CH605827A5 - 2,4-diamino-5-(3,5-dialkoxy-4-halo-benzyl)-pyrimidines - Google Patents

2,4-diamino-5-(3,5-dialkoxy-4-halo-benzyl)-pyrimidines

Info

Publication number
CH605827A5
CH605827A5 CH1424374A CH1424374A CH605827A5 CH 605827 A5 CH605827 A5 CH 605827A5 CH 1424374 A CH1424374 A CH 1424374A CH 1424374 A CH1424374 A CH 1424374A CH 605827 A5 CH605827 A5 CH 605827A5
Authority
CH
Switzerland
Prior art keywords
water
solution
mixture
acid
hours
Prior art date
Application number
CH1424374A
Other languages
German (de)
English (en)
Inventor
Ivan Dr Kompis
Max Dr Hoffer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CH1568073A priority Critical patent/CH591457A5/de
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CH1424374A priority patent/CH605827A5/de
Priority to ZA00746946A priority patent/ZA746946B/xx
Priority to JP49127244A priority patent/JPS6119628B2/ja
Priority to US05/521,384 priority patent/US4024145A/en
Priority to DK579374AA priority patent/DK136470B/da
Priority to SE7413958A priority patent/SE419444B/xx
Priority to DE2452889A priority patent/DE2452889C2/de
Priority to BE150277A priority patent/BE821932A/fr
Priority to NLAANVRAGE7414528,A priority patent/NL184619C/xx
Priority to CA213,261A priority patent/CA1018166A/fr
Priority to AT892374A priority patent/AT342597B/de
Priority to AU75105/74A priority patent/AU491362B2/en
Priority to GB4842574A priority patent/GB1449387A/en
Priority to GB539776A priority patent/GB1449388A/en
Priority to FR7437149A priority patent/FR2250533B1/fr
Priority to CA226,346A priority patent/CA1017743A/fr
Priority to CA234,838A priority patent/CA1042891A/fr
Priority to US05/769,971 priority patent/US4076810A/en
Publication of CH605827A5 publication Critical patent/CH605827A5/de
Priority to JP59155724A priority patent/JPS6064968A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CH1424374A 1973-11-08 1974-10-24 2,4-diamino-5-(3,5-dialkoxy-4-halo-benzyl)-pyrimidines CH605827A5 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
CH1568073A CH591457A5 (fr) 1973-11-08 1973-11-08
CH1424374A CH605827A5 (en) 1973-11-08 1974-10-24 2,4-diamino-5-(3,5-dialkoxy-4-halo-benzyl)-pyrimidines
ZA00746946A ZA746946B (en) 1973-11-08 1974-10-29 Novel benzylpyrimidines
JP49127244A JPS6119628B2 (fr) 1973-11-08 1974-11-06
US05/521,384 US4024145A (en) 1973-11-08 1974-11-06 Benzylpyrimidine derivatives
DK579374AA DK136470B (da) 1973-11-08 1974-11-06 Analogifremgangsmåde til fremstilling af 2,4-diamino-5-benzylpyrimidinderivater eller salte deraf.
SE7413958A SE419444B (sv) 1973-11-08 1974-11-06 Forfarande for framstellning av nya 2,4-diamino-5-bensylpyrimidinderivat
NLAANVRAGE7414528,A NL184619C (nl) 1973-11-08 1974-11-07 Werkwijze ter bereiding van anti-bacterieel werkzame farmaceutische preparaten alsmede werkwijze ter bereiding van voor toepassing daarbij geschikte 5-benzyl-2,4-diaminopyrimidinederivaten.
BE150277A BE821932A (fr) 1973-11-08 1974-11-07 Nouvelles benzylpyrimidines
DE2452889A DE2452889C2 (de) 1973-11-08 1974-11-07 Neue Benzylpyrimidine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
CA213,261A CA1018166A (fr) 1973-11-08 1974-11-07 Benzylpyrimidines
AT892374A AT342597B (de) 1973-11-08 1974-11-07 Verfahren zur herstellung von neuen benzylpyrimidinen und deren salzen
AU75105/74A AU491362B2 (en) 1974-11-07 Novel benzylpyrimides
GB539776A GB1449388A (en) 1973-11-08 1974-11-08 Hydrocinnamic acid nitriles
GB4842574A GB1449387A (en) 1973-11-08 1974-11-08 Benzylpyrimidine derivatives
FR7437149A FR2250533B1 (fr) 1973-11-08 1974-11-08
CA226,346A CA1017743A (fr) 1973-11-08 1975-05-06 Benzylpyrimidines
CA234,838A CA1042891A (fr) 1974-10-24 1975-09-05 Benzylpyrimidines
US05/769,971 US4076810A (en) 1973-11-08 1977-02-18 Benzylpyrimidine antibacterial composition
JP59155724A JPS6064968A (ja) 1973-11-08 1984-07-27 ベンジルピリミジンの製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41403073A 1973-11-08 1973-11-08
CH1424374A CH605827A5 (en) 1973-11-08 1974-10-24 2,4-diamino-5-(3,5-dialkoxy-4-halo-benzyl)-pyrimidines

Publications (1)

Publication Number Publication Date
CH605827A5 true CH605827A5 (en) 1978-10-13

Family

ID=25714034

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1424374A CH605827A5 (en) 1973-11-08 1974-10-24 2,4-diamino-5-(3,5-dialkoxy-4-halo-benzyl)-pyrimidines

Country Status (5)

Country Link
JP (1) JPS6064968A (fr)
BE (1) BE821932A (fr)
CA (1) CA1018166A (fr)
CH (1) CH605827A5 (fr)
ZA (1) ZA746946B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1212907B (it) * 1983-12-21 1989-11-30 Romeo Aurelio Preparazione di fenoli alogenati
DE112012006810B4 (de) 2012-08-14 2021-01-21 Mitsubishi Electric Corporation Doppeldeckaufzug

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2065367C2 (de) * 1969-03-06 1985-04-04 The Wellcome Foundation Ltd., London Verfahren zur Herstellung von 2,4- Diamino-5-benzylpyrimidinen
JPS494462A (fr) * 1972-04-25 1974-01-16
JPS5216632A (en) * 1975-07-30 1977-02-08 Matsushita Electric Ind Co Ltd High voltage generation apparatus

Also Published As

Publication number Publication date
ZA746946B (en) 1975-11-26
JPH0341467B2 (fr) 1991-06-24
JPS6064968A (ja) 1985-04-13
CA1018166A (fr) 1977-09-27
BE821932A (fr) 1975-05-07

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Owner name: F. HOFFMANN-LA ROCHE AG

PL Patent ceased