CH650925A5 - Capsule contenenti il principio attivo di un allergene e procedimento per la loro preparazione. - Google Patents
Capsule contenenti il principio attivo di un allergene e procedimento per la loro preparazione. Download PDFInfo
- Publication number
- CH650925A5 CH650925A5 CH3074/82A CH307482A CH650925A5 CH 650925 A5 CH650925 A5 CH 650925A5 CH 3074/82 A CH3074/82 A CH 3074/82A CH 307482 A CH307482 A CH 307482A CH 650925 A5 CH650925 A5 CH 650925A5
- Authority
- CH
- Switzerland
- Prior art keywords
- allergen
- capsules
- excipient
- active principle
- powder
- Prior art date
Links
- 239000013566 allergen Substances 0.000 title claims abstract description 39
- 239000002775 capsule Substances 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title claims description 11
- 238000002360 preparation method Methods 0.000 title claims description 6
- 239000004480 active ingredient Substances 0.000 title description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims description 10
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 7
- 239000008101 lactose Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 4
- 238000005119 centrifugation Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 244000182067 Fraxinus ornus Species 0.000 claims 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 239000012456 homogeneous solution Substances 0.000 claims 1
- 238000007670 refining Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 241000238876 Acari Species 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 230000002969 morbid Effects 0.000 description 3
- 206010006482 Bronchospasm Diseases 0.000 description 2
- 241000238710 Dermatophagoides Species 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 230000002009 allergenic effect Effects 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000007885 bronchoconstriction Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000001694 hyposensitizing effect Effects 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22136/81A IT1220979B (it) | 1981-06-04 | 1981-06-04 | Capsule contenenti un allergene e procedimento per la loro preparazione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH650925A5 true CH650925A5 (it) | 1985-08-30 |
Family
ID=11192020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH3074/82A CH650925A5 (it) | 1981-06-04 | 1982-05-18 | Capsule contenenti il principio attivo di un allergene e procedimento per la loro preparazione. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4681752A (OSRAM) |
| EP (1) | EP0067130B1 (OSRAM) |
| JP (1) | JPS57212114A (OSRAM) |
| AT (1) | ATE20518T1 (OSRAM) |
| CA (1) | CA1207663A (OSRAM) |
| CH (1) | CH650925A5 (OSRAM) |
| DE (1) | DE3271829D1 (OSRAM) |
| DK (1) | DK153920C (OSRAM) |
| FR (1) | FR2512670B1 (OSRAM) |
| GR (1) | GR76810B (OSRAM) |
| IL (1) | IL65875A (OSRAM) |
| IT (1) | IT1220979B (OSRAM) |
| NO (1) | NO156275C (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US5811128A (en) * | 1986-10-24 | 1998-09-22 | Southern Research Institute | Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor |
| US5204113A (en) * | 1987-04-09 | 1993-04-20 | Fisons Plc | Pharmaceutical compositions containing pentamidine |
| WO1988007855A1 (en) * | 1987-04-09 | 1988-10-20 | Fisons Plc | Pharmaceutical compositions containing pentamidine |
| US5021554A (en) * | 1989-02-24 | 1991-06-04 | Eli Lilly And Company | Process for protein particle size reduction using a fluid-energy mill |
| WO1992016554A1 (en) * | 1991-03-14 | 1992-10-01 | The University Of Melbourne | Protein allergens of the species cynodon dactylon |
| CA2097932A1 (en) * | 1991-10-11 | 1993-04-12 | Shojiro Yamazaki | Antibody containing composition |
| US5641510A (en) * | 1994-07-01 | 1997-06-24 | Genentech, Inc. | Method for treating capsules used for drug storage |
