CH591457A5 - - Google Patents

Info

Publication number
CH591457A5
CH591457A5 CH1568073A CH1568073A CH591457A5 CH 591457 A5 CH591457 A5 CH 591457A5 CH 1568073 A CH1568073 A CH 1568073A CH 1568073 A CH1568073 A CH 1568073A CH 591457 A5 CH591457 A5 CH 591457A5
Authority
CH
Switzerland
Prior art keywords
bromo
acid
pyrimidine
diamino
compound
Prior art date
Application number
CH1568073A
Other languages
German (de)
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CH1568073A priority Critical patent/CH591457A5/de
Priority claimed from CH1424374A external-priority patent/CH605827A5/de
Priority to US05/521,384 priority patent/US4024145A/en
Priority to JP49127244A priority patent/JPS6119628B2/ja
Priority to IL46008A priority patent/IL46008A/xx
Priority to DK579374AA priority patent/DK136470B/da
Priority to SE7413958A priority patent/SE419444B/xx
Priority to AU75105/74A priority patent/AU491362B2/en
Priority to NLAANVRAGE7414528,A priority patent/NL184619C/xx
Priority to AT892374A priority patent/AT342597B/de
Priority to DE2452889A priority patent/DE2452889C2/de
Priority to FR7437149A priority patent/FR2250533B1/fr
Priority to GB4842574A priority patent/GB1449387A/en
Priority to GB539776A priority patent/GB1449388A/en
Priority to CA226,346A priority patent/CA1017743A/fr
Priority to US05/769,971 priority patent/US4076810A/en
Publication of CH591457A5 publication Critical patent/CH591457A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH1568073A 1973-11-08 1973-11-08 CH591457A5 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
CH1568073A CH591457A5 (fr) 1973-11-08 1973-11-08
US05/521,384 US4024145A (en) 1973-11-08 1974-11-06 Benzylpyrimidine derivatives
JP49127244A JPS6119628B2 (fr) 1973-11-08 1974-11-06
IL46008A IL46008A (en) 1973-11-08 1974-11-06 2,4-diamino-5-(4-halo-3,5-dialkoxybenzyl)-pyrimidines, their manufacture and antibacterial compositions containing them
DK579374AA DK136470B (da) 1973-11-08 1974-11-06 Analogifremgangsmåde til fremstilling af 2,4-diamino-5-benzylpyrimidinderivater eller salte deraf.
SE7413958A SE419444B (sv) 1973-11-08 1974-11-06 Forfarande for framstellning av nya 2,4-diamino-5-bensylpyrimidinderivat
DE2452889A DE2452889C2 (de) 1973-11-08 1974-11-07 Neue Benzylpyrimidine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
AU75105/74A AU491362B2 (en) 1974-11-07 Novel benzylpyrimides
NLAANVRAGE7414528,A NL184619C (nl) 1973-11-08 1974-11-07 Werkwijze ter bereiding van anti-bacterieel werkzame farmaceutische preparaten alsmede werkwijze ter bereiding van voor toepassing daarbij geschikte 5-benzyl-2,4-diaminopyrimidinederivaten.
AT892374A AT342597B (de) 1973-11-08 1974-11-07 Verfahren zur herstellung von neuen benzylpyrimidinen und deren salzen
FR7437149A FR2250533B1 (fr) 1973-11-08 1974-11-08
GB4842574A GB1449387A (en) 1973-11-08 1974-11-08 Benzylpyrimidine derivatives
GB539776A GB1449388A (en) 1973-11-08 1974-11-08 Hydrocinnamic acid nitriles
CA226,346A CA1017743A (fr) 1973-11-08 1975-05-06 Benzylpyrimidines
US05/769,971 US4076810A (en) 1973-11-08 1977-02-18 Benzylpyrimidine antibacterial composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1568073A CH591457A5 (fr) 1973-11-08 1973-11-08
CH1424374A CH605827A5 (en) 1973-11-08 1974-10-24 2,4-diamino-5-(3,5-dialkoxy-4-halo-benzyl)-pyrimidines

Publications (1)

Publication Number Publication Date
CH591457A5 true CH591457A5 (fr) 1977-09-15

Family

ID=25714033

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1568073A CH591457A5 (fr) 1973-11-08 1973-11-08

Country Status (2)

Country Link
US (1) US4024145A (fr)
CH (1) CH591457A5 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
CA2095518A1 (fr) * 1990-11-14 1992-05-15 Jeffrey M. Blaney Inhibition specifique de la dihydrofolate-reductase et composes utilises
KR100822530B1 (ko) 2004-03-05 2008-04-16 에프. 호프만-라 로슈 아게 Ｐ2ｘ3 및 ｐ2ｘ2/3 길항물질로서의 다이아미노피리미딘
JP4850913B2 (ja) * 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３及びｐ２ｘ２／３調節因子としてのジアミノピリジン
CN101253159B (zh) * 2005-09-01 2011-12-07 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物
EP1924564B1 (fr) * 2005-09-01 2016-11-09 F.Hoffmann-La Roche Ag Diaminopyrimidines en tant que modulateurs de p2x3 et p2x2/3

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2658897A (en) * 1951-06-27 1953-11-10 Burroughs Wellcome Co 2, 4-diamino-5-benzyl pyrimidines
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes
CH513181A (de) * 1969-06-12 1971-09-30 Hoffmann La Roche Verfahren zur Herstellung von N-Oxyden von Benzylpyrimidinen

Also Published As

Publication number Publication date
US4024145A (en) 1977-05-17

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Legal Events

Date Code Title Description
PUE Assignment

Owner name: F. HOFFMANN-LA ROCHE AG

PL Patent ceased