CH614931A5 - - Google Patents

Info

Publication number
CH614931A5
CH614931A5 CH1419575A CH1419575A CH614931A5 CH 614931 A5 CH614931 A5 CH 614931A5 CH 1419575 A CH1419575 A CH 1419575A CH 1419575 A CH1419575 A CH 1419575A CH 614931 A5 CH614931 A5 CH 614931A5
Authority
CH
Switzerland
Application number
CH1419575A
Inventor
Artur Dr Rueegger
Max Kuhn
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to CH1419575A priority Critical patent/CH614931A5/xx
Priority to DE2661031A priority patent/DE2661031C2/de
Priority to DE2648121A priority patent/DE2648121C2/de
Priority to ZA00766340A priority patent/ZA766340B/xx
Priority to FI763049A priority patent/FI60701C/fi
Priority to DK483176A priority patent/DK148907C/da
Priority to NO763667A priority patent/NO763667L/no
Priority to US05/736,106 priority patent/US4108985A/en
Priority to SE7611906A priority patent/SE432247B/xx
Priority to NL7612026A priority patent/NL7612026A/xx
Priority to JP51131314A priority patent/JPS5259180A/ja
Priority to IE2439/76A priority patent/IE44749B1/en
Priority to NZ182496A priority patent/NZ182496A/xx
Priority to PH19079A priority patent/PH14725A/en
Priority to GB19922/79A priority patent/GB1567202A/en
Priority to CA264,703A priority patent/CA1087609A/en
Priority to AU19262/76A priority patent/AU513538B2/en
Priority to GB45485/76A priority patent/GB1567201A/en
Priority to IE2379/81A priority patent/IE44750B1/en
Priority to YU02700/76A priority patent/YU270076A/xx
Priority to BE172045A priority patent/BE847941A/xx
Priority to PT65791A priority patent/PT65791B/pt
Priority to AT812276A priority patent/AT359642B/de
Priority to IL50836A priority patent/IL50836A/xx
Priority to ES452942A priority patent/ES452942A1/es
Priority to FR7633231A priority patent/FR2330387A1/fr
Priority to FR7711993A priority patent/FR2338251A1/fr
Priority to US05/914,118 priority patent/US4210581A/en
Priority to AT0768178A priority patent/AT364453B/de
Priority to CH543479A priority patent/CH619735A5/de
Priority to NZ191876A priority patent/NZ191876A/xx
Publication of CH614931A5 publication Critical patent/CH614931A5/xx
Priority to CA353,123A priority patent/CA1106303A/en
Priority to FI802084A priority patent/FI60718C/fi
Priority to SE8202039A priority patent/SE8202039L/sv
Priority to DK277085A priority patent/DK277085A/da
Priority to JP61215602A priority patent/JPS6277399A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/885—Trichoderma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH1419575A 1975-11-04 1975-11-04 CH614931A5 (ru)

Priority Applications (36)