| EP0711804A3 (de) | 1994-11-14 | 1999-09-22 | Ciba SC Holding AG | Kryptolichtschutzmittel |
| EP0896525B1 (en) * | 1996-04-29 | 2003-08-27 | Dura Pharmaceuticals, Inc. | Methods of dry powder inhalation |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| CA2479751C (en) | 2002-03-20 | 2008-06-03 | Trent Poole | Inhalation apparatus |
| RU2216353C1 (ru) * | 2002-10-16 | 2003-11-20 | Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН | Способ получения гранулированной лекарственной формы из аллергена клещей рода dermatophagoides farinae |
| CA2575692C (en) | 2004-08-20 | 2014-10-14 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
| DK1791542T3 (en) | 2004-08-23 | 2015-06-15 | Mannkind Corp | Diketopiperazinsalte for pharmaceutical delivery |
| ES2640282T3 (es) | 2005-09-14 | 2017-11-02 | Mannkind Corporation | Método de formulación de fármacos basado en el aumento de la afinidad de superficies de micropartículas cristalinas para agentes activos |
| EP1986679B1 (en) | 2006-02-22 | 2017-10-25 | MannKind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| ES2929343T3 (es) | 2008-06-13 | 2022-11-28 | Mannkind Corp | Inhalador de polvo seco accionado por aspiración para la administración de fármacos |
| US8485180B2 (en) * | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| ES2904623T3 (es) | 2008-06-20 | 2022-04-05 | Mannkind Corp | Aparato interactivo para establecer un perfil en tiempo real de esfuerzos de inhalación |
| TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| WO2010105094A1 (en) | 2009-03-11 | 2010-09-16 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
| MY157166A (en) | 2009-06-12 | 2016-05-13 | Mankind Corp | Diketopiperazine microparticles with defined specific surface areas |
| CA2778698A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| MX359281B (es) | 2010-06-21 | 2018-09-21 | Mannkind Corp | Sistema y metodos para suministrar un farmaco en polvo seco. |
| KR101940832B1 (ko) | 2011-04-01 | 2019-01-21 | 맨카인드 코포레이션 | 의약 카트리지용 블리스터 패키지 |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| IN2014DN03093A (OSRAM) | 2011-10-24 | 2015-05-15 | Mannkind Corp | |
| BR112015000529B1 (pt) | 2012-07-12 | 2022-01-11 | Mannkind Corporation | Inalador de pó seco |
| WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
| WO2014144895A1 (en) | 2013-03-15 | 2014-09-18 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| AU2014290438B2 (en) | 2013-07-18 | 2019-11-07 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| CA2920488C (en) | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Insufflation apparatus and methods |
| WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3148121A (en) * | 1960-01-27 | 1964-09-08 | Miles Lab | Water-insoluble whole inhalant complex and method of making same |
| GB1055465A (en) * | 1962-09-27 | 1967-01-18 | Vantorex Ltd | Allergenic aerosol compositions |
| GB1182779A (en) * | 1966-09-17 | 1970-03-04 | Fisons Pharmaceuticals Ltd | Inhalation Device |
| GB1247614A (en) * | 1969-06-20 | 1971-09-29 | Miles Lab | Improved therapeutic and diagnostic allergenic extract and process for preparing same |
| BR6915418D0 (pt) * | 1969-10-13 | 1973-03-13 | Synergistics Inc | Processo de preparacao de um composto antigeno de acaros e de seu soro e sua titulacao |
| GB1381872A (en) * | 1971-06-22 | 1975-01-29 | Fisons Ltd | Pharmaceutical compositions for inhalation |
| US3995023A (en) * | 1972-12-11 | 1976-11-30 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Process for the production of allergen-containing extracts |
| NL7316346A (OSRAM) * | 1972-12-11 | 1974-06-13 | ||
| FR2466991A1 (fr) * | 1979-10-08 | 1981-04-17 | Pasteur Institut | Perfectionnement a la preparation d'allergene |
-
1981
- 1981-06-04 IT IT22136/81A patent/IT1220979B/it active
-
1982
- 1982-04-29 DE DE8282830117T patent/DE3271829D1/de not_active Expired
