FI77982B - TANDPUTSMEDEL. - Google Patents

Description

1 77982

This invention relates to a dentifrice composition. In particular, it relates to a dentifrice composition having the desired Theological properties suitable for mechanically or pressurized filling and pressing of a dentifrice dispenser.

A dentifrice is generally known for its ointment or gel-like consistency and may be commonly referred to as a toothpaste, toothpaste or, in some cases, a clear gel-like or opalescent gel-like toothpaste. It can actually be described as semi-solid, for example being substantially solid when it is on the toothbrush bristles and substantially liquid as during manufacture during mixing and filling into the container or when pressure is applied to it to squeeze the dentifrice from the container.

A gelling or binding agent typically imparts a creamy machine latency to dentifrices. In the past, gelling agents have been selected primarily to impart easy oral dispersibility to the dentifrice. Many gelling agents such as cellulose-based agents, seaweed derivatives, vegetable gums and clays meet this requirement. However, some gelling agents, while desirable in dentifrices packaged in flexible tubes, cause inconvenience when dentifrices are packaged in mechanically or pressurized dispensers.

Dentifrices containing conventional polishing agents such as alpha-aluminum trihydroxide and conventional gelling agents such as sodium carboxymethyl-2,77982 cellulose or hydroxyethylcellulose or mixtures thereof may be desirably filled into flexible tubes or mechanically or mechanically filled. However, when the dentifrice contains several active ingredients, difficulties can occur when attempting to fill the dentifrice into a mechanically or pressure dispenser and / or when attempting to squeeze it therefrom. In particular, leaks from the dispenser nozzles may occur during filling or transport and the product may be difficult to compress in a theologically desired strip-like shape,

Dentifrices that are thick or tend to thicken can become increasingly difficult for the consumer to squeeze from the toothpaste tubes over time. In other words, the consumer may need to increase the compressive force applied to the toothpaste tube containing such a toothpaste during the period of use to soften or liquefy the semi-solid toothpaste to squeeze it out. This has not been a major problem in the past, as formulations can be adjusted using less gelling agent to find a balance where the product is not too soft at the beginning and too thick at the end, and in any case consumers were accustomed to using the amount of compression needed for the desired amount of dentifrice. for squeezing the toothbrush bristles.

Dental cleaners that are soft when squeezed from a tube can also be tolerated if they change to a firmer shape on toothbrush bristles within seconds. Thus, the type of gelling agent can be varied greatly for tube-cleaned dentifrices. Really, Copenhagen Pectin Factory Ltd. of Little Skensved, Denmark, a subsidiary of Hercules Inc. in Wilmington, Delaware, USA, has proposed Genuvisco Type 0819, iota-3,77982 carrageenan (i-carrageenan), as a possible thickener for toothpaste, i-carrageenan available from PMC Corp. , From the Merine Colloids Division, Springfield, New Jersey, as Vis-Car TP-5, has also been proposed for a toothpaste containing dicalcium phosphate or silicic acid. Further, i-carrageenan has been disclosed as a disintegrant component together with k-carrageenan and alkali metal alginate in dentifrices containing galactan-galactose in JP Patent 56,115,711.

When using a dentifrice dispenser that operates mechanically or under pressure, conventional techniques to reduce toothpaste thickening may not be entirely satisfactory, because when compared to a dentifrice filled with a flexible tube, and remains so for the period required for transportation, storage and use. In other words, after filling, the dentifrice substantially regains the latency of the machine which it had prior to the riveting effect during filling during mixing for transport, storage and use. Conventional gel disintegrants, such as sodium carboxymethylcellulose, hydroxyethylcellulose, or mixtures thereof, may desirably be used in dentifrices containing an alpha-aluminum trihydroxide polish support that must be filled into the dispenser. However, when such a dentifrice contains active ingredients from many sources, such as fluorine from two sources, a sensitizer such as allantoin (C7HgN403) and a vasodilator such as pyridylcarbinol,

t ^ ~~ ^ CH2 - OH

4,77982 difficulties occur when filling a toothpaste mechanically or with a pressure dispenser. In particular, the dentifrice may leak through the gap between the shaft and the piston, which are especially used in mechanically operated dispensers, and leakage occurs in the nozzles of the dispenser. Furthermore, the dentifrice strip that is compressed from a mechanically or pressure operated dispenser may be irregular or non-continuous. Since it is particularly desirable to prepare a dentifrice containing an alpha-aluminum trihydroxide polish containing several active ingredients, such as those mentioned above, due to the compatibility of such substances with the polish, an alternative gelling system was needed.

