CH632011A5 - Process for the preparation of 7-methoxycephalosporin derivatives - Google Patents
Process for the preparation of 7-methoxycephalosporin derivatives Download PDFInfo
- Publication number
- CH632011A5 CH632011A5 CH492181A CH492181A CH632011A5 CH 632011 A5 CH632011 A5 CH 632011A5 CH 492181 A CH492181 A CH 492181A CH 492181 A CH492181 A CH 492181A CH 632011 A5 CH632011 A5 CH 632011A5
- Authority
- CH
- Switzerland
- Prior art keywords
- group
- water
- compound
- methoxy
- column
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 36
- 229930184397 7-Methoxycephalosporin Natural products 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 230000008569 process Effects 0.000 title claims abstract description 8
- -1 amine salt Chemical group 0.000 claims abstract description 78
- 150000001875 compounds Chemical class 0.000 claims abstract description 78
- 239000001963 growth medium Substances 0.000 claims abstract description 57
- 241000187747 Streptomyces Species 0.000 claims abstract description 34
- 150000003839 salts Chemical group 0.000 claims abstract description 28
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 14
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 13
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 10
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 8
- 150000001340 alkali metals Chemical class 0.000 claims abstract description 7
- 239000002585 base Substances 0.000 claims abstract description 7
- 229910001385 heavy metal Inorganic materials 0.000 claims abstract description 7
- 235000015097 nutrients Nutrition 0.000 claims abstract description 7
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims abstract description 6
- 150000001342 alkaline earth metals Chemical class 0.000 claims abstract description 5
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 3
- IKWLIQXIPRUIDU-ZCFIWIBFSA-N (6r)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound OC(=O)C1=CCS[C@@H]2CC(=O)N12 IKWLIQXIPRUIDU-ZCFIWIBFSA-N 0.000 claims description 36
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 8
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- 229940124587 cephalosporin Drugs 0.000 claims description 5
- 150000001780 cephalosporins Chemical class 0.000 claims description 5
- 125000004521 1,3,4-thiadiazol-2-yl group Chemical group S1C(=NN=C1)* 0.000 claims description 4
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- 239000002609 medium Substances 0.000 description 18
- 238000004809 thin layer chromatography Methods 0.000 description 17
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- 235000019764 Soybean Meal Nutrition 0.000 description 16
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- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 description 12
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP50155646A JPS5279081A (en) | 1975-12-25 | 1975-12-25 | Preparation of novel 7-methoxycephalosporins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH632011A5 true CH632011A5 (en) | 1982-09-15 |
Family
ID=15610507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH492181A CH632011A5 (en) | 1975-12-25 | 1981-07-30 | Process for the preparation of 7-methoxycephalosporin derivatives |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5279081A (enExample) |
| AT (1) | AT353954B (enExample) |
| BE (1) | BE849763A (enExample) |
| CH (1) | CH632011A5 (enExample) |
| DE (1) | DE2660659C2 (enExample) |
| SE (1) | SE447268B (enExample) |
| SU (2) | SU904533A3 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5961597U (ja) * | 1982-10-16 | 1984-04-23 | 第一フエ−ズ株式会社 | 発熱性電子回路用モ−ルド構造 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794554A (fr) * | 1972-01-31 | 1973-07-26 | Lilly Co Eli | Nouveaux derives de penicilline et de cephalusporine |
-
1975
- 1975-12-25 JP JP50155646A patent/JPS5279081A/ja active Granted
-
1976
- 1976-12-18 DE DE19762660659 patent/DE2660659C2/de not_active Expired
- 1976-12-22 BE BE173563A patent/BE849763A/xx not_active IP Right Cessation
- 1976-12-23 AT AT958176A patent/AT353954B/de not_active IP Right Cessation
-
1977
- 1977-12-27 SU SU772558106A patent/SU904533A3/ru active
-
1980
- 1980-09-01 SE SE8006064A patent/SE447268B/sv not_active IP Right Cessation
- 1980-12-26 SU SU803222795A patent/SU948292A3/ru active
-
1981
- 1981-07-30 CH CH492181A patent/CH632011A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE8006064L (sv) | 1980-09-01 |
| BE849763A (fr) | 1977-04-15 |
| SU948292A3 (ru) | 1982-07-30 |
| SU904533A3 (ru) | 1982-02-07 |
| AT353954B (de) | 1979-12-10 |
| SE447268B (sv) | 1986-11-03 |
| JPS5279081A (en) | 1977-07-02 |
| JPS5635159B2 (enExample) | 1981-08-14 |
| ATA958176A (de) | 1979-05-15 |
| DE2660659C2 (de) | 1983-11-24 |
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| AT369376B (de) | Verfahren zur herstellung von neuen cephem- und chephamverbindungen | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |