CH187362A - Process for the production of symm. Cyanuric acid di (2-methyl-4-aminoquinolyl-6) diamide. - Google Patents

Process for the production of symm. Cyanuric acid di (2-methyl-4-aminoquinolyl-6) diamide.

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Publication number
CH187362A
CH187362A CH187362DA CH187362A CH 187362 A CH187362 A CH 187362A CH 187362D A CH187362D A CH 187362DA CH 187362 A CH187362 A CH 187362A
Authority
CH
Switzerland
Prior art keywords
methyl
diamide
symm
production
aminoquinolyl
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH187362A publication Critical patent/CH187362A/en

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Description

  

  Verfahren zur Herstellung von     symm.        Cyanursäure-di-          (2-methyl-4-aminoehinolyl-6)-diamid.       Gegenstand des vorliegenden Patentes ist  ein Verfahren zur Herstellung von     symm.          Cyanursäure-di-(2-methyl-4-aminochinolyT-6)-          diamid,    das dadurch gekennzeichnet ist, dass  man etwa 2     Mol        4#6-Diarhino-2-methyl-          chinolin    mit etwa einem     Mol        Cyanurchlorid     umsetzt, und das so erhaltene     Dihydrochlorid     des     NiN2-Di(2-methyl-4-aminocIiinolyl-6)

  -          chlorcyanurdiamids    mit Mineralsäuren erhitzt.  



  Die neue Verbindung bildet ein leicht  wasserlösliches     Dihydrochlorid,    sie zersetzt  sich gegen 290  . Sie soll als Arzneimittel  Verwendung finden.  



  <I>Beispiel:</I>  19 g 4 -     6-Diamino-2-methylchinolin,    ge  löst in 150     cm3        Eisessig,    werden unter Rühren  bei     Wasserbadtemperatur    mit 10 g     Cyanur-          chlorid    versetzt. Es bildet sich ein farbloser  Brei, der nach etwa zweistündigem Erwärmen    abgesaugt und mit heissem Eisessig und  Äther gewaschen wird. Das farblose, feine  Pulver stellt das     Dihydrochlorid    des     NiNz-          Di-        (2-methyl-4-aminocbinolyl-6)-chlorcyanui@-          diamids    dar.  



  25 g dieser Verbindung werden etwa       '/g    Stunde mit 300     cm3    2     n-Salzsäure    unter       Rückfluss    gekocht. Nach dem Erkalten wird  das gebildete     Dihydrochlorid    obiger Verbin  dung abgesaugt und mit Aceton gewaschen.  Ausbeute 20 g. Es geht beim Erwärmen mit  Wasser leicht in Lösung, die Lösung ist  dickflüssig. Mit Hilfe von verdünnter Natron  lauge wird aus der Lösung die freie Base  ausgefällt. Sie. ist in     alkoholisch-wässeriger     Natronlauge löslich, wird jedoch durch viel  Wasser wieder gefällt. Mit viel Alkohol  geht sie bei längerem Kochen in Lösung.  Sie zersetzt sich unter Dunkelfärbung gegen  <B>2900.</B>



  Process for the production of symm. Cyanuric acid di (2-methyl-4-aminoehinolyl-6) diamide. The present patent is a process for the production of symm. Cyanuric acid di (2-methyl-4-aminoquinolyT-6) - diamide, which is characterized in that about 2 moles of 4 # 6-diarhino-2-methyl-quinoline are reacted with about one mole of cyanuric chloride, and the resultant NiN2-Di (2-methyl-4-aminocIiinolyl-6) dihydrochloride

  - Chlorcyanurdiamids heated with mineral acids.



  The new compound forms a readily water-soluble dihydrochloride, it decomposes against 290. It should be used as a medicine.



  <I> Example: </I> 19 g of 4-6-diamino-2-methylquinoline, dissolved in 150 cm3 of glacial acetic acid, are mixed with 10 g of cyanuric chloride while stirring at the water bath temperature. A colorless paste forms which, after heating for about two hours, is suctioned off and washed with hot glacial acetic acid and ether. The colorless, fine powder is the dihydrochloride of NiNz-di- (2-methyl-4-aminocbinolyl-6) -chlorcyanui @ - diamide.



  25 g of this compound are refluxed with 300 cm3 of 2N hydrochloric acid for about 1 / g hour. After cooling, the dihydrochloride formed is filtered off with suction and washed with acetone. Yield 20g. It easily dissolves when heated with water, the solution is thick. The free base is precipitated from the solution with the aid of dilute sodium hydroxide solution. You. is soluble in alcoholic aqueous sodium hydroxide solution, but is precipitated again with a lot of water. With a lot of alcohol, it will dissolve after prolonged cooking. It decomposes with a darkening to <B> 2900. </B>

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von symm. Cyan ursäure-di- (2-methyl-4-aminochinolyl-6)- diamid, dadurch gekennzeichnet, dass man etwa 2 Mol 4 # 6-Diamino-2-methylchinolin mit etwa einem Mol Cyanurchlorid umsetzt, das so erhaltene Dihydrochlorid des NiN2- Di (2-methyl-4-aminochinolyl-6) PATENT CLAIM: Process for the production of symm. Cyanuric acid di- (2-methyl-4-aminochinolyl-6) - diamide, characterized in that about 2 moles of 4 # 6-diamino-2-methylquinoline are reacted with about one mole of cyanuric chloride, the resulting dihydrochloride of NiN2- Di (2-methyl-4-aminoquinolyl-6) -chlorcyanur- diamids mit Mineralsäuren erhitzt und mit Hilfe von Natronlauge die freie Base asn der Lösung ausfällt. Die neue Verbindung bildet ein leicht wasserlösliches Dibydrochlorid, sie zersetzt sich gegen<B>2900.</B> Sie soll als Arzneimittel Verwendung finden. -chlorcyanur- diamids heated with mineral acids and with the help of sodium hydroxide solution the free base precipitates asn the solution. The new compound forms a readily water-soluble dibydrochloride, it decomposes to <B> 2900. </B> It is said to be used as a medicinal product.
CH187362D 1932-11-04 1933-10-04 Process for the production of symm. Cyanuric acid di (2-methyl-4-aminoquinolyl-6) diamide. CH187362A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE187362X 1932-11-04
CH184422T 1933-10-04

Publications (1)

Publication Number Publication Date
CH187362A true CH187362A (en) 1936-10-31

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ID=25721032

Family Applications (1)

Application Number Title Priority Date Filing Date
CH187362D CH187362A (en) 1932-11-04 1933-10-04 Process for the production of symm. Cyanuric acid di (2-methyl-4-aminoquinolyl-6) diamide.

Country Status (1)

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CH (1) CH187362A (en)

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