CH235434A - Process for the preparation of N, N'-4,4'-diphthalylamino-diphenylsulfone. - Google Patents

Process for the preparation of N, N'-4,4'-diphthalylamino-diphenylsulfone.

Info

Publication number
CH235434A
CH235434A CH235434DA CH235434A CH 235434 A CH235434 A CH 235434A CH 235434D A CH235434D A CH 235434DA CH 235434 A CH235434 A CH 235434A
Authority
CH
Switzerland
Prior art keywords
diphthalylamino
diphenylsulfone
preparation
acetic acid
water
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellschaft V Siegfried
Original Assignee
Vorm B Siegfried Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vorm B Siegfried Ag filed Critical Vorm B Siegfried Ag
Publication of CH235434A publication Critical patent/CH235434A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung von     N,N'-4,4'-Diphthalyl-amino-diphenylsulfon.       Gegenstand der vorliegenden     Erfindung     ist ein Verfahren zur Herstellung von     N,N'-          4,4'-Diphthalyl-amino-diphenylsalfon,    wel  ches dadurch gekennzeichnet ist, dass man       4,4'-Diaininodiphenylsulfon    mit     Phthalsäure-          anby        drid    in essigsaurer Lösung bei Raum  temperatur umsetzt.  



  Die neue Verbindung soll als Arzneimit  tel     sowie    als     Zwischenprodukt    zur Herstel  lung von Arzneimitteln Verwendung finden.  <I>Beispiel:</I>  17,4 g     4,4'-Diaminodiphenylsulfon    löst  man in Eisessig und versetzt bei Raumtem  peratur mit einer essigsauren Lösung von  21 g     Phthalsäureanh3Tdrid.    Nach einigem  Stehen giesst man auf Eiswasser und filtriert  vom ausgeschiedenen Niederschlag, der, aus  Wasser umkristallisiert, ein schwach gelb  lich gefärbtes Kristallpulver darstellt mit  einem Schmelzpunkt über 300 .

   Durch Um  fällen aus     Sodalösung    mit     verdünnter    Salz  säure erhält man das     reine    Kondensations-         produkt        C@$H-#QO"N,S,    das folgende Analy  sendaten ergibt:     -          S:    berechnet 5;88%, gefunden 5,65%  N: berechnet     5,14%,    gefunden 5,25%  Durch Lösen der Säure in     Sodalösnng    auf  Zusatz von Sprit erhält' man das wasserlös  liche     Natriumsalz.  



  Process for the preparation of N, N'-4,4'-diphthalylamino-diphenylsulfone. The present invention is a process for the preparation of N, N'-4,4'-diphthalyl-amino-diphenylsalfon, wel Ches is characterized in that 4,4'-diaininodiphenylsulfone with phthalic anby drid in acetic acid solution at room temperature.



  The new compound is to be used as a drug and as an intermediate in the manufacture of drugs. <I> Example: </I> 17.4 g of 4,4'-diaminodiphenyl sulfone are dissolved in glacial acetic acid and an acetic acid solution of 21 g of phthalic acid anhydride is added at room temperature. After standing for a while, it is poured onto ice water and filtered from the precipitate which has separated out, which, when recrystallized from water, is a pale yellowish colored crystal powder with a melting point above 300.

   By precipitating from soda solution with dilute hydrochloric acid, the pure condensation product C @ $ H- # QO "N, S is obtained, the following analysis data results: - S: calculated 5; 88%, found 5.65% N: Calculated 5.14%, found 5.25% By dissolving the acid in soda solution with the addition of fuel, the water-soluble sodium salt is obtained.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von N,N'-4,4'- Diphthalylamino-diphenylsulfon, dadurch ge- kenuzeichnet, dass man 4,4'-Diaminodiphenyl- sulfon mit Phthalsäureanhydrid in essigsau rer Lösung bei Raumtemperatur umsetzt. Das so erhaltene neue Produkt 'bildet-ein sehwach gelblich gefärbtes Kristallpulver mit einem Schmelzpunkt von über 300 , das. in Form seines Natriumsalzes in Wasser lös lich ist. PATENT CLAIM: Process for the production of N, N'-4,4'-diphthalylamino-diphenylsulfone, characterized in that 4,4'-diaminodiphenylsulfone is reacted with phthalic anhydride in acetic acid solution at room temperature. The new product obtained in this way forms a visibly yellowish colored crystal powder with a melting point of over 300, which is soluble in water in the form of its sodium salt.
CH235434D 1942-12-03 1942-12-03 Process for the preparation of N, N'-4,4'-diphthalylamino-diphenylsulfone. CH235434A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH235434T 1942-12-03
CH232604T 1942-12-03

Publications (1)

Publication Number Publication Date
CH235434A true CH235434A (en) 1944-11-30

Family

ID=25727743

Family Applications (1)

Application Number Title Priority Date Filing Date
CH235434D CH235434A (en) 1942-12-03 1942-12-03 Process for the preparation of N, N'-4,4'-diphthalylamino-diphenylsulfone.

Country Status (1)

Country Link
CH (1) CH235434A (en)

Similar Documents

Publication Publication Date Title
CH235434A (en) Process for the preparation of N, N&#39;-4,4&#39;-diphthalylamino-diphenylsulfone.
DE1000395C2 (en) Process for the preparation of substituted 4-oxycoumarins
CH235440A (en) Process for the preparation of 4-quinolinylamino-4&#39;-acetylaminodiphenylsulfone.
DE897103C (en) Process for the preparation of 2-diphenylacetyl-1, 3-indanedione and its non-toxic metal salts
CH312530A (en) Process for making a pyridazone.
DE216270C (en)
DE747472C (en) Process for the preparation of alkenylquinoline-4-carboxylic acids and their salts
Clark et al. Tephrosin. II. Isotephrosin
DE433099C (en) Process for the preparation of oxindole-3-acetic acids and their homologues which are halogen-substituted in the aromatic nucleus
DE927149C (en) Process for the production of hexachlorindenone and pentachloroxyindenone or of 1,3-diketohexachlorohydrindene
AT311332B (en) Process for the preparation of a new ester of 3,3-bis (p-hydroxyphenyl) -2-indolinone and its salts
DE234054C (en)
AT262298B (en) Process for the preparation of the new 2- (N &lt;4&gt; -phthaloyl) -sulfanilamido-5-methoxypyrimidine or its salts with non-toxic bases
DE654559C (en) Process for the preparation of naphthalenedicarboxylic acid derivatives
DE609025C (en) Process for the preparation of condensation products of the arylene thiazole series
DE600708C (en) Process for the preparation of 2- [3-acylamino-6-halobenzyl] -benzoic acids
DE474560C (en) Process for the preparation of chlorine substitution products of the halides of arylthioglycolic acids
DE462137C (en) Process for the preparation of primary amino alcohols of the quinoline series
DE677327C (en) Process for the preparation of 1, 4-dichloroanthraquinone and its substitution products
DE745127C (en) Process for the preparation of oxyarylsulfones
DE589146C (en) Process for the preparation of C, C-disubstituted barbituric acids
CH205078A (en) Process for the preparation of a new compound of the thiazolidine series.
DE528113C (en) Process for the preparation of pyridinarsic acids
CH235435A (en) Process for the preparation of 4-phthalylamino-4&#39;-acetylamino-diphenylsulfone.
CH187361A (en) Process for the preparation of N1N2-di- (2-methyl-4-aminoquinolyl-6) -melamine.