Surprisingly, among the alternative types of gelling agents, the mixture of a cellulose-based gelling agent and the i-carrageenan gives a very good alpha-aluminum trihydroxide and multi-active dentifrice which can be filled and pressed mechanically or by pressure. It should be noted that xanthan is incompatible with a cellulose-based gelling agent because it may contain cellulase.

It is an advantage of the present invention to provide a dentifrice that is easily filled and compressed with a mechanically or pressurized dose of dentifrice 1 i divided.

Other advantages will be apparent from the following specifications.

In certain aspects, the present invention relates to a dentifrice suitable for dispensing with a mechanically or pressurized dispenser containing 20 -0% w / w wetting agent, about 0.1-5 wt-X gelling agent mixture, about 20-75 wt-X alpha-aluminum - S 77982 trihydroxide polish, sodium fluoride and sodium monofluorophosphate in an amount to give about 300-10,000 ppm fluorine, about 0.05-0.5 wt-X allantoin desensitizer and about 0.05-0.5 wt. -X pyridylcarbinol vasodilator, wherein said mixture of gelling agents is a mixture of a cellulose-based gelling agent or xanthan and i-carrageenan in a weight ratio of either cellulose-based gelling agent or xanthan to about 5: 1 to about 5: 1.

In a dentifrice formulation, the medium contains a liquid phase relative to the gelling agent to form a compressible cream mass having the desired consistency. The liquid phase in the dentifrice may contain mainly water and a wetting agent such as polyols including glycerol, sorbitol, maltitol, xylitol, low molecular weight polyethylene glycol (e.g. 400 or 600), propylene glycol or the like including suitable mixtures thereof. It is generally preferred to use water and a wetting agent, such as glycerol, sorbitol or polyethylene glycol, as the liquid phase, typically in amounts of 10 to 50 wt.% Of water and about 20 to 50 wt.% Of wetting agent.

The dentifrice contains an alpha-aluminum trihydroxide polish in amounts of about 20-75% by weight. Alpha-aluminum trihydroxide is typically prepared by the Bayer process and used as particles having a size of less than about 40 microns, mainly about 3-20 microns. Other polishes may be present, such as insoluble metaphosphate, dicalcium phosphate, calcined alumina, silicic acid, or calcium carbonate in small amounts compared to alpha-aluminum trihydroxide.

The gelling agent mixture of this invention is present in the dentifrice in an amount of about 0.1 to 5% by weight. It contains either a cellulose-based gelling agent or xanthan 6,77982 mixed with i-carrageenan, wherein the weight ratio of said cellulosic base gelling agent or xanthan to said i-carrageenan is from about 5: 1 to about 1: 5, preferably from about 1: 1 to about 1: 3, and the amount of total gelling agent is preferably about 0.2 to 3% by weight.

As mentioned above, i-carrageenan is commercially available as Genuvieco Type 0819 and Viscar TP-5 and is not recommended for use in toothpaste. Such use in toothpaste is described in JP Patent 56,115,711, in which i-carrageenan is mentioned as a possible component in a gel-forming system together with k-carrageenan and alkali metal alginate. In U.S. Patent 4,353,890, i-carrageenan is disclosed as an alternative to k-carrageenan as a toothpaste gel former, in which the toothpaste is subjected to microwave irradiation to reduce the tendency of the carrageenan to generally thin during manufacture. Carrageenan may be the sole gelling agent or may be mixed with other gelling agents. In the present invention, a dentifrice containing i-carrageenan, which must be filled into a mechanically or pressure-operated dispenser, does not require microwave irradiation.

The prior art generally discussed above does not disclose that a gelling system consisting of a cellulose-based gelling agent, and i-carrageenan, can provide dentifrices containing an alpha-aluminum trihydroxide polishing agent and many active ingredients having the necessary properties. from squeezing.

