CH615436A5 - Process for the preparation of the syn-isomer or of a mixture of syn- and anti-isomers of novel 7-alpha-substituted 7-beta-acylaminoceph-3-em-4-carboxylic acids - Google Patents

Process for the preparation of the syn-isomer or of a mixture of syn- and anti-isomers of novel 7-alpha-substituted 7-beta-acylaminoceph-3-em-4-carboxylic acids Download PDF

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Publication number
CH615436A5
CH615436A5 CH927374A CH927374A CH615436A5 CH 615436 A5 CH615436 A5 CH 615436A5 CH 927374 A CH927374 A CH 927374A CH 927374 A CH927374 A CH 927374A CH 615436 A5 CH615436 A5 CH 615436A5
Authority
CH
Switzerland
Prior art keywords
compound
formula
group
syn
acid
Prior art date
Application number
CH927374A
Other languages
German (de)
English (en)
Inventor
Brian Laundon
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of CH615436A5 publication Critical patent/CH615436A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
CH927374A 1973-07-06 1974-07-05 Process for the preparation of the syn-isomer or of a mixture of syn- and anti-isomers of novel 7-alpha-substituted 7-beta-acylaminoceph-3-em-4-carboxylic acids CH615436A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3227373A GB1472534A (en) 1973-07-06 1973-07-06 7beta-hydroxyiminoacylamido-cephalosporins

Publications (1)

Publication Number Publication Date
CH615436A5 true CH615436A5 (en) 1980-01-31

Family

ID=10336049

Family Applications (1)

Application Number Title Priority Date Filing Date
CH927374A CH615436A5 (en) 1973-07-06 1974-07-05 Process for the preparation of the syn-isomer or of a mixture of syn- and anti-isomers of novel 7-alpha-substituted 7-beta-acylaminoceph-3-em-4-carboxylic acids

Country Status (16)

Country Link
US (1) US4007174A (xx)
JP (1) JPS5069093A (xx)
AT (1) AT335061B (xx)
BE (1) BE817304A (xx)
CA (1) CA1055016A (xx)
CH (1) CH615436A5 (xx)
DE (1) DE2432415A1 (xx)
DK (1) DK360874A (xx)
ES (1) ES428015A1 (xx)
FR (1) FR2235696B1 (xx)
GB (1) GB1472534A (xx)
IE (1) IE39595B1 (xx)
LU (1) LU70477A1 (xx)
NL (1) NL7409179A (xx)
SE (1) SE7408892L (xx)
ZA (1) ZA744349B (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4092477A (en) * 1971-05-14 1978-05-30 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4165429A (en) * 1976-06-28 1979-08-21 Yamanouchi Pharmaceutical Co., Ltd. 7α-METHOXY-CEPHALOSPORANIC ACID DERIVATIVES
GB1592149A (en) * 1976-10-08 1981-07-01 Fujisawa Pharmaceutical Co 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof
SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
US5574154A (en) * 1994-09-29 1996-11-12 Alnejma Bulk Pharmaceutical Co. A.B.P.C. Process for the preparation of cephalosporanic compounds
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) * 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
CA2533292C (en) * 2003-07-21 2013-12-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
AU2004258949B2 (en) * 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
AU2004258944B2 (en) * 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
JP2007502296A (ja) * 2003-08-11 2007-02-08 アドバンシス ファーマスーティカル コーポレイション ロバストペレット
US8062672B2 (en) * 2003-08-12 2011-11-22 Shionogi Inc. Antibiotic product, use and formulation thereof
WO2005023184A2 (en) * 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
WO2005027877A1 (en) * 2003-09-15 2005-03-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
EP1701705A4 (en) * 2003-12-24 2007-08-08 Advancis Pharmaceutical Corp IMPROVED ABSORPTION OF MODIFIED RELEASE DOSAGE FORMS
WO2006014427A1 (en) * 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE311519B (xx) * 1962-12-14 1969-06-16 Astra Ab
GB1208015A (en) * 1967-03-23 1970-10-07 Glaxo Lab Ltd Cephalosporins
US3573294A (en) * 1968-03-14 1971-03-30 Glaxo Lab Ltd 7 - (arylglyoxamido)cephalosporanic acids and their salts and alpha-carbonyl derivatives
GB1433141A (en) * 1972-07-07 1976-04-22 Glaxo Lab Ltd Antibiotics
GB1389194A (en) * 1971-01-29 1975-04-03 Glaxo Lab Ltd Antibiotics

Also Published As

Publication number Publication date
FR2235696A1 (xx) 1975-01-31
AU7072374A (en) 1976-01-08
ATA556074A (de) 1976-06-15
SE7408892L (xx) 1975-01-07
ZA744349B (en) 1975-07-30
JPS5069093A (xx) 1975-06-09
ES428015A1 (es) 1976-07-16
CA1055016A (en) 1979-05-22
BE817304A (fr) 1975-01-06
LU70477A1 (xx) 1976-05-31
NL7409179A (nl) 1975-01-08
FR2235696B1 (xx) 1976-12-24
DK360874A (xx) 1975-03-03
US4007174A (en) 1977-02-08
AT335061B (de) 1977-02-25
IE39595L (en) 1975-01-06
GB1472534A (en) 1977-05-04
IE39595B1 (en) 1978-11-22
DE2432415A1 (de) 1975-01-30

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