CH644116A5 - Imidazolderivate. - Google Patents

Imidazolderivate. Download PDF

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Publication number
CH644116A5
CH644116A5 CH632180A CH632180A CH644116A5 CH 644116 A5 CH644116 A5 CH 644116A5 CH 632180 A CH632180 A CH 632180A CH 632180 A CH632180 A CH 632180A CH 644116 A5 CH644116 A5 CH 644116A5
Authority
CH
Switzerland
Prior art keywords
methyl
pyridyl
hydrogen
thio
melting point
Prior art date
Application number
CH632180A
Other languages
German (de)
English (en)
Inventor
Anna Dr Krasso
Henri Prof Dr Ramuz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CH632180A priority Critical patent/CH644116A5/de
Priority to DK300981A priority patent/DK300981A/da
Priority to PH26015A priority patent/PH17937A/en
Priority to NL8103690A priority patent/NL8103690A/xx
Priority to US06/290,032 priority patent/US4435406A/en
Priority to IL63576A priority patent/IL63576A/xx
Priority to ZA815633A priority patent/ZA815633B/xx
Priority to NZ198047A priority patent/NZ198047A/en
Priority to AU74089/81A priority patent/AU541834B2/en
Priority to IT23556/81A priority patent/IT1138156B/it
Priority to DE19813132613 priority patent/DE3132613A1/de
Priority to CA000384169A priority patent/CA1134829A/en
Priority to FR8115936A priority patent/FR2488890A1/fr
Priority to GB8125486A priority patent/GB2082580B/en
Priority to BE0/205721A priority patent/BE890024A/fr
Priority to JP56129475A priority patent/JPS5770886A/ja
Priority to AT0364381A priority patent/AT376665B/de
Priority to IE1912/81A priority patent/IE51507B1/en
Priority to LU83571A priority patent/LU83571A1/de
Priority to SE8104941A priority patent/SE452765B/sv
Priority to US06/560,699 priority patent/US4599347A/en
Priority to US06/560,698 priority patent/US4554280A/en
Publication of CH644116A5 publication Critical patent/CH644116A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/06—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH632180A 1980-08-21 1980-08-21 Imidazolderivate. CH644116A5 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
CH632180A CH644116A5 (de) 1980-08-21 1980-08-21 Imidazolderivate.
DK300981A DK300981A (da) 1980-08-21 1981-07-07 Fremgangsmaade til fremstilling af imidazolderivater
PH26015A PH17937A (en) 1980-08-21 1981-08-05 Imidazole derivatives,their compositions and use thereof
NL8103690A NL8103690A (nl) 1980-08-21 1981-08-05 Imidazoolderivaten.
US06/290,032 US4435406A (en) 1980-08-21 1981-08-05 Imidazole derivatives
IL63576A IL63576A (en) 1980-08-21 1981-08-14 Tricyclic imidazolethio(sulfinyl)alkyl pyridine derivatives,their manufacture and pharmaceutical compositions containing them
ZA815633A ZA815633B (en) 1980-08-21 1981-08-14 Imidazole derivatives
NZ198047A NZ198047A (en) 1980-08-21 1981-08-14 Tricyclic imidazole derivatives carrying a pyrid-2-ylmethylthio substituent
AU74089/81A AU541834B2 (en) 1980-08-21 1981-08-14 Imidazole derivatives
IT23556/81A IT1138156B (it) 1980-08-21 1981-08-18 Immidazol-derivati
DE19813132613 DE3132613A1 (de) 1980-08-21 1981-08-18 Imidazolderivate
CA000384169A CA1134829A (en) 1980-08-21 1981-08-19 Imidazole derivatives
FR8115936A FR2488890A1 (fr) 1980-08-21 1981-08-19 Derives tricycliques de l'imidazole, leur preparation et leurs utilisations therapeutiques
GB8125486A GB2082580B (en) 1980-08-21 1981-08-20 Tricyclic imidazole derivatives
BE0/205721A BE890024A (fr) 1980-08-21 1981-08-20 Derives tricycliques de l'imidazole, leur preparation et leurs utilisations therapeutiques
JP56129475A JPS5770886A (en) 1980-08-21 1981-08-20 Imidazole derivative
AT0364381A AT376665B (de) 1980-08-21 1981-08-20 Verfahren zur herstellung von neuen imidazolderivaten und von deren saeureadditionssalzen
IE1912/81A IE51507B1 (en) 1980-08-21 1981-08-20 Tricyclic imidazole derivatives
LU83571A LU83571A1 (de) 1980-08-21 1981-08-20 Imidazolderivate
SE8104941A SE452765B (sv) 1980-08-21 1981-08-20 Tricykliska imidazolderivat, deras framstellning, farmaceutiska kompositioner och anvendning
US06/560,699 US4599347A (en) 1980-08-21 1983-12-12 Tetrahydro-naphth (2.3-d) imidazole derivatives
US06/560,698 US4554280A (en) 1980-08-21 1983-12-12 Pyridyl methyl thio or sulfinyl indeno(5,6-d)imidazoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH632180A CH644116A5 (de) 1980-08-21 1980-08-21 Imidazolderivate.

