JPH0463849B2 - - Google Patents

Description

[Detailed description of the invention]

TECHNICAL FIELD This invention relates to dentifrice compositions. In particular, the present invention relates to dentifrice compositions having desirable rheological properties suitable for effective filling into and extrusion from mechanically actuated or differential pressure dentifrice dispensers. Dentifrices are generally recognized by their creamy or gel-like consistency and are commonly referred to as dental creams, toothpastes, and in some cases may be referred to as clear gel or opacified gel toothpastes. . In fact, it is characterized as a semi-solid, e.g.
It is essentially solid when placed on the bristles of a toothbrush and essentially liquid during agitation manufacturing and filling the container or when pressure is applied to force the dentifrice out of the container. The creamy consistency of dentifrices is imparted by gelling or binding agents. In the past, gelling agents have been selected primarily to provide ease of dispersion of dentifrices within the oral cavity. Many gelling agents satisfy this criterion, such as cellulosic materials, seaweed derivatives, gums and clays. However, some gelling agents are generally desirable for dentifrices that are housed in flexible tubes, but not for dentifrices that are housed in mechanically operated dispensers or differential pressure dispensers. Sometimes it causes shortcomings. A dentifrice containing a conventional abrasive such as alpha alumina trihydrate and sodium carboxymethyl cellulose or hydroxyethyl cellulose or mixtures thereof is preferably placed in a flexible tube or mechanically actuated or differential pressure dispenser. They can be filled and extruded from them. However, when the dentifrice contains many active ingredients, difficulties arise when attempting to fill the dentifrice into a mechanically actuated or differential pressure dispenser and/or when attempting to push it out of it. In particular, leakage from orifices in dispensers occurs during filling or shipping, and the product is difficult to extrude in rheologically desirable ribbon formats. Dentifrices that are viscous or tend to become viscous can become increasingly difficult for consumers to extrude from dentifrice tubes over long periods of time. In other words, the consumer must apply increased pressure to the dentifrice tube containing this type of dentifrice during the period of use in order to soften or liquefy the mass of semi-solid dentifrice and push it down. This has not been a major problem in the past. This is because the formulation can be adjusted to balance using less gelling agent and not being too soft at the beginning of use and too thick at the end of use; have adjusted the amount of pressure necessary to force the desired amount of dentifrice onto the toothbrush bristles. Dentifrices that are not viscous when extruded from the tube have also been tolerated in use if they clump harder on the toothbrush bristles within a few seconds. In this way, the type of gelling agent could be varied widely for the dentifrice contained within the tube. In fact, Copenhagen Pectin Factory of Toril Skensved, Denmark (a subsidiary of Hercules Inc. of Wilmington, Del., U.S.A.) has developed its product Genubisco Type 0819, a potential thickener for toothpastes.
have proposed iota carrageenan (i-carrageenan). i-Carrageenan, obtained from FMC's Marine Colloids Division of Springfield, N.J., has also been proposed as Biscarin TP-5 for use in toothpastes with potential in toothpastes containing dicalcium phosphate or silica. Ta. Moreover, i-carrageenan is
Lion Tobrushsha's Japanese Patent Publication dated September 11, 1981
56 115711, galactan has been disclosed as a thickening agent component together with K-carrageenan and alkali metal alginates for dentifrices containing galactose. Conventional techniques for reducing dentifrice viscosity are not fully satisfactory when using mechanically or differentially operated dentifrice dispensers. This is because, compared to dentifrice that is filled into a flexible tube, when using a dispenser the dentifrice is relatively less viscous during filling;
This is because it must regain its consistency and maintain its consistency during shipping, storage, and use.