- 1982-04-29 EP EP82830117A patent/EP0067130B1/en not_active Expired
- 1982-04-29 AT AT82830117T patent/ATE20518T1/de not_active IP Right Cessation
- 1982-05-11 CA CA000402725A patent/CA1207663A/en not_active Expired
- 1982-05-18 CH CH3074/82A patent/CH650925A5/it not_active IP Right Cessation
- 1982-05-19 FR FR8208989A patent/FR2512670B1/fr not_active Expired
- 1982-05-25 IL IL65875A patent/IL65875A/xx not_active IP Right Cessation
- 1982-05-27 DK DK239782A patent/DK153920C/da not_active IP Right Cessation
- 1982-06-02 GR GR68324A patent/GR76810B/el unknown
- 1982-06-02 NO NO821832A patent/NO156275C/no not_active IP Right Cessation
- 1982-06-04 JP JP57096855A patent/JPS57212114A/ja active Granted
-
1984
- 1984-04-04 US US06/597,241 patent/US4681752A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL65875A0 (en) | 1982-08-31 |
| DK153920C (da) | 1989-02-06 |
| ATE20518T1 (de) | 1986-07-15 |
| JPH0575726B2 (OSRAM) | 1993-10-21 |
| DE3271829D1 (en) | 1986-07-31 |
| CA1207663A (en) | 1986-07-15 |
| US4681752A (en) | 1987-07-21 |
| EP0067130B1 (en) | 1986-06-25 |
| FR2512670B1 (fr) | 1986-12-19 |
| DK239782A (da) | 1982-12-05 |
| JPS57212114A (en) | 1982-12-27 |
| EP0067130A3 (en) | 1984-01-11 |
| NO821832L (no) | 1982-12-06 |
| NO156275B (no) | 1987-05-18 |
| IT1220979B (it) | 1990-06-21 |
| IL65875A (en) | 1986-09-30 |
| NO156275C (no) | 1987-08-26 |
| GR76810B (OSRAM) | 1984-09-04 |
| FR2512670A1 (fr) | 1983-03-18 |
| IT8122136A0 (it) | 1981-06-04 |
| EP0067130A2 (en) | 1982-12-15 |
| DK153920B (da) | 1988-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CH650925A5 (it) | Capsule contenenti il principio attivo di un allergene e procedimento per la loro preparazione. | |
| KR100514971B1 (ko) | 부데소니드의 미분 결정질 입자를 함유하는 조성물 | |
| RU2098122C1 (ru) | Фармацевтическая композиция для лечения воспалительных заболеваний или заболеваний, связанных с обструкцией дыхательных путей | |
| EP0055041B1 (en) | Composition for curing respiratory diseases | |
| DE69533128T2 (de) | Pharmazeutische akzeptabel dnase zusammensetzung | |
| DE69828886T2 (de) | Neuartige formulierung zur inhalation mit einer bulkdichte zwischen 0.28 und 0.38 g/ml, verfahren zur herstellung der formulierung sowie anwendung derselben | |
| DE69635578T2 (de) | Verfahren und system zur behandlung dispergierbarer feiner pulver | |
| DE69530519T2 (de) | Parathyroidhormon pth enthaltende therapeutische zubereitung zur inhalation | |
| KR20010032303A (ko) | 연질 펠렛상 약제 및 그 제조방법 | |
| JPH04504427A (ja) | エアロゾルキャリヤー | |
| EP1009394B1 (en) | New formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml, comprising formoterol | |
| DE60109202T2 (de) | Pharmazeutische aerosolformulierung | |
| JP2025523909A (ja) | フドステインの霧化吸入溶液組成物、薬用アセンブリおよびその応用 | |
| US5244663A (en) | Therapeutic method against allergy | |
| AU728768B2 (en) | New formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml, comprising terbutaline sulphate, a process for preparing the formulation and the use thereof | |
| CN107334729B (zh) | 一种单唾液酸四己糖神经节苷脂钠口服液及其用途 | |
| CN108186594B (zh) | 一种孟鲁司特钠咀嚼片及其制备方法 | |
| CN113116907A (zh) | 环黄芪醇的医药用途 | |
| Pardy et al. | Control of Breathing in Chronic Obstructive Pulmonary Disease: The Effect of Histamine Inhalation | |
| CN118236329A (zh) | 一种三乙酰穿心莲内酯纳米晶及其制备方法和应用 | |
| CN100360116C (zh) | 适于吸入的粉末制剂 | |
| GB2099698A (en) | Allergen capsule | |
| RU2245157C2 (ru) | Биологически активная добавка для профилактики и лечения гриппа "фитогриппин" | |
| Matthys et al. | Deposition of aerosols and bronchial clearance measurements | |
| CN108379237A (zh) | 一种治疗泌尿道感染的药物微囊制剂及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NV | New agent |
Representative=s name: JACOBACCI & PERANI S.A. |
|
| PFA | Name/firm changed |
Owner name: LABORATORIO FARMACEUTICO LOFARMA S.A.S.;GAETANO ME |
|
| PL | Patent ceased |