Publications (1)

Publication Number Publication Date
CH644116A5 true CH644116A5 (de) 1984-07-13

Family

ID=4307711

Family Applications (1)

Application Number Title Priority Date Filing Date
CH632180A CH644116A5 (de) 1980-08-21 1980-08-21 Imidazolderivate.

Country Status (20)

Country Link
US (3) US4435406A (cg-RX-API-DMAC7.html)
JP (1) JPS5770886A (cg-RX-API-DMAC7.html)
AT (1) AT376665B (cg-RX-API-DMAC7.html)
AU (1) AU541834B2 (cg-RX-API-DMAC7.html)
BE (1) BE890024A (cg-RX-API-DMAC7.html)
CA (1) CA1134829A (cg-RX-API-DMAC7.html)
CH (1) CH644116A5 (cg-RX-API-DMAC7.html)
DE (1) DE3132613A1 (cg-RX-API-DMAC7.html)
DK (1) DK300981A (cg-RX-API-DMAC7.html)
FR (1) FR2488890A1 (cg-RX-API-DMAC7.html)
GB (1) GB2082580B (cg-RX-API-DMAC7.html)
IE (1) IE51507B1 (cg-RX-API-DMAC7.html)
IL (1) IL63576A (cg-RX-API-DMAC7.html)
IT (1) IT1138156B (cg-RX-API-DMAC7.html)
LU (1) LU83571A1 (cg-RX-API-DMAC7.html)
NL (1) NL8103690A (cg-RX-API-DMAC7.html)
NZ (1) NZ198047A (cg-RX-API-DMAC7.html)
PH (1) PH17937A (cg-RX-API-DMAC7.html)
SE (1) SE452765B (cg-RX-API-DMAC7.html)
ZA (1) ZA815633B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0221041A3 (en) * 1985-10-29 1987-10-28 Aktiebolaget Hässle Benzimidazole derivatives, process for their preparation and their pharmaceutical use

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA825106B (en) * 1981-08-13 1983-04-27 Haessle Ab Novel pharmaceutical compositions
DE3216843C2 (de) * 1982-05-05 1986-10-23 Ludwig Heumann & Co GmbH, 8500 Nürnberg 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
US4686232A (en) * 1983-02-28 1987-08-11 Sumitomo Chemical Company, Limited Fungicidal aniline derivatives
HU191756B (en) * 1983-05-03 1987-04-28 Byk Gulden Lomberg Chem Fab Process for preparing new fluoro-alkoxy-benzimidazole derivatives
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
ZW4585A1 (en) * 1984-04-19 1985-11-20 Hoffmann La Roche Imidazole derivatives
PL144822B1 (en) * 1984-05-12 1988-07-30 Boehringer Mannheim Gmbh Method of obtaining novel pyrolobenzimidazoles
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
GB8526154D0 (en) * 1985-02-06 1985-11-27 Kotobuki Seiyaku Co Ltd 2-substituted cyclo-heptoimidazoles
DK337086A (da) * 1985-08-12 1987-02-13 Hoffmann La Roche Benzimidazolderivater
WO1987005296A1 (en) * 1986-03-07 1987-09-11 Pfizer Inc. 2-[(2-pyridyl)methylsulfinyl]thienoimidazoles and related compounds as antiulcer agents
SE8604566D0 (sv) * 1986-10-27 1986-10-27 Haessle Ab Novel compunds
NZ234564A (en) 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
SE8604998D0 (sv) 1986-11-21 1986-11-21 Haessle Ab Novel pharmacological compounds
DE3701277A1 (de) * 1987-01-17 1988-07-28 Boehringer Mannheim Gmbh Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel
FR2614618B1 (fr) * 1987-04-30 1989-07-07 Cird Derives heterocycliques polycycliques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire
US5223515A (en) * 1988-08-18 1993-06-29 Takeda Chemical Industries, Ltd. Injectable solution containing a pyridyl methylsulfinylbenzimidazole
US5175286A (en) * 1988-09-20 1992-12-29 Hisamitsu Pharmaceutical Co., Inc. Dibenz[b,e]oxepin derivatives
IE64199B1 (en) * 1988-12-22 1995-07-12 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
SE8804629D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
SE8804628D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New compounds
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
SE9002206D0 (sv) 1990-06-20 1990-06-20 Haessle Ab New compounds
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5395952A (en) * 1991-06-03 1995-03-07 Sumitomo Chemical Company, Limited Benzimidazole derivatives agricultural and horticultural fungicides containing the same as an active ingredient and intermediate compounds thereof
US6207198B1 (en) * 1995-09-21 2001-03-27 Schwarz Pharma Ag Composition containing an acid-labile omeprazole and process for its preparation
DE19745692A1 (de) * 1997-07-24 1999-01-28 Bayer Ag Verfahren zur Herstellung von 2-Chlor-benzimidazol-Derivaten
AU753389C (en) * 1997-12-31 2007-08-09 Pfizer Products Inc. Aryl fused azapolycyclic compounds
CN100349868C (zh) * 2002-07-17 2007-11-21 京都药品工业株式会社 二氢吲哚化合物和其医药用途
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
CN102140099A (zh) * 2010-02-02 2011-08-03 山东轩竹医药科技有限公司 新的吡啶衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE5129C1 (cg-RX-API-DMAC7.html) 1894-05-19
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (cg-RX-API-DMAC7.html) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0221041A3 (en) * 1985-10-29 1987-10-28 Aktiebolaget Hässle Benzimidazole derivatives, process for their preparation and their pharmaceutical use

Also Published As

Publication number Publication date
SE8104941L (sv) 1982-02-22
NZ198047A (en) 1985-05-31
FR2488890B1 (cg-RX-API-DMAC7.html) 1985-01-11
ATA364381A (de) 1984-05-15
AU7408981A (en) 1982-02-25
IE51507B1 (en) 1987-01-07
BE890024A (fr) 1982-02-22
NL8103690A (nl) 1982-03-16
GB2082580B (en) 1984-03-07
IL63576A0 (en) 1981-11-30
US4435406A (en) 1984-03-06
PH17937A (en) 1985-02-05
LU83571A1 (de) 1983-06-08
DE3132613A1 (de) 1982-06-24
FR2488890A1 (fr) 1982-02-26
US4554280A (en) 1985-11-19
SE452765B (sv) 1987-12-14
ZA815633B (en) 1982-08-25
IE811912L (en) 1982-02-21
IL63576A (en) 1985-10-31
IT8123556A0 (it) 1981-08-18
CA1134829A (en) 1982-11-02
AT376665B (de) 1984-12-27
IT1138156B (it) 1986-09-17
AU541834B2 (en) 1985-01-24
DK300981A (da) 1982-02-22
US4599347A (en) 1986-07-08
GB2082580A (en) 1982-03-10
JPS5770886A (en) 1982-05-01

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