In other words, the dentifrice after filling regains the consistency it had before the liquefaction effect during shear filling for shipping, storage and use. Conventional gelling agents such as sodium carboxymethyl cellulose, hydroxyethyl cellulose, or mixtures thereof are preferably used for dentifrices containing alpha alumina trihydrate to be loaded into dispensers. However, such dentifrices contain at least two sources of fluoride, desensitizing agents such as allantoin (C ₇ H ₆ N ₄ O ₃ ) and pyridicarbinol. Difficulties arise when dentifrices are loaded into mechanically actuated or differential pressure dispensers when they contain multiple sources of active ingredients, such as vasodilators. In particular, dentifrice seeps through the space between the rod and the piston particularly used in mechanically actuated dispensers, causing leakage at the dispenser orifice. Additionally, the ribbon of dentifrice extruded from a mechanically actuated or differential pressure dispenser may be irregular or discontinuous. Since it is particularly desirable to create alpha-alumina trihydrate abrasive-containing dentifrices that contain several active ingredients as described above based on the compatibility of those materials with the abrasives, other gelling system was needed. Surprisingly, among other types of gelling agents, mixtures of cellulosic gelling agents and i-carrageenan can be filled into and extruded from mechanically actuated or differential pressure dispensers. To provide an excellent dentifrice containing alumina trihydrate and several active ingredients. It is noteworthy that xanthan was not compatible with cellulosic gelling agents since it contains cellulases. It is an advantage of the present invention to provide a dentifrice that can be easily filled and extruded into a mechanically actuated or differential pressure dentifrice dispenser. Other advantages will become apparent from consideration of the following specification. According to some of its aspects, the invention provides an aqueous humectant vehicle of about 20-80% by weight, about 0.1-80% by weight of an aqueous humectant vehicle;
5% by weight gelling agent mixture, about 20-75% by weight Alpha alumina trihydrate abrasive, from about 300
sodium fluoride and sodium monofluorine phosphate in amounts to provide 10000 ppm of fluorine, about 0.05−0.5% by weight allantoin desensitizer, and about 0.05−0.5% by weight of allantoin desensitizer;
Relates to a dentifrice in a mechanically actuated or differential pressure dispenser consisting of 0.5% by weight of a pyridylcarbinol vasodilator, in which case:
The gelling agent mixture is a mixture of a cellulosic gelling agent or xanthan and i-carrageenan, and the weight ratio of either the cellulosic gelling agent or xanthan to i-carrageenan is about 5:
1 to about 1:5. In dentifrice formulations, the dentifrice vehicle consists of a liquid phase proportional to a gelling agent to form an extrudable creamy mass of the desired consistency. The liquid phase in dentifrice is primarily water and humectants such as glycerin, sorbitol, maltitol, xylitol, low molecular weight polyethylene glycols (e.g. 400 or 600),
propylene glycol, suitable mixtures thereof,
Consists of. Usually the liquid phase is water and a humectant such as glycerin, sorbitol or polyethylene glycol, typically about 10-55% water and about 10% by weight.
Advantageously, amounts of humectant of 20-50% by weight are used. The toothpaste contains approximately Alpha alumina trihydrate abrasive.
Contains in an amount of 20-75% by weight. Alpha alumina trihydrate is typically produced by the Bayer method.
It is used as particles having a particle size of less than about 40 microns, primarily about 3-20 microns. Other abrasives may also be included, such as insoluble sodium metaphosphate, dicalcium phosphate, calcined alumina, silica or calcium carbonate, in small amounts relative to alpha alumina trihydrate. The gelling agent mixture of the present invention is present in the dentifrice in an amount of about 0.1-5% by weight. It comprises either a cellulosic gelling agent or xanthan together with i-carrageenan, wherein the weight ratio of the cellulosic gelling agent or xanthan to i-carrageenan is from about 5:1 to about 1:5, preferably is from about 1:1 to about 1:3, and the total gelling agent mixture is preferably about 0.2-3% by weight. As mentioned above, iota carrageenan is commercially available as Genubisco type 0819 and biscarine.
It is available as TP-5 and has been recommended for use in toothpastes. This type of usage in toothpaste was described in Lion Tobashisha's Japanese Patent Publication No. 56 115711;
Therein, i-carrageenan is mentioned together with K-carrageenan and alkali metal alginates as possible components of the gelling system. In Scotto U.S. Pat. No. 4,353,890, i-carrageenan is disclosed as a replacement for K-carrageenan as a toothpaste gelling agent, in which case:
The toothpaste is subjected to microwave radiation to reduce the tendency of carrageenan to become viscous, typically during manufacturing. The carrageenan may be the sole gelling agent or may be mixed with other gelling agents. In the present invention, dentifrice containing i-carrageenan to be loaded into a mechanically actuated or differential pressure dispenser does not require microwave radiation. The prior art methods generally discussed above are based on cellulose gelling agents and i-carrageenan gelling systems that have the properties necessary for effective loading into and extrusion from mechanically actuated or differential pressure dispensers. There is no indication that it is possible to provide a dentifrice containing an alumina trihydrate abrasive and a number of active ingredients. It is noteworthy that U.S. Pat. No. 4,029,760 to Retzk et al. discloses oral compositions in which i-carrageenin is indicated as an anti-gingivitis agent in place of other carrageenins. Carrageenins are highly depolymerized derivatives of carrageenans. Carrageenan does not appear to provide anti-gingivitis effects. Toothpastes are typically made by low-temperature processes, e.g.
