BR9709748A - Método de inalação de pó seco - Google Patents
Método de inalação de pó secoInfo
- Publication number
- BR9709748A BR9709748A BR9709748-9A BR9709748A BR9709748A BR 9709748 A BR9709748 A BR 9709748A BR 9709748 A BR9709748 A BR 9709748A BR 9709748 A BR9709748 A BR 9709748A
- Authority
- BR
- Brazil
- Prior art keywords
- dry powder
- inhaler
- composition
- microns
- flow rate
- Prior art date
Links
- 239000000843 powder Substances 0.000 title abstract 3
- 239000003814 drug Substances 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 239000000443 aerosol Substances 0.000 abstract 1
- 239000000428 dust Substances 0.000 abstract 1
- 230000003434 inspiratory effect Effects 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Flow Control (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Patente de Invenção: <B>"MéTODO DE INALAçãO DE Pó SECO"<D>. Um método para a inalação de uma droga em pó seco inclui as etapas de prover uma composição de droga em pó seco tendo um tamanho de partícula de droga de a partir de cerca de 1-7 mícrons e um diâmetro aerodinâmico médio de massa do aerossol dispersado de a patir de cerca de 3,5 a 5,5 mícrons. Esta composição é carregada para um inalador que é em geral independente da velocidade de fluxo, e com o inalador tendo uma resistência ao fluxo de inspiração de cerca de 0,12 a 0,21 (cm H~ 2~O)^ ¢^) acima da faixa de cerca de 15-60 L/min. O paciente inala a composição de droga do inalador com uma velocidade de fluxo de inspiração de cerca de 15-60 L/min, resultando em uma eficiência de liberação medida pela fração respirável maior do que 20%.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1642896P | 1996-04-29 | 1996-04-29 | |
PCT/US1997/006621 WO1997040819A1 (en) | 1996-04-29 | 1997-04-21 | Methods of dry powder inhalation |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9709748A true BR9709748A (pt) | 2000-01-11 |
Family
ID=21777075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9709748-9A BR9709748A (pt) | 1996-04-29 | 1997-04-21 | Método de inalação de pó seco |
Country Status (16)
Country | Link |
---|---|
US (1) | US6116237A (pt) |
EP (1) | EP0896525B1 (pt) |
JP (2) | JP2000510109A (pt) |
AT (1) | ATE247948T1 (pt) |
AU (1) | AU724503B2 (pt) |
BR (1) | BR9709748A (pt) |
CA (1) | CA2252814A1 (pt) |
CZ (1) | CZ343798A3 (pt) |
DE (1) | DE69724420T2 (pt) |
DK (1) | DK0896525T3 (pt) |
ES (1) | ES2205210T3 (pt) |
HU (1) | HUP9901575A3 (pt) |
IL (1) | IL126701A (pt) |
NO (1) | NO984999D0 (pt) |
NZ (1) | NZ332669A (pt) |
WO (1) | WO1997040819A1 (pt) |
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US5503869A (en) * | 1994-10-21 | 1996-04-02 | Glaxo Wellcome Inc. | Process for forming medicament carrier for dry powder inhalator |
US5645051A (en) * | 1995-04-21 | 1997-07-08 | Dura Pharmaceuticals, Inc. | Unit dose dry powder inhaler |
US5622166A (en) * | 1995-04-24 | 1997-04-22 | Dura Pharmaceuticals, Inc. | Dry powder inhaler delivery system |
WO1997040819A1 (en) * | 1996-04-29 | 1997-11-06 | Dura Pharmaceuticals, Inc. | Methods of dry powder inhalation |
-
1997
- 1997-04-21 WO PCT/US1997/006621 patent/WO1997040819A1/en active IP Right Grant
- 1997-04-21 DE DE69724420T patent/DE69724420T2/de not_active Expired - Lifetime
- 1997-04-21 AU AU27371/97A patent/AU724503B2/en not_active Ceased
- 1997-04-21 EP EP97921298A patent/EP0896525B1/en not_active Revoked
- 1997-04-21 ES ES97921298T patent/ES2205210T3/es not_active Expired - Lifetime
- 1997-04-21 JP JP09538984A patent/JP2000510109A/ja active Pending
- 1997-04-21 IL IL12670197A patent/IL126701A/en not_active IP Right Cessation
- 1997-04-21 NZ NZ332669A patent/NZ332669A/xx unknown
- 1997-04-21 CA CA002252814A patent/CA2252814A1/en not_active Abandoned
- 1997-04-21 BR BR9709748-9A patent/BR9709748A/pt not_active IP Right Cessation
- 1997-04-21 HU HU9901575A patent/HUP9901575A3/hu unknown
- 1997-04-21 DK DK97921298T patent/DK0896525T3/da active
- 1997-04-21 AT AT97921298T patent/ATE247948T1/de active
- 1997-04-21 CZ CZ983437A patent/CZ343798A3/cs unknown
- 1997-04-24 US US08/847,287 patent/US6116237A/en not_active Expired - Lifetime
-
1998
- 1998-10-27 NO NO984999A patent/NO984999D0/no not_active Application Discontinuation
-
2009
- 2009-02-24 JP JP2009040744A patent/JP2009148586A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0896525A4 (en) | 2001-01-10 |
JP2000510109A (ja) | 2000-08-08 |
HUP9901575A2 (hu) | 1999-08-30 |
AU2737197A (en) | 1997-11-19 |
DK0896525T3 (da) | 2003-12-01 |
EP0896525B1 (en) | 2003-08-27 |
US6116237A (en) | 2000-09-12 |
ATE247948T1 (de) | 2003-09-15 |
EP0896525A1 (en) | 1999-02-17 |
DE69724420T2 (de) | 2004-06-09 |
AU724503B2 (en) | 2000-09-21 |
IL126701A0 (en) | 1999-08-17 |
HUP9901575A3 (en) | 1999-11-29 |
IL126701A (en) | 2001-08-08 |
CA2252814A1 (en) | 1997-11-06 |
NO984999L (no) | 1998-10-27 |
JP2009148586A (ja) | 2009-07-09 |
DE69724420D1 (de) | 2003-10-02 |
NO984999D0 (no) | 1998-10-27 |
CZ343798A3 (cs) | 1999-02-17 |
WO1997040819A1 (en) | 1997-11-06 |
ES2205210T3 (es) | 2004-05-01 |
NZ332669A (en) | 1999-02-25 |
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