CH310734A - Process for the preparation of a bactericidal salicylanilide. - Google Patents
Process for the preparation of a bactericidal salicylanilide.Info
- Publication number
- CH310734A CH310734A CH310734DA CH310734A CH 310734 A CH310734 A CH 310734A CH 310734D A CH310734D A CH 310734DA CH 310734 A CH310734 A CH 310734A
- Authority
- CH
- Switzerland
- Prior art keywords
- salicylanilide
- bactericidal
- preparation
- dichloro
- oxy
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren <B>zur Herstellung eines bakteriziden</B> Salicylanilides. Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung eines bakteriziden Salicylanilides. Das Verfahren ist dadurch ge kennzeichnet, dass man 1 Mol 3,5-Dichlor-2- oxy-benzol-2-carbonsäure auf 1 Mol 2,3,4-Tri- ehlor-anilin einwirken lässt.
Die erhaltene neue Verbindung, das 3,5- Dichlor- 2 - oxy-benzoyl - 2',3',4' -trichlor-anilid, schmilzt bei 224-225 . Sie soll als Desinfek tionsmittel für nicht arzneiliche Zwecke Ver wendung finden.
.Beispiel; Die Lösung von 19,5 Teilen 2,3,4-Trichlor- anilin in 400 Volumteilen Chlorbenzol wird mit 21 Teilen 3,5-Dichlor-2-oxy-benzol-l-car- bonsäure, 0,4 Teilen Aluminiumchlorid und 6 Teilen Phosphortrichlorid versetzt. Die ent standene Suspension wird so lange zum Sie den erhitzt, bis kein Salzsäuregas mehr ent- weicht.
Die entstandene Lösung wird von ge- ringen Anteilen Ungelöstem abfiltriert, mit Sodalösung neutralisiert und das Chlorbenzol mit Wasserdampf entfernt. Das nach dem Ab filtrieren und Umkristallisieren aus Äthylen- glykolmonomethyläther erhaltene 3,5-Dichlor- 2-oxy-benzoyl-2',3',4'-trichlor-anilid schmilzt bei 224-2250.
Process <B> for the production of a bactericidal </B> salicylanilide. The present patent relates to a process for the preparation of a bactericidal salicylanilide. The process is characterized in that 1 mole of 3,5-dichloro-2-oxy-benzene-2-carboxylic acid is allowed to act on 1 mole of 2,3,4-tri-chloro-aniline.
The new compound obtained, 3,5-dichloro-2-oxy-benzoyl-2 ', 3', 4 '-trichloro-anilide, melts at 224-225. It should be used as a disinfectant for non-medicinal purposes.
.Example; The solution of 19.5 parts of 2,3,4-trichloroaniline in 400 parts by volume of chlorobenzene is mixed with 21 parts of 3,5-dichloro-2-oxy-benzene-1-carboxylic acid, 0.4 part of aluminum chloride and 6 parts Phosphorus trichloride added. The resulting suspension is heated until no more hydrochloric acid gas escapes.
Small amounts of undissolved material are filtered off from the resulting solution, neutralized with soda solution and the chlorobenzene is removed with steam. The 3,5-dichloro-2-oxy-benzoyl-2 ', 3', 4'-trichloro-anilide obtained after the filter and recrystallization from ethylene glycol monomethyl ether melts at 224-2250.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH304558T | 1951-12-29 | ||
| CH310734T | 1952-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH310734A true CH310734A (en) | 1955-10-31 |
Family
ID=25734868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH310734D CH310734A (en) | 1951-12-29 | 1952-11-28 | Process for the preparation of a bactericidal salicylanilide. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH310734A (en) |
-
1952
- 1952-11-28 CH CH310734D patent/CH310734A/en unknown
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