Produced at 25°C or by a thermal process, for example at about 60°C. i-carrageenan can be used in either low temperature or thermal processing techniques. Since xanthan is produced by low temperature processing, when used, it can be easily mixed with and incorporated into the dentifrice with i-carrageenan by low temperature processing. i-carrageenan can only be used with thermal treatment. The physical properties of i-carrageenan of Genubisco type 0819 are as follows: 1. Viscosity of a 0.30% solution of Genubisco type 0819 in a poor solvent made using a thermal process (60°C): Viscosity at 32 rpm = 110 ± 17 centipoise Viscosity at 64 rpm = 70 ± 11 centipoise Viscosity at 128 rpm = 45 ± 7 centipoise Measured on Haak-Roth Visco RV3 at 25°C. 2. Viscosity of 0.30% of Genubisco type 0819 in poor solvent made using low temperature process (25°C): At 32 rpm, viscosity = 85 ± 13 centipoise At 64 rpm, viscosity = 55 ± 8 centipoise At 128 rpm, viscosity = 37 ± 6 Centipoise Measured with a Haak-Rotbisco RV3 at 25°C. 3 Particle size: Less than 1% rubbery on 0.075mm test sieve (DIN80, 200 US sieve) 4 Moisture content: 12% or less 5 PH: 8.5 ± 1.5 as a 0.5% solution in distilled water at 25°C 6 Color: White to cream in color. Viscarin TP-5 i-carrageenan has the following physical properties: Color: light brown to brown Particle size: >95.0% passes US standard sieve, 25 nm. Moisture: 12.0% max (Senco water scale) PH: 7.0 to 9.5, 1.5% solution, 30°C Typical desirable cellulosic gelling agents include alkali metal carboxymethyl cellulose, methyl cellulose, hydroxymethyl cellulose and hydroxypropyl cellulose . Sodium carboxymethyl cellulose is preferred. The mixed gel system is present in an amount of about 0.1-5% by weight of the dentifrice;
The weight ratio of cellulosic gelling agent to i-carrageenan is from about 5:1 to about 1:5, preferably about 1:1.
to about 1:3, most preferably about 1:1.
Thus, a typical preferred dentifrice contains about 0.3% each of a cellulosic gelling agent and an i-carrageenan.
A total of about 0.9-1.2% gelling agent can be included, including -0.9% and a weight ratio between about 1:1 and about 1:1 to 1:3. It is worth noting that the brands of sodium carboxymethyl cellulose that can be used are:

[Table] Additionally, the brands of hydroxyethyl cellulose that can be used include the following.

【table】

[Table] i-Carrageenan and cellulosic gelling agent are mechanically treated together or separately with the liquid phase and thermally treated (typically at about 60°C) before mixing with the liquid phase of the dental cream vehicle. Alternatively, mixing can be done using cold processing techniques (typically at about 25°C). Xanthan gums are fermentation products produced by the action of bacteria of the genus Xanthomonas on carbohydrates. Four species of Xanthomonas, viz.
It has been reported in the literature that X. cyanpetris, X. fazeoli, X. marbosiarum, and X. carote are the most effective gum producers. Although the exact chemical structure has not been determined, it is generally accepted that it is a heteropolysaccharide with a molecular weight in the millions. It contains D-glucose, D-mannose and D-glucuronic acid in a molar ratio of 2.8:3:2.0. The molecule contains 4.7% acetyl and approximately 3% pyruvate. The proposed chemical structural form is the "industrial rubbery" by Matsukuni and Kang, edited by R.L. Whistler, CHXX1, 2nd edition, New York.
