CH616647A5 - - Google Patents

Download PDF

Info

Publication number
CH616647A5
CH616647A5 CH968376A CH968376A CH616647A5 CH 616647 A5 CH616647 A5 CH 616647A5 CH 968376 A CH968376 A CH 968376A CH 968376 A CH968376 A CH 968376A CH 616647 A5 CH616647 A5 CH 616647A5
Authority
CH
Switzerland
Prior art keywords
formula
derivatives
benzocycloheptene
radical
carbon atoms
Prior art date
Application number
CH968376A
Other languages
English (en)
French (fr)
Inventor
Lucien Nedelec
Andre Pierdet
Claude Dumont
Marie-Helene Kannengiesser
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of CH616647A5 publication Critical patent/CH616647A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CH968376A 1975-07-28 1976-07-28 CH616647A5 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7523499A FR2319332A1 (fr) 1975-07-28 1975-07-28 Nouveaux derives de l'aminobenzocycloheptene et leurs sels, procede de preparation et application a titre de medicaments desdits produits

Publications (1)

Publication Number Publication Date
CH616647A5 true CH616647A5 (el) 1980-04-15

Family

ID=9158434

Family Applications (1)

Application Number Title Priority Date Filing Date
CH968376A CH616647A5 (el) 1975-07-28 1976-07-28

Country Status (23)

Country Link
US (1) US4091115A (el)
JP (1) JPS5217455A (el)
AT (1) AT346303B (el)
AU (1) AU503674B2 (el)
BE (1) BE844555A (el)
CA (1) CA1088070A (el)
CH (1) CH616647A5 (el)
DD (1) DD126800A5 (el)
DE (1) DE2633889C2 (el)
DK (1) DK143105C (el)
ES (2) ES450166A1 (el)
FI (1) FI63014C (el)
FR (1) FR2319332A1 (el)
GB (1) GB1503119A (el)
HU (1) HU175289B (el)
IE (1) IE44014B1 (el)
IL (1) IL50116A (el)
LU (1) LU75470A1 (el)
NL (1) NL7608398A (el)
PT (1) PT65413B (el)
SE (1) SE7607944L (el)
SU (1) SU682121A3 (el)
ZA (1) ZA764546B (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2365339A1 (fr) * 1976-09-23 1978-04-21 Roussel Uclaf Nouveaux derives de l'aminobenzocycloheptene, ainsi que leurs sels, procede de preparation et application a titre de medicaments de ces nouveaux produits
DK390477A (da) * 1977-05-23 1978-11-24 Sandoz Ag Fremgangsmaade til fremstilling af cycloheptenderivater
FR2409256A1 (fr) * 1977-11-18 1979-06-15 Roussel Uclaf Nouveaux derives de la 5h-benzocycloepten-7-amine et leurs sels, procede de preparation et application a titre de medicament
FR2633617B1 (fr) * 1988-07-04 1991-02-08 Adir Nouveaux derives du benzocycloheptene, leur procede de preparation et les compositions pharmaceutiques les renfermant
JPH051033A (ja) * 1991-06-18 1993-01-08 Tanabe Seiyaku Co Ltd ベンゾシクロヘプテン誘導体及びその製法
JP2003291819A (ja) * 2002-03-29 2003-10-15 Sanyo Electric Co Ltd 台 車
EP1670755A4 (en) * 2003-10-08 2007-02-28 Harvard College PYROVALERON ANALOGUE AND ITS THERAPEUTIC APPLICATIONS
EP2164324B1 (en) * 2007-06-15 2014-08-13 University Of Florida Research Foundation Therapeutic compounds
CN102076654B (zh) * 2008-04-28 2014-07-23 詹森药业有限公司 苯并环庚烷及苯并噁庚英衍生物
US9024071B2 (en) * 2009-05-05 2015-05-05 University Of Florida Research Foundation, Inc. Therapeutic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1202791B (de) * 1960-09-19 1965-10-14 Smith Kline French Lab Verfahren zur Herstellung substituierter Cyclopropylamine
US3253037A (en) * 1962-06-19 1966-05-24 Ciba Geigy Corp N-2-alkynyl-amino-benzocylo-alkanes
US3836534A (en) * 1969-05-01 1974-09-17 Colgate Palmolive Co 5-piperazino-6-hydroxy-5h-benzo-cycloheptenes
US3751420A (en) * 1971-04-01 1973-08-07 Squibb & Sons Inc Monoolmonoene amines

