CH389635A - Verfahren zur Herstellung basisch substituierter Pyrimido-(5,4-d)-pyrimidine - Google Patents
Verfahren zur Herstellung basisch substituierter Pyrimido-(5,4-d)-pyrimidineInfo
- Publication number
- CH389635A CH389635A CH51461A CH51461A CH389635A CH 389635 A CH389635 A CH 389635A CH 51461 A CH51461 A CH 51461A CH 51461 A CH51461 A CH 51461A CH 389635 A CH389635 A CH 389635A
- Authority
- CH
- Switzerland
- Prior art keywords
- pyrimidines
- pyrimidine
- cyano
- formula
- pyrimido
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 12
- JOZPEVMCAKXSEY-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine Chemical class N1=CN=CC2=NC=NC=C21 JOZPEVMCAKXSEY-UHFFFAOYSA-N 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title claims description 4
- 150000002357 guanidines Chemical class 0.000 claims description 5
- 125000003277 amino group Chemical group 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- 150000001879 copper Chemical class 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 239000000460 chlorine Substances 0.000 claims description 2
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- -1 2-amino-6-anilino-5-bromo-4cyano-pyrimidine Chemical compound 0.000 description 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 8
- 239000000843 powder Substances 0.000 description 6
- 229910021529 ammonia Inorganic materials 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- YHDMWGVBXYRWBZ-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine-2,4,6,8-tetramine Chemical class N1=C(N)N=C(N)C2=NC(N)=NC(N)=C21 YHDMWGVBXYRWBZ-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 150000003141 primary amines Chemical class 0.000 description 2
- 150000003335 secondary amines Chemical class 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- GPRBTMDKQOKNAR-UHFFFAOYSA-N 2,4,6-tri(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-8-amine Chemical compound N1(CCCCC1)C=1N=C(C2=C(N1)C(=NC(=N2)N2CCCCC2)N)N2CCCCC2 GPRBTMDKQOKNAR-UHFFFAOYSA-N 0.000 description 1
- DOYDBEIMAJENIB-UHFFFAOYSA-N 2,4-dimorpholin-4-ylpyrimido[5,4-d]pyrimidine-6,8-diamine Chemical compound O1CCN(CC1)C=1N=C(C2=C(N=1)C(=NC(=N2)N)N)N1CCOCC1 DOYDBEIMAJENIB-UHFFFAOYSA-N 0.000 description 1
- IXUYISWDRMQAKU-UHFFFAOYSA-N 2-morpholin-4-ylguanidine Chemical compound NC(=N)NN1CCOCC1 IXUYISWDRMQAKU-UHFFFAOYSA-N 0.000 description 1
- GGXZTPOYWBJVMF-UHFFFAOYSA-N 5-chloro-2,6-di(piperidin-1-yl)pyrimidine-4-carbonitrile Chemical compound N1(CCCCC1)C1=NC(=C(C(=N1)C#N)Cl)N1CCCCC1 GGXZTPOYWBJVMF-UHFFFAOYSA-N 0.000 description 1
- UMDPDPQVNYYPIG-UHFFFAOYSA-N 5-chloro-2,6-dimorpholin-4-ylpyrimidine-4-carbonitrile Chemical compound O1CCN(CC1)C1=NC(=C(C(=N1)C#N)Cl)N1CCOCC1 UMDPDPQVNYYPIG-UHFFFAOYSA-N 0.000 description 1
- IXCKLNQXWHXLFK-UHFFFAOYSA-N CNC(N=C1C#N)=NC(N2CCCC2)=C1Cl Chemical compound CNC(N=C1C#N)=NC(N2CCCC2)=C1Cl IXCKLNQXWHXLFK-UHFFFAOYSA-N 0.000 description 1
- MONZVFKYSHEOHI-UHFFFAOYSA-N CNC=1N=C(C2=C(N=1)C(=NC(=N2)N1CCCC1)N)N1CCCC1 Chemical compound CNC=1N=C(C2=C(N=1)C(=NC(=N2)N1CCCC1)N)N1CCCC1 MONZVFKYSHEOHI-UHFFFAOYSA-N 0.000 description 1
- LMAPKHLXFBHOHO-UHFFFAOYSA-N O1CCN(CC1)C=1N=C(C2=C(N=1)C(=NC(=N2)N1CCOCC1)N)N1CCOCC1 Chemical compound O1CCN(CC1)C=1N=C(C2=C(N=1)C(=NC(=N2)N1CCOCC1)N)N1CCOCC1 LMAPKHLXFBHOHO-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- BYSFISKKPBELHQ-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidin-4-amine Chemical compound N1=CN=C2C(N)=NC=NC2=C1 BYSFISKKPBELHQ-UHFFFAOYSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DET0017822 | 1960-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH389635A true CH389635A (de) | 1965-03-31 |