(1973). Methods for the growth, isolation and purification of xanthan gums are also found in that publication. Further description of xanthan gums can be found in Manufacturing Chemist, May 1960, pages 206-208 (page 208 on the potential use of the gums described therein for formulating toothpastes). (including description). i-Carrageenan and xanthan are added to the liquid phase of a dental cream vehicle and treated at low temperatures (typically around 25
°C) technique. The dentifrice is packaged in a container from which it can be easily extruded, such as a differential pressure or mechanically actuated dental cream spacer. Its rheological properties are described in a British patent application issued on September 9, 1981.
It is highly desirable when using mechanically actuated dispensing containers of the type described in 2070695A. This dispensing container has a dispensing spout, a tension member, a center rod,
Consists of a piston and a hand control for actuation. The disclosure of this published application is incorporated herein by reference. The differential pressure dispensing container can be of the aerosol or vacuum type. Suitable differential pressure dispensers include those consisting of a collapsible product storage bag disposed within a rigid container containing a propellant fluid. In such dispensing containers, operation of the valve allows only the product to be discharged, and the propellant fluid is separated from the product by a fluid-impermeable bag. Dispensers of this type are described in US Pat. Nos. 3,828,977 and 3,838,976. These are the so-called Sepro Despancers. So-called Excel containers also use pressure. Yet another type of dispensing container is the barrier piston container described in US Pat. No. 4,171,757. This type of container includes a valve, a product storage chamber, and an essentially fluid-tight barrier piston that separates the propellant fluid from the packaged product (so-called diamond containers). The dentifrice contains a mixture of sodium fluoride and sodium monofluorophosphate as active agents and contains approximately 300-
10000ppm, about 750-2000ppm when cold, especially 1400-
Provide 2000 ppm fluorine, for example about 1400-1670 ppm. It is preferred to use a binary fluoride system with sodium monofluorophosphate and sodium fluoride, in which about 30-40% of the fluorine (e.g. about 30-
35%) is provided by sodium fluoride. Sodium monofluorophosphate Na ₂ PO ₃ F as available commercially varies considerably in purity. it is,
Any suitable purity may be used as long as the purity does not substantially adversely affect the desired properties. Generally, a purity of at least 80% is desirable. For best results it should be at least 85
%, preferably at least 90% by weight of monofluorophosphate, with the remainder being primarily manufacturing by-products or impurities such as sodium fluoride and water-soluble sodium phosphate salts. Stated another way, the sodium monofluorophosphate used has a total fluoride content of about 12% or more, preferably 12.7% or more, and a free sodium fluoride content of more than 1.5%, preferably 1.2%. at least 12%, preferably at least 12.1%, all calculated as fluoride. As mentioned above, the sodium fluoride in the binary mixture is a separate fluorine-containing component from the sodium monofluorophosphate. Preferably, about 225-800 ppm of fluorine is provided to the dental cream by sodium fluoride. Additional active agent is provided to the dentifrice by the presence of an allantoin desensitizer at about 0.05-0.5% by weight, preferably about 0.08-0.2%. This type of drug desensitizes the injured periodontal tissue and promotes its recovery. Allantoin can be obtained from ABM Industrial Products Ltd, Stockport, Uddley, Cheshire, UK. The pyridicarbinol active agent in an amount of about 0.05-5.0% by weight, preferably about 0.08-0.2% by weight, imparts a vasodilatory effect to the dentifrice. When using dentifrices containing alpha alumina trihydrate abrasives, two-component fluoride systems, allantoin desensitizers, and pyridylcarbinol vasodilators, as described above, use a mechanically actuated or differential pressure dispenser. The filling and extrusion methods used are effective and rheologically desirable with the gel system of the present invention. Filling is carried out by conventional techniques. For example, when using a mechanically actuated dispenser of the type described in UK Patent Application No. 2070695A, a predetermined amount of dentifrice is forced through a nozzle to fill a dispenser that is open at the bottom and includes a center rod.