Also Published As

Publication number Publication date
FR2319332A1 (fr) 1977-02-25
FI762107A (el) 1977-01-29
DE2633889A1 (de) 1977-02-17
DK338376A (da) 1977-01-29
AU1629576A (en) 1978-02-02
HU175289B (hu) 1980-06-28
DK143105B (da) 1981-03-30
LU75470A1 (el) 1977-04-06
CA1088070A (fr) 1980-10-21
PT65413B (fr) 1978-06-09
IL50116A (en) 1979-10-31
DK143105C (da) 1981-11-09
FI63014B (fi) 1982-12-31
DE2633889C2 (de) 1982-12-23
ES461268A1 (es) 1978-08-16
JPS5217455A (en) 1977-02-09
IE44014L (en) 1977-01-28
SE7607944L (sv) 1977-01-29
IL50116A0 (en) 1976-09-30
ES450166A1 (es) 1977-11-16
NL7608398A (nl) 1977-02-01
AT346303B (de) 1978-11-10
ZA764546B (en) 1977-09-28
AU503674B2 (en) 1979-09-13
DD126800A5 (el) 1977-08-10
FI63014C (fi) 1983-04-11
IE44014B1 (en) 1981-07-29
ATA555776A (de) 1978-03-15
FR2319332B1 (el) 1978-11-17
US4091115A (en) 1978-05-23
PT65413A (fr) 1976-08-01
BE844555A (fr) 1977-01-27
SU682121A3 (ru) 1979-08-25
GB1503119A (en) 1978-03-08

Similar Documents

Publication Publication Date Title
EP0307303B1 (fr) [(Pyrimidinyl-2)-aminoalkyl]-1 pipéridines, leur préparation et leur application en thérapeutique
FR2534257A1 (fr) Nouveaux derives de la 6-amino 7-hydroxy 4,5,6,7-tetrahydro-imidazo/4,5,1-j-k/ /1/ benzazepin-2(1h)-one, leurs sels, application a titre de medicaments, compositions les renfermant et un intermediaire
CH628344A5 (fr) Procede de preparation de nouveaux derives du piperidyl-indole et de leurs sels.
CH616647A5 (el)
EP0343050B1 (fr) Dérivés de phényl-6 pipérazinyl-alkyl-3 1H,3H-pyrimidinedione-2,4, leur préparation et leur application en thérapeutique
CH617923A5 (el)
EP0147312B1 (fr) Nouvelles imidazo /1,2-c/ pyrimidines et leurs sels, leur procédé de préparation, leur application à titre de médicaments et les compositions les renfermant
CH619935A5 (el)
EP0301936B1 (fr) Dérivés de pipéridine, leur préparation et leur application en thérapeutique
EP0062580B1 (fr) Dérivés de l'imidazo(1,2-a)quinoléines
EP0002156B1 (fr) Nouveaux dérivés de la 5H-benzocyclohepten-7 amine et leurs sels, leur procédé de préparation, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant
EP0173585B1 (fr) Médicaments à base de dérivés de la pipéridine, nouveaux dérivés de la pipéridine et leurs procédés de préparation
FR2510575A1 (fr) Nouveaux composes bicycliques, leur procede de preparation et composition pharmaceutique les renfermant
CH617661A5 (el)
EP0034546B1 (fr) Nouveaux dérivés du cycloheptindole et leurs sels d'addition avec les acides, leur préparation, leur application comme médicaments et les compositions les renfermant
EP0456279B1 (fr) Dérivés condensés de la pipéridine, leur procédé de préparation et les intermédiaires de préparation, leur application comme médicaments et compositions pharmaceutiques les renfermant
CA1063619A (fr) Procede de preparation de nouveaux acides benzylamino alcanoiques et les produits qui en resultent
EP0157762B1 (fr) Nouvelles piperidinoguanidines substituees, leur procede de preparation et les compositions pharmaceutiques en renfermant
EP0106860B1 (fr) Nouvelles carboxamidoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant
EP0433163A2 (fr) Nouveau procédé de préparation d'imidazobenzodiazépines et de leurs sels
EP0349424B1 (fr) Dérivés de la 20,21-dinoréburnaménine substitués en 15 par un groupement aminé et leurs sels, leur procédé de préparation et les intermédiaires ainsi obtenus, leur application comme médicaments et les compositions pharmaceutiques les renfermant
EP0034989B1 (fr) Nouveaux dérivés du cycloheptindolol et leurs sels avec les acides, leur préparation, leur application comme médicaments et les compositions les renfermant
FR2528835A1 (fr) Nouvelles piperidinoguanidines substituees, leur procede de preparation et les compositions pharmaceutiques en renfermant
EP0197807B1 (fr) Nouveaux dérivés de la pyrazolobenzoxazine, leurs sels, procédé et intermédiaires de préparation, application à titre de médicaments et compositions les renfermant
EP0076713A1 (fr) Nouveaux dérivés de l'aminométhyl 1H-indole 4-méthanol et leurs sels, leur procédé et les intermédiaires de préparation, leur application à titre de médicaments, les compositions les renfermant

Legal Events

Date Code Title Description
PL Patent ceased