IT1082732B - Orto esteri polimerici e procedimento per la loro preparazione - Google Patents

Orto esteri polimerici e procedimento per la loro preparazione

Info

Publication number
IT1082732B
IT1082732B IT67771/77A IT6777177A IT1082732B IT 1082732 B IT1082732 B IT 1082732B IT 67771/77 A IT67771/77 A IT 67771/77A IT 6777177 A IT6777177 A IT 6777177A IT 1082732 B IT1082732 B IT 1082732B
Authority
IT
Italy
Prior art keywords
garden
procedure
preparation
polymeric
foreign
Prior art date
Application number
IT67771/77A
Other languages
English (en)
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of IT1082732B publication Critical patent/IT1082732B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G4/00—Condensation polymers of aldehydes or ketones with polyalcohols; Addition polymers of heterocyclic oxygen compounds containing in the ring at least once the grouping —O—C—O—
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polyethers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
IT67771/77A 1976-04-08 1977-04-07 Orto esteri polimerici e procedimento per la loro preparazione IT1082732B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/675,185 US4066747A (en) 1976-04-08 1976-04-08 Polymeric orthoesters housing beneficial drug for controlled release therefrom

Publications (1)

Publication Number Publication Date
IT1082732B true IT1082732B (it) 1985-05-21

Family

ID=24709398

Family Applications (1)

Application Number Title Priority Date Filing Date
IT67771/77A IT1082732B (it) 1976-04-08 1977-04-07 Orto esteri polimerici e procedimento per la loro preparazione

Country Status (10)