A piston having a diameter corresponding to the inner diameter of the dispenser and a center hole that allows insertion of the center rod is slid into the piston. The dispenser is then sealed with a bottom disc. Any suitable surfactant or detergent material can be included in the refrigerant composition. Such compatible materials are desirable and similarly selected to provide additional cleaning, foaming, and antimicrobial properties depending on the particular type of surfactant. These detergents are usually water-soluble compounds;
It may be anionic, nonionic or cationic in structure. It is usually preferred to use water-soluble non-soap or synthetic organic detergents. Suitable detergent materials are known and include, for example, water-soluble salts of higher fatty acid monoglyceride monosulfate detergents (e.g. sodium coconut fatty acid monoglyride monosulfate), higher alkyl sulfates (e.g. sodium lauryl sulfate), alkylaryls. sulfonates (e.g., higher fatty acid esters of sodium dodecylbenzene sulfonate, 1,2-dihydroxypropanesulfonate), and the like. Other surfactants have 12 or more in the acyl group.
Includes substantially saturated higher aliphatic acylamides of lower aliphatic aminocarboxylic acid compounds, such as those having 16 carbons. The amino acid moiety is generally derived from a lower aliphatic saturated monoaminocarboxylic acid having about 2 to 6 carbons, usually a monocarboxylic acid compound. Suitable compounds are fatty acid amides of glycine, sarcosine, alanine, 3-aminopropionic acid and vallinine having about 12 to 16 carbons in the acyl group. It is preferred, however, to use N-lauroyl, myristoyl, and palmitoyl sarcoside compounds for optimal effect. The amide compounds can be used in the free acid form or preferably as their water-soluble salts, such as alkali metal, ammonium, amine and alkylolamine salts. Particular examples thereof are sodium and potassium N-lauroyl, myritele and ethanolamine N-lauroylglyside and alanine. For convenience, expressions such as "aminocarboxylic acid compound" and "sarcoside" refer to compounds of this type having a free carboxylic acid group of a water-soluble carboxylate salt. Such materials are utilized in pure or substantially pure form. They should contain as little as possible soaps or similar higher fatty acids, which tend to reduce the activity of these compounds. In normal practice, the amount of such higher fatty acid material will be no more than 15% by weight of the amide and insufficient to substantially adversely affect the amide, and preferably no more than about 10% of the amide material. It is. Various other materials may be incorporated into the dentifrices of the present invention. Examples of these are colorants, brighteners, methyl p
- preservatives such as hydroxybenzoates, stabilizers, tetrasodium pyrophosphate, silicones, chlorophyll compounds, and ammoniated substances such as urea, diammonium phosphate and mixtures thereof. These adjuvants are incorporated into the compositions of the invention in amounts that do not substantially adversely affect the desired properties and characteristics, and are suitably selected and used in conventional amounts. For certain purposes, it may also be desirable to include antimicrobial agents in the compositions of the present invention. from about 0.01% to about 5%, preferably from about 0.05% to about 5% by weight of the dentifrice composition.
Typical antimicrobial agents that can be used in an amount of 1.0% are: N-4 (chlorobenzyl- ^N5- (2,4-dichlorobenzyl) biguanide; p-chlorophenyl biguanide; 4-chlorobenzhydryl biguanide; 4-chlorobenzyl biguanide) Benzhydrylguanylurea; N-3-lauroxypropyl- ^N5 -p-chlorobenzyl biguanide; 1,6-di-p-chlorobenzylguanide; 1-(lauryldimethylammonium)-8-
(p-chlorobenzyldimethylammonium)-octane dichloride; 5,6-dichloro-2-guanindinobenzimidazole; N'-p-chlorophenyl- ^N5 -lauryl biguanide 5-amino-1,3-bis(2-ethylhexyl )-5-methylhexahydropyrimidine; and non-toxic acid addition salts thereof. Any suitable flavoring or sweetening agent may be used to flavor the compositions of the invention.
Examples of suitable flavoring ingredients include aromatic oils such as oils of orchid, trumpet, sassafras, clover, salvia, eucalyptus, marjoram, cinnamon, lemon and orange, and methyl salicylate. Suitable sweeteners are sucrose,
Contains lactose, maltose, sorbitol, sodium cyclamate, dipeptides of sodium saccharin (US Pat. No. 3,939,261) and oxathiazine salts (US Pat. No. 3,932,606). Suitable flavoring and sweetening agents together make up about 0.01 to 5% of the composition.
or more. Dentifrice has a pH that is practical for use. 3 to 10.5
A pH of 1 is particularly desirable. This reference to PH is meant to be the PH measured directly on the dentifrice.
