CH307886A - Process for the preparation of a bactericidal salicylanilide. - Google Patents
Process for the preparation of a bactericidal salicylanilide.Info
- Publication number
- CH307886A CH307886A CH307886DA CH307886A CH 307886 A CH307886 A CH 307886A CH 307886D A CH307886D A CH 307886DA CH 307886 A CH307886 A CH 307886A
- Authority
- CH
- Switzerland
- Prior art keywords
- salicylanilide
- bactericidal
- preparation
- dichloro
- mol
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung eines hakteriziden Salieylanilides. Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung eines bakteriziden Salicylanilides. Das Verfahren ist dadurch gekennzeichnet, dass man 1 hlol 3,5-Dijod- salicylsäure auf 1 Mo1 3,4-Dichl.or-anilin ein wirken lässt.
Die erhaltene neue Verbindung, das 3,5- Dijod-salicylsäure-3',4'-dichlor-anilid, schmilzt bei 198-199 . Sie soll als Desinfektionsmittel für nicht arzneiliche Zwecke Verwendung finden.
<I>Beispiel:</I> 98 Teile 3,5-Dijod-salieylsäure und 40 Teile 3,4-Diehlor-anilin werden in 450 Teilen Chlorbenzol gelöst und ein Teil Aluminium chlorid und 15 Teile Phosphortrichlorid zu gegeben. Diese Suspension wird so lange zum Sieden erhitzt, bis kein Chlorwasserstoff mehr entweicht, was nach ungefähr 2-3 Stunden der Fall ist. Die chlorbenzolische Lösung wird dann mit Wasser vermischt und mit Soda brillantalkalisch gestellt. Das Chlorbenzol wird mit Wasserdampf abgeblasen und der Destillationsrückstand, nach dem Abfiltrieren und Trocknen, aus Chlorbenzol umkristalli siert.
Das erhaltene 3,5-Dijod-salicylsäure- 3',4'-dichlor-anilid schmilzt bei 198-199.
Process for the preparation of a bactericidal salieylanilide. The present patent relates to a process for the preparation of a bactericidal salicylanilide. The process is characterized in that 1 hlol of 3,5-diiodosalicylic acid is allowed to act on 1 mol of 3,4-dichloro-aniline.
The new compound obtained, 3,5-diiodosalicylic acid-3 ', 4'-dichloro-anilide, melts at 198-199. It should be used as a disinfectant for non-medicinal purposes.
<I> Example: </I> 98 parts of 3,5-diiodosalicic acid and 40 parts of 3,4-diehloro aniline are dissolved in 450 parts of chlorobenzene and one part of aluminum chloride and 15 parts of phosphorus trichloride are added. This suspension is heated to the boil until no more hydrogen chloride escapes, which is the case after about 2-3 hours. The chlorobenzene solution is then mixed with water and made brilliantly alkaline with soda. The chlorobenzene is blown off with steam and the distillation residue, after filtering off and drying, is recrystallized from chlorobenzene.
The 3,5-diiodosalicylic acid-3 ', 4'-dichloro-anilide obtained melts at 198-199.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH307886T | 1951-12-29 | ||
| CH304558T | 1951-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH307886A true CH307886A (en) | 1955-06-15 |
Family
ID=25734855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH307886D CH307886A (en) | 1951-12-29 | 1951-12-29 | Process for the preparation of a bactericidal salicylanilide. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH307886A (en) |
-
1951
- 1951-12-29 CH CH307886D patent/CH307886A/en unknown
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