It should be noted that U5 patent 4,029,760 discloses an oral cleanser in which i-carrageenan is disclosed as an alternative to other carrageenans as an anti-gingivitis agent. The carrageen genes are highly depolymerized derivatives of carrageenans. Carrageenans do not appear to have an anti-gingivitis effect.

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Dentifrices are generally prepared by a cold process, e.g. about 25 ° C or a hot process, i. about o 60 C. i-carrageenan can be used in both cold and hot process technology. Because xanthan is made by a cold process when used, it can be easily mixed with i-carrageenan and used in conjunction with cold process dentifrices. i-carrageenan can only be used in heat processing.

The physical properties of Genuvisco Type 0819 i-carrageenan are shown below: 1 Viscosity of 0.3 X solution of GENUVISCO Type 0819 in pure solvent prepared using hot process o <60 ° C:

Viscosity * 110 + 17 cP 32 rpm: 11a

Viscosity »70 + 11 cP 64 rpm

Viscosity = 45 + 7 cP 128 rpm: min

Measured with HAAKE Rotovieco RV3 at 25 ° C.

2 GENUVISCO Type 0819 0.30 X viscosity of X solution in pure solvent prepared using a cold process o <25 C>:

Viscosity - 450 ± 60 cP measured with a Brookfield Viscometer o LVT at 25 ° C

Viscosity = 85 +, 13 cP 32 rpm 11a

Viscosity = 55 + 8 cP 64 rpm: 11a

Viscosity = 37 ± 6 cP 128 rpm: 11a o

Measured with HAAKE Rotovieco RV3 at 25 ° C.

3 Particle size: Less than 1 X vegetable rubber with 0.075 mm test sieve <DIN 80, 200 US mesh).

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4 Humidity: Less than 12 X

PH 5: 8.5 +. 1.5 0.5 in X solution in distilled water at 25 ° C.

6 Color: From white to cream.

Viscar TP-5 i-carrageenan has the following physical properties: Color: light skin brown to skin brown

Particle size: more than 95.0% through US Standard Sieve, 250 nm (series no. 60).

Humidity: maximum 12.0% (Cenco Moisture Balance) o pH: 7.0 - 9.5, 1.5 X solution, 30 C.

Typical desired cellulose-based gelling agents include alkali metal carboxymethylcellulose, methylcellulose, hydroxymethylcellulose and hydroxypropylcellulose. Sodium carboxymethylcellulose is preferred. The mixture gel system is present in an amount of 0.1-5% by weight X of the amount of dentifrice, and the weight ratio of the cellulose-based gelling agent to i-carrageenan is from about 5: 1 to about 1: 5, preferably from about 1: 1 to about 1: 3 and most preferably 1: 1 . Thus, a typical, preferred dentifrice may contain about 0.9 to 1.2 X of total gelling agent, including about 0.3 to 0.9 X of each cellulose-based gelling agent and i-carrageenan, in a weight ratio of between about 1: 1 and 1: 3.

It should be noted that the grades of sodium carboxymethylcellulose that may be used include the following: 9 77982

table 1

Supplier CMC plate Viekoaity

Hercules 7MXF 300-500

Hercules 7MFD 300-500

Hercules 9M31F 900-1200

Hercules 9M31XF 900-1200

Hercules 12M31XF 900-1200

Hercules 7MF 300-500

Hercules 12M31PD 900-1200

Hercules 7M8SXF 200-800

Wolff Walsrode Walocel CRT 1000 PA 07 700-1200 *

Nyma Nymcel ZMF.33 50-80 *

Enka Akucell AC 1642 80-120 *

Enka Akucell AC 1632 60-120

Croe Cellogen HP-SA 700-900

Uddeholm Cekol MVEP 500-800

Hoechst Tylose CB 200 120-260 * o 1 X-solution (Brookfield; 25 C) ** o

Hoeppler Viscometer (2 X; 20 C).

Further, the grades of hydroxyethylcellulose that may be used include:

Table 2

Seedling .ia HBC grade Viscosity

Hercules Natrosol 250M and MR 4500-6500

Hercules Natrosol ^ 250 HR 1500-2500

and 250 H

*

Hercules Natrosol 250 HHR 3400-5000

and 250 HH

BP Chemicals Cellobond 5000 A 4200-5600 BP Chemicals Cellobond 7000 A 6000-7000

Hoechst Tylose H 4000 P ^ 3000-5000

Hoechst Tylose H 10000 P 7000-12000 1 ° 77982 * o 1% solution (Brookfield; 25 ° C).