Country Link
US (4) US4066747A (it)
JP (1) JPS52123500A (it)
AU (1) AU507701B2 (it)
CA (1) CA1112798A (it)
CH (1) CH633567A5 (it)
DE (1) DE2715502A1 (it)
FR (1) FR2347396A1 (it)
GB (1) GB1518638A (it)
IT (1) IT1082732B (it)
SE (1) SE421321B (it)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4387215A (en) * 1973-03-30 1983-06-07 Bailey William J Polycyclic ring-opened polymers
US4328204A (en) * 1977-03-02 1982-05-04 Ethicon, Inc. Absorbable polymer-drug compounds and method for making same
US4211674A (en) * 1978-04-10 1980-07-08 Polak's Frutal Works B.V. Cyclic acetals and ketals and their use in perfume compositions
US4282201A (en) * 1979-02-02 1981-08-04 Alza Corporation Pharmaceutical comprising drug and polymer
DE2928636A1 (de) * 1979-07-16 1981-02-12 Hoechst Ag Strahlungsempfindliches gemisch und verfahren zur herstellung von reliefbildern
US4425473A (en) 1980-02-04 1984-01-10 Toagosei Chemical Industry Co., Ltd. Polymerizable bicyclic orthoester compounds
US4304767A (en) * 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
US4322323A (en) * 1980-12-01 1982-03-30 Alza Corporation Erodible device comprising surfactant for modifying the rate of erosion of the device
US4346709A (en) * 1980-11-10 1982-08-31 Alza Corporation Drug delivery devices comprising erodible polymer and erosion rate modifier
US4489056A (en) * 1982-06-30 1984-12-18 Merck & Co., Inc. Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance
US4530840A (en) * 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
JPS6067531A (ja) * 1983-09-22 1985-04-17 Toshiba Corp 樹脂組成物
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same
US4969872A (en) * 1989-03-08 1990-11-13 Alza Corporation Intravenous system for delivering a beneficial agent with delivery rate control via permeable surface area variance
US5030457A (en) * 1989-08-28 1991-07-09 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
WO1991003510A1 (en) * 1989-08-28 1991-03-21 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
US5461140A (en) * 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US6440457B1 (en) * 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
US5912268A (en) * 1995-05-22 1999-06-15 Alza Corporation Dosage form and method for treating incontinence
US6262115B1 (en) 1995-05-22 2001-07-17 Alza Coporation Method for the management of incontinence
EP0747375A1 (en) * 1995-06-05 1996-12-11 General Electric Company Method for making orthoester monomers
US6919373B1 (en) 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
US20040062799A1 (en) * 1997-09-29 2004-04-01 Ayer Atul D. Therapeutic composition and delivery system for administering drug
US6486248B2 (en) 2001-01-08 2002-11-26 Milliken & Company Liquid colorant and method
WO2002100344A2 (en) * 2001-06-11 2002-12-19 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
KR100958552B1 (ko) * 2001-06-11 2010-05-17 제노포트 인코포레이티드 Ｇａｂａ 유사체의 프로드러그, 이의 조성물 및 용도
US20050208132A1 (en) * 2002-07-29 2005-09-22 Gayatri Sathyan Methods and dosage forms for reducing side effects of benzisozazole derivatives
US20050232995A1 (en) * 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US7101912B2 (en) 2002-12-06 2006-09-05 Xenoport, Inc. Carbidopa prodrugs and derivatives, and compositions and uses thereof
US20040162351A1 (en) * 2002-12-11 2004-08-19 Gallop Mark A. Orally administered dosage forms of fused GABA analog prodrugs having reduced toxicity
CA2520468A1 (en) * 2003-03-31 2004-10-21 Xenoport, Inc. Treating or preventing hot flashes using prodrugs of gaba analogs
EP2354120A1 (en) 2003-08-20 2011-08-10 XenoPort, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
BRPI0413756A (pt) * 2003-08-20 2006-10-31 Xenoport Inc composto, métodos para tratar ou evitar espasticidade ou um sintoma de espasticidade, doença de refluxo gastro-esofágico, vìcio em droga, vìcio em ou abuso de álcool, ou vìcio em ou abuso de nicotina, e tosse ou êmese em um paciente, e, composição farmacêutica
JP2007505149A (ja) * 2003-09-11 2007-03-08 ゼノポート，インコーポレイティド ギャバ類似体のプロドラッグを用いる尿失禁の治療および／あるいは予防
BRPI0414481A (pt) * 2003-09-17 2006-11-14 Xenoport Inc métodos de tratamento ou de prevenção da sìndrome das pernas inquietas em um paciente e de melhoria do sono em um paciente com sìndrome das pernas inquietas, e, composição farmacêutica
US7329413B1 (en) * 2003-11-06 2008-02-12 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof
US7323585B2 (en) * 2004-06-04 2008-01-29 Xenoport, Inc. Levodopa prodrugs, and compositions and uses thereof
NZ551511A (en) * 2004-06-04 2010-09-30 Xenoport Inc Levodopa prodrugs, and compositions and uses thereof
US20060128676A1 (en) * 2004-07-13 2006-06-15 Pharmacofore, Inc. Compositions of nicotinic agonists and therapeutic agents and methods for treating or preventing diseases or pain
WO2006050472A2 (en) * 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
US7566738B2 (en) * 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
CN102429882B (zh) 2004-11-04 2015-03-25 什诺波特有限公司 加巴喷丁前体药物持续释放口服剂型
CA2609440A1 (en) 2005-02-23 2006-08-31 Prexa Pharmaceuticals, Inc. Dopamine transporter inhibitors for use in treatment of movement disorders and other cns indications
WO2006091790A1 (en) * 2005-02-23 2006-08-31 Xenoport, Inc. Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use
WO2007002013A2 (en) 2005-06-20 2007-01-04 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
WO2007027476A2 (en) * 2005-08-26 2007-03-08 Xenoport, Inc. Treating premature ejaculation using gabapentin and pregabalin prodrugs
JP5153641B2 (ja) * 2005-12-05 2013-02-27 ゼノポート，インコーポレーテッド レボドパプロドラッグメシラート、その組成物、およびその使用法
WO2007140272A2 (en) 2006-05-26 2007-12-06 Pharmacofore, Inc. Controlled release of phenolic opioids
EP2044142A2 (en) * 2006-06-29 2009-04-08 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US9744137B2 (en) * 2006-08-31 2017-08-29 Supernus Pharmaceuticals, Inc. Topiramate compositions and methods of enhancing its bioavailability
US7585996B2 (en) * 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
US7740699B2 (en) * 2006-10-05 2010-06-22 E.I. Du Pont De Nemours And Company Orthoformate-protected polyols
ES2555066T3 (es) 2006-11-17 2015-12-28 Supernus Pharmaceuticals, Inc. Formulaciones de liberación sostenida de topiramato
AU2007332904A1 (en) * 2006-12-08 2008-06-19 Xenoport, Inc. Use of prodrugs of GABA analogs for treating diseases
US7709527B2 (en) * 2006-12-21 2010-05-04 Xenoport, Inc. Levodopa dimethyl-substituted diester prodrugs compositions, and methods of use
TW200843731A (en) * 2006-12-21 2008-11-16 Xenoport Inc Catechol protected levodopa diester prodrugs, compositions, and methods of use
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
EP2349973A2 (en) * 2008-10-20 2011-08-03 XenoPort, Inc. Methods of synthesizing a levodopa ester prodrug
US8399513B2 (en) * 2008-10-20 2013-03-19 Xenoport, Inc. Levodopa prodrug mesylate hydrate
US20110060040A1 (en) * 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
JP2013520521A (ja) 2009-11-09 2013-06-06 ゼノポート，インコーポレーテッド レボドパプロドラッグの医薬組成物及び経口剤形並びに使用方法
WO2011091164A1 (en) * 2010-01-22 2011-07-28 Xenoport, Inc. Oral dosage forms having a high loading of a tranexamic acid prodrug
US9089531B2 (en) 2010-09-28 2015-07-28 The Regents Of The University Of California GABA agonists in the treatment of disorders associated with metabolic syndrome and GABA combinations in treatment or prophylaxis of type I diabetes
EP3355885A4 (en) 2015-10-01 2019-04-24 Elysium Therapeutics, Inc. MULTI-SUBUNIT OPIOID PRODRUGS WITH RESISTANCE TO OVERDOSE AND MISUSE
US10335406B2 (en) 2015-10-01 2019-07-02 Elysium Therapeutics, Inc. Opioid compositions resistant to overdose and abuse
EP3595663A4 (en) 2017-03-17 2021-01-13 Elysium Therapeutics, Inc. MULTI-UNIT OPIOID MEDICINES RESISTANT TO OVERDOSE AND ABUSE

