CH581660A5 - - Google Patents

Info

Publication number
CH581660A5
CH581660A5 CH875371A CH875371A CH581660A5 CH 581660 A5 CH581660 A5 CH 581660A5 CH 875371 A CH875371 A CH 875371A CH 875371 A CH875371 A CH 875371A CH 581660 A5 CH581660 A5 CH 581660A5
Authority
CH
Switzerland
Application number
CH875371A
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH581660A5 publication Critical patent/CH581660A5/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH875371A 1970-06-16 1971-06-15 CH581660A5 (no)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
GB320473A GB1348985A (en) 1970-06-16 1970-06-16 Esters of cephalosporin compounds
GB2915870 1970-06-16
GB3341570 1970-07-09
GB4655670 1970-09-30
GB5873170 1970-12-10
GB329871 1971-01-27
GB329771 1971-01-27
GB329671 1971-01-27
GB417971 1971-02-08
GB448071 1971-02-11
GB447971 1971-02-11
GB558871 1971-02-26

Publications (1)

Publication Number Publication Date
CH581660A5 true CH581660A5 (no) 1976-11-15

Family

ID=57538775

Family Applications (1)

Application Number Title Priority Date Filing Date
CH875371A CH581660A5 (no) 1970-06-16 1971-06-15

Country Status (18)

Country Link
US (1) US4297488A (no)
JP (3) JPS5946955B2 (no)
AR (1) AR197864A1 (no)
AT (1) AT321457B (no)
CA (1) CA965089A (no)
CH (1) CH581660A5 (no)
CS (3) CS194176B2 (no)
DE (1) DE2129675C3 (no)
DK (2) DK157320C (no)
EG (1) EG10530A (no)
FI (2) FI56686C (no)
GB (2) GB1348984A (no)
HK (1) HK20878A (no)
IE (1) IE35656B1 (no)
IL (1) IL36989A (no)
NO (2) NO145883C (no)
PH (1) PH11550A (no)
YU (1) YU35602B (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR206201A1 (es) * 1972-06-29 1976-07-07 Ciba Geigy Ag Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos
SE428022B (sv) * 1972-06-29 1983-05-30 Ciba Geigy Ag 7beta-amino-cefam-3-on-4-karboxylsyraforeningar till anvendning for framstellning av cefalosporinderivat
AR206204A1 (es) * 1972-10-16 1976-07-07 Lilly Co Eli Procedimiento para la preparacion de 7-acilamido-7-alcoxicefalosporinas
US3962232A (en) * 1973-11-05 1976-06-08 Eli Lilly And Company 7-methoxycephalosporins
GB1449420A (en) * 1973-11-26 1976-09-15 Sankyo Co 7alpha-methoxycephalosporing derivatives
CH617703A5 (en) * 1973-12-21 1980-06-13 Glaxo Operations Ltd Process for the preparation of the syn-isomer or of a mixture of syn- and anti-isomers of novel antibiotically active 7 beta -acylamino-ceph-3-em-4-carboxylic acids
DK151027C (da) * 1974-08-09 1988-03-07 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af 7alfa-methoxy-7beta-(2-aminothiazol-4-ylacetamido)cephalosporiner eller farmaceutisk acceptable salte eller estere deraf
NL189298C (nl) * 1975-11-21 1993-03-01 Merck & Co Inc Werkwijze voor de bereiding van een farmaceutisch preparaat met antibiotische werking en werkwijze voor de bereiding van een thienamycinederivaat.
AU512383B2 (en) * 1975-11-21 1980-10-09 Merck & Co., Inc. Thinenamycin derivatives
CH632508A5 (de) * 1975-11-21 1982-10-15 Merck & Co Inc Verfahren zur herstellung von neuen estern des n-acylierten thienamycins.
US4368198A (en) * 1976-03-03 1983-01-11 Sumitomo Chemical Company Limited Cephalosporins
JPS5321191A (en) * 1976-08-10 1978-02-27 Shionogi & Co Ltd 7-arylmalonamidocephem derivatives
US4101661A (en) 1977-06-03 1978-07-18 Warner-Lambert Novel antibacterial amide compounds and process means for producing the same
JPS6052713B2 (ja) * 1978-04-11 1985-11-20 三共株式会社 ７−メトキシセフアロスポリン化合物、その製法及びその化合物を主成分とする抗菌剤
JPS5583791A (en) * 1978-12-18 1980-06-24 Meiji Seika Kaisha Ltd 7-methoxycephalosporin derivative and its preparation
GB2161803B (en) * 1981-07-25 1986-07-23 Beecham Group Plc Intermediates for b-lactam antibiotics
US4623645A (en) 1983-04-18 1986-11-18 Merck & Co., Inc. Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
US5132301A (en) * 1983-05-02 1992-07-21 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
EP0168177A3 (en) * 1984-06-28 1987-04-01 Pfizer Limited Cephalosporin antibiotics
GB8531202D0 (en) * 1985-12-18 1986-01-29 Pfizer Ltd Cephalosporin antibiotics
JPS6466192A (en) * 1987-09-07 1989-03-13 Meiji Seika Kaisha Beta-lactams and their preparation
JPH04118219U (ja) * 1991-03-27 1992-10-22 石川島播磨重工業株式会社 横押しベンダ−の自動送り装置
US6159706A (en) * 1997-12-23 2000-12-12 Newbiotics, Inc. Application of enzyme prodrugs as anti-infective agents
WO2004083217A1 (en) * 2003-03-20 2004-09-30 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefoxitin
AU2003294161A1 (en) * 2003-03-20 2004-10-11 Orchid Chemicals And Pharmaceuticals Ltd An improved process for the preparation of cefoxitin
WO2006006040A2 (en) * 2004-07-05 2006-01-19 Orchid Chemicals & Pharmaceuticals Limited News diamine salts of cephalosporin antibiotics and their preparation
ITMI20071951A1 (it) * 2007-10-09 2008-01-08 Acs Dobfar Spa Processo per la produzione di 7-metossi-3-desacetilcefalotina
CN101429538B (zh) * 2008-12-12 2011-05-25 河北九派制药有限公司 7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法
CN102391290B (zh) * 2011-05-31 2013-01-02 深圳信立泰药业股份有限公司 头孢西丁酸无水结晶物、其制备方法及由其制备头孢西丁钠的方法
CN104230956B (zh) * 2012-04-24 2016-07-06 齐鲁安替（临邑）制药有限公司 一种头孢西丁的制备方法
CN102633819A (zh) * 2012-04-24 2012-08-15 齐鲁安替（临邑）制药有限公司 一种头孢西丁的制备方法
CN105385746A (zh) * 2015-11-02 2016-03-09 四川清山绿水实业发展有限公司 一种头孢西丁酸的合成方法
CN111217836A (zh) * 2020-03-20 2020-06-02 侯二美 一种头孢西丁的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1960643A1 (de) * 1968-12-12 1970-07-02 Ciba Geigy Verfahren zur Herstellung neuer Derivate der 7-Aminocephalosporansaeure
US4173702A (en) * 1969-08-12 1979-11-06 Eli Lilly And Company 7-(5-Amino-5-carboxyvaler-amido)-3-(carbamoyloxymethyl)-7-methoxy-3-cephem-4-carboxylic acid
BE754693A (fr) 1969-08-12 1971-02-11 Lilly Co Eli Nouvel antibiotique et procede pour le preparer
US3914157A (en) * 1970-03-13 1975-10-21 Merck & Co Inc Preparation of antibiotics by fermentation
US3719563A (en) * 1970-08-03 1973-03-06 Lilly Co Eli Process for producing 7-(5-amino-5-carboxyvaleramido)-7-methoxycephalosporamic acid
US3687947A (en) * 1970-10-29 1972-08-29 Lilly Co Eli Method for recovery of cephaloridine
US3985742A (en) * 1971-12-01 1976-10-12 Merck & Co., Inc. Process for preparing 3-hydroxymethyl cephalosporins
US3801464A (en) * 1972-02-09 1974-04-02 Lilly Co Eli Antibiotic a16886 and process for production thereof
USB526096I5 (no) 1972-06-07 1976-02-03
US3920639A (en) * 1973-04-23 1975-11-18 Squibb & Sons Inc Cyanomethylthioacetyl-7-methoxycephalosporins
US3962232A (en) * 1973-11-05 1976-06-08 Eli Lilly And Company 7-methoxycephalosporins
GB1449420A (en) * 1973-11-26 1976-09-15 Sankyo Co 7alpha-methoxycephalosporing derivatives
US4017487A (en) * 1973-12-01 1977-04-12 Merck & Co., Inc. 7β-(D-5-amino-5-carboxyvaleramido)-7-methoxy-3-substituted-3-cephem-4-carboxylic acid antibiotics
US4036696A (en) * 1975-01-14 1977-07-19 Merck & Co., Inc. Preparation of antibiotics by fermentation
US4005081A (en) * 1975-09-11 1977-01-25 E. R. Squibb & Sons, Inc. 3-Heterothiomethyl-7α-methoxy-7β-tetrazolylmethylthioacetamido-3-cephem derivatives
US4165429A (en) * 1976-06-28 1979-08-21 Yamanouchi Pharmaceutical Co., Ltd. 7α-METHOXY-CEPHALOSPORANIC ACID DERIVATIVES