** o

Hoeppler Viscometer (2%; 25 ° C).

The i-carrageenan and the saline-based gel former may be mechanically mixed together prior to mixing with the liquid phase of the dentifrice medium, or may be mixed separately with the liquid phase, hot processing (typically about 60 ° C), or cold processing (typically about 25 ° C).

Xanthan gum is a fermentation product made from carbohydrates by the action of Xant-homonas bacterium. Four species of Xanthomonas, namely X. campetris, X. phaseoli, X. malvocearum and X. carotae, have been reported in the literature to be the most efficient vegetable rubber producers. Although the exact chemical structure has not been determined, it is generally accepted to be a heteropolysaccharide with a molecular weight of several million. It contains D-glucose, D-mannose and D-glucuronic acid in a molar ratio of 2.0: 3: 2.0. The molecule contains 4.7% acetyls and about 3 * pyruvate. The proposed chemical structural configuration can be found in McNeely and Kang, Industrial Gums, ed. RL Whistler, CH XXI, 2nd Edition, New York 1973. A method for growing, isolating and purifying xanthan gum can also be found in this publication. A further description of xanthan gum can be found in Manufacturing Chemist, May 1960, pages 206-20Θ (including a reference on page 208 to the potential use of vegetable gum where it is described in the formulation of toothpastes).

i-carrageenan and xanthan may be mechanically mixed together prior to mixing with the liquid phase of the toothpaste medium or may be mixed separately with the liquid phase o by a cold processing technique (typically about 25 ° C).

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The dentifrice is packaged in a susceptibility container, Joeta ee can be easily extruded, such as in a pressure or mechanically operated toothpaste dispenser. Rheological properties are highly desirable when using a mechanically operated dispensing container of the type described in GB Patent Application 2,070,695A. This dispensing container comprises a dispensing nozzle, a drive part, a central shaft, a piston and an operating hand lever. The information in this application is incorporated herein by reference.

The pressurized dispensing container may be of the aerosol or vacuum type. Suitable pressure dispensers include those containing a collapsible product bag housed in a rigid container containing propellant fluid. In such a dosing tank, the operation of the valve only allows the product to exit, the propellant being separated from the product by means of a liquid-impermeable bag. Dispensing devices of this type are described in U.S. Patents 3,828,977 and 3,838,976. Sepro-metered-by. The so-called Exxel tanks also use pressure.

Another type of dispenser is the closure piston container described in U.S. Patent 4,171,757. Such a container comprises a valve, a product-containing compartment, and a substantially liquid-tight closure piston separating the propelled container from the product (so-called Diamond container).

The dentifrice contains as active ingredient a mixture of sodium fluoride and sodium monofluorophosphate to give about 300-10,000 ppm of fluorine, i. about 750-2000 ppm, and in particular about 1400-2000 ppm such as about 1400-1670 ppm, such a binary fluoride system of sodium monofluorophosphate and sodium fluoride is preferably used in which about 30-40% of the fluoride <i.e. about 30-35 X) is provided by sodium fluoride.

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Sodium monofluorophosphate, Na 2 PO 3 F, is commercially available and can vary considerably in purity. It can be used in any suitable purity, provided that no impurity has a substantially detrimental effect on the desired properties. Usually cleanliness is desired! at least Θ0 X. For best results, it should be at least 85 X, and preferably at least 90 wt.% sodium monofluorophosphate, with the remainder being mainly impurities or by-products from the preparation, such as sodium fluoride and water-soluble sodium phosphate salt. In other words, the sodium monofluorophosphate used must have a total fluoride content of more than 12 X, preferably more than 12.7 X, not more than 1.5 X, preferably not more than 1.2 X of free sodium fluoride; at least 12 X, preferably at least 12.1 X all fluoride calculated.

As indicated above, sodium fluoride in the binary mixture has a fluorine-containing component separate from the monofluorophosphate. Sodium fluoride is preferably obtained in about 225-800 ppm fluorine for toothpaste.

