CH187361A - Process for the preparation of N1N2-di- (2-methyl-4-aminoquinolyl-6) -melamine. - Google Patents
Process for the preparation of N1N2-di- (2-methyl-4-aminoquinolyl-6) -melamine.Info
- Publication number
- CH187361A CH187361A CH187361DA CH187361A CH 187361 A CH187361 A CH 187361A CH 187361D A CH187361D A CH 187361DA CH 187361 A CH187361 A CH 187361A
- Authority
- CH
- Switzerland
- Prior art keywords
- melamine
- methyl
- preparation
- aminoquinolyl
- methylquinoline
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung von NiNz-Di-(2-methyl-4-aminoehinolyl-6)-melamin. Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung von N1N2-D1- (2-methyl-4-amir)ochinolyl-6)-melamin, das dadurch gekennzeichnet ist, dass man etwa 2117.o14. 6-Diamino-2-methylchinolin mit etwa 1 Mol Aminoeyanurdichlorid umsetzt.
Die neue Verbindung bildet ein wasser lösliches Hydrochlorid, sie zersetzt sich bei 245". Sie soll als Arzneimittel Verwendung finden.
Beispiel: 14 g 4.6-Diamino-2-methylchinolin, ge löst in 50 cm3 Nitrobenzol bei etwa<B>1000,</B> werden unter Rühren mit 3,5 g Amino- cyanurdichlorid (Berichte 32 [1899], S. 695) versetzt. Darauf wird die Temperatur auf <B>1500</B> gesteigert und kurze Zeit gehalten. Nach dem Erkalten wird mit etwas Äther verdünnt und der Niederschlag abgesangt. Dieser wird in heisser, verdünnter Essigsäure gelöst, die Lösung mit Salzsäure angesäuert und mit Natriumchloridlösung versetzt.
Das so erhaltene Salz wird durch nochmaliges Lösen in Wasser, Filtrieren der Lösung und Aussalzen gereinigt. Es stimmt in seinen Eigenschaften und seinem gesamten Ver halten mit der in Patent 183390 beschriebenen Verbindung überein.
Process for the preparation of NiNz-di- (2-methyl-4-aminoehinolyl-6) -melamine. The subject of the present patent is a process for the preparation of N1N2-D1- (2-methyl-4-amir) oquinolyl-6) -melamine, which is characterized in that about 2117.o14. 6-diamino-2-methylquinoline is reacted with about 1 mole of aminoeyanuric dichloride.
The new compound forms a water-soluble hydrochloride, it decomposes at 245 ". It is said to be used as a medicinal product.
Example: 14 g of 4,6-diamino-2-methylquinoline, dissolved in 50 cm3 of nitrobenzene at about 1000, are mixed with 3.5 g of aminocyanuric dichloride while stirring (Reports 32 [1899], p. 695 ) offset. The temperature is then increased to <B> 1500 </B> and held for a short time. After cooling, it is diluted with a little ether and the precipitate sang off. This is dissolved in hot, dilute acetic acid, the solution is acidified with hydrochloric acid and sodium chloride solution is added.
The salt obtained in this way is purified by redissolving it in water, filtering the solution and salting out. It agrees in its properties and its overall behavior with the compound described in patent 183390.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE187361X | 1932-11-04 | ||
| CH184422T | 1933-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH187361A true CH187361A (en) | 1936-10-31 |
Family
ID=25721031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH187361D CH187361A (en) | 1932-11-04 | 1933-10-04 | Process for the preparation of N1N2-di- (2-methyl-4-aminoquinolyl-6) -melamine. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH187361A (en) |
-
1933
- 1933-10-04 CH CH187361D patent/CH187361A/en unknown
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