of xanthan and i-carrageenan each. Again, satisfactory results could be obtained when each of the three toothpastes described above was modified to contain 50,000 parts (Nf alumina trihydrate in a set of said toothpastes and 52,000 parts of Uf alumina trihydrate in a second set of said three toothpastes , with a corresponding adjustment of the water content.

Phosphoric acid can be used instead of benzoic acid with similar results.

Example 4 The following toothpaste was prepared by cold process and filled into the same dispenser as in Example 3. 22225 Sorbitol (70%) 23,000 Sodium saccharin 0.170 I-carrageenan (Genuvisco 0819) 0.750 Xanthan (Keltrol) 0.250 Methyl p-hydroxybenzoate 0.080 Allantoin 0.150 Sodium fluoride Sodium monofluorophosphate 0,760 Pyridylcarbinol 0,100 OG -aiuminium oxiatrinyarate (Alma c-sss) s1, øoo Benzoic acid 0,140 Sodium lauryl sulphate 1,667 10 15 461 012 21 Titanium dioxide 0,500 Flavor 1,200 Deionized water from the toothpaste and the extraction of the toothpaste months at 43 ° C.

Similar desirable results were obtained with 50,000 parts of CK, alumina trihydrate. Each variant also gives similar results with gel systems containing (a) 0.825 parts of i-carrageenan and 0.275 parts of xanthan and (b) 0.675 parts of i-carrageenan and 0.225 parts of xanthan.

Similar desired effects were achieved when the toothpastes according to the examples were filled in a pressure dispenser.

It will be apparent to those skilled in the art that further modifications of the examples illustrating the invention may be made.

Claims (7)

10 15 20 25 30 461 012 22 1. A dispenser, characterized in that it comprises 20 to 80% by weight of an aqueous humectant vehicle, 0.1 to 5% by weight of gelling agent mixture, - 75% by weight of ° C alumina trihydrate as polishing agent, sodium fluoride and sodium monofluorophosphate in an amount giving 300 to 10,000 ppm fluorine, 0.05 - 0.5% by weight allantoin as desensitizing agent and 0.05 - 0 , 5% by weight of pyridylcarbinol as vasodilator, wherein said gelling agent mixture is a mixture of either a cellulosic gelling agent or xanthan with i-carrageenan in a weight ratio of cellulose gelling agent or xanthan to i-carrageenan of 5: 1 - 1: 5. Toothpaste according to claim 1, characterized in that the weight ratio of said cellulose gelling agent or said xanthan to said in-carrageenan is 3: 1 - 1: 3 and that the gelling agent mixture is present in an amount of 0.2 - 3% by weight. Toothpaste according to claim 2, characterized in that said cellulose gelling agent is present and that it is sodium carboxymethylcellulose. Toothpaste according to claim 2, characterized in that said xanthan is present. Toothpaste according to claim 2, characterized in that the weight ratio of said cellulose gelling agent or said xanthan to said i-carrageenan is about 1: 1. Toothpaste according to claim 1, characterized in that said sodium fluoride and said sodium monofluorophosphate are present in an amount to give 750 - 2,000 ppm 461 012 23 fluorine and that 30 - 40% of the fluorine is provided by said sodium fluoride. ' Toothpaste according to claim 1, characterized in that the toothpaste is contained in a mechanically actuated dispenser.