The new active ingredient in the dentifrice is obtained by the addition of about 0.05 to 0.5% by weight, preferably about 0.08 to 0.2%, of the allantoin desensitizer. Such a substance removes the sensitivity of wounded gingival tissue and promotes its healing. Allantoin can be obtained from ABM Industrial Products Ltd., Woodley, Stockport, Cheshire, England.

The active ingredient pyridylcarbinol in an amount of about 0.05 to 0.5% by weight, preferably about 0.08 to 0.2%, gives the dentifrice a vasodilating effect.

When using a dentifrice containing an alpha-aluminum trihydroxide polish, a binary fluoride system, an α1-lantoin desensitizer and a pyridylcarbinol vasodilator as described in the invention, the .

Filling is performed by conventional techniques. For example, when using a mechanically operated dispenser of the type described in GB Patent Application 2,070,695A, a predetermined amount of dentifrice is pressed through a nozzle to fill a dispenser that is open at the bottom and includes a central shaft. A piston having a diameter corresponding to the inside diameter of the dispenser and having a hole in the center to allow the central shaft to be mounted thereon is immersed in place. The dispenser is then closed with a base plate.

Any suitable surfactant or detergent may be included in the dentifrice compositions. Such compatible agents are desirable to impart additional cleansing, foaming or antibacterial properties depending on the particular type of surfactant and are selected as well. These detergents are generally water-soluble compounds and may be anionic, nonionic or cationic in structure. It is generally preferred to use water-soluble, non-soap-based or synthetic organic detergents. Suitable cleaning agents are known and include, for example, a monosulfate detergent for higher fatty acid monoglycerides (i.e., sodium coconut fatty acid monoglyceride monosulfate), higher alkyl sulfate (i.e., sodium lauryl sulfate) water soluble salts.

Surfactants further comprise amides of higher aliphatic acyls of lower aliphatic aminocarboxylic acid compounds, such as those having 12 to 16 carbons in the acyl radical. The amino acid moiety is generally derived from lower aliphatic saturated monoaminocarboxylic acids having from about 2 to about 6 carbons, generally monocarbocarboxylic acid compounds. Suitable conjugates include the fatty acid amides of glycerol, araquin, alanine, 3-aminopropionic acid and valine having from about 12 to 16 carbons in the allyl group. However, it is preferred to use N-lauroyl, myriatoyl and palmitoyl sarcoidide pathways for optimal efficiencies.

Amide pathways can be used in the form of free acids or, preferably, water-soluble salts thereof, such as alkali ammonium, amine and alkylamine. Specific examples thereof are sodium and potassium N-lauroyl, myristoyl and palmitoyl aroids, ammonium and ethanolamine N-lauroyl glycidide and alanine. For ease of reference herein, reference to "aminocarboxylic acid compound", "sarcoside" and the like relates to compounds having the free carboxyl group of water-soluble carboxylate salts.

Such substances are used in pure or substantially pure form. They should be as free as is practical from soap or a similar higher fatty acid substance which tends to reduce the activity of these compounds. In general practice, the amount of such higher fatty acid material is less than 15% by weight of the amide and insufficient to substantially adversely affect it, and preferably less than about 10X of said amide material.

Various other agents may be included in the dentifrice of this invention. Examples of these are dyes or proteins, preservatives such as methyl p-hydroxybenzoate, stabilizers, tetrasodium pyrophosphate, silicones, chlorophyll compounds and ammonized substances such as urea, diammonium phosphate and mixtures thereof. These additives are incorporated into the immediate compositions in an amount that does not adversely affect the desired properties and characteristics and are suitably selected and used in conventional amounts.

For some purposes, it may be desirable to include an antibacterial agent in the composition of this invention. Typical antibacterial agents that can be used in amounts of about 0.01X to 5X, preferably about 0.05% to about 1.0% by weight X, of the dentifrice mixture include: 1 5 N -4- <chlorobenzyl-N - (2,4- diklorobenteyy1i) -biguanidi; p-chlorophenylbiguanide; 4-klorobentshydryylibiguanidi; 4-chlorobenzehydryl-iiganyl-urea; N-3-lauroxypropyl-N-p-chlorobenzyl biguanide; 1,6-di-p-klorobentsyylibiguanidi; L <lauryylidimetyyliammonium) -8- <p klorobentsyylidimetyyli-ammonium) oktaanidikloridi; 5,6-dichloro-2-guanidinobenzimidazole; N-p-chlorophenyl-N-lauryl biguanide; 5-amino-1,3-bis (2-ethylhexyl) -5-methylhexahydropyrimidine; and their non-toxic acid addition salts.

Any flavoring or sweetening agent may be used in the composition of this invention to formulate the flavor. Examples of suitable seasoning compositions include seasoning oils, eo. mint, peppermint, winter, sassafras, cloves, sage, eucalyptus, marjoram, cinnamon, lemon and orange oils as well as methyl salicylate. Suitable sweeteners include sucrose, lactose, maltose, sorbitol, sodium cyclamate, sodium saccharin dipeptides of U.S. Patent 3,939,261, and oxathiazine salts of U.S. Patent 3,932,606. A suitable flavoring and sweetening agent may together comprise about 0.01-5 X or more of the composition.

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The pH of dentifrices must be useful for use. A pH range of 3-10.5 is particularly desirable. The reference to pH is meant to determine its pH directly from the dentifrice. If desired, substances such as benthic or citric acid can be added to adjust the pH to say 4-0.5.

The following examples further illustrate the nature of this invention, but it is to be understood that the invention is not limited thereto. All amounts of the various ingredients are by weight unless otherwise specified.

Example 1

The following dentifrice is prepared by a conventional room temperature-cold method and filled into a mechanically operated dispenser as described in GB Patent Application 2,070,695A.

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Sorbitol (70%> 23,000

Sodium saccharin 0.170 i-carrageenan (Genuvisco 0819) 0.500

Sodium carboxymethylcellulose <7MFD> 0.500

Methyl p-hydroxybenzoate 0.000

Allantoin 0.150

Sodium fluoride 0.100

Sodium monofluorophosphate 0.760

Pyridylcarbinol 0.100

Alpha-aluminum trihydroxide (Alcoa C-333) 51,000

Benzoic acid 0.140

Sodium lauryl eluate 1.667

Titanium dioxide 0.500

Flavoring 1,200

Ion-exchanged water 20,133 i7 77982

The dentifrice effectively fills the dispenser o and does not leak for more than a month during storage at 43 ° C.

Similar satisfactory results are obtained when the dentifrice is modified to contain 0.55 parts of each i-carrageenan and sodium carboxymethylcellulose in one case and 0.45 parts of each i-carrageenan and sodium carboxymethylcellulose in another case, with corresponding amounts of water. Indeed, no leakage and good compressibility after 3 months of storage at 43 ° C have been observed with these dentifrices.

Satisfactory results have again been observed when each of the three dentifrices described above has been modified to contain 50,000 parts of alpha-aluminum trihydroxide in one set of these dentifrices and 52,000 parts of alpha-aluminum trihydroxide in another set with three amounts of dentifrice in water.

Example 2

The following dentifrice is prepared by the cold method and filled into the same dispenser as in Example 1.

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Sorbitol <70%> 23,000

Sodium accharin 0.170 i-carrageenan (Genuvisco 0819) 0.666

Sodium carboxymethylcellulose (7MFD) 0.334

Methyl p-hydroxybenzoate 0.080

Allantoin 0.150

Sodium fluoride 0.100

Sodium monofluorophosphate 0.760

Pyridylcarbinol 0.100

Alpha-aluminum trihydrocide (Alcoa C-333) 51,500 1β 77982

Bentoic acid 0.140

Sodium lauryl sulphate 1,667

Titanium dioxide 0.500

Flavoring 1,200

Ion-exchanged water 19,633

The dentifrice effectively fills the dispenser and compresses well from the dispenser after 1 month of storage at 43 ° C.

Similar desired effects are obtained when the dentifrice propellant of the examples is filled into a pressurized dispenser.

When sodium carboxymethylcellulose is used as the sole gelling agent, poor leaching occurs. When hydroxyethylcellulose is used as the sole gelling agent, leakage occurs. However, when hydroxyethylcellulose is mixed with i-carrageenan, the desired filling and extensibility are achieved.

Example 3

The following dentifrice is prepared by a conventional room temperature-cold method and filled into a mechanically operable dose dispenser according to GB Patent Application 2,070,695A.