Application Number Priority Date Filing Date Title
CH1419575A CH614931A5 (ru) 1975-11-04 1975-11-04
DE2661031A DE2661031C2 (ru) 1975-11-04 1976-10-23
DE2648121A DE2648121C2 (de) 1975-11-04 1976-10-23 Dihydro-cyclosporin C, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel
ZA00766340A ZA766340B (en) 1975-11-04 1976-10-25 Improvements in or relating to organic compounds
FI763049A FI60701C (fi) 1975-11-04 1976-10-26 Foerfarande foer framstaellning av terapeutiskt anvaendbar dihydrocyklosporin c
DK483176A DK148907C (da) 1975-11-04 1976-10-26 Analogifremgangsmaade til fremstilling af dihydrocyclosporin c
NO763667A NO763667L (ru) 1975-11-04 1976-10-27
US05/736,106 US4108985A (en) 1975-11-04 1976-10-27 Dihydrocyclosporin c
SE7611906A SE432247B (sv) 1975-11-04 1976-10-27 Sett att framstella dihydro-cyklosporin c
NL7612026A NL7612026A (nl) 1975-11-04 1976-10-29 Werkwijzen voor het bereiden en toepassen van een cyclisch amidederivaat.
GB45485/76A GB1567201A (en) 1975-11-04 1976-11-02 Sandoz ltd
IE2439/76A IE44749B1 (en) 1975-11-04 1976-11-02 Dihydrocyclosporin c
NZ182496A NZ182496A (en) 1975-11-04 1976-11-02 Cyclosporin c from tolypocladium inflatum gams or cylindrocarpon lucidum booth dihydrocyclosporin c
PH19079A PH14725A (en) 1975-11-04 1976-11-02 A cyclosporin derivative
GB19922/79A GB1567202A (en) 1975-11-04 1976-11-02 Sandoz ltd
CA264,703A CA1087609A (en) 1975-11-04 1976-11-02 Dihydrocyclosporin c
AU19262/76A AU513538B2 (en) 1975-11-04 1976-11-02 Dihydrocyclosporin c and cyclosporin c
JP51131314A JPS5259180A (en) 1975-11-04 1976-11-02 Improving concerning organic compound
IE2379/81A IE44750B1 (en) 1975-11-04 1976-11-02 Cyclosporin c
IL50836A IL50836A (en) 1975-11-04 1976-11-03 Dihydrocyclosphorin c,a process for the preparation thereoof and pharmaceutical compositions containing this compound
BE172045A BE847941A (fr) 1975-11-04 1976-11-03 Nouveau compose peptidique, sa preparation et son application comme medicament
PT65791A PT65791B (fr) 1975-11-04 1976-11-03 Procede pour la preparation de nouveaux composes organiques a effet pharmaceutique
AT812276A AT359642B (de) 1975-11-04 1976-11-03 Verfahren zur herstellung eines neuen ring- peptids
YU02700/76A YU270076A (en) 1975-11-04 1976-11-03 Process for preparing new organic compunds
ES452942A ES452942A1 (es) 1975-11-04 1976-11-03 Procedimiento para la produccion de dihidrociclosporina c.
FR7633231A FR2330387A1 (fr) 1975-11-04 1976-11-04 Nouveau compose peptidique, sa preparation et son application comme medicament
FR7711993A FR2338251A1 (fr) 1975-11-04 1977-04-21 Nouveau compose peptidique et sa preparation
US05/914,118 US4210581A (en) 1975-11-04 1978-06-09 Organic compounds
AT0768178A AT364453B (de) 1975-11-04 1978-10-27 Verfahren zur herstellung eines neuen ringpeptids
CH543479A CH619735A5 (ru) 1975-11-04 1979-06-11
NZ191876A NZ191876A (en) 1975-11-04 1979-10-18 Cyclosporin c and its preparation
CA353,123A CA1106303A (en) 1975-11-04 1980-05-30 Cyclosporin c from tolypocladium or cylindrocarbon
FI802084A FI60718C (fi) 1975-11-04 1980-06-30 En ny ringpeptid cyklosporin c anvaendbar som mellanprodukt vid framstaellning av dihydrocyklosporin c och ett foerfarande foer dess framstaellning
SE8202039A SE8202039L (sv) 1975-11-04 1982-03-30 Cyklosporin c och sett att framstella denna forening
DK277085A DK277085A (da) 1975-11-04 1985-06-19 Mellemprodukt til anvendelse ved fremstilling af dihydrocyclosporin c
JP61215602A JPS6277399A (ja) 1975-11-04 1986-09-11 シクロスポリンｃ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1419575A CH614931A5 (ru) 1975-11-04 1975-11-04

Publications (1)

Publication Number Publication Date
CH614931A5 true CH614931A5 (ru) 1979-12-28

Family

ID=4398730

Family Applications (2)

Application Number Title Priority Date Filing Date
CH1419575A CH614931A5 (ru) 1975-11-04 1975-11-04
CH543479A CH619735A5 (ru) 1975-11-04 1979-06-11