If desired, benzoic acid or citric acid can be added to adjust the pH, for example from 4 to 8.5. The following examples further illustrate the nature of the invention, but it is not to be understood that the invention is limited thereto. All amounts of various ingredients are by weight unless otherwise specified. Example 1 The following dentifrice was made by a conventional room temperature cryogenic process and filled into a mechanically actuated dispenser as described in GB 2070695A. Sorbitol 23.000 Sodium saccharin 0.170 i-Carrageenan (Genubisco 0819) 0.500 Sodium carboxymethyl cellulose (7MFD) 0.500 Methyl p-hydroxybenzoate 0.080 Allantoin 0.150 Sodium fluoride 0.100 Sodium monofluorophosphate 0.760 Pyridyl carbinol 0.100 Alpha alumina trihydrate ( Alcoa C-333)
51.000 Benzoic Acid 0.140 Sodium Lauryl Sulfate 1.667 Titanium Dioxide 0.500 Flavoring 1.200 Deionized Water 20.133 This dentifrice filled the dispenser effectively and did not leak during storage at 43°C for one month. This dentifrice was well extruded from the dispenser even after being stored at 43°C for one month. Similar satisfactory results were obtained when the dentifrice contained 0.55 parts each of i-carrageenan and sodium carboxymethyl cellulose in the first case and 0.45 parts each of i-carrageenan and sodium carboxymethyl cellulose in the second case. when modified to contain and correspondingly adjust the water content.
Obtained. In fact, good extrudability with no leakage over a period of 3 months at 43° C. is observed for these dentifrices. Each of the three dentifrices described above was combined with one set of these dentifrices containing 50,000 parts alpha alumina trihydrate and the second set containing 52,000 parts alpha alumina trihydrate; Satisfactory results were again obtained when modifying to adjust the water content accordingly. Example 2 A dentifrice is then made by a low temperature process and filled into the same dispenser as in Example 1. Sorbitol (70%) 23.000 Sodium saccharin 0.170 i-Carrageenan (Genubisco 0819) 0.666 Sodium carboxymethyl cellulose (7MFD) 0.334 Methyl p-hydroxybenzoate 0.080 Allantoin 0.150 Sodium fluoride 0.100 Sodium monofluorophosphate 0.760 Pyridylcarbinol 0.100 Alpha Alumina trihydrate (Alcol C-333)
51.500 Benzoic acid 0.140 Sodium lauryl sulfate 1.667 Titanium dioxide 0.500 Flavoring agent 1.200 Deionized water 19.633 This dentifrice is efficiently filled into a dispenser and extruded well without leaking from the dispenser even after being stored for one month at 43°C. be done. A similar desired effect is obtained when the example dentifrice is loaded into a differential pressure dispenser. Extrusion failures occur when sodium carboxymethyl cellulose is used as the only gelling agent. Leakage occurs when hydroxyethyl cellulose is used as the sole gelling agent. However, hydroxyethylcellulose i-
When mixed with carrageenan, the desired filling and extrusion is achieved. Example 3 The following dentifrices are made by a conventional room temperature cryogenic process and filled into mechanically actuated dispensers in GB 2070695A. Sorbitol (70%) 23.000 Sodium Saccharin 0.170 i-Carrageenan (Genubisco 0819) 0.500 Xanthan (Keltrol) 0.500 Methyl p-Hydroxybenzoate 0.080 Allantoin 0.150 Sodium Fluoride 0.100 Sodium Monofluorophosphate 0.760 Pyridylcal Vinol 0.100 Alpha Alumina 3 Water salt (Alcoa C-333)
51.000 Benzoic acid 0.140 Sodium lauryl sulfate 1.667 Titanium dioxide 0.500 Flavoring agent 1.200 Deionized water 20.133 This dentifrice fills efficiently into the dispenser and does not leak during storage at 43°C for one month.
