CH631990A5 - Process for preparing a dimeric indole-dihydroindolecarboxamide - Google Patents

Process for preparing a dimeric indole-dihydroindolecarboxamide Download PDF

Info

Publication number
CH631990A5
CH631990A5 CH1089377A CH1089377A CH631990A5 CH 631990 A5 CH631990 A5 CH 631990A5 CH 1089377 A CH1089377 A CH 1089377A CH 1089377 A CH1089377 A CH 1089377A CH 631990 A5 CH631990 A5 CH 631990A5
Authority
CH
Switzerland
Prior art keywords
vlb
deacetyl
group
carboxamide
general formula
Prior art date
Application number
CH1089377A
Other languages
German (de)
English (en)
Inventor
George Joseph Cullinan
Koert Gerzon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CH631990A5 publication Critical patent/CH631990A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CH1089377A 1976-09-08 1977-09-06 Process for preparing a dimeric indole-dihydroindolecarboxamide CH631990A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72165076A 1976-09-08 1976-09-08

Publications (1)

Publication Number Publication Date
CH631990A5 true CH631990A5 (en) 1982-09-15

Family

ID=24898757

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1089377A CH631990A5 (en) 1976-09-08 1977-09-06 Process for preparing a dimeric indole-dihydroindolecarboxamide

Country Status (27)

Country Link
JP (1) JPS5340799A (US06272168-20010807-M00014.png)
AR (3) AR226411A1 (US06272168-20010807-M00014.png)
AT (1) AT360513B (US06272168-20010807-M00014.png)
AU (1) AU511055B2 (US06272168-20010807-M00014.png)
BE (1) BE858451A (US06272168-20010807-M00014.png)
CA (1) CA1082179A (US06272168-20010807-M00014.png)
CH (1) CH631990A5 (US06272168-20010807-M00014.png)
DD (1) DD133055A5 (US06272168-20010807-M00014.png)
DE (1) DE2739443A1 (US06272168-20010807-M00014.png)
DK (1) DK146822C (US06272168-20010807-M00014.png)
ES (1) ES462229A1 (US06272168-20010807-M00014.png)
FR (1) FR2364220A1 (US06272168-20010807-M00014.png)
GB (1) GB1586709A (US06272168-20010807-M00014.png)
GR (1) GR69783B (US06272168-20010807-M00014.png)
HU (1) HU180722B (US06272168-20010807-M00014.png)
IE (1) IE45558B1 (US06272168-20010807-M00014.png)
IL (1) IL52731A0 (US06272168-20010807-M00014.png)
MX (1) MX4740E (US06272168-20010807-M00014.png)
NL (1) NL7709806A (US06272168-20010807-M00014.png)
NZ (1) NZ184932A (US06272168-20010807-M00014.png)
PH (1) PH14771A (US06272168-20010807-M00014.png)
PL (1) PL104309B1 (US06272168-20010807-M00014.png)
PT (1) PT66984B (US06272168-20010807-M00014.png)
RO (3) RO77922A (US06272168-20010807-M00014.png)
SE (1) SE434953B (US06272168-20010807-M00014.png)
YU (1) YU209777A (US06272168-20010807-M00014.png)
ZA (1) ZA774988B (US06272168-20010807-M00014.png)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30561E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
AR225153A1 (es) * 1978-10-10 1982-02-26 Lilly Co Eli Un procedimiento para la preparacion de sulfato de vindesina
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
US4362664A (en) * 1980-12-29 1982-12-07 Eli Lilly And Company Vinblastine oxazolidinedione disulfides and related compounds
JPH075608B2 (ja) * 1986-01-13 1995-01-25 イ−ル−セルタ−ク ソシエテ アノニム ビンブラスチン誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine

Also Published As

Publication number Publication date
IL52731A0 (en) 1977-10-31
RO72474A (ro) 1982-05-10
CA1082179A (en) 1980-07-22
DK398577A (da) 1978-03-09
MX4740E (es) 1982-08-25
GR69783B (US06272168-20010807-M00014.png) 1982-07-07
NL7709806A (nl) 1978-03-10
ES462229A1 (es) 1978-07-16
PT66984B (en) 1979-02-13
DE2739443A1 (de) 1978-03-09
BE858451A (fr) 1978-03-07
FR2364220B1 (US06272168-20010807-M00014.png) 1980-04-25
YU209777A (en) 1982-08-31
AT360513B (de) 1981-01-12
ZA774988B (en) 1979-03-28
IE45558B1 (en) 1982-09-22
ATA644277A (de) 1980-06-15
JPS624398B2 (US06272168-20010807-M00014.png) 1987-01-30
SE434953B (sv) 1984-08-27
JPS5340799A (en) 1978-04-13
DE2739443C2 (US06272168-20010807-M00014.png) 1991-08-14
AU2803977A (en) 1979-02-22
RO77921A (ro) 1981-12-25
DD133055A5 (de) 1978-11-29
IE771700L (en) 1978-03-08
PL200607A1 (pl) 1978-05-22
AR226411A1 (es) 1982-07-15
DK146822C (da) 1984-06-25
PH14771A (en) 1981-12-09
SE7710059L (sv) 1978-03-09
GB1586709A (en) 1981-03-25
DK146822B (da) 1984-01-16
PL104309B1 (pl) 1979-08-31
HU180722B (en) 1983-04-29
NZ184932A (en) 1979-11-01
AR230642A1 (es) 1984-05-31
AR231643A1 (es) 1985-01-31
PT66984A (en) 1977-10-01
FR2364220A1 (fr) 1978-04-07
RO77922A (ro) 1981-12-25
AU511055B2 (en) 1980-07-24

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