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH543479A CH619735A5 (ru) 1975-11-04 1979-06-11

Country Status (23)

Country Link
US (1) US4108985A (ru)
JP (2) JPS5259180A (ru)
AT (1) AT359642B (ru)
AU (1) AU513538B2 (ru)
BE (1) BE847941A (ru)
CA (1) CA1087609A (ru)
CH (2) CH614931A5 (ru)
DE (2) DE2648121C2 (ru)
DK (1) DK148907C (ru)
ES (1) ES452942A1 (ru)
FI (1) FI60701C (ru)
FR (2) FR2330387A1 (ru)
GB (2) GB1567201A (ru)
IE (2) IE44749B1 (ru)
IL (1) IL50836A (ru)
NL (1) NL7612026A (ru)
NO (1) NO763667L (ru)
NZ (1) NZ182496A (ru)
PH (1) PH14725A (ru)
PT (1) PT65791B (ru)
SE (2) SE432247B (ru)
YU (1) YU270076A (ru)
ZA (1) ZA766340B (ru)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210581A (en) * 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
FR2410658A1 (fr) * 1977-11-30 1979-06-29 Science Union & Cie Nouveau produit biologique d'origine fongique, son obtention et son application a la therapeutique
DE2907460A1 (de) * 1978-03-07 1979-09-13 Sandoz Ag Neue resorbierbare galenische kompositionen
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4201771A (en) * 1979-03-12 1980-05-06 Merck & Co., Inc. Antibiotic A43F
JPS5665853A (en) * 1979-11-01 1981-06-03 Sankyo Co Ltd Mycoplanesin derivative and its preparation
EP0098457B1 (en) * 1980-02-14 1987-08-05 Sandoz Ag (1s,2r,3r)- and (1r,2s,3s)-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes useful in the total synthesis of cyclosporins and processes for their production
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
US4370266A (en) * 1980-04-07 1983-01-25 Sankyo Company, Limited Mycoplanecin derivatives and their preparation
EP0056782B1 (en) * 1981-01-09 1984-08-01 Sandoz Ag Novel cyclosporins
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
GB8422253D0 (en) * 1984-09-04 1984-10-10 Sandoz Ltd Organic compounds
ATE92501T1 (de) 1984-10-04 1993-08-15 Sandoz Ag Monoklonale antikoerper gegen zyklosporine.
US4727035A (en) * 1984-11-14 1988-02-23 Mahoney Walter C Immunoassay for cyclosporin
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
ATE95193T1 (de) * 1987-06-17 1993-10-15 Sandoz Ag Cyclosporine und deren benutzung als arzneimittel.
DE3888357T2 (de) * 1987-06-22 1994-09-15 Merck & Co Inc Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.
GB8717300D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
GB8717299D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Peptides
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
WO1989001772A1 (en) * 1987-09-03 1989-03-09 University Of Georgia Research Foundation, Inc. Ocular cyclosporin composition
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
US4943560A (en) * 1988-04-06 1990-07-24 Regents Of The University Of Minnesota Solvent system for chronic vascular infusion of hydrophobic drugs
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en) * 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
WO1992013094A1 (fr) * 1991-01-25 1992-08-06 Fujisawa Pharmaceutical Co., Ltd. Procede pour produire de la cyclosporine a et/ou c
ES2065273B1 (es) * 1993-05-25 1995-09-16 Biogal Gyogyszergyar Procedimiento para la purificacion de ciclosporina a.
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
ES2229473T3 (es) 1997-01-30 2005-04-16 Novartis Ag Composiciones farmaceuticas sin aceite que contienen ciclosporina a.
US6008191A (en) * 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
US6187747B1 (en) 1997-09-08 2001-02-13 Panacea Biotech Limited Pharmaceutical composition comprising cyclosporin
IN188719B (ru) * 1997-09-08 2002-11-02 Panacea Biotec Ltd
US6346511B1 (en) 1997-09-08 2002-02-12 Panacea Biotec Limited Pharmaceutical composition comprising cyclosporin
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
NZ502362A (en) 1997-10-08 2001-05-25 Isotechnika Inc Deuterated cyclosporine A derivatives and their use as immunomodulating agents
ATE312843T1 (de) 1998-07-01 2005-12-15 Debiopharm Sa Neues cyclosporin mit verbesserter wirkung
AU2002333098B2 (en) * 2001-10-19 2006-03-16 Isotechnika Pharma Inc. Novel cyclosporin analog microemulsion preconcentrates
WO2003033526A2 (en) * 2001-10-19 2003-04-24 Isotechnika Inc. Synthesis of cyclosporin analogs
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
JP2008514702A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
US7378391B2 (en) 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
JP2008515886A (ja) 2004-10-06 2008-05-15 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
US10137083B2 (en) * 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
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WO2008036244A1 (en) * 2006-09-18 2008-03-27 The Burham Institute For Medical Research Use of cyclosporin a to sensitize resistant cancer cells to death receptor ligands
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
EP2391376A4 (en) * 2009-01-30 2012-08-01 Enanta Pharm Inc ANALOGUES OF CYCLOSPORIN FOR PREVENTING OR TREATING HEPATITIS C INFECTION
US8481483B2 (en) * 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) * 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8623814B2 (en) * 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
WO2012009715A2 (en) 2010-07-16 2012-01-19 S&T Global Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012021796A2 (en) 2010-08-12 2012-02-16 S&T Global, Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
AU2011342284C1 (en) 2010-12-15 2017-07-13 Contravir Pharmaceuticals, Inc. Cyclosporine analogue molecules modified at amino acid 1 and 3
WO2012145426A1 (en) 2011-04-18 2012-10-26 The Trustees Of Columbia University In The City Of New York Methods to treat cancer using cyclosporine and cyclosporine derivatives
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
CN105579046A (zh) 2013-08-26 2016-05-11 英安塔制药有限公司 用于预防或治疗丙型肝炎的环孢菌素类似物
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Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
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Also Published As

