CH633567A5 - Verfahren zur herstellung von neuen polymeren orthoestern. - Google Patents

Verfahren zur herstellung von neuen polymeren orthoestern. Download PDF

Info

Publication number
CH633567A5
CH633567A5 CH437077A CH437077A CH633567A5 CH 633567 A5 CH633567 A5 CH 633567A5 CH 437077 A CH437077 A CH 437077A CH 437077 A CH437077 A CH 437077A CH 633567 A5 CH633567 A5 CH 633567A5
Authority
CH
Switzerland
Prior art keywords
carbon atoms
orthoesters
group
formula
chem
Prior art date
Application number
CH437077A
Other languages
German (de)
English (en)
Inventor
Richard C Capozza
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of CH633567A5 publication Critical patent/CH633567A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G4/00—Condensation polymers of aldehydes or ketones with polyalcohols; Addition polymers of heterocyclic oxygen compounds containing in the ring at least once the grouping —O—C—O—
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polyethers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CH437077A 1976-04-08 1977-04-06 Verfahren zur herstellung von neuen polymeren orthoestern. CH633567A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/675,185 US4066747A (en) 1976-04-08 1976-04-08 Polymeric orthoesters housing beneficial drug for controlled release therefrom

Publications (1)

Publication Number Publication Date
CH633567A5 true CH633567A5 (de) 1982-12-15

Family

ID=24709398

Family Applications (1)

Application Number Title Priority Date Filing Date
CH437077A CH633567A5 (de) 1976-04-08 1977-04-06 Verfahren zur herstellung von neuen polymeren orthoestern.

Country Status (10)

Country Link
US (4) US4066747A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS52123500A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU507701B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1112798A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH633567A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2715502A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2347396A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1518638A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1082732B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE421321B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4387215A (en) * 1973-03-30 1983-06-07 Bailey William J Polycyclic ring-opened polymers
US4328204A (en) * 1977-03-02 1982-05-04 Ethicon, Inc. Absorbable polymer-drug compounds and method for making same
US4211674A (en) * 1978-04-10 1980-07-08 Polak's Frutal Works B.V. Cyclic acetals and ketals and their use in perfume compositions
US4282201A (en) * 1979-02-02 1981-08-04 Alza Corporation Pharmaceutical comprising drug and polymer
DE2928636A1 (de) * 1979-07-16 1981-02-12 Hoechst Ag Strahlungsempfindliches gemisch und verfahren zur herstellung von reliefbildern
US4425473A (en) 1980-02-04 1984-01-10 Toagosei Chemical Industry Co., Ltd. Polymerizable bicyclic orthoester compounds
US4304767A (en) * 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
US4346709A (en) * 1980-11-10 1982-08-31 Alza Corporation Drug delivery devices comprising erodible polymer and erosion rate modifier
US4322323A (en) * 1980-12-01 1982-03-30 Alza Corporation Erodible device comprising surfactant for modifying the rate of erosion of the device
US4489056A (en) * 1982-06-30 1984-12-18 Merck & Co., Inc. Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance
US4530840A (en) * 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
JPS6067531A (ja) * 1983-09-22 1985-04-17 Toshiba Corp 樹脂組成物
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same
US4969872A (en) * 1989-03-08 1990-11-13 Alza Corporation Intravenous system for delivering a beneficial agent with delivery rate control via permeable surface area variance
US5030457A (en) * 1989-08-28 1991-07-09 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
WO1991003510A1 (en) * 1989-08-28 1991-03-21 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
US5461140A (en) * 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US6440457B1 (en) * 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
US6262115B1 (en) 1995-05-22 2001-07-17 Alza Coporation Method for the management of incontinence
US5912268A (en) * 1995-05-22 1999-06-15 Alza Corporation Dosage form and method for treating incontinence
EP0747375A1 (en) * 1995-06-05 1996-12-11 General Electric Company Method for making orthoester monomers
US6919373B1 (en) * 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
US20040062799A1 (en) * 1997-09-29 2004-04-01 Ayer Atul D. Therapeutic composition and delivery system for administering drug
US6486248B2 (en) 2001-01-08 2002-11-26 Milliken & Company Liquid colorant and method
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
EP1404310A4 (en) * 2001-06-11 2005-01-12 Xenoport Inc ORAL ADMINISTRATIVE DOSAGE FORMS OF GABA ANALOG PRODRUGS WITH REDUCED TOXICITY
US7420002B2 (en) * 2001-06-11 2008-09-02 Xenoport Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
US20050208132A1 (en) * 2002-07-29 2005-09-22 Gayatri Sathyan Methods and dosage forms for reducing side effects of benzisozazole derivatives
US20050232995A1 (en) * 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
AU2003293423A1 (en) 2002-12-06 2004-06-30 Xenoport, Inc. Carbidopa prodrugs and uses thereof
US20040162351A1 (en) * 2002-12-11 2004-08-19 Gallop Mark A. Orally administered dosage forms of fused GABA analog prodrugs having reduced toxicity
AU2004227995B2 (en) * 2003-03-31 2010-06-03 Xenoport, Inc. Treating or preventing hot flashes using prodrugs of GABA analogs
EP2354120A1 (en) 2003-08-20 2011-08-10 XenoPort, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
MXPA06001876A (es) * 2003-08-20 2006-05-17 Xenoport Inc Prodrogas de aciloxialquil carbamato, metodos de sintesis y uso.
MXPA06002731A (es) * 2003-09-11 2006-06-05 Xenoport Inc Tratamiento y/o prevencion de incontinencia urinaria utilizando profarmacos de analogos de gaba.
CA2538802C (en) * 2003-09-17 2015-01-27 Xenoport, Inc. Treating or preventing restless legs syndrome using prodrugs of gaba analogs
US7329413B1 (en) * 2003-11-06 2008-02-12 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof
US7323585B2 (en) * 2004-06-04 2008-01-29 Xenoport, Inc. Levodopa prodrugs, and compositions and uses thereof
RU2365580C2 (ru) * 2004-06-04 2009-08-27 Ксенопорт, Инк. Пролекарства леводопа, композиции на их основе и их применения
US20060128676A1 (en) * 2004-07-13 2006-06-15 Pharmacofore, Inc. Compositions of nicotinic agonists and therapeutic agents and methods for treating or preventing diseases or pain
WO2006050472A2 (en) * 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
US7566738B2 (en) * 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
US8795725B2 (en) * 2004-11-04 2014-08-05 Xenoport, Inc. GABA analog prodrug sustained release oral dosage forms
WO2006091790A1 (en) * 2005-02-23 2006-08-31 Xenoport, Inc. Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use
JP5199678B2 (ja) 2005-02-23 2013-05-15 プレクサ ファーマシューティカルズ， インコーポレイテッド 運動障害および他のｃｎｓ適応症の処置に使用することにおけるドーパミントランスポータ阻害剤
KR20080022203A (ko) * 2005-06-20 2008-03-10 제노포트 인코포레이티드 트라넥삼산의 아실옥시알킬 카르바메이트 프로드러그, 합성방법 및 용도
EP1928450A2 (en) * 2005-08-26 2008-06-11 Xenoport, Inc. Treating premature ejaculation using gabapentin and pregabalin prodrugs
US7563821B2 (en) 2005-12-05 2009-07-21 Xenoport, Inc. Levodopa prodrug mesylate, compositions thereof, and uses thereof
MX2008014794A (es) 2006-05-26 2009-04-08 Pharmacofore Inc Liberacion controlada de opioides fenolicos.
WO2008005371A2 (en) * 2006-06-29 2008-01-10 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US9744137B2 (en) * 2006-08-31 2017-08-29 Supernus Pharmaceuticals, Inc. Topiramate compositions and methods of enhancing its bioavailability
US7585996B2 (en) * 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
US7740699B2 (en) * 2006-10-05 2010-06-22 E.I. Du Pont De Nemours And Company Orthoformate-protected polyols
WO2008061226A2 (en) 2006-11-17 2008-05-22 Supernus Pharmaceuticals Inc. Sustained-release formulations of topiramate
US20080161393A1 (en) * 2006-12-08 2008-07-03 Barrett Ronald W Use of prodrugs of GABA analogs for treating disease
WO2008079387A1 (en) * 2006-12-21 2008-07-03 Xenoport, Inc. Catechol protected levodopa diester prodrugs, compositions, and methods of use
JP2011502953A (ja) 2006-12-21 2011-01-27 ゼノポート，インコーポレーテッド ジメチル置換されたレボドパジエステルのプロドラッグ、組成物及び使用方法
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
WO2010047775A2 (en) * 2008-10-20 2010-04-29 Xenoport, Inc. Methods of synthesizing a levodopa ester prodrug
US8399513B2 (en) 2008-10-20 2013-03-19 Xenoport, Inc. Levodopa prodrug mesylate hydrate
US20110060040A1 (en) * 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
JP2013520521A (ja) 2009-11-09 2013-06-06 ゼノポート，インコーポレーテッド レボドパプロドラッグの医薬組成物及び経口剤形並びに使用方法
US20110184060A1 (en) * 2010-01-22 2011-07-28 Xenoport, Inc. Oral dosage forms having a high loading of a tranexamic acid prodrug
CN107050456B (zh) 2010-09-28 2022-08-12 加利福尼亚大学董事会 治疗代谢综合征相关疾病的gaba激动剂和治疗或预防i型糖尿病的gaba组合
GB2556817B (en) 2015-10-01 2019-11-06 Elysium Therapeutics Inc Polysubunit opioid prodrugs resistant to overdose and abuse
US10335406B2 (en) 2015-10-01 2019-07-02 Elysium Therapeutics, Inc. Opioid compositions resistant to overdose and abuse
CA3056239C (en) 2017-03-17 2023-09-12 Elysium Therapeutics, Inc. Polysubunit opioid prodrugs resistant to overdose and abuse