Family
ID=7548727
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH51461A CH389635A (de) | 1960-02-02 | 1961-01-17 | Verfahren zur Herstellung basisch substituierter Pyrimido-(5,4-d)-pyrimidine |
| CH51361A CH421972A (de) | 1960-02-02 | 1961-01-17 | Verfahren zur Herstellung von basisch substituierten Pyrimidincarbonsäuren-(4) bzw. ihren Derivaten |
| CH622165A CH423785A (de) | 1960-02-02 | 1961-01-17 | Verfahren zur Herstellung von substituierten Pyrimidincarbonsäuren-(4) |
| CH108461A CH430736A (de) | 1960-02-02 | 1961-01-30 | Verfahren zur Herstellung von v-Triazino(5,4-d) pyrimidinen |
| CH971966A CH431551A (de) | 1960-02-02 | 1961-01-30 | Verfahren zur Herstellung von v-Triazino (5,4-d) pyrimidinen |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH51361A CH421972A (de) | 1960-02-02 | 1961-01-17 | Verfahren zur Herstellung von basisch substituierten Pyrimidincarbonsäuren-(4) bzw. ihren Derivaten |
| CH622165A CH423785A (de) | 1960-02-02 | 1961-01-17 | Verfahren zur Herstellung von substituierten Pyrimidincarbonsäuren-(4) |
| CH108461A CH430736A (de) | 1960-02-02 | 1961-01-30 | Verfahren zur Herstellung von v-Triazino(5,4-d) pyrimidinen |
| CH971966A CH431551A (de) | 1960-02-02 | 1961-01-30 | Verfahren zur Herstellung von v-Triazino (5,4-d) pyrimidinen |
Country Status (5)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3694441A (en) * | 1971-03-05 | 1972-09-26 | David William Dunwell | Pyrimidotriazinone compounds |
| US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| WO2005003100A2 (en) | 2003-07-03 | 2005-01-13 | Myriad Genetics, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
| US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| EP1833482A4 (en) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3056783A (en) * | 1960-12-16 | 1962-10-02 | Searle & Co | 4-chloro-1, 2, 3-triazino[5, 4-d]pyrimidines |
| US3056782A (en) * | 1960-12-16 | 1962-10-02 | Searle & Co | Alkyl and alkoxy derivatives of 5, 7-dialkyl-6, 8-dioxo-5, 6, 7, 8-tetrahydro-1, 2, 3-triazino[5, 4-d]pyrimidines |
-
1961
- 1961-01-17 CH CH51461A patent/CH389635A/de unknown
- 1961-01-17 CH CH51361A patent/CH421972A/de unknown
- 1961-01-17 CH CH622165A patent/CH423785A/de unknown
- 1961-01-30 SE SE926/61A patent/SE301318B/xx unknown
- 1961-01-30 SE SE927/61A patent/SE301319B/xx unknown
- 1961-01-30 CH CH108461A patent/CH430736A/de unknown
- 1961-01-30 CH CH971966A patent/CH431551A/de unknown
- 1961-02-01 BE BE599769A patent/BE599769A/fr unknown
- 1961-02-01 BE BE599767A patent/BE599767A/fr unknown
- 1961-02-01 BE BE599768A patent/BE599768A/fr unknown
- 1961-02-01 DK DK43261AA patent/DK105206C/da active
-
1964
- 1964-06-16 US US375655A patent/US3213090A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CH421972A (de) | 1966-10-15 |
| CH423785A (de) | 1966-11-15 |
| CH430736A (de) | 1967-02-28 |
| US3213090A (en) | 1965-10-19 |
| SE301318B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-06-04 |
| DK105206C (da) | 1966-09-05 |
| BE599769A (fr) | 1961-05-29 |
| CH431551A (de) | 1967-03-15 |
| BE599767A (fr) | 1961-05-29 |
| BE599768A (fr) | 1961-05-29 |
| SE301319B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-06-04 |
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