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2636884A (en) * 1953-04-28 J-moxoeane
US3328427A (en) * 1963-10-31 1967-06-27 Celanese Corp Mono, ortho and oxetane esters of trimethylol compounds
DE1592655C2 (de) * 1966-07-13 1972-03-30 Gewerkschaft Victor, Chemische Werke, 4620 Castrop Rauxel Düngemittelgranulat mit kontollierter Nährstoffabgabe
US4015970A (en) * 1968-09-06 1977-04-05 Airwick Industries, Inc. Granular products for soil treatment
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3696123A (en) * 1970-03-19 1972-10-03 Siegfried H Schroeter Dihydrocarbonoxyoxethanes
US3673216A (en) * 1970-05-01 1972-06-27 Gen Electric Alkoxyoxetanes
US3914402A (en) * 1973-06-14 1975-10-21 Alza Corp Ophthalmic dosage form, for releasing medication over time
US3911098A (en) * 1974-02-11 1975-10-07 American Cyanamid Co Medicament carrier

Also Published As

Publication number Publication date
DE2715502C2 (it) 1988-01-28
FR2347396A1 (fr) 1977-11-04
JPS52123500A (en) 1977-10-17
AU2393377A (en) 1978-10-12
US4155740A (en) 1979-05-22
GB1518638A (en) 1978-07-19
SE421321B (sv) 1981-12-14
FR2347396B1 (it) 1980-12-12
AU507701B2 (en) 1980-02-21
US4119579A (en) 1978-10-10
US4136252A (en) 1979-01-23
CH633567A5 (de) 1982-12-15
DE2715502A1 (de) 1977-10-20
SE7703816L (sv) 1977-10-09
CA1112798A (en) 1981-11-17
JPS619968B2 (it) 1986-03-27
US4066747A (en) 1978-01-03

Similar Documents

Publication Publication Date Title
IT1082732B (it) Orto esteri polimerici e procedimento per la loro preparazione
IT1092262B (it) Spirolattoni e procedimento per la loro preparazione
IT1094423B (it) Alchil perflucro omega fluoroformil esteri e loro praparazione
AR217087A1 (es) N-benzoil n'-piridiloxifenilureas y metodo de preparacion de las mismas
IT1176629B (it) Esteri di polioli, loro preparazione e loro impiego
IT1098042B (it) Mitroimmidazoli e procedimento per la loro preparazione
IT1091303B (it) Fenossi-ammino-propanoli e procedimento per la loro produzione
IT1073611B (it) Bis tetraalogenoftalati alchilen diammonici e procedimento per la loro preparazione
IT1064932B (it) Vulcanizzati termoplastici e procedimento per la loro preparazione
TR19158A (tr) 2',3,6'-trikloro-4-siyano-4'-benzoil-uereido,difenil eterler,bunlarin hazirlanisina ait usuller ve bunlarin ensektisidler olarak kullanilmalari
IT1166756B (it) 1,3-diaril-2-imino-imidazolidine e 2-imino-esaidro-pirimidine sostituite e procedimento per la loro preparazione
IT1075298B (it) Aminoalchilpirrolbenzossazalcani e metodo per la loro preparazione
IT1074670B (it) Polifosfazeni vulcanizzati e procedimento per la loro preparazione
IT1108968B (it) Acetilenprostaglandine e procedimento per la loro preparazione
IT1075299B (it) Pirrolbenzossazalcani e metodo per la loro preparazione
IT1111353B (it) Alcossisilani polimerici e procedimento per la loro produzione ed applicazione
IT1085285B (it) Esteri,procedimento per la loro preparazione e loro impiego come prodotti disinfestanti
IT7850337A0 (it) Imidazo-chinolin-dioni e procedimento per la loro preparazione
IT1093629B (it) Esteri,procedimento per la loro preparazione e loro impiego come disinfestanti
IT7949302A0 (it) Antibiotici e loro preparazione
IT1083603B (it) Acilossi n n diacil malonammidi e procedimento per la loro preparazione
IT1108793B (it) Antibiotici e procedimento per la loro preparazione
IT1086270B (it) Uracil-derivati e procedimento per la loro preparazione
IT7922035A0 (it) Alcossialchilidenidrazinopiridazine e procedimento per la loro preparazione.
IT1100193B (it) Esteri n,n-dialchil-o-pirimidinil-carbammici,procedimento per la loro preparazione e loro impiego come insetticidi