CH307888A - Process for the preparation of a bactericidal salicylanilide. - Google Patents
Process for the preparation of a bactericidal salicylanilide.Info
- Publication number
- CH307888A CH307888A CH307888DA CH307888A CH 307888 A CH307888 A CH 307888A CH 307888D A CH307888D A CH 307888DA CH 307888 A CH307888 A CH 307888A
- Authority
- CH
- Switzerland
- Prior art keywords
- salicylanilide
- bactericidal
- preparation
- trichloro
- mol
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
<B>Verfahren</B> zur Herstellung eines bakteriziden Salieylanilides. Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung eines bakteriziden Salicylanilides. Das Verfahren ist dadurch ge kennzeichnet, dass man 1 Mol 4,5-Dichlor- salicy1säure auf 1 Mol 3,4,5-Trichlor-anilin einwirken lässt.
Die erhaltene neue Verbindung, das 4,5 - Diehlor-salicylsäure -3',4',5'-trichlor-anilid, schmilzt bei 276-277 . Sie soll als Desinfek tionsmittel für nicht arzneiliche Zwecke Ver wendung finden.
<I>Beispiel:</I> 52 Teile 4,5-Dichlor-salicylsäure und 50 Teile 3,4,5-Trichlor-anilin werden in 450 Teilen Chlorbenzol gelöst und ein Teil Aluminiumchlorid und 15 Teile Phosphor- triehlorid zugegeben. Diese Suspension wird so lange zum Sieden erhitzt, bis kein Chlor wasserstoff mehr entweicht, was nach unge- fähr 2-3 .Stunden der Fall ist. Die chlorben- zolische Lösung wird dann mit Wasser ver mischt und mit Soda brillantalkalisch gestellt.
Das Chlorbenzol wird mit Wasserdampf ab geblasen und der Destillationsrückstand, nach dem Abfiltrieren und Trocknen, aus Chlor benzol umkristallisiert. Das erhaltene 4,5- Dichlor - salicylsäur e - 'a ,W"5r- trichlor - anilid schmilzt bei 278-277 .
<B> Process </B> for the production of a bactericidal salieylanilide. The present patent relates to a process for the preparation of a bactericidal salicylanilide. The process is characterized in that 1 mol of 4,5-dichloro-salicic acid is allowed to act on 1 mol of 3,4,5-trichloro-aniline.
The new compound obtained, 4,5-diehlor-salicylic acid -3 ', 4', 5'-trichloro-anilide, melts at 276-277. It should be used as a disinfectant for non-medicinal purposes.
<I> Example: </I> 52 parts of 4,5-dichlorosalicylic acid and 50 parts of 3,4,5-trichloro-aniline are dissolved in 450 parts of chlorobenzene and one part of aluminum chloride and 15 parts of phosphorus trichloride are added. This suspension is heated to boiling until no more hydrogen chloride escapes, which is the case after about 2-3 hours. The chlorobenzene solution is then mixed with water and made brilliantly alkaline with soda.
The chlorobenzene is blown off with steam and the distillation residue, after filtering off and drying, recrystallized from chlorobenzene. The 4,5-dichloro-salicylic acid e - 'a, W "5r-trichloro-anilide obtained melts at 278-277.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH307888T | 1951-12-29 | ||
| CH304558T | 1951-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH307888A true CH307888A (en) | 1955-06-15 |
Family
ID=25734857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH307888D CH307888A (en) | 1951-12-29 | 1951-12-29 | Process for the preparation of a bactericidal salicylanilide. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH307888A (en) |
-
1951
- 1951-12-29 CH CH307888D patent/CH307888A/en unknown
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