Also Published As

Publication number Publication date
DK157320B (da) 1989-12-11
IE35656B1 (en) 1976-04-14
NO145884C (no) 1982-06-16
NO145883C (no) 1982-06-16
FI56686C (fi) 1980-03-10
CA965089A (en) 1975-03-25
HK20878A (en) 1978-04-28
DK158672C (da) 1991-01-14
FI772428A (no) 1977-08-12
JPS5677286A (en) 1981-06-25
IE35656L (en) 1971-12-16
EG10530A (en) 1976-12-31
CS194155B2 (en) 1979-11-30
YU148071A (en) 1980-09-25
IL36989A (en) 1977-08-31
JPS5677284A (en) 1981-06-25
JPS5946956B2 (ja) 1984-11-15
FI57954C (fi) 1980-11-10
FI57954B (fi) 1980-07-31
IL36989A0 (en) 1971-08-25
DE2129675C3 (de) 1981-07-09
CS194177B2 (en) 1979-11-30
PH11550A (en) 1978-03-31
DK444478A (da) 1978-10-06
AT321457B (de) 1975-04-10
DK157320C (da) 1990-05-07
JPS5946955B2 (ja) 1984-11-15
US4297488A (en) 1981-10-27
JPS5946954B2 (ja) 1984-11-15
NO145884B (no) 1982-03-08
YU35602B (en) 1981-04-30
CS194176B2 (en) 1979-11-30
AR197864A1 (es) 1974-05-15
DK158672B (da) 1990-07-02
GB1348984A (en) 1974-03-27
DE2129675A1 (de) 1971-12-23
JPS5677285A (en) 1981-06-25
GB1348985A (en) 1974-03-27
NO145883B (no) 1982-03-08
FI56686B (fi) 1979-11-30
DE2129675B2 (de) 1980-10-30

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Legal Events

Date Code Title Description
PL Patent ceased