CH615442A5 - Process for the preparation of 17alpha,21-diesters of 17alpha,21-dihydroxysteroids of the pregnane series - Google Patents

Process for the preparation of 17alpha,21-diesters of 17alpha,21-dihydroxysteroids of the pregnane series Download PDF

Info

Publication number
CH615442A5
CH615442A5 CH996575A CH996575A CH615442A5 CH 615442 A5 CH615442 A5 CH 615442A5 CH 996575 A CH996575 A CH 996575A CH 996575 A CH996575 A CH 996575A CH 615442 A5 CH615442 A5 CH 615442A5
Authority
CH
Switzerland
Prior art keywords
formula
group
compound
acid
compounds
Prior art date
Application number
CH996575A
Other languages
German (de)
English (en)
Inventor
Gordon Hanley Phillipps
Donald Keith Vallance
Niall Galbraith Weir
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of CH615442A5 publication Critical patent/CH615442A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH996575A 1974-07-31 1975-07-30 Process for the preparation of 17alpha,21-diesters of 17alpha,21-dihydroxysteroids of the pregnane series CH615442A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB33786/74A GB1516095A (en) 1974-07-31 1974-07-31 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series

Publications (1)

Publication Number Publication Date
CH615442A5 true CH615442A5 (en) 1980-01-31

Family

ID=10357423

Family Applications (1)

Application Number Title Priority Date Filing Date
CH996575A CH615442A5 (en) 1974-07-31 1975-07-30 Process for the preparation of 17alpha,21-diesters of 17alpha,21-dihydroxysteroids of the pregnane series

Country Status (13)

Country Link
JP (1) JPS51125059A ( )
BE (1) BE831931A ( )
CA (1) CA1058610A ( )
CH (1) CH615442A5 ( )
DE (1) DE2534051A1 ( )
DK (1) DK139303B ( )
ES (1) ES439852A1 ( )
FR (1) FR2280383A1 ( )
GB (1) GB1516095A ( )
IE (1) IE42124B1 ( )
NL (1) NL7509075A ( )
SE (1) SE7508654L ( )
ZA (1) ZA754907B ( )

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
FR2600653B1 (fr) * 1986-06-24 1988-12-16 Pasteur Strasbourg Universite Composes de synthese associative d'acides amines soufres ou non soufres avec des derives du d-4 pregnene 3,20-dione ou avec des derives du d-1,4 pregnadiene 3,20-dione aux proprietes glucocorticoides et anti-inflammatoires, procedes d'obtention, compositions pharmaceutiques les contenant. proprietes pharmacologiques et applications
DE4333920A1 (de) 1993-10-05 1995-04-13 Hoechst Ag Corticoid-17,21-dicarbonsäureester sowie Corticosteroid-17-carbonsäureester-21-kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044212B (it) * 1971-03-17 1980-03-20 Sigma Tau Ind Farmaceuti Esteri del besametazone e betametazone
GB1440063A (en) * 1972-08-11 1976-06-23 Glaxo Lab Ltd 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids

Also Published As

Publication number Publication date
CA1058610A (en) 1979-07-17
BE831931A (fr) 1976-01-30
NL7509075A (nl) 1976-02-03
ES439852A1 (es) 1977-03-01
JPS51125059A (en) 1976-11-01
DE2534051A1 (de) 1976-02-19
IE42124B1 (en) 1980-06-04
DK139303B (da) 1979-01-29
DK346975A ( ) 1976-02-01
SE7508654L (sv) 1976-02-02
ZA754907B (en) 1976-07-28
GB1516095A (en) 1978-06-28
FR2280383A1 (fr) 1976-02-27
AU8353175A (en) 1977-02-03
DK139303C ( ) 1979-08-06
FR2280383B1 ( ) 1978-10-06
IE42124L (en) 1976-01-31

Similar Documents

Publication Publication Date Title
DE60013266T2 (de) Steroidnitrate zur behandlung von oxidativen schädigungen und endothelialer dysfunktion
CH619968A5 ( )
DE68910211T2 (de) Estramustin-ester.
DE2948733A1 (de) Steroidspirothiazolidinderivate, verfahren zur herstellung derselben und diese enhaltende arzneimittel
EP0152868B1 (de) Isoxazol-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2263100A1 (de) Neue heterozyklische ester von benzopyranopyridinen
CH615442A5 (en) Process for the preparation of 17alpha,21-diesters of 17alpha,21-dihydroxysteroids of the pregnane series
DE1926359A1 (de) oxylkansaeuren
DE2335750B2 (de) D-6-methylergolin-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2513136C3 (de) N-(1-Benzylpiperid-4-yl)-benzamide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
DE3881657T2 (de) 21-alkoxy-steroid-derivate.
DE2655130C3 (de) Eine praktisch lösungsmittelfreie Kristallform des Cefacetril-Natriumsalzes
DE2001305C3 (de) Cytostatisch wirksame Corticosteroid-21 -ester, deren Herstellung sowie diese enthaltende Arzneimittel
DE2716172C2 (de) Bis(6-[(hexahydro-1H-azepin-1-yl)-methylenamino]-penicillanoyloxy)-methan, seine Herstellung und dieses enthaltendes Arzneimittel
DE2251872C3 (de) Salze des N- [(5-Carboxy-methoxy-2-phenyl-ybenzopyron-7-yl)-oxyacetyl] -tetrahydropapaverins, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
EP0313935A2 (de) Enolether von 6-Chlor-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno(2,3-e)-1,2-thiazin-3-carbonsäureamid-1,1-dioxid, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
DE2442124A1 (de) Butyramid-derivate, verfahren zu deren herstellung und diese substanzen enthaltende arzneimittel
DE69206321T2 (de) Ursane Derivate, ihre Herstellung und die enthaltende pharmazeutische Zusammensetzung.
DE3116891A1 (de) Steroid-oxazole
DE3034005C2 (de) Indolessigsäure-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
DE2428201A1 (de) Anthranilsaeurederivate, verfahren zu deren herstellung und diese derivate enthaltende arzneimittel
DE2656678C2 (de) 4-Amino-trans-decahydrochinolin-Derivate und Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE2222931C3 (de) Piperidinoalkylphenthiazine, Verfahren zur Herstellung derselben sowie diese enthaltende pharmazeutische Mittel
DE2423897C3 (de) N-(p-FluorbenzoyIpropyl)-4piperidylamide, Verfahren zu ihrer Herstellung und pharmazeutische Präparate
DE2010722C3 (de) Cyclische Acetale der Pregnanreihe, ihre Herstellung und diese enthaltende pharmazeutische Mittel

Legal Events

Date Code Title Description
PL Patent ceased