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Sorbitol (70 X) 23,000

Sodium saccharin 0.170 i-carrageenan (Genuvisco 0819) 0.500

Keanthan (Keltrol) 0.500

Methyl p-hydroxybenzoate 0.080

Allantoin 0.150

Sodium fluoride 0.100

Sodium monofluorophosphate 0.760 is 77982

Pyridylcarbinol 0.100

Alpha-aluminum trihydroxide (Alcoa C-333) 51,000

Bentoic acid 0.140

Sodium lauryl sulphate 1,667

Titanium diode 0.500

Flavoring 1,200

Ion-exchanged water 20,133

The dentifrice effectively fills the dispenser βίο and leaks during storage for more than a month at 43 ° C. It squeezes well out of the dispenser after one month of storage at o 43 ° C.

Similar satisfactory results have been obtained when the dentifrice has been modified to contain 0.55 parts of each i-carrageenan and xanthan in the first case and 0.45 parts of each i-carrageenan and xanthan in the second case, with corresponding adjustments to the amounts of water. Indeed, no leakage and good extrusion rate have been observed after 3 months of storage at 43 ° C with dentifrices containing 0.45 parts of both xanthan and i-carrageenan.

Satisfactory results have again been observed when each of the three dentifrices described above has been modified to contain 50,000 parts of alpha-aluminum trihydroxide in one set of these dentifrices and 52,000 parts of alpha-aluminum trihydroxide in another set of three amounts of dentifrices with corresponding amounts of water.

Phosphoric acid can be used in place of benzoic acid with the same results.

Example 4

The following dentifrice was prepared by the cold method and filled into the same dispenser as in Example 3.

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Sorbitol <70 X) 23,000

Sodium saccharin 0.170 i-carrageenan (Genuvieco 0Θ19) 0.750

Xanthan (Keltrol) 0.250

Methyl p-hydroxybenzoate 0.080

Allantoin 0.150

Sodium fluoride 0.100

Sodium monofluorophenate 0.760

Pyridylcarbinol 0.100 AIf α-aluminum initr ihydroke idi (Alcoa C-333) 51,000

Benzoic acid 0.140

Sodium lauryl sulphate 1,667

Titanium dioxide 0.500

Flavoring 1,200

Ion-exchanged water 20,133

The dentifrice effectively fills the dispenser and does not leak and squeezes well out of the dispenser after 3 months of storage at 43 ° C.

Similar desired results have been obtained with 50,000 parts of alpha-aluminum trihydroxide. All variations also give similar results with the gelling system (a) 0.825 parts i-carrageenan and 0.275 parts xanthan and <b) 0.675 parts i-carrageenan and 0.225 parts xanthan. Similar desired effects have been obtained when the dentifrices of the examples are filled into a pressurized dispenser.

It will be apparent to those skilled in the art that further modification of the examples illustrating the invention may be made in addition to these.

Claims (7)

1. Toothpaste, suitable for dosing with a mechanical or pressure-operated dispenser, comprising approx. 20-80% by weight of an aqueous humectant vehicle, approx. 0.1-5% by weight of gelling agent mixture, approx. 20-75% by weight of alpha-aluminum tri-hydroxide as a polishing agent, sodium fluoride and sodium monofluorophosphate in an amount which gives approx. 300 to 10,000 ppm fluorine, approx. 0.05-0.5% by weight of allantoin as a desensitizer and approx. 0.05-0.5% by weight of pyridylcarbinol as a vasodilator, characterized in that said gelling agent mixture is a mixture either of a cellulose gelling agent or xanthan with i-carrageenan in a weight ratio of cellulose gelling agent or xanthan to i-carrageenan of approx. 5: 1 to approx. 1: 5. A toothpaste agent according to claim 1, characterized in that the weight ratio of said cellulose gelling agent or said xanthan to i-carrageenan is approx. 3: 1 to approx. 1: 3 and that the gelling agent mixture is present in an amount of ca. 0.2-3% by weight. 3. A dental pad according to claim 2, characterized in that said cellulose gelling agent is present and that it is sodium salt of carboxymethyl cellulose. A dental pad according to claim 2, characterized in that said xanthan is present.