After storage for one month at 43°C, it is well extruded from the dispenser. Similar results were obtained using this dentifrice in one case each
It is obtained when modified to contain 0.55 parts of i-carrageenan and xanthan and in the second case 0.45 parts each of i-carrageenan and xanthan and adjust the water content accordingly. In fact, no leakage and good extrudability after storage for 3 months at 43 DEG C. are observed for dentifrices containing 0.45 parts each of xanthan and i-carrageenan. Again, each of the three dentifrices mentioned above,
In one set of these dentifrices, 50,000 parts of alpha alumina trihydrate were included; in the second set,
containing 52,000 parts of alpha alumina trihydrate and modified to adjust the water content accordingly;
Satisfactory results are observed. Phosphoric acid can be used in place of benzoic acid with the same results. Example 2 The following dentifrice is made by a low temperature process and filled into the same dispenser as in Example 3. Sorbitol (70%) 23.000 Sodium Saccharin 0.170 i-Carrageenan (Genubisco 0819) 0.750 Xanthan (Keltrol) 0.250 Methyl p-Hydroxybenzoate 0.080 Allantoin 0.150 Sodium Fluoride 0.100 Sodium Monofluorophosphate 0.760 Pyridylcal Vinol 0.100 Alpha Alumina 3 Water salt (Alcoa C-333)
51.000 Benzoic acid 0.140 Sodium lauryl sulfate 1.667 Titanium dioxide 0.500 Flavoring agent 1.200 Deionized water 20.133 This dentifrice is efficiently filled into a dispenser and extruded well without leakage from the dispenser after storage at 43°C for 3 months. be done. Similar desirable results are obtained with 50,000 parts of alpha alumina trihydrate. (a) 0.825 parts i-
carrageenan and 0.275 parts of xanthan, and (b)
Variations involving gel systems containing 0.675 parts i-carrageenan and 0.225 parts xanthan also give similar results. A similar desired effect is obtained when loading the example dentifrice into a differential pressure dispenser. It will be apparent to those skilled in the art that other variations of the embodiments illustrating the invention may be made.

Claims (1)

Claims: 1. About 20-80% by weight of an aqueous humectant vehicle, about
0.1-5% by weight gelling agent mixture, about 20-75% by weight Alpha-alumina trihydrate abrasive, about 300%
Sodium fluoride and sodium monofluorophosphate in an amount to provide 10,000 ppm fluorine from about 0.05−
0.5% by weight allantoin desensitizer and approx.
0.05-0.5 wt. The mixture is in a weight ratio of 5:1 to about 1:5. Dentifrice in mechanically actuated or differential pressure dispensers. 2 the weight ratio of the cellulosic gelling agent to the i-carrageenan or the xanthan to the i-carrageenan is from about 3:1 to about 1:3;
The dentifrice of claim 1, wherein the gelling agent mixture is present in an amount of about 0.2-3% by weight. 3. The dentifrice of claim 2, wherein the cellulosic gelling agent is present and is sodium carboxymethyl cellulose. 4. The dentifrice according to claim 2, wherein the xanthan is present. 5. The dentifrice of claim 2, wherein the weight ratio of said cellulosic gelling agent to said i-carrageenan or said xanthan to said i-carrageenan is about 1:1. 6 The sodium fluoride and the sodium monofluorophosphate are present in amounts to provide about 750-2000 ppm fluorine, with about 30-40% of the fluorine being provided by the sodium fluoride. A dentifrice according to claim 1. 7. The dentifrice of claim 1, wherein the dentifrice is contained in a mechanically actuated dispenser. 8 Approximately 20-80% by weight aqueous humectant vehicle, approx.
0.1-5% by weight gelling agent mixture, about 20-75% by weight Alpha-alumina trihydrate abrasive, about 300%
Sodium fluoride and sodium monofluorophosphate in an amount to provide 10,000 ppm fluorine from about 0.05−
0.5% by weight allantoin desensitizer and approx.
-0.5% by weight of a pyridylcarbinol vasodilator, wherein the gelling agent mixture comprises a cellulosic gelling agent and i-carrageenan of about 5:1 cellulosic gelling agent to i-carrageenan; Approximately 1:5
a method of manufacturing a dispenser containing a dentifrice, the mixture having a weight ratio of; forcing a predetermined amount of said dentifrice through a nozzle into a mechanically actuated dispenser with an open bottom and a central bar; a piston having a diameter corresponding to the inner diameter of the dispenser and a central hole for receiving the central rod, and then sliding the piston around the central rod, and then sealing the dispenser with a bottom disc. A method consisting of doing something.