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2636884A (en) * 1953-04-28 J-moxoeane
US3328427A (en) * 1963-10-31 1967-06-27 Celanese Corp Mono, ortho and oxetane esters of trimethylol compounds
DE1592655C2 (de) * 1966-07-13 1972-03-30 Gewerkschaft Victor, Chemische Werke, 4620 Castrop Rauxel Düngemittelgranulat mit kontollierter Nährstoffabgabe
US4015970A (en) * 1968-09-06 1977-04-05 Airwick Industries, Inc. Granular products for soil treatment
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3696123A (en) * 1970-03-19 1972-10-03 Siegfried H Schroeter Dihydrocarbonoxyoxethanes
US3673216A (en) * 1970-05-01 1972-06-27 Gen Electric Alkoxyoxetanes
US3914402A (en) * 1973-06-14 1975-10-21 Alza Corp Ophthalmic dosage form, for releasing medication over time
US3911098A (en) * 1974-02-11 1975-10-07 American Cyanamid Co Medicament carrier

Also Published As

Publication number Publication date
JPS619968B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1986-03-27
DE2715502A1 (de) 1977-10-20
US4066747A (en) 1978-01-03
US4136252A (en) 1979-01-23
AU2393377A (en) 1978-10-12
JPS52123500A (en) 1977-10-17
SE421321B (sv) 1981-12-14
US4155740A (en) 1979-05-22
AU507701B2 (en) 1980-02-21
IT1082732B (it) 1985-05-21
SE7703816L (sv) 1977-10-09
DE2715502C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-01-28
FR2347396B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-12-12
GB1518638A (en) 1978-07-19
US4119579A (en) 1978-10-10
CA1112798A (en) 1981-11-17
FR2347396A1 (fr) 1977-11-04

Similar Documents

Publication Publication Date Title
CH633567A5 (de) Verfahren zur herstellung von neuen polymeren orthoestern.
US4079038A (en) Poly(carbonates)
CH635355A5 (de) Verfahren zur herstellung von neuen polymeren.
DE1595850A1 (de) Verfahren zur Herstellung eines Katalysators auf Basis von zweiwertigen Metallen,insbesondere fuer die Polymerisation von cyclischen AEthern
KR100408611B1 (ko) 선택된금속화합물촉매를사용하는시클릭에테르의중합방법
DE69333518T2 (de) Depolymerisation zu zyclischen Ethern unter Verwendung der Katalysatoren aus gewählten Metallverbindungen
DE2607768A1 (de) Katalytisches verfahren zur herstellung von olefinoxiden
EP0495339A2 (de) Verbessertes Verfahren zur Herstellung von Glycidylethern
EP0115641A2 (de) Verfahren zur Herstellung von bifunktionellen Polyphenylenethern
DE2362971A1 (de) Als katalysatoren bei kationischen polymerisationen geeignete organische ammoniumhexafluorantimonate und verfahren zu ihrer herstellung
EP1028990B1 (de) Verfahren zur herstellung teilkristalliner polyetherpolyole
DE69504033T2 (de) Polyetherpolymere aus 3,4-epoxy-1-butene
JPH0768336B2 (ja) オリゴオキシエチレン側鎖を有するポリエーテル共重合体の製法
Yokoyama et al. Synthesis and polymerization of 2, 6, 7-trioxabicyclo [2.2. 2] octane and its derivatives
DE2842271C2 (de) Esterdiolalkoxylate
EP0992524B1 (de) Verfahren zur Herstellung von Polyetherpolyolen
DD148957A1 (de) Verfahren zur herstellung von hochmolekularen polyetheralkoholen
US3264266A (en) Polymer prepared by reacting an acetal, propylene oxide and styrene with boron trifluoride diethyl etherate catalyst
Petrus et al. Synthesis of ω‐Hydroxy Fatty Acid Alkyl Esters by Macrocyclic Lactones Alcoholysis Catalyzed by Homoleptic and Heteroleptic Zinc Aryloxides
DE3121180C2 (de) Verfahren zur Herstellung von Mono- oder Poly-alkylen-glykol-diäthern
DE2301789C3 (de) Siloxan-Polyoxyalkylen-Blockmischpolymere, Verfahren zu deren Herstellung und Verwendung
CH621137A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
Quinn Polypinocarveol.
DE2528368C3 (de) Verfahren zur Herstellung von heterocyclischen Verbindungen
KR101196416B1 (ko) 유기주석 화합물

Legal Events

Date Code Title Description
PL Patent ceased
PL Patent ceased