Publication number Publication date
BE847941A (fr) 1977-05-03
IE44749L (en) 1977-05-04
AT359642B (de) 1980-11-25
FR2330387B1 (ru) 1980-03-14
SE7611906L (sv) 1977-05-05
JPS5259180A (en) 1977-05-16
SE432247B (sv) 1984-03-26
GB1567202A (en) 1980-05-14
GB1567201A (en) 1980-05-14
CA1087609A (en) 1980-10-14
ES452942A1 (es) 1978-01-16
FR2338251A1 (fr) 1977-08-12
DK148907B (da) 1985-11-11
IL50836A0 (en) 1977-01-31
CH619735A5 (ru) 1980-10-15
DE2648121C2 (de) 1986-05-28
FI60701C (fi) 1982-03-10
NL7612026A (nl) 1977-05-06
NZ182496A (en) 1981-12-15
AU1926276A (en) 1978-05-11
ATA812276A (de) 1980-04-15
YU270076A (en) 1982-05-31
JPS6253520B2 (ru) 1987-11-10
IE44750B1 (en) 1982-03-24
PT65791A (fr) 1976-12-01
IL50836A (en) 1979-10-31
US4108985A (en) 1978-08-22
AU513538B2 (en) 1980-12-11
FI60701B (fi) 1981-11-30
DK148907C (da) 1986-04-07
DK483176A (da) 1977-05-05
FR2338251B1 (ru) 1984-01-13
NO763667L (ru) 1977-05-05
FR2330387A1 (fr) 1977-06-03
JPS6277399A (ja) 1987-04-09
PT65791B (fr) 1978-07-05
IE44750L (en) 1977-05-04
DE2648121A1 (de) 1977-05-12
JPS6210240B2 (ru) 1987-03-05
DE2661031C2 (ru) 1988-05-05
ZA766340B (en) 1978-06-28
SE8202039L (sv) 1982-03-30
FI763049A (ru) 1977-05-05
IE44749B1 (en) 1982-03-24
PH14725